Targeting Gas6/TAM in cancer cells and tumor microenvironment

Knockdown of AXL Receptor Tyrosine Kinase in Osteosarcoma Cells Leads to Decreased Proliferation and Increased Apoptosis

(2017) Y. Zhang et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Tumor microenvironment (TME)-driven immune suppression in B cell malignancy

(2016) Nicole S. Nicholas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanosensing Controlled Directly by Tyrosine Kinases

(2016) Bo Yang et al.   NANO LETTERS

Pathways of parallel progression

(2016) Cyrus M. Ghajar et al.   NATURE

Erratum: Aberrant Mer receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia

(2016) A B Lee-Sherick et al.   ONCOGENE

MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme

(2016) Alexandra Sufit et al.   PLoS One

TAM Receptor–Dependent Regulation of SOCS3 and MAPKs Contributes to Proinflammatory Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages

(2015) Shasha Zheng et al.   JOURNAL OF IMMUNOLOGY

AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective

(2015) Samuel H. Myers et al.   JOURNAL OF MEDICINAL CHEMISTRY

Polarization of tumor-associated macrophages and Gas6/Axl signaling in oral squamous cell carcinoma

(2015) Kuo-Chou Chiu et al.   ORAL ONCOLOGY

Axl inhibition: a potential road to a novel acute myeloid leukemia therapy?

(2015) Melanie Janning et al.   Expert Review of Hematology

Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells

(2015) Mikaella Vouri et al.   Oncotarget

The role of AXL and the in vitro activity of the receptor tyrosine kinase inhibitor BGB324 in Ewing sarcoma

(2015) Emmy D.G. Fleuren et al.   Oncotarget

Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancer

(2015) Christopher T. Cummings et al.   Oncotarget

Axl as a mediator of cellular growth and survival

(2015) Haley Axelrod et al.   Oncotarget

GAS6/AXL Axis Regulates Prostate Cancer Invasion, Proliferation, and Survival in the Bone Marrow Niche

(2015) Yusuke Shiozawa et al.   NEOPLASIA

Prevalence of Prostate Cancer Metastases after Intravenous Inoculation Provides Clues into the Molecular Basis of Dormancy in the Bone Marrow Microenvironment

(2015) Younghun Jung et al.   NEOPLASIA

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

(2014) Magdalena Paolino et al.   NATURE

An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis

(2014) Mihalis S Kariolis et al.   Nature Chemical Biology

Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

(2014) Erin D Lew et al.   eLife

Gas6/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma patients

(2013) Ju Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gas6 induces cancer cell migration and epithelial–mesenchymal transition through upregulation of MAPK and Slug

(2013) Yunhee Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Evaluation of Tyro3 Expression, Gas6-Mediated Akt Phosphorylation, and the Impact of Anti-Tyro3 Antibodies in Melanoma Cell Lines

(2013) Stephen J. Demarest et al.   BIOCHEMISTRY

Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma

(2013) I. Ben-Batalla et al.   BLOOD

M1 and M2 Macrophages: Oracles of Health and Disease

(2013) Charles Mills   CRITICAL REVIEWS IN IMMUNOLOGY

MERTK receptor tyrosine kinase is a therapeutic target in melanoma

(2013) Jennifer Schlegel et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppression of SERPINA1-albumin complex formation by galectin-3 overexpression leads to paracrine growth promotion of chronic myelogenous leukemia cells

(2013) Ryuko Nakayama et al.   LEUKEMIA RESEARCH

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

(2013) Muhammed Murtaza et al.   NATURE

First Axl inhibitor enters clinical trials

(2013) Cormac Sheridan   NATURE BIOTECHNOLOGY

Aberrant Mer receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia

(2013) A B Lee-Sherick et al.   ONCOGENE

Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival

(2013) S Ammoun et al.   ONCOGENE

Preclinical validation of AXL receptor as a target for antibody-based pancreatic cancer immunotherapy

(2013) W Leconet et al.   ONCOGENE

Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer

(2013) L. Bosurgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biology of the TAM Receptors

(2013) G. Lemke   Cold Spring Harbor Perspectives in Biology

Inhibition of MerTK increases chemosensitivity and decreases oncogenic potential in T-cell acute lymphoblastic leukemia

(2013) L N Brandao et al.   Blood Cancer Journal

Meta-Analysis of Microarray Data IdentifiesGAS6Expression as an Independent Predictor of Poor Survival in Ovarian Cancer

(2013) Michelle Buehler et al.   Biomed Research International

Proteomic Profiling of Androgen-independent Prostate Cancer Cell Lines Reveals a Role for Protein S during the Development of High Grade and Castration-resistant Prostate Cancer

(2012) Punit Saraon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia Stabilizes GAS6/Axl Signaling in Metastatic Prostate Cancer

(2012) Anjali Mishra et al.   MOLECULAR CANCER RESEARCH

Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer

(2012) R M A Linger et al.   ONCOGENE

Activation of TYRO3/AXL Tyrosine Kinase Receptors in Thyroid Cancer

(2011) E. Avilla et al.   CANCER RESEARCH

SLUG promotes prostate cancer cell migration and invasion via CXCR4/CXCL12 axis

(2011) Berna Uygur et al.   Molecular Cancer

Galectin-3C Inhibits Tumor Growth and Increases the Anticancer Activity of Bortezomib in a Murine Model of Human Multiple Myeloma

(2011) Leonardo Mirandola et al.   PLoS One

GCS-100, a novel galectin-3 antagonist, modulates MCL-1, NOXA, and cell cycle to induce myeloma cell death

(2010) M. J. Streetly et al.   BLOOD

Induction, regulation, and biologic function of Axl receptor tyrosine kinase in Kaposi sarcoma

(2010) R. Liu et al.   BLOOD

Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma

(2010) Xianzhou Song et al.   CANCER

R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer

(2010) S. J. Holland et al.   CANCER RESEARCH

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

A systems view of epithelial–mesenchymal transition signaling states

(2010) Stuart Thomson et al.   CLINICAL & EXPERIMENTAL METASTASIS

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies

(2010) X Ye et al.   ONCOGENE

Slug/SNAI2 regulates cell proliferation and invasiveness of metastatic prostate cancer cell lines

(2010) Modjtaba Emadi Baygi et al.   TUMOR BIOLOGY

Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6

(2009) S. Loges et al.   BLOOD

Novel Mechanism of Lapatinib Resistance in HER2-Positive Breast Tumor Cells: Activation of AXL

(2009) L. Liu et al.   CANCER RESEARCH

Silencing of galectin-3 changes the gene expression and augments the sensitivity of gastric cancer cells to chemotherapeutic agents

(2009) Teak-Chin Cheong et al.   CANCER SCIENCE

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Lack of Protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis

(2009) Tal Burstyn-Cohen et al.   JOURNAL OF CLINICAL INVESTIGATION

Proliferation of vascular smooth muscle cells in glioblastoma multiforme

(2009) Hiroaki Takeuchi et al.   JOURNAL OF NEUROSURGERY

Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis

(2009) Y Li et al.   ONCOGENE

Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

(2009) C. Gjerdrum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of protein C (PC), protein S (PS) and thrombomodulin (TM) in human colorectal cancer

(2009) Ewa Sierko et al.   THROMBOSIS RESEARCH

Axl and Growth Arrest Specific Gene 6 Are Frequently Overexpressed in Human Gliomas and Predict Poor Prognosis in Patients with Glioblastoma Multiforme

(2008) M. Hutterer et al.   CLINICAL CANCER RESEARCH

Proteomic Analysis of Ovarian Cancer Cells Reveals Dynamic Processes of Protein Secretion and Shedding of Extra-Cellular Domains

(2008) Vitor M. Faça et al.   PLoS One

Transitions between epithelial and mesenchymal states in development and disease

(2008) Buzz Baum et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY