Antitumor activity of an engineered decoy receptor targeting CLCF1–CNTFR signaling in lung adenocarcinoma

Comparing and contrasting predictive biomarkers for immunotherapy and targeted therapy of NSCLC

(2019) D. Ross Camidge et al.   Nature Reviews Clinical Oncology

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

(2019) Yu Shi et al.   NATURE

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

(2018) Jianfang Liu et al.   CELL

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

(2018) Matthew R. Janes et al.   CELL

CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

(2018) Shicheng Su et al.   CELL

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase

(2018) Dietrich A. Ruess et al.   NATURE MEDICINE

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

(2018) Gabrielle S. Wong et al.   NATURE MEDICINE

SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo

(2018) Sara Mainardi et al.   NATURE MEDICINE

Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer

(2018) Leena Gandhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden

(2018) Matthew D. Hellmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

MicroRNA-21 in cancer-associated fibroblasts supports lung adenocarcinoma progression

(2018) Akiko Kunita et al.   Scientific Reports

RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers

(2018) Robert J. Nichols et al.   NATURE CELL BIOLOGY

Neoadjuvant PD-1 Blockade in Resectable Lung Cancer

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy

(2018) Kieren D. Marini et al.   Science Translational Medicine

Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS

(2017) Zhan Yao et al.   NATURE

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

(2017) Anna Labernadie et al.   NATURE CELL BIOLOGY

Targeting ALK: Precision Medicine Takes on Drug Resistance

(2017) Jessica J. Lin et al.   Cancer Discovery

IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis

(2016) G. D. Brooks et al.   CANCER RESEARCH

Engineering antibody therapeutics

(2016) Mark L Chiu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy

(2016) X. Wu et al.   MOLECULAR CANCER THERAPEUTICS

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

(2016) Jonathan M. L. Ostrem et al.   NATURE REVIEWS DRUG DISCOVERY

Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism

(2016) P. Lito et al.   SCIENCE

Emerging Strategies for Developing Next-Generation Protein Therapeutics for Cancer Treatment

(2016) James R. Kintzing et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition

(2015) Zhan Yao et al.   CANCER CELL

Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

(2015) J. C. Hunter et al.   MOLECULAR CANCER RESEARCH

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts

(2015) Jean Albrengues et al.   Nature Communications

Acquired resistance to TKIs in solid tumours: learning from lung cancer

(2014) D. Ross Camidge et al.   Nature Reviews Clinical Oncology

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Aflibercept—a Decoy VEGF Receptor

(2014) Kristen K. Ciombor et al.   Current Oncology Reports

Regulation of Hypoxia-inducible Factor 1α (HIF-1α) by Lysophosphatidic Acid Is Dependent on Interplay between p53 and Krüppel-like Factor 5

(2013) Sei-Jung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The quest to overcome resistance to EGFR-targeted therapies in cancer

(2013) Curtis R Chong et al.   NATURE MEDICINE

Neuronal STAT3 activation is essential for CNTF- and inflammatory stimulation-induced CNS axon regeneration

(2013) M Leibinger et al.   Cell Death & Disease

Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non-Small Cell Lung Cancer In Vivo

(2012) S. Vicent et al.   CANCER RESEARCH

CNTF receptor subunit α as a marker for glioma tumor-initiating cells and tumor grade

(2012) Jie Lu et al.   JOURNAL OF NEUROSURGERY

Methyl-CpG binding column-based identification of nine genes hypermethylated in colorectal cancer

(2011) Paulina Kober et al.   MOLECULAR CARCINOGENESIS

gp130 at the nexus of inflammation, autoimmunity, and cancer

(2010) J. S. Silver et al.   JOURNAL OF LEUKOCYTE BIOLOGY

High-Resolution, Small Animal Radiation Research Platform With X-Ray Tomographic Guidance Capabilities

(2008) John Wong et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Ciliary Neurotrophic Factor, Cardiotrophin-like Cytokine, and Neuropoietin Share a Conserved Binding Site on the Ciliary Neurotrophic Factor Receptor α Chain

(2008) François Rousseau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY