Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity

Myeloid Cell COX-2 deletion reduces mammary tumor growth through enhanced cytotoxic T-lymphocyte function

(2014) Edward P. Chen et al.   CARCINOGENESIS

Functional expression cloning identifies COX-2 as a suppressor of antigen-specific cancer immunity

(2014) C Göbel et al.   Cell Death & Disease

Interleukin-17 Indirectly Promotes M2 Macrophage Differentiation through Stimulation of COX-2/PGE2 Pathway in the Cancer Cells

(2014) Qingli Li et al.   Cancer Research and Treatment

Regulatory T cells in cancer: An overview and perspectives on Cyclooxygenase-2 and Foxp3 DNA methylation

(2013) Mehmet Sahin et al.   HUMAN IMMUNOLOGY

Cyclooxygenase-2 Inhibition Blocks M2 Macrophage Differentiation and Suppresses Metastasis in Murine Breast Cancer Model

(2013) Yi-Rang Na et al.   PLoS One

Prostaglandin E2 (PGE2) suppresses natural killer cell function primarily through the PGE2 receptor EP4

(2011) Dawn Holt et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Deletion of cyclooxygenase 2 in mouse mammary epithelial cells delays breast cancer onset through augmentation of type 1 immune responses in tumors

(2011) Nune Markosyan et al.   CARCINOGENESIS

PGE2 inhibits natural killer and γδ T cell cytotoxicity triggered by NKR and TCR through a cAMP-mediated PKA type I-dependent signaling

(2010) Ludovic Martinet et al.   BIOCHEMICAL PHARMACOLOGY

Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity

(2010) David G. DeNardo et al.   CANCER AND METASTASIS REVIEWS

Pivotal Advance: Tumor-mediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE2 catabolism in myeloid cells

(2010) Evgeniy Eruslanov et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

(2009) A. Greenhough et al.   CARCINOGENESIS

Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner

(2009) Xiang-Liang Yuan et al.   CLINICAL IMMUNOLOGY

Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung

(2009) R. E. Harris   INFLAMMOPHARMACOLOGY

Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK function

(2008) Namita Kundu et al.   BREAST CANCER RESEARCH AND TREATMENT

Cyclooxygenase-2 in Synaptic Signaling

(2008) Hongwei Yang et al.   CURRENT PHARMACEUTICAL DESIGN