Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities

Gerosuppressant Metformin: less is more

(2016) Javier A. Menendez et al.   Aging-US

Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs

(2016) Bruna Corominas-Faja et al.   Aging-US

Metformin: Multi-faceted protection against cancer

(2015) Sonia Del Barco et al.   Oncotarget

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Endoplasmic Reticulum Stress in Nonalcoholic Fatty Liver Disease

(2012) Michael J. Pagliassotti   Annual Review of Nutrition

The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus

(2012) Letícia de Almeida Brondani et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Mitochondria drive autophagy pathology via microtubule disassembly

(2012) Daniela M. Arduíno et al.   Autophagy

Skeletal muscle mitochondrial energetics in obesity and type 2 diabetes mellitus: Endocrine aspects

(2012) Céline Aguer et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Mitochondria and endocrine function of adipose tissue

(2012) Gema Medina-Gómez   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Cellular and molecular mechanisms of mitochondrial function

(2012) Laura D. Osellame et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

SkQ1 slows development of age-dependent destructive processes in retina and vascular layer of eyes of wistar and OXYS rats

(2012) V. B. Saprunova et al.   BIOCHEMISTRY-MOSCOW

Bioenergetic role of mitochondrial fusion and fission

(2012) Benedikt Westermann   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Plant-derived polyphenols regulate expression of miRNA paralogs miR-103/107 and miR-122 and prevent diet-induced fatty liver disease in hyperlipidemic mice

(2012) Jorge Joven et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

RETRACTED: The Ubiquitin Ligase Mul1 Induces Mitophagy in Skeletal Muscle in Response to Muscle-Wasting Stimuli

(2012) Sudarsanareddy Lokireddy et al.   Cell Metabolism

Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways

(2012) Kenneth C.H. Fearon et al.   Cell Metabolism

Role of mitochondria in nonalcoholic fatty liver disease-from origin to propagation

(2012) Ignazio Grattagliano et al.   CLINICAL BIOCHEMISTRY

Gastrointestinal Surgery for Obesity and Diabetes: Weight Loss and Control of Hyperglycemia

(2012) H. M. Heneghan et al.   Current Atherosclerosis Reports

Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress

(2012) C. Tang et al.   DIABETOLOGIA

Adiponectin: mechanistic insights and clinical implications

(2012) A. T. Turer et al.   DIABETOLOGIA

Fat: an evolving issue

(2012) J. R. Speakman et al.   Disease Models & Mechanisms

Autophagy Activity Is Up-Regulated in Adipose Tissue of Obese Individuals and Modulates Proinflammatory Cytokine Expression

(2012) H. J. Jansen et al.   ENDOCRINOLOGY

How adiponectin, leptin, and ghrelin orchestrate together and correlate with the severity of nonalcoholic fatty liver disease

(2012) Mariana V. Machado et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Changes in Body Weight, Glucose Homeostasis, Lipid Profiles, and Metabolic Syndrome after Restrictive Bariatric Surgery

(2012) V. To et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation

(2012) Ian P Salt et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Multifunctional targets of dietary polyphenols in disease: A case for the chemokine network and energy metabolism

(2012) J. Joven et al.   FOOD AND CHEMICAL TOXICOLOGY

Sjøgren's syndrome-associated oxidative stress and mitochondrial dysfunction: Prospects for chemoprevention trials

(2012) Giovanni Pagano et al.   FREE RADICAL RESEARCH

Metformin: a cheap and well-tolerated drug that provides benefits for viral infections

(2012) J Joven et al.   HIV MEDICINE

The Role of Free Radicals in the Aging Brain and Parkinson’s Disease: Convergence and Parallelism

(2012) Hemant Kumar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fueling the flame: bioenergy couples metabolism and inflammation

(2012) T. F. Liu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Prevention of non-communicable diseases in New York City

(2012) Deborah Dowell et al.   LANCET

Skeletal muscle mitochondrial dysfunction precedes right ventricular impairment in experimental pulmonary hypertension

(2012) Irina Enache et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Neither brown nor white

(2012) Barbara Cannon et al.   NATURE

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity

(2012) Christine M Kusminski et al.   NATURE MEDICINE

Synergism of plant-derived polyphenols in adipogenesis: Perspectives and implications

(2012) María Herranz-López et al.   PHYTOMEDICINE

Preservation of Metabolic Flexibility in Skeletal Muscle by a Combined Use of n-3 PUFA and Rosiglitazone in Dietary Obese Mice

(2012) Olga Horakova et al.   PLoS One

Activity-Based Protein Profiling Reveals Mitochondrial Oxidative Enzyme Impairment and Restoration in Diet-Induced Obese Mice

(2012) Natalie C. Sadler et al.   PLoS One

Metformin Reduces Hepatic Expression of SIRT3, the Mitochondrial Deacetylase Controlling Energy Metabolism

(2012) Marcin Buler et al.   PLoS One

Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378

(2012) M. Carrer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction in white adipose tissue

(2012) Christine M. Kusminski et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Resolution of inflammation in obesity-induced liver disease

(2012) Bibiana Rius et al.   Frontiers in Immunology

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Adipose tissue inflammation and cancer cachexia: Possible role of nuclear transcription factors

(2011) M.L. Batista et al.   CYTOKINE

AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study

(2011) J. G. Boyle et al.   DIABETOLOGIA

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

(2011) Anabela P. Rolo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

(2011) Sandra Galic et al.   JOURNAL OF CLINICAL INVESTIGATION

Caloric restriction

(2011) John R. Speakman et al.   MOLECULAR ASPECTS OF MEDICINE

Continuous administration of polyphenols from aqueous rooibos (Aspalathus linearis) extract ameliorates dietary-induced metabolic disturbances in hyperlipidemic mice

(2011) R. Beltrán-Debón et al.   PHYTOMEDICINE

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Redox imbalance of red blood cells impacts T lymphocyte homeostasis: implication in carotid atherosclerosis

(2011) Brigitta Buttari et al.   THROMBOSIS AND HAEMOSTASIS

Mitochondrial dysfunction in nonalcoholic steatohepatitis

(2011) Gaetano Serviddio et al.   Expert Review of Gastroenterology & Hepatology

Alterations in the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1α or PGC-1β and mitofusin 2 in skeletal muscle in type 2 diabetes

(2010) Antonio Zorzano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial longevity pathways

(2010) Anna Raffaello et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Expression of cytokine genes in the aorta is altered by the deficiency in MCP-1: Effect of a high-fat, high-cholesterol diet

(2010) Anna Rull et al.   CYTOKINE

Dynamic, M2-Like Remodeling Phenotypes of CD11c+ Adipose Tissue Macrophages During High-Fat Diet-Induced Obesity in Mice

(2010) M. E. Shaul et al.   DIABETES

Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

(2010) J. M. Wentworth et al.   DIABETES

Adenosine 5′-Monophosphate-Activated Protein Kinase-Mammalian Target of Rapamycin Cross Talk Regulates Brown Adipocyte Differentiation

(2010) Rocio Vila-Bedmar et al.   ENDOCRINOLOGY

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5

(2010) Paul W Caton et al.   JOURNAL OF ENDOCRINOLOGY

Metabolomic Assessment of the Effect of Dietary Cholesterol in the Progressive Development of Fatty Liver Disease

(2010) Maria Vinaixa et al.   JOURNAL OF PROTEOME RESEARCH

Tackling of unhealthy diets, physical inactivity, and obesity: health effects and cost-effectiveness

(2010) Michele Cecchini et al.   LANCET

Insulin Resistance, Inflammation, and Obesity: Role of Monocyte Chemoattractant Protein-1 (orCCL2) in the Regulation of Metabolism

(2010) Anna Rull et al.   MEDIATORS OF INFLAMMATION

Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration?

(2010) Maarten E. Witte et al.   MITOCHONDRION

Selection of Reference Genes for qRT-PCR in High Fat Diet-Induced Hepatic Steatosis Mice Model

(2010) Lingyan Xu et al.   MOLECULAR BIOTECHNOLOGY

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One

Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance

(2010) Giovanni Tarantino   WORLD JOURNAL OF GASTROENTEROLOGY

Metabolic phenotyping of genetically modified mice: An NMR metabonomic approach☆

(2009) Anna Rull et al.   BIOCHIMIE

The Role of Impaired Mitochondrial Lipid Oxidation in Obesity

(2009) M. M. Rogge   Biological Research for Nursing

Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes

(2009) Antonio Zorzano et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Adipocyte Apoptosis, a Link between Obesity, Insulin Resistance, and Hepatic Steatosis

(2009) Naim Alkhouri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin in patients with non-alcoholic fatty liver disease: A randomized, controlled trial

(2009) John Willy Haukeland et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Identification and Characterization of Metabolically Benign Obesity in Humans

(2008) Norbert Stefan   ARCHIVES OF INTERNAL MEDICINE

The Perfect Storm: Obesity, Adipocyte Dysfunction, and Metabolic Consequences

(2008) S. de Ferranti et al.   CLINICAL CHEMISTRY

Selective extraction, separation, and identification of anthocyanins from Hibiscus sabdariffa L. using solid phase extraction-capillary electrophoresis-mass spectrometry (time-of-flight /ion trap)

(2008) Antonio Segura-Carretero et al.   ELECTROPHORESIS

Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGL

(2008) Mandeep P. Gaidhu et al.   JOURNAL OF LIPID RESEARCH

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomics of mitochondrial inner and outer membranes

(2008) Anne M. Distler et al.   PROTEOMICS

It's Not How Fat You Are, It's What You Do with It That Counts

(2008) Samuel Virtue et al.   PLOS BIOLOGY