Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk

Progressive stages of mitochondrial destruction caused by cell toxic bile salts

(2013) Sabine Schulz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mitochondrial dysfunction represses HIF-1α protein synthesis through AMPK activation in human hepatoma HepG2 cells

(2013) Chia-Chi Hsu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

(2013) Russell A. Miller et al.   NATURE

Metformin-Induced Hepatotoxicity

(2012) F. Miralles-Linares et al.   DIABETES CARE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis

(2011) M. Ananthanarayanan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice

(2011) Angela Woods et al.   BIOCHEMICAL JOURNAL

Cellular Energy Depletion Resets Whole-Body Energy by Promoting Coactivator-Mediated Dietary Fuel Absorption

(2011) Atul R. Chopra et al.   Cell Metabolism

Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity

(2011) J. Prawitt et al.   DIABETES

Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA

(2011) Igor Orlov et al.   EMBO JOURNAL

Control of nuclear receptor activities in metabolism by post-translational modifications

(2011) Wahiba Berrabah et al.   FEBS LETTERS

Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modifications

(2010) Jongsook Kim Kemper   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Proteasomal degradation of retinoid X receptor α reprograms transcriptional activity of PPARγ in obese mice and humans

(2010) Bruno Lefebvre et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification and validation of the pathways and functions regulated by the orphan nuclear receptor, ROR alpha1, in skeletal muscle

(2010) S. Raichur et al.   NUCLEIC ACIDS RESEARCH

AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome

(2009) Bei B. Zhang et al.   Cell Metabolism

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

(2009) Philippe Lefebvre et al.   PHYSIOLOGICAL REVIEWS

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

Compensatory Induction of Liver Efflux Transporters in Response to ANIT-Induced Liver Injury Is Impaired in FXR-Null Mice

(2009) Yue J. Cui et al.   TOXICOLOGICAL SCIENCES

Bile acids and signal transduction: Role in glucose homeostasis

(2008) Amy Nguyen et al.   CELLULAR SIGNALLING

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis

(2008) Young Joo Park et al.   HEPATOLOGY

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY