Obesity genetics in mouse and human: back and forth, and back again
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Obesity genetics in mouse and human: back and forth, and back again
Authors
Keywords
-
Journal
PeerJ
Volume 3, Issue -, Pages e856
Publisher
PeerJ
Online
2015-03-24
DOI
10.7717/peerj.856
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Genetic studies of body mass index yield new insights for obesity biology
- (2015) Adam E. Locke et al. NATURE
- Biologically Inactive Leptin and Early-Onset Extreme Obesity
- (2015) Martin Wabitsch et al. NEW ENGLAND JOURNAL OF MEDICINE
- Bhlhe40, a potential diabetic modifier gene on Dbm1 locus, negatively controls myocyte fatty acid oxidation
- (2015) Shigeru Takeshita et al. GENES & GENETIC SYSTEMS
- New candidate loci identified by array-CGH in a cohort of 100 children presenting with syndromic obesity
- (2014) Marie-Laure Vuillaume et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Hypomorphism for RPGRIP1L, a Ciliary Gene Vicinal to the FTO Locus, Causes Increased Adiposity in Mice
- (2014) George Stratigopoulos et al. Cell Metabolism
- Functional Characterization of Obesity-Associated Variants Involving the α and β Isoforms of Human SH2B1
- (2014) Laura R. Pearce et al. ENDOCRINOLOGY
- Testing Gene-Gene Interactions in Genome Wide Association Studies
- (2014) Jie Kate Hu et al. GENETIC EPIDEMIOLOGY
- CRISPR/Cas9 for genome editing: progress, implications and challenges
- (2014) F. Zhang et al. HUMAN MOLECULAR GENETICS
- A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity
- (2014) J Philippe et al. INTERNATIONAL JOURNAL OF OBESITY
- Renal-Retinal Ciliopathy Gene Sdccag8 Regulates DNA Damage Response Signaling
- (2014) R. Airik et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Obesity-associated variants within FTO form long-range functional connections with IRX3
- (2014) Scott Smemo et al. NATURE
- Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31
- (2014) Unnur Styrkarsdottir et al. NATURE GENETICS
- Non-viral vectors for gene-based therapy
- (2014) Hao Yin et al. NATURE REVIEWS GENETICS
- CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences
- (2014) Y. Lin et al. NUCLEIC ACIDS RESEARCH
- Timed Deletion of Twist1 in the Limb Bud Reveals Age-Specific Impacts on Autopod and Zeugopod Patterning
- (2014) David A. F. Loebel et al. PLoS One
- KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation
- (2013) Laura R. Pearce et al. CELL
- Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice
- (2013) Brian W. Parks et al. Cell Metabolism
- The role of the transcription factor ETV5 in insulin exocytosis
- (2013) Ruth Gutierrez-Aguilar et al. DIABETOLOGIA
- Conventional Knockout ofTbc1d1in Mice Impairs Insulin- and AICAR-Stimulated Glucose Uptake in Skeletal Muscle
- (2013) Janine Dokas et al. ENDOCRINOLOGY
- Congenital Proprotein Convertase 1/3 Deficiency Causes Malabsorptive Diarrhea and Other Endocrinopathies in a Pediatric Cohort
- (2013) Martín G. Martín et al. GASTROENTEROLOGY
- Engineering subtle targeted mutations into the mouse genome
- (2013) Douglas B. Menke GENESIS
- Gene × Environment Interactions in Obesity: The State of the Evidence
- (2013) Shafqat Ahmad et al. HUMAN HEREDITY
- A Homozygous Mutation in theTUBGene Associated with Retinal Dystrophy and Obesity
- (2013) Arundhati Dev Borman et al. HUMAN MUTATION
- Genetic association analysis of 30 genes related to obesity in a European American population
- (2013) P Li et al. INTERNATIONAL JOURNAL OF OBESITY
- Exome sequencing of Bardet–Biedl syndrome patient identifies a null mutation in the BBSome subunitBBIP1(BBS18)
- (2013) Sophie Scheidecker et al. JOURNAL OF MEDICAL GENETICS
- Exome Sequencing Finds a Novel PCSK1 Mutation in a Child With Generalized Malabsorptive Diarrhea and Diabetes Insipidus
- (2013) Michael Yourshaw et al. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
- Severe obesity and diabetes insipidus in a patient with PCSK1 deficiency
- (2013) Graeme R. Frank et al. MOLECULAR GENETICS AND METABOLISM
- Whole-genome sequence–based analysis of high-density lipoprotein cholesterol
- (2013) Alanna C Morrison et al. NATURE GENETICS
- Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- (2013) Sonja I Berndt et al. NATURE GENETICS
- Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity
- (2013) Eleanor Wheeler et al. NATURE GENETICS
- Epistasis and quantitative traits: using model organisms to study gene–gene interactions
- (2013) Trudy F. C. Mackay NATURE REVIEWS GENETICS
- Whole-Exome sequencing identifies novelLEPRmutations in individuals with severe early onset obesity
- (2013) Richard Gill et al. Obesity
- Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPAR
- (2013) F. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity
- (2013) M. Asai et al. SCIENCE
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse
- (2013) Fiona McMurray et al. PLoS Genetics
- Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry
- (2013) Shafqat Ahmad et al. PLoS Genetics
- Five Years of GWAS Discovery
- (2012) Peter M. Visscher et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Development of hybrid viral vectors for gene therapy
- (2012) Shuohao Huang et al. BIOTECHNOLOGY ADVANCES
- Recent advances in targeted genome engineering in mammalian systems
- (2012) Ning Sun et al. Biotechnology Journal
- DEPTOR Cell-Autonomously Promotes Adipogenesis, and Its Expression Is Associated with Obesity
- (2012) Mathieu Laplante et al. Cell Metabolism
- Genetics of Obesity: What have we Learned?
- (2012) Helene Choquet et al. CURRENT GENOMICS
- Tub Has a Key Role in Insulin and Leptin Signaling and Action In Vivo in Hypothalamic Nuclei
- (2012) Patrícia O. Prada et al. DIABETES
- Candidate genes for obesity-susceptibility show enriched association within a large genome-wide association study for BMI
- (2012) Karani S. Vimaleswaran et al. HUMAN MOLECULAR GENETICS
- Loss of function of Ifi202b by a microdeletion on chromosome 1 of C57BL/6J mice suppresses 11β-hydroxysteroid dehydrogenase type 1 expression and development of obesity
- (2012) Heike Vogel et al. HUMAN MOLECULAR GENETICS
- Exome sequencing and complex disease: practical aspects of rare variant association studies
- (2012) R. Do et al. HUMAN MOLECULAR GENETICS
- Challenges in reproducibility of genetic association studies: lessons learned from the obesity field
- (2012) A Li et al. INTERNATIONAL JOURNAL OF OBESITY
- New routes for transgenesis of the mouse
- (2012) José E. Belizário et al. JOURNAL OF APPLIED GENETICS
- Genetic Variation in the Glucose-Dependent Insulinotropic Polypeptide Receptor Modifies the Association between Carbohydrate and Fat Intake and Risk of Type 2 Diabetes in the Malmö Diet and Cancer Cohort
- (2012) Emily Sonestedt et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Human SH2B1 mutations are associated with maladaptive behaviors and obesity
- (2012) Michael E. Doche et al. JOURNAL OF CLINICAL INVESTIGATION
- The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity
- (2012) David A. Buchner et al. MAMMALIAN GENOME
- High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families
- (2012) Sadia Saeed et al. MOLECULAR GENETICS AND METABOLISM
- Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
- (2012) Atsuhiko Ichimura et al. NATURE
- Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
- (2012) Eli A Stahl et al. NATURE GENETICS
- Genome-wide association studies in mice
- (2012) Jonathan Flint et al. NATURE REVIEWS GENETICS
- Nutritional regulation of genome-wide association obesity genes in a tissue-dependent manner
- (2012) Piriya Yoganathan et al. Nutrition & Metabolism
- Loss-of-Function Mutations in MC4R Are Very Rare in the Greek Severely Obese Adult Population
- (2012) Konstantinos Rouskas et al. Obesity
- Functional Inactivation of the Genome-Wide Association Study Obesity Gene Neuronal Growth Regulator 1 in Mice Causes a Body Mass Phenotype
- (2012) Angela W. S. Lee et al. PLoS One
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- The lighter side of BDNF
- (2011) Emily E. Noble et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- The Arrestin Domain-Containing 3 Protein Regulates Body Mass and Energy Expenditure
- (2011) Parth Patwari et al. Cell Metabolism
- Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity
- (2011) J. W. M. Creemers et al. DIABETES
- Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity
- (2011) R. D. Cox et al. Disease Models & Mechanisms
- Technical approaches for mouse models of human disease
- (2011) M. J. Justice et al. Disease Models & Mechanisms
- Characterization of the Hyperphagic Response to Dietary Fat in the MC4R Knockout Mouse
- (2011) Dollada Srisai et al. ENDOCRINOLOGY
- Use of mouse models in studying type 2 diabetes mellitus
- (2011) Angela W.S. Lee et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- Genetic analysis in the Collaborative Cross breeding population
- (2011) Vivek M. Philip et al. GENOME RESEARCH
- Genetic analysis of complex traits in the emerging Collaborative Cross
- (2011) David L. Aylor et al. GENOME RESEARCH
- Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis
- (2011) S. N. Yazbek et al. GENOME RESEARCH
- Effective weight management practice: a review of the lifestyle intervention evidence
- (2011) S F L Kirk et al. INTERNATIONAL JOURNAL OF OBESITY
- Biology of Obesity: Lessons from Animal Models of Obesity
- (2011) Keizo Kanasaki et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol
- (2011) Magalie S. Leduc et al. JOURNAL OF LIPID RESEARCH
- Exome sequencing: a transformative technology
- (2011) Andrew B Singleton LANCET NEUROLOGY
- Intersubspecific subcongenic mouse strain analysis reveals closely linked QTLs with opposite effects on body weight
- (2011) Md. Bazlur R. Mollah et al. MAMMALIAN GENOME
- Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus
- (2011) Sébastien Jacquemont et al. NATURE
- Viral vectors for gene delivery to the central nervous system
- (2011) Thomas B. Lentz et al. NEUROBIOLOGY OF DISEASE
- Systems genetics of susceptibility to obesity-induced diabetes in mice
- (2011) Richard C. Davis et al. PHYSIOLOGICAL GENOMICS
- Next-generation human genetics
- (2011) Jay Shendure GENOME BIOLOGY
- Assessment of Feeding Behavior in Laboratory Mice
- (2010) Kate L.J. Ellacott et al. Cell Metabolism
- Identification of Body Fat Mass as a Major Determinant of Metabolic Rate in Mice
- (2010) K. J. Kaiyala et al. DIABETES
- TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle
- (2010) D. An et al. DIABETES
- A Recurring Problem With the Analysis of Energy Expenditure in Genetic Models Expressing Lean and Obese Phenotypes
- (2010) A. A. Butler et al. DIABETES
- Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice
- (2010) J. E. Ayala et al. Disease Models & Mechanisms
- Recurrent 200-kb deletions of 16p11.2 that include the SH2B1 gene are associated with developmental delay and obesity
- (2010) Ruxandra Bachmann-Gagescu et al. GENETICS IN MEDICINE
- Robust, Reversible Gene Knockdown Using a Single Lentiviral Short Hairpin RNA Vector
- (2010) Cheryl Y. Brown et al. HUMAN GENE THERAPY
- Npc1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance
- (2010) D. Jelinek et al. HUMAN MOLECULAR GENETICS
- Rare melanocortin-3 receptor mutations with in vitro functional consequences are associated with human obesity
- (2010) M. Mencarelli et al. HUMAN MOLECULAR GENETICS
- Cut-like Homeobox 1 (CUX1) Regulates Expression of the Fat Mass and Obesity-associated and Retinitis Pigmentosa GTPase Regulator-interacting Protein-1-like (RPGRIP1L) Genes and Coordinates Leptin Receptor Signaling
- (2010) George Stratigopoulos et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Congenic and bioinformatics analyses resolved a major-effect Fob3b QTL on mouse Chr 15 into two closely linked loci
- (2010) Zala Prevoršek et al. MAMMALIAN GENOME
- A new highly penetrant form of obesity due to deletions on chromosome 16p11.2
- (2010) R. G. Walters et al. NATURE
- Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy
- (2010) Edgar A Otto et al. NATURE GENETICS
- Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- (2010) Elizabeth K Speliotes et al. NATURE GENETICS
- Overexpression of Fto leads to increased food intake and results in obesity
- (2010) Chris Church et al. NATURE GENETICS
- Genome editing with engineered zinc finger nucleases
- (2010) Fyodor D. Urnov et al. NATURE REVIEWS GENETICS
- Profound Obesity Secondary to Hyperphagia in Mice Lacking Kinase Suppressor of Ras 2
- (2010) Jean-Pierre Revelli et al. Obesity
- Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats
- (2010) Yi-Chun Loraine Tung et al. PLoS One
- Identification of Genes and Networks Driving Cardiovascular and Metabolic Phenotypes in a Mouse F2 Intercross
- (2010) Jonathan M. J. Derry et al. PLoS One
- Rare Variants Create Synthetic Genome-Wide Associations
- (2010) Samuel P. Dickson et al. PLOS BIOLOGY
- Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups
- (2010) André Scherag et al. PLoS Genetics
- Physical Activity Attenuates the Genetic Predisposition to Obesity in 20,000 Men and Women from EPIC-Norfolk Prospective Population Study
- (2010) Shengxu Li et al. PLOS MEDICINE
- An integrated view of the correlations between genomic and phenomic variables
- (2009) Dong Yang et al. Journal of Genetics and Genomics
- A novel homozygous missense mutation of the leptin gene (N103K) in an obese Egyptian patient
- (2009) I. Mazen et al. MOLECULAR GENETICS AND METABOLISM
- Large, rare chromosomal deletions associated with severe early-onset obesity
- (2009) Elena G. Bochukova et al. NATURE
- Deficiency of a β-arrestin-2 signal complex contributes to insulin resistance
- (2009) Bing Luan et al. NATURE
- Inactivation of the Fto gene protects from obesity
- (2009) Julia Fischer et al. NATURE
- Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks
- (2009) Xia Yang et al. NATURE GENETICS
- Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
- (2009) David Meyre et al. NATURE GENETICS
- The genetics of quantitative traits: challenges and prospects
- (2009) Trudy F. C. Mackay et al. NATURE REVIEWS GENETICS
- Gene–environment interactions and obesity—Further aspects of genomewide association studies
- (2009) Camilla H. Andreasen et al. NUTRITION
- Characterizing the obesogenic environment: the state of the evidence with directions for future research
- (2009) S. F. L. Kirk et al. Obesity Reviews
- Mutational Analysis of the Pro-opiomelanocortin Gene in French Obese Children Led to the Identification of a Novel Deleterious Heterozygous Mutation Located in the α-Melanocyte Stimulating Hormone Domain
- (2009) Beatrice Dubern et al. PEDIATRIC RESEARCH
- MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family
- (2009) L. F. Chan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene
- (2009) Chris Church et al. PLoS Genetics
- ENU Mutagenesis, a Way Forward to Understand Gene Function
- (2008) Abraham Acevedo-Arozena et al. Annual Review of Genomics and Human Genetics
- Reduced body weight is a common effect of gene knockout in mice
- (2008) Danielle R Reed et al. BMC GENETICS
- Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees
- (2008) F. Stutzmann et al. DIABETES
- Human Obesity: A Heritable Neurobehavioral Disorder That Is Highly Sensitive to Environmental Conditions
- (2008) S. O'Rahilly et al. DIABETES
- The Obesity Gene, FTO, Is of Ancient Origin, Up-Regulated during Food Deprivation and Expressed in Neurons of Feeding-Related Nuclei of the Brain
- (2008) Robert Fredriksson et al. ENDOCRINOLOGY
- Detailed phenotype–genotype study in five patients with chromosome 6q16 deletion: narrowing the critical region for Prader–Willi-like phenotype
- (2008) Maria Clara Bonaglia et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Estimation of significance thresholds for genomewide association scans
- (2008) Frank Dudbridge et al. GENETIC EPIDEMIOLOGY
- R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population
- (2008) D. Meyre et al. HUMAN MOLECULAR GENETICS
- Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study
- (2008) M. A. Calton et al. HUMAN MOLECULAR GENETICS
- Unexpected Endocrine Features and Normal Pigmentation in a Young Adult Patient Carrying a Novel Homozygous Mutation in the POMC Gene
- (2008) Karine Clément et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Obesity and the Metabolic Syndrome in Developing Countries
- (2008) Anoop Misra et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Update on Obesity
- (2008) Daniel H. Bessesen JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome
- (2008) Kamal Rahmouni et al. JOURNAL OF CLINICAL INVESTIGATION
- Common nonsynonymous variants in PCSK1 confer risk of obesity
- (2008) Michael Benzinou et al. NATURE GENETICS
- Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity
- (2008) Alexandra Chadt et al. NATURE GENETICS
- Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
- (2008) Gudmar Thorleifsson et al. NATURE GENETICS
- Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
- (2008) Cristen J Willer et al. NATURE GENETICS
- Brain-Derived Neurotrophic Factor and Obesity in the WAGR Syndrome
- (2008) Joan C. Han et al. NEW ENGLAND JOURNAL OF MEDICINE
- Public Health Genomics: Translating Obesity Genomics Research Into Population Health Benefits
- (2008) Tanya Agurs-Collins et al. Obesity
- Genetic Architecture of Adiposity and Organ Weight Using Combined Generation QTL Analysis
- (2008) Gloria L. Fawcett et al. Obesity
- Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis
- (2008) H. Shao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Patterns of Positive Selection in Six Mammalian Genomes
- (2008) Carolin Kosiol et al. PLoS Genetics
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started