Omega-3 polyunsaturated fatty acids for cardiovascular diseases: present, past and future

Is the Effect of Omega-3 Polyunsaturated Fatty Acids Dependent on Life-Style, Severity of Disease, and Use of Concomitant Medications?

(2017) Ichiro Tatsuno   Journal of Atherosclerosis and Thrombosis

Omega-3 Fatty Acid Therapy: The Tide Turns for a Fish Story

(2017) James H. O’Keefe et al.   MAYO CLINIC PROCEEDINGS

A Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies of Eicosapentaenoic and Docosahexaenoic Long-Chain Omega-3 Fatty Acids and Coronary Heart Disease Risk

(2017) Dominik D. Alexander et al.   MAYO CLINIC PROCEEDINGS

A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA (ComparED) Study

(2016) Janie Allaire et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effect of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial InfarctionClinical Perspective

(2016) Bobak Heydari et al.   CIRCULATION

Effect of omega-3 fatty acid supplementation on arterial elasticity in patients with familial hypercholesterolaemia on statin therapy

(2016) D.C. Chan et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Association of serum eicosapentaenoic acid to arachidonic acid ratio with microalbuminuria in a population of community-dwelling Japanese

(2015) Ako Fukami et al.   ATHEROSCLEROSIS

Effect of TAK-085 on Low-density Lipoprotein Particle Size in Patients with Hypertriglyceridemia: A Double-blind Randomized Clinical Study

(2015) Ichiro Tatsuno et al.   Cardiovascular Therapeutics

Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function

(2015) Vasundhara Kain et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174 000 participants in 27 randomised trials

(2015)   LANCET

Intakes of omega-3 polyunsaturated fatty acids and blood pressure change over time: Possible interaction with genes involved in 20-HETE and EETs metabolism

(2015) Angela Tagetti et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

High long-chain n-3 fatty acid intake attenuates the effect of high resting heart rate on cardiovascular mortality risk: A 24-year follow-up of Japanese general population

(2014) Takashi Hisamatsu et al.   Journal of Cardiology

Icosapent Ethyl (eicosapentaenoic acid ethyl ester): Effects on Apolipoprotein C-III in Patients from the MARINE and ANCHOR Studies

(2014) Christie M. Ballantyne et al.   Journal of Clinical Lipidology

18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload–induced maladaptive cardiac remodeling

(2014) Jin Endo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increasing long-chain n-3PUFA consumption improves small peripheral artery function in patients at intermediate–high cardiovascular risk

(2014) Jordi Merino et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Triglycerides and cardiovascular disease

(2014) Børge G Nordestgaard et al.   LANCET

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Long-chain polyunsaturated fatty acid sources and evaluation of their nutritional and functional properties

(2014) Elahe Abedi et al.   Food Science & Nutrition

Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: The Hisayama Study

(2013) Toshiharu Ninomiya et al.   ATHEROSCLEROSIS

Omega-6 and omega-3 polyunsaturated fatty acid levels are reduced in whole blood of Italian patients with a recent myocardial infarction: the AGE-IM study

(2013) Franca Marangoni et al.   ATHEROSCLEROSIS

Omega-3 PUFAs improved endothelial function and arterial stiffness with a parallel antiinflammatory effect in adults with metabolic syndrome

(2013) Dimitris Tousoulis et al.   ATHEROSCLEROSIS

Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in Japanese: A 24-year follow-up of NIPPON DATA80

(2013) Naoko Miyagawa et al.   ATHEROSCLEROSIS

2013 ACCF/AHA Guideline for the Management of Heart Failure: Executive Summary

(2013) Clyde W. Yancy et al.   CIRCULATION

Efficacy and safety of TAK-085 compared with eicosapentaenoic acid in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: The omega-3 fatty acids randomized double-blind (ORD) study

(2013) Ichiro Tatsuno et al.   Journal of Clinical Lipidology

Long-term safety and efficacy of TAK-085 in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: The omega-3 fatty acids randomized long-term (ORL) study

(2013) Ichiro Tatsuno et al.   Journal of Clinical Lipidology

Fish Oil and Post-Operative Atrial Fibrillation

(2013) Dariush Mozaffarian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

n–3 Fatty Acids in Patients with Multiple Cardiovascular Risk Factors

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

The association between dietary omega-3 fatty acids and cardiovascular death: the Singapore Chinese Health Study

(2013) Angela S Koh et al.   European Journal of Preventive Cardiology

Circulating and Dietary Omega‐3 and Omega‐6 Polyunsaturated Fatty Acids and Incidence of CVD in the Multi‐Ethnic Study of Atherosclerosis

(2013) Marcia C. de Oliveira Otto et al.   Journal of the American Heart Association

N‐3 Polyunsaturated Fatty Acids to Prevent Atrial Fibrillation: Updated Systematic Review and Meta‐Analysis of Randomized Controlled Trials

(2013) Javier Mariani et al.   Journal of the American Heart Association

Effects of Serum n-3 to n-6 Polyunsaturated Fatty Acids Ratios on Coronary Atherosclerosis in Statin-Treated Patients With Coronary Artery Disease

(2012) Tsuyoshi Nozue et al.   AMERICAN JOURNAL OF CARDIOLOGY

Effect of omega-3 fatty acids supplementation on endothelial function: A meta-analysis of randomized controlled trials

(2012) Qianqian Wang et al.   ATHEROSCLEROSIS

Fish consumption and risk of stroke and its subtypes: accumulative evidence from a meta-analysis of prospective cohort studies

(2012) P Xun et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Association Between Omega-3 Fatty Acid Supplementation and Risk of Major Cardiovascular Disease Events

(2012) Evangelos C. Rizos et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

n–3 Fatty Acids and Cardiovascular Outcomes in Patients with Dysglycemia

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Patients With Very High Triglyceride Levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] Trial)

(2011) Harold E. Bays et al.   AMERICAN JOURNAL OF CARDIOLOGY

Fish Intake and the Risk of Incident Heart Failure

(2011) Rashad J. Belin et al.   Circulation-Heart Failure

Residual Cardiovascular Risk Despite Optimal LDL Cholesterol Reduction with Statins: The Evidence, Etiology, and Therapeutic Challenges

(2011) Uchechukwu K. Sampson et al.   Current Atherosclerosis Reports

Relationships between Plasma Fatty Acid Composition and Coronary Artery Disease

(2011) Hiroshige Itakura et al.   Journal of Atherosclerosis and Thrombosis

Resolvin E1 protects the rat heart against reperfusion injury

(2010) K. T. Keyes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Effects ofn-3 polyunsaturated fatty acids and of rosuvastatin on left ventricular function in chronic heart failure: a substudy of GISSI-HF trial

(2010) Stefano Ghio et al.   EUROPEAN JOURNAL OF HEART FAILURE

Docosahexaenoic Acid-Enriched Fish Oil Attenuates Kidney Disease and Prolongs Median and Maximal Life Span of Autoimmune Lupus-Prone Mice

(2010) G. V. Halade et al.   JOURNAL OF IMMUNOLOGY

A rapid method for determining arachidonic:eicosapentaenoic acid ratios in whole blood lipids: correlation with erythrocyte membrane ratios and validation in a large Italian population of various ages and pathologies

(2010) Angela M Rizzo et al.   Lipids in Health and Disease

n–3 Fatty Acids and Cardiovascular Events after Myocardial Infarction

(2010) Daan Kromhout et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of fish oil on ventricular tachyarrhythmia in three studies in patients with implantable cardioverter defibrillators

(2009) I. A. Brouwer et al.   EUROPEAN HEART JOURNAL

Reduction in Acute Myocardial Infarction Mortality in the United States

(2009) Harlan M. Krumholz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

(2009) Matthew Spite et al.   NATURE

Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice

(2008) Richard Yang Cao et al.   ATHEROSCLEROSIS

Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators

(2008) Aksam J. Merched et al.   FASEB JOURNAL

Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial

(2008) GISSI-HF investigators   LANCET

Reduction in the Recurrence of Stroke by Eicosapentaenoic Acid for Hypercholesterolemic Patients

(2008) Kortaro Tanaka et al.   STROKE

Orally administered eicosapentaenoic acid reduces and stabilizes atherosclerotic lesions in ApoE-deficient mice

(2007) Miwa Matsumoto et al.   ATHEROSCLEROSIS