Obesity and aging: Molecular mechanisms and therapeutic approaches

Grape seed polyphenol extract and cognitive function in healthy young adults: a randomised, placebo-controlled, parallel-groups acute-on-chronic trial

(2020) Lynne Bell et al.   NUTRITIONAL NEUROSCIENCE

Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells

(2020) Sabena M. Conley et al.   Frontiers in Cell and Developmental Biology

Methionine Restriction Alleviates High-Fat Diet-induced Obesity: Involvement of Diurnal Metabolism of Lipids and Bile Acids

(2020) Luanfeng Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Redox regulation by NRF2 in aging and disease

(2019) Cody J. Schmidlin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Possible anti-obesity effects of phytosterols and phytostanols supplementation in humans: A systematic review and dose-response meta-analysis of randomized controlled trials

(2019) Ehsan Ghaedi et al.   PHYTOTHERAPY RESEARCH

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

(2019) Allyson K. Palmer et al.   AGING CELL

Acarbose improves health and lifespan in aging HET3 mice

(2019) David E. Harrison et al.   AGING CELL

Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice

(2019) Byron J Smith et al.   BMC MICROBIOLOGY

Parthenolide, a feverfew-derived phytochemical, ameliorates obesity and obesity-induced inflammatory responses via the Nrf2/Keap1 pathway

(2019) Chae Young Kim et al.   PHARMACOLOGICAL RESEARCH

Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

(2019) Slaven Stekovic et al.   Cell Metabolism

Omega-3 Fatty Acids and Neurodegenerative Diseases: New Evidence in Clinical Trials

(2019) Rossella Avallone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Early genistein exposure of California mice and effects on the gut microbiota–brain axis

(2019) Brittney L Marshall et al.   JOURNAL OF ENDOCRINOLOGY

Punicalagin, a Pomegranate‐Derived Ellagitannin, Suppresses Obesity and Obesity‐Induced Inflammatory Responses Via the Nrf2/Keap1 Signaling Pathway

(2019) Bobin Kang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The FoxO–Autophagy Axis in Health and Disease

(2019) Zhiyong Cheng   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Proteostasis failure and cellular senescence in long‐term cultured postmitotic rat neurons

(2019) Shoma Ishikawa et al.   AGING CELL

A Novel Anti-Inflammatory Role of Omega-3 PUFAs in Prevention and Treatment of Atherosclerosis and Vascular Cognitive Impairment and Dementia

(2019) Marialaura Simonetto et al.   Nutrients

Protective effects of phenformin on zebrafish embryonic neurodevelopmental toxicity induced by X-ray radiation

(2019) Lu Gan et al.   Artificial Cells Nanomedicine and Biotechnology

The Ketogenic Diet: Evidence for Optimism but High-Quality Research Needed

(2019) David S Ludwig   JOURNAL OF NUTRITION

Ablation of PPARγ in subcutaneous fat exacerbates age-associated obesity and metabolic decline

(2018) Lingyan Xu et al.   AGING CELL

Higher spermidine intake is linked to lower mortality: a prospective population-based study

(2018) Stefan Kiechl et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Senescence Alters PPARγ (Peroxisome Proliferator–Activated Receptor Gamma)-Dependent Fatty Acid Handling in Human Adipose Tissue Microvascular Endothelial Cells and Favors InflammationHighlights

(2018) Anaïs Briot et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

(2018) Sarah J. Mitchell et al.   Cell Metabolism

Tofogliflozin decreases body fat mass and improves peripheral insulin resistance

(2018) Ren Matsuba et al.   DIABETES OBESITY & METABOLISM

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial dysfunction in obesity

(2018) Aline Haas de Mello et al.   LIFE SCIENCES

Pattern of polyphenol intake and the long-term risk of dementia in older persons

(2018) Sophie Lefèvre-Arbogast et al.   NEUROLOGY

Metabolic effects, safety, and acceptability of very low-calorie ketogenic dietetic scheme on candidates for bariatric surgery

(2018) Vincenzo Pilone et al.   Surgery for Obesity and Related Diseases

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-aged Adults in the Framingham Study

(2018) Galit Weinstein et al.   JAMA Neurology

Parallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity

(2018) William Trim et al.   Frontiers in Immunology

Effects of SGLT2 inhibitors on systemic and tissue low-grade inflammation: the potential contribution to diabetes complications and cardiovascular disease

(2018) Fabrice Bonnet et al.   DIABETES & METABOLISM

Increased Tau Phosphorylation and Impaired Brain Insulin/IGF Signaling in Mice Fed a High Fat/High Cholesterol Diet

(2018) Narayan R. Bhat et al.   JOURNAL OF ALZHEIMERS DISEASE

Long-Term Metformin Usage and Cognitive Function among Older Adults with Diabetes

(2018) Tze Pin Ng et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of mitochondria in aging

(2018) Ji Yong Jang et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic Green Tea Consumption Decreases Body Mass, Induces Aromatase Expression, and Changes Proliferation and Apoptosis in Adult Male Rat Adipose Tissue

(2018) Rosário Monteiro et al.   JOURNAL OF NUTRITION

The Major Green Tea Polyphenol, (-)-Epigallocatechin-3-Gallate, Inhibits Obesity, Metabolic Syndrome, and Fatty Liver Disease in High-Fat–Fed Mice

(2018) Mousumi Bose et al.   JOURNAL OF NUTRITION

Green Tea Extract Protects Leptin-Deficient, Spontaneously Obese Mice from Hepatic Steatosis and Injury

(2018) Richard S. Bruno et al.   JOURNAL OF NUTRITION

β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

(2018) Young-min Han et al.   MOLECULAR CELL

Red ginseng-derived saponin fraction suppresses the obesity-induced inflammatory responses via Nrf2-HO-1 pathway in adipocyte-macrophage co-culture system

(2018) Chae Young Kim et al.   BIOMEDICINE & PHARMACOTHERAPY

Intracerebroventricular injection of resveratrol ameliorated Aβ-induced learning and cognitive decline in mice

(2018) Yu Qi et al.   METABOLIC BRAIN DISEASE

Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4

(2018) Ryan Kolb et al.   ONCOGENE

Glycolytic Inhibitor 2-Deoxy-D-Glucose at Chronic Low Dose Mimics Calorie Restriction in Rats Through Mitohormetic Induction of Reactive Oxygen Species

(2018) Komal Saraswat et al.   REJUVENATION RESEARCH

Moderate weight loss attenuates chronic endoplasmic reticulum stress and mitochondrial dysfunction in human obesity

(2018) Sandra López-Domènech et al.   Molecular Metabolism

Canagliflozin, a sodium glucose cotransporter 2 inhibitor, attenuates obesity-induced inflammation in the nodose ganglion, hypothalamus, and skeletal muscle of mice

(2017) Farhana Naznin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Changes in telomere length 3–5 years after gastric bypass surgery

(2017) R Dershem et al.   INTERNATIONAL JOURNAL OF OBESITY

The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury

(2017) Hassan Al-Ali et al.   JOURNAL OF NEUROSCIENCE

Phytosterols improve immunity and exert anti-inflammatory activity in weaned piglets

(2017) Qiaoling Hu et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Obesity in geroscience — is cellular senescence the culprit?

(2017) Claudio Franceschi   Nature Reviews Endocrinology

The effects of omega-3 fatty acids and vitamin E co-supplementation on clinical and metabolic status in patients with Parkinson's disease: A randomized, double-blind, placebo-controlled trial

(2017) Mohsen Taghizadeh et al.   NEUROCHEMISTRY INTERNATIONAL

Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty

(2017) Michael B. Stout et al.   PHYSIOLOGY

Physical activity and telomere length in U.S. men and women: An NHANES investigation

(2017) Larry A. Tucker   PREVENTIVE MEDICINE

Polyphenol Levels Are Inversely Correlated with Body Weight and Obesity in an Elderly Population after 5 Years of Follow Up (The Randomised PREDIMED Study)

(2017) Xiaohui Guo et al.   Nutrients

Metformin extends C. elegans lifespan through lysosomal pathway

(2017) Jie Chen et al.   eLife

Omega-3 polyunsaturated fatty acids for cardiovascular diseases: present, past and future

(2017) Yasuhiro Watanabe et al.   Expert Review of Clinical Pharmacology

The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature

(2017) Danny Ben-Avraham et al.   Science Advances

Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK

(2017) Sung-Jun Park et al.   EBioMedicine

The etiology of oxidative stress in insulin resistance

(2017) Samantha Hurrle et al.   Biomedical Journal

The effects of graded levels of calorie restriction: VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways

(2016) Davina Derous et al.   Aging-US

Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: a substudy of the PREDIMED trial

(2016) Alexander Medina-Remón et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The potential health effects of dietary phytoestrogens

(2016) Ivonne M C M Rietjens et al.   BRITISH JOURNAL OF PHARMACOLOGY

Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease

(2016) José J. Fuster et al.   CIRCULATION RESEARCH

Molecular mechanisms of appetite and obesity: a role for brain AMPK

(2016) P. B. Martinez de Morentin et al.   CLINICAL SCIENCE

A short leucocyte telomere length is associated with development of insulin resistance

(2016) Simon Verhulst et al.   DIABETOLOGIA

Ketogenic diet treatment increases longevity inKcna1-null mice, a model of sudden unexpected death in epilepsy

(2016) Kristina A. Simeone et al.   EPILEPSIA

Hepatic Steatosis and Insulin Resistance, But Not Steatohepatitis, Promote Atherogenic Dyslipidemia in NAFLD

(2016) Fernando Bril et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

(2016) Do-Geun Kim et al.   Journal of Neuroinflammation

The PI3K/Akt/mTOR pathway regulates the replicative senescence of human VSMCs

(2016) Pan Tan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

(2016) Aharon Helman et al.   NATURE MEDICINE

A diet enriched with plant sterols prevents the memory impairment induced by cholesterol loss in senescence-accelerated mice

(2016) Azucena Pérez-Cañamás et al.   NEUROBIOLOGY OF AGING

Nonalcoholic fatty liver disease is associated with cognitive function in adults

(2016) Sang Won Seo et al.   NEUROLOGY

A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity

(2016) Victoria A. Catenacci et al.   Obesity

Role of Antioxidants and Natural Products in Inflammation

(2016) Palanisamy Arulselvan et al.   Oxidative Medicine and Cellular Longevity

Endocrine disruption by dietary phyto-oestrogens: impact on dimorphic sexual systems and behaviours

(2016) Heather B. Patisaul   PROCEEDINGS OF THE NUTRITION SOCIETY

Obesity-associated NLRC4 inflammasome activation drives breast cancer progression

(2016) Ryan Kolb et al.   Nature Communications

Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy

(2016) J. Incio et al.   Cancer Discovery

Short-term safety, tolerability and efficacy of a very low-calorie-ketogenic diet interventional weight loss program versus hypocaloric diet in patients with type 2 diabetes mellitus

(2016) A Goday et al.   Nutrition & Diabetes

Polyamines in aging and disease

(2016) Nadège Minois et al.   Aging-US

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Obesity and Cancer: Local and Systemic Mechanisms

(2015) Neil M. Iyengar et al.   Annual Review of Medicine

Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice

(2015) Yiqiang Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Chronic acarbose treatment alleviates age-related behavioral and biochemical changes in SAMP8 mice

(2015) Jing-Jing Tong et al.   BEHAVIOURAL BRAIN RESEARCH

Long-term acarbose administration alleviating the impairment of spatial learning and memory in the SAMP8 mice was associated with alleviated reduction of insulin system and acetylated H4K8

(2015) Wen-Wen Yan et al.   BRAIN RESEARCH

Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity

(2015) Sini Heinonen et al.   DIABETES

Roles of Nrf2 in cell proliferation and differentiation

(2015) Shohei Murakami et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of AMPK by metformin inhibits TGF-β-induced collagen production in mouse renal fibroblasts

(2015) Jiamei Lu et al.   LIFE SCIENCES

Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies

(2015) Prasenjit Manna et al.   Metabolic Syndrome and Related Disorders

Dietary supplementation with the polyphenol-rich açaí pulps (Euterpe oleracea Mart. and Euterpe precatoria Mart.) improves cognition in aged rats and attenuates inflammatory signaling in BV-2 microglial cells

(2015) Amanda N. Carey et al.   NUTRITIONAL NEUROSCIENCE

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Working stiff: How obesity boosts cancer risk

(2015) Lisa M. Arendt et al.   Science Translational Medicine

Years of life lost and healthy life-years lost from diabetes and cardiovascular disease in overweight and obese people: a modelling study

(2015) Steven A Grover et al.   Lancet Diabetes & Endocrinology

Obesity genetics in mouse and human: back and forth, and back again

(2015) Fereshteh T. Yazdi et al.   PeerJ

Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies

(2014) Mark Yarchoan et al.   ACTA NEUROPATHOLOGICA

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

MECHANISMS IN ENDOCRINOLOGY: White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ

(2014) Antonio Giordano et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Exogenous administration of spermine improves glucose utilization and decreases bodyweight in mice

(2014) Satish Kumar Sadasivan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Psychological and metabolic stress: A recipe for accelerated cellular aging?

(2014) Elissa Epel   Hormones-International Journal of Endocrinology and Metabolism

Oxidative Stress in Obesity: A Critical Component in Human Diseases

(2014) Lucia Marseglia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanism of Metformin-dependent Inhibition of Mammalian Target of Rapamycin (mTOR) and Ras Activity in Pancreatic Cancer

(2014) Vijayalekshmi Nair et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Short-Term High-Fat-and-Fructose Feeding Produces Insulin Signaling Alterations Accompanied by Neurite and Synaptic Reduction and Astroglial Activation in the Rat Hippocampus

(2014) Erika Calvo-Ochoa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

World Gastroenterology Organisation Global Guidelines

(2014) Douglas R. LaBrecque et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk

(2014) Fleur Lien et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration

(2014) Lindsay J. Spielman et al.   JOURNAL OF NEUROIMMUNOLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Type 2 Diabetes and Antidiabetic Medications in Relation to Dementia Diagnosis

(2014) Chin Cheng et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Caloric restriction mimetics: towards a molecular definition

(2014) Frank Madeo et al.   NATURE REVIEWS DRUG DISCOVERY

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease

(2014) Forouzan Faghihzadeh et al.   NUTRITION RESEARCH

Mechanisms of heart failure in obesity

(2014) Imo A. Ebong et al.   Obesity Research & Clinical Practice

Antiinflammatory Effect of Phytosterols in Experimental Murine Colitis Model: Prevention, Induction, Remission Study

(2014) Rita Aldini et al.   PLoS One

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

(2014) W. De Haes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prediabetes-induced vascular alterations exacerbate central pathology in APPswe/PS1dE9 mice

(2014) Juan Jose Ramos-Rodriguez et al.   PSYCHONEUROENDOCRINOLOGY

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

(2014) Sarah J. Mitchell et al.   Cell Reports

Association between Class III Obesity (BMI of 40–59 kg/m2) and Mortality: A Pooled Analysis of 20 Prospective Studies

(2014) Cari M. Kitahara et al.   PLOS MEDICINE

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

(2013) David E. Harrison et al.   AGING CELL

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation

(2013) Sarah Sczelecki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase

(2013) Peter Toth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Spermidine-triggered autophagy ameliorates memory during aging

(2013) Stephan J Sigrist et al.   Autophagy

Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathway

(2013) Yong-Na Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Benefit of physical fitness against inflammation in obesity: Role of beta adrenergic receptors

(2013) Suzi Hong et al.   BRAIN BEHAVIOR AND IMMUNITY

Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials

(2013) Nassib Bezerra Bueno et al.   BRITISH JOURNAL OF NUTRITION

Obesity Promotes Breast Cancer by CCL2-Mediated Macrophage Recruitment and Angiogenesis

(2013) L. M. Arendt et al.   CANCER RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation

(2013) Silvia Bijland et al.   CLINICAL SCIENCE

Long-term efficacy and safety of canagliflozin monotherapy in patients with type 2 diabetes inadequately controlled with diet and exercise: findings from the 52-week CANTATA-M study

(2013) Kaj Stenlöf et al.   CURRENT MEDICAL RESEARCH AND OPINION

MicroRNA-146b promotes adipogenesis by suppressing the SIRT1-FOXO1 cascade

(2013) Jiyun Ahn et al.   EMBO Molecular Medicine

High carbohydrate–low protein consumption maximizes Drosophila lifespan

(2013) Kimberley D. Bruce et al.   EXPERIMENTAL GERONTOLOGY

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

Phytoestrogens and the metabolic syndrome

(2013) Alois Jungbauer et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Metformin limits ceramide-induced senescence in C2C12 myoblasts

(2013) Kavita S. Jadhav et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities

(2013) Anna Hernández-Aguilera et al.   MEDIATORS OF INFLAMMATION

Green Tea Extract Supplementation Induces the Lipolytic Pathway, Attenuates Obesity, and Reduces Low-Grade Inflammation in Mice Fed a High-Fat Diet

(2013) Cláudio A. Cunha et al.   MEDIATORS OF INFLAMMATION

Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice

(2013) Virginia L. Malloy et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

(2013) Varun K Gupta et al.   NATURE NEUROSCIENCE

Canagliflozin: Effects in overweight and obese subjects without diabetes mellitus

(2013) Harold E. Bays et al.   Obesity

Correction: Green Tea Polyphenols Reduced Fat Deposits in High Fat-Fed Rats via erk1/2-PPARγ-Adiponectin Pathway

(2013) Chong Tian et al.   PLoS One

Deletion of Hepatic FoxO1/3/4 Genes in Mice Significantly Impacts on Glucose Metabolism through Downregulation of Gluconeogenesis and Upregulation of Glycolysis

(2013) Xiwen Xiong et al.   PLoS One

Ketone bodies as signaling metabolites

(2013) John C. Newman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage

(2012) C. Algire et al.   Cancer Prevention Research

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

Inflamm-ageing

(2012) Elisa Cevenini et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise

(2012) K. Stenlöf et al.   DIABETES OBESITY & METABOLISM

Physiological, pathological and potential therapeutic roles of adipokines

(2012) Inês Falcão-Pires et al.   DRUG DISCOVERY TODAY

Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue

(2012) X. Julia Xu et al.   JOURNAL OF LIPID RESEARCH

Metformin in cancer: translational challenges

(2012) Ryan J O Dowling et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Resveratrol attenuates oxidative damage and ameliorates cognitive impairment in the brain of senescence-accelerated mice

(2012) Gui-Shan Liu et al.   LIFE SCIENCES

The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001

(2012) Rebecca E. De Angel et al.   MOLECULAR CARCINOGENESIS

Green tea (-)-epigallocatechin gallate inhibits IGF-I and IGF-IIstimulation of 3T3-L1 preadipocyte mitogenesis via the 67-kDa laminin receptor, but not AMP-activated protein kinase pathway

(2012) Hui-Chen Ku et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

(2012) Nagalingam R Sundaresan et al.   NATURE MEDICINE

Green tea powder and Lactobacillus plantarum affect gut microbiota, lipid metabolism and inflammation in high-fat fed C57BL/6J mice

(2012) Ulrika Axling et al.   Nutrition & Metabolism

Green tea polyphenols benefits body composition and improves bone quality in long-term high-fat diet–induced obese rats

(2012) Chwan-Li Shen et al.   NUTRITION RESEARCH

Anti-obesity effect of resveratrol-amplified grape skin extracts on 3T3-L1 adipocytes differentiation

(2012) Xian-Hua Zhang et al.   Nutrition Research and Practice

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

PGC-1  Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

(2012) T. Tsunemi et al.   Science Translational Medicine

Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning

(2012) Michael N. Pollak   Cancer Discovery

“Is obesity linked to aging?”

(2011) Irene P. Tzanetakou et al.   AGEING RESEARCH REVIEWS

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Caloric restriction: powerful protection for the aging heart and vasculature

(2011) Edward P. Weiss et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondria removal by autophagy

(2011) Ke Wang et al.   Autophagy

Rapamycin Partially Mimics the Anticancer Effects of Calorie Restriction in a Murine Model of Pancreatic Cancer

(2011) Laura M. Lashinger et al.   Cancer Prevention Research

Metformin slows down aging and extends life span of female SHR mice

(2011) Vladimir N. Anisimov et al.   CELL CYCLE

Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo

(2011) Vladimir N. Anisimov et al.   CELL CYCLE

Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions

(2011) Bolin Liu et al.   CELL CYCLE

Sirtuin 1-Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin

(2011) Z. Zheng et al.   DIABETES

Minireview: IGF, Insulin, and Cancer

(2011) Emily J. Gallagher et al.   ENDOCRINOLOGY

Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high-fat-diet feeding

(2011) Aparna Purushotham et al.   FASEB JOURNAL

High molecular weight persimmon tannin ameliorates cognition deficits and attenuates oxidative damage in senescent mice induced by d-galactose

(2011) Yan Tian et al.   FOOD AND CHEMICAL TOXICOLOGY

Inflammation, Oxidative Stress, and Obesity

(2011) Alba Fernández-Sánchez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acute effects of epigallocatechin gallate from green tea on oxidation and tissue incorporation of dietary lipids in mice fed a high-fat diet

(2011) M Friedrich et al.   INTERNATIONAL JOURNAL OF OBESITY

Shorter telomeres are associated with obesity and weight gain in the elderly

(2011) O T Njajou et al.   INTERNATIONAL JOURNAL OF OBESITY

Effects of Green Tea Polyphenol (−)-Epigallocatechin-3-gallate on Newly Developed High-Fat/Western-Style Diet-Induced Obesity and Metabolic Syndrome in Mice

(2011) Yu-Kuo Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

An Integrative Genomics Approach Identifies Activation of Thioredoxin/Thioredoxin Reductase-1-Mediated Oxidative Stress Defense Pathway and Inhibition of Angiogenesis in Obese Nondiabetic Human Subjects

(2011) Swapan K. Das et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

(2011) Sandra Galic et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular Inflammation as an Underlying Mechanism of the Aging Process and Age-related Diseases

(2011) H.Y. Chung et al.   JOURNAL OF DENTAL RESEARCH

Green Tea Extract Suppresses NFκB Activation and Inflammatory Responses in Diet-Induced Obese Rats with Nonalcoholic Steatohepatitis

(2011) Hea Jin Park et al.   JOURNAL OF NUTRITION

Effects of genistein and daidzein on hippocampus neuronal cell proliferation and BDNF expression in H19-7 neural cell line

(2011) Meixia Pan et al.   Journal of Nutrition Health & Aging

Resveratrol improves cognitive function in mice by increasing production of insulin-like growth factor-I in the hippocampus

(2011) Naoaki Harada et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Green tea extract protects against nonalcoholic steatohepatitis in ob/ob mice by decreasing oxidative and nitrative stress responses induced by proinflammatory enzymes

(2011) Min-Yu Chung et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Aging-Associated Changes in Physical Performance and Energy Metabolism in the Senescence-Accelerated Mouse

(2011) S. Haramizu et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

(−)-Epigallocatechin-3-gallate blocks 3T3-L1 adipose conversion by inhibition of cell proliferation and suppression of adipose phenotype expression

(2011) Cheuk Ying Chan et al.   LIFE SCIENCES

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation

(2011) Brooks M. Hybertson et al.   MOLECULAR ASPECTS OF MEDICINE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Multiple signal pathways in obesity-associated cancer

(2011) J. Chen   Obesity Reviews

A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs

(2011) E L McKinsey et al.   ONCOGENE

2-Deoxy-D-Glucose Treatment Induces Ketogenesis, Sustains Mitochondrial Function, and Reduces Pathology in Female Mouse Model of Alzheimer's Disease

(2011) Jia Yao et al.   PLoS One

Fats, inflammation and insulin resistance: insights to the role of macrophage and T-cell accumulation in adipose tissue

(2011) Karen A. Harford et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Effect of exercise training intensity on murine T-regulatory cells and vaccination response

(2011) J. Wang et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

SRT1720 improves survival and healthspan of obese mice

(2011) Robin K. Minor et al.   Scientific Reports

Age-associated development of inflammation in Wistar rats: Effects of caloric restriction

(2011) Daniel Horrillo et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

Inverse association between adiposity and telomere length: The fels longitudinal study

(2010) Miryoung Lee et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Oxidative Stress as Pathogenesis of Cardiovascular Risk Associated with Metabolic Syndrome

(2010) Hajime Otani   ANTIOXIDANTS & REDOX SIGNALING

Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis

(2010) A. DeCensi et al.   Cancer Prevention Research

Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes

(2010) R. Novosyadlyy et al.   CANCER RESEARCH

Antioxidant and moisture-retention activities of the polysaccharide from Nostoc commune

(2010) Haifeng Li et al.   CARBOHYDRATE POLYMERS

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Cytokine Abnormalities in the Etiology of the Cardiometabolic Syndrome

(2010) Vincent G. DeMarco et al.   CURRENT HYPERTENSION REPORTS

Oncogene-induced senescence: the bright and dark side of the response

(2010) Vassilis G Gorgoulis et al.   CURRENT OPINION IN CELL BIOLOGY

(−) Epigallocatechin gallate suppresses the differentiation of 3T3-L1 preadipocytes through transcription factors FoxO1 and SREBP1c

(2010) Hyojung Kim et al.   CYTOTECHNOLOGY

Dapagliflozin Monotherapy in Type 2 Diabetic Patients With Inadequate Glycemic Control by Diet and Exercise: A randomized, double-blind, placebo-controlled, phase 3 trial

(2010) E. Ferrannini et al.   DIABETES CARE

Can endogenous hyperinsulinaemia explain the increased risk of cancer development and mortality in type 2 diabetes: evidence from mouse models

(2010) Derek LeRoith   DIABETES-METABOLISM RESEARCH AND REVIEWS

Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1

(2010) David B. Rhee et al.   DNA REPAIR

Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes

(2010) Yvonne Fierz et al.   ENDOCRINE-RELATED CANCER

Adiposity and insulin resistance correlate with telomere length in middle-aged Arabs: the influence of circulating adiponectin

(2010) Omar S Al-Attas et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The pros and cons of phytoestrogens

(2010) Heather B. Patisaul et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP

(2010) A. K. Walker et al.   GENES & DEVELOPMENT

Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells

(2010) Maria Notarnicola et al.   Genes and Nutrition

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency in the Nuclear Factor E2-related Factor-2 Transcription Factor Results in Impaired Adipogenesis and Protects against Diet-induced Obesity

(2010) Jingbo Pi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Is Soy Consumption Good or Bad for the Breast?

(2010) Leena Hilakivi‐Clarke et al.   JOURNAL OF NUTRITION

Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids

(2010) Yuriko Adkins et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice

(2010) Hea Jin Park et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Chronic Inflammation in Obesity and the Metabolic Syndrome

(2010) Rosário Monteiro et al.   MEDIATORS OF INFLAMMATION

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

(2010) Masato Iwabu et al.   NATURE

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

(2010) Kanti Bhooshan Pandey et al.   Oxidative Medicine and Cellular Longevity

Weight control and prevention of metabolic syndrome by green tea

(2010) Sudathip Sae-tan et al.   PHARMACOLOGICAL RESEARCH

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Green tea (−)-epigallocatechin gallate inhibits insulin stimulation of 3T3-L1 preadipocyte mitogenesis via the 67-kDa laminin receptor pathway

(2009) Hui-Chen Ku et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice

(2009) Yu Yamazaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models

(2009) Carl E. Stafstrom et al.   ANNALS OF NEUROLOGY

Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation

(2009) Klelia D. Salpea et al.   ATHEROSCLEROSIS

(−)-Epigallocatechin-3-gallate Enhances Uncoupling Protein 2 Gene Expression in 3T3-L1 Adipocytes

(2009) Mak-Soon LEE et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Modulatory effects of black v. green tea aqueous extract on hyperglycaemia, hyperlipidaemia and liver dysfunction in diabetic and obese rat models

(2009) Gamal Ramadan et al.   BRITISH JOURNAL OF NUTRITION

Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research

(2009) S. D. Hursting et al.   CARCINOGENESIS

The Role of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) in Alzheimer’s Disease

(2009) Qingguang Jiang et al.   CNS DRUGS

An Emerging Role of mTOR in Lipid Biosynthesis

(2009) Mathieu Laplante et al.   CURRENT BIOLOGY

Stress-Activated MAP Kinase Cascades in Cellular Senescence

(2009) Junichi Maruyama et al.   CURRENT MEDICINAL CHEMISTRY

Oxidative Stress and Insulin Resistance: The Coronary Artery Risk Development in Young Adults study

(2009) K. Park et al.   DIABETES CARE

The influence of glucose-lowering therapies on cancer risk in type 2 diabetes

(2009) C. J. Currie et al.   DIABETOLOGIA

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney

(2009) K. J. Jung et al.   INFLAMMATION RESEARCH

Adipose tissue: A motor for the inflammation associated with obesity

(2009) Vidula Vachharajani et al.   IUBMB LIFE

Effects of Soy Phytoestrogens on Reference Memory and Neuronal Cholinergic Enzymes in Ovariectomized Rats

(2009) Yoon-Bok Lee et al.   JOURNAL OF MEDICINAL FOOD

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age

(2009) L. Sun et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Exercise as a Mean to Control Low-Grade Systemic Inflammation

(2009) Neha Mathur et al.   MEDIATORS OF INFLAMMATION

Therapeutic potential of lipase inhibitor orlistat in Alzheimer’s disease

(2009) Jing Du et al.   MEDICAL HYPOTHESES

Soy, phytoestrogens and metabolism: A review

(2009) Christopher R. Cederroth et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Genetic reduction of circulating insulin-like growth factor-1 inhibits azoxymethane-induced colon tumorigenesis in mice

(2009) Susan E. Olivo-Marston et al.   MOLECULAR CARCINOGENESIS

Tumours with PI3K activation are resistant to dietary restriction

(2009) Nada Y. Kalaany et al.   NATURE

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Connecting obesity, aging and diabetes

(2009) Rexford S. Ahima   NATURE MEDICINE

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet

(2009) Nora Chen et al.   NUTRITION RESEARCH

Weight and plasma lipid control by decaffeinated green tea

(2009) Doriane Richard et al.   PHARMACOLOGICAL RESEARCH

Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System

(2009) Işin Çakir et al.   PLoS One

Increased muscle PGC-1  expression protects from sarcopenia and metabolic disease during aging

(2009) T. Wenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Chronic ingestion of 2-deoxy-d-glucose induces cardiac vacuolization and increases mortality in rats

(2009) Robin K. Minor et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pparγ2 Is a Key Driver of Longevity in the Mouse

(2009) Carmen Argmann et al.   PLoS Genetics

Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase

(2008) Jing SHANG et al.   ACTA PHARMACOLOGICA SINICA

Chronic liver disease in an ageing population

(2008) J. Frith et al.   AGE AND AGEING

Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity

(2008) Magdalini A. Papandreou et al.   BEHAVIOURAL BRAIN RESEARCH

Resveratrol inhibits nonalcoholic fatty liver disease in rats

(2008) Luis Bujanda et al.   BMC GASTROENTEROLOGY

Dietary Energy Balance Modulates Signaling through the Akt/Mammalian Target of Rapamycin Pathways in Multiple Epithelial Tissues

(2008) Tricia Moore et al.   Cancer Prevention Research

Dietary Energy Restriction Modulates the Activity of AMP-Activated Protein Kinase, Akt, and Mammalian Target of Rapamycin in Mammary Carcinomas, Mammary Gland, and Liver

(2008) W. Jiang et al.   CANCER RESEARCH

Reduced Susceptibility to Two-Stage Skin Carcinogenesis in Mice with Low Circulating Insulin-Like Growth Factor I Levels

(2008) T. Moore et al.   CANCER RESEARCH

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

Rosiglitazone-Associated Fractures in Type 2 Diabetes: An analysis from A Diabetes Outcome Progression Trial (ADOPT)

(2008) S. E. Kahn et al.   DIABETES CARE

Neuroendocrine factors in the regulation of inflammation: Excessive adiposity and calorie restriction

(2008) Luigi Fontana   EXPERIMENTAL GERONTOLOGY

Depression in Parkinson's disease: A double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation

(2008) Ticyana Moralez da Silva et al.   JOURNAL OF AFFECTIVE DISORDERS

Exercise training-induced lowering of inflammatory (CD14+CD16+) monocytes: a role in the anti-inflammatory influence of exercise?

(2008) Kyle L. Timmerman et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Complete Rescue of Cerebrovascular Function in Aged Alzheimer's Disease Transgenic Mice by Antioxidants and Pioglitazone, a Peroxisome Proliferator-Activated Receptor   Agonist

(2008) N. Nicolakakis et al.   JOURNAL OF NEUROSCIENCE

Conclusion that isoflavones exert estrogenic effects on breast tissue and may raise breast cancer risk unfounded

(2008) Mark Messina   MOLECULAR NUTRITION & FOOD RESEARCH

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

(2008) Darren J. Baker et al.   NATURE CELL BIOLOGY

Role of Neuroimmunomodulation in Aging

(2008) Mónica De la Fuente   NEUROIMMUNOMODULATION

PPARG Pro12Ala genotype and risk of cognitive decline in elders? Maybe with diabetes

(2008) Wendy Johnson et al.   NEUROSCIENCE LETTERS

Protective effect of isoflavones from Trifolium pratense on dopaminergic neurons

(2008) Han-Qing Chen et al.   NEUROSCIENCE RESEARCH

Telomere Length Is Associated With Obesity Parameters but With a Gender Difference

(2008) Katarina Nordfjäll et al.   Obesity

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production

(2008) Scott K. Powers et al.   PHYSIOLOGICAL REVIEWS

Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes

(2008) Srujana Rayalam et al.   PHYTOTHERAPY RESEARCH

Inhibitory effects of green tea catechin on the lipid accumulation in 3T3-L1 adipocytes

(2008) Mak-Soon Lee et al.   PHYTOTHERAPY RESEARCH

Antilipogenic effect of green tea extract in C57BL/6J-Lepob/obmice

(2008) Hye-Jin Kim et al.   PHYTOTHERAPY RESEARCH

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

(2008) Gino Boily et al.   PLoS One

Functionally significant insulin-like growth factor I receptor mutations in centenarians

(2008) Y. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiotensin II–Mediated Oxidative DNA Damage Accelerates Cellular Senescence in Cultured Human Vascular Smooth Muscle Cells via Telomere-Dependent and Independent Pathways

(2007) Karl E. Herbert et al.   CIRCULATION RESEARCH

Neuroprotective effects of genistein on dopaminergic neurons in the mice model of Parkinson's disease

(2007) Li-Xing Liu et al.   NEUROSCIENCE RESEARCH

PPAR-γ Pro12Ala genotype and risk of cognitive decline in elders

(2006) K. Yaffe et al.   NEUROBIOLOGY OF AGING