Article
Multidisciplinary Sciences
Eric T. Klopack, Eileen M. Crimmins, Steve W. Cole, Teresa E. Seeman, Judith E. Carroll
Summary: Exposure to stress is associated with accelerated immune aging, characterized by a decrease in naive T cells and an increase in terminally differentiated T cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cardiac & Cardiovascular Systems
Virginia Smit, Jill de Mol, Frank H. Schaftenaar, Marie A. C. Depuydt, Rimke J. Postel, Diede Smeets, Fenne W. M. Verheijen, Laurens Bogers, Janine van Duijn, Robin A. F. Verwilligen, Hendrika W. Grievink, Mireia N. A. Bernabe Kleijn, Eva van Ingen, Maaike J. M. de Jong, Lauren Goncalves, Judith A. H. M. Peeters, Harm J. Smeets, Anouk Wezel, Julia K. Polansky, Menno P. J. de Winther, Christoph J. Binder, Dimitrios Tsiantoulas, Ilze Bot, Johan Kuiper, Amanda C. Foks
Summary: This study found that aging promotes advanced atherosclerosis in mice and induces immunological alterations. The expression of genes involved in atherogenic processes shifted with age, and age-associated T- and B-cells emerged in atherosclerotic plaques and blood. Further research on age-associated immunity may contribute to novel diagnostic and therapeutic tools for cardiovascular disease.
CARDIOVASCULAR RESEARCH
(2023)
Review
Immunology
Jasper Iske, Tomohisa Matsunaga, Hao Zhou, Stefan G. Tullius
Summary: The transplantation of aged organs may have negative effects on recipients due to the accumulation of senescent cells, which can promote aging in recipient cells through the secretion of pro-inflammatory molecules. Studies have shown that transplanting old organs may limit the physical reserve of recipients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Gabor Papp, Krisztina Szabo, Ilona Jambor, Marianna Mile, Alexandra Reka Berki, Attila Csaba Arany, Gabriella Makra, Peter Szodoray, Zoltan Csiki, Laszlo Balogh
Summary: Regular exercise in healthy elderly individuals can lead to improvements in body composition and physical performance, as well as significant changes in the ratios of natural killer cells, T and B lymphocyte subtypes, and functional capability of Treg cells. This indicates a positive impact on age-related redistribution of naive and memory cell proportions and immune regulation in older ages.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Stefania Cuzzubbo, Sara Mangsbo, Divya Nagarajan, Kinana Habra, Alan Graham Pockley, Stephanie E. B. McArdle
Summary: The discovery of tumor antigens has led to the development of cancer vaccines, but many antigens lack immunogenicity. Adjuvants are added to vaccine formulations to trigger immune responses. Aging can lead to immunosenescence and chronic inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Leah Zuroff, Ayman Rezk, Koji Shinoda, Diego A. Espinoza, Yehezqel Elyahu, Bo Zhang, Andrew A. Chen, Russell T. Shinohara, Dina Jacobs, Roy N. Alcalay, Thomas F. Tropea, Alice Chen-Plotkin, Alon Monsonego, Rui Li, Amit Bar-Or
Summary: In the study comparing untreated MS patients with normal controls, it was found that MS patients exhibited early and persistent redistribution of naive and memory CD4 T-cell compartments. While most CD4 and CD8 T-cell aging trajectories were similar between groups, MS patients demonstrated abnormal age-associated increases, particularly in patients over 60.
Review
Immunology
Yunan Wang, Chen Dong, Yudian Han, Zhifeng Gu, Chi Sun
Summary: Immunosenescence, the immune related changes caused by aging, plays crucial roles in various age-related diseases, including neurodegenerative diseases, tumors, cardiovascular diseases, autoimmune diseases, and COVID-19. However, the mechanisms, association with aging and successful aging, as well as the effects on diseases, are not clearly understood. This review highlights the involvement of aging-related phenotypic changes, deterioration of immune organ function, and alterations of immune cell subsets in the process of immunosenescence, which significantly impact the occurrence and development of age-related diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Genetics & Heredity
Antero Salminen
Summary: Tissue-resident fibroblasts are mesenchymal cells that play a crucial role in maintaining the structural integrity of the extracellular matrix. Under various stresses, including those associated with aging, these fibroblasts can differentiate into myofibroblasts which not only contribute to tissue fibrosis but also interact with immune cells to regulate immune responses. The differentiation of myofibroblasts is induced by factors such as TGF-β cytokine and reactive oxygen species (ROS), which also play important roles in mediating signaling between immunosuppressive cells.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Review
Cell Biology
Leah S. Hohman, Lisa C. Osborne
Summary: This review discusses emerging data on age-related loss of intestinal barrier integrity and suggests that IEC dysfunction may play a central role in age-associated alterations in microbiota composition and immune homeostasis.
Review
Public, Environmental & Occupational Health
Zhe Li, Weiguang Zhang, Yuting Duan, Yue Niu, Yizhi Chen, Xiaomin Liu, Zheyi Dong, Ying Zheng, Xizhao Chen, Zhe Feng, Yong Wang, Delong Zhao, Xuefeng Sun, Guangyan Cai, Hongwei Jiang, Xiangmei Chen
Summary: Biological age (BA) is a model that evaluates the function of aging individuals and provides a more accurate measure of human aging than chronological age (CA). The choice of biomarkers, standards, and statistical methods can influence BA estimation approaches. Traditional methods include MLR, PCA, KDM, and deep learning, and this review summarizes the markers used for each organ/system and the literature on BA research. Future research should focus on exploring new aging markers, standardizing marker selection, and developing new methods for building BA models.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Genetics & Heredity
Antero Salminen
Summary: 1. Low-grade inflammation is associated with aging and age-related diseases.
2. Persistent inflammation activates compensatory immunosuppression with aging.
3. The numbers of immunosuppressive cells increase with aging and age-related diseases.
4. Immunosuppressive mechanisms evoke harmful bystander effects in host tissues.
5. Immunosuppression promotes tissue degeneration with aging and age-related diseases.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Immunology
Vivian M. Castro-Herrera, Helena L. Fisk, Mandy Wootton, Mark Lown, Eleri Owen-Jones, Mandy Lau, Rachel Lowe, Kerenza Hood, David Gillespie, F. D. Richard Hobbs, Paul Little, Christopher C. Butler, Elizabeth A. Miles, Philip C. Calder
Summary: The study indicates that the combination of two probiotic organisms did not have a significant effect on the immune system of older people, but there was evidence that these probiotics may improve response to seasonal influenza vaccination.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Peter Broede, Maren Claus, Patrick D. Gajewski, Stephan Getzmann, Klaus Golka, Jan G. Hengstler, Edmund Wascher, Carsten Watzl
Summary: This study compared immunosenescence biomarkers with chronological age for predicting low cardiorespiratory fitness (CRF) and found that immune age could outperform chronological age as a predictor for low CRF. Factors such as obesity, physical inactivity, chronological age, and immune age were associated with increased probability of low CRF.
Article
Nutrition & Dietetics
Ruben Torregrosa-Munumer, Elena Vara, Jesus angel Fernandez-Tresguerres, Ricardo Gredilla
Summary: The study found that resveratrol can reverse age-related changes in inflammatory, oxidative, and apoptotic markers in the rat heart, suggesting it may have beneficial effects as an anti-aging compound to revert age-related changes in cardiac function.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Cell Biology
Aurelia Santoro, Elisa Bientinesi, Daniela Monti
Summary: The article discusses the changes in the immune system and inflammation during aging, and how they impact diseases and longevity in older people. Centenarians serve as a model for studying age-related changes in the immune system, showcasing an improved ability to adapt and remodel in response to harmful stimuli. Inflammaging is considered an adaptive process that can trigger anti-inflammatory responses to counteract age-related pro-inflammatory environments.
AGEING RESEARCH REVIEWS
(2021)
Article
Geriatrics & Gerontology
Antonio Garrido, Julia Cruces, Noemi Ceprian, Isabel Corpas, Jesus A. Tresguerres, Monica De la Fuente
Article
Immunology
Caroline Hunsche, Irene Martinez de Toda, Monica de la Fuente
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Biochemistry & Molecular Biology
Carmen Vida, Hikaru Kobayashi, Antonio Garrido, Irene Martinez de Toda, Eva Carro, Jose Antonio Molina, Monica De la Fuente
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Antonio Garrido, Julia Cruces, Noemi Ceprian, Elena Vara, Monica de la Fuente
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Geriatrics & Gerontology
Irene Martinez de Toda, Carmen Vida, Antonio Garrido, Monica De la Fuente
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Neurosciences
Irene Martinez de Toda, Lara Miguelez, Carmen Vida, Eva Carro, Monica De la Fuente
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Geriatrics & Gerontology
Irene Martinez de Toda, Lara Miguelez, Leon Siboni, Carmen Vida, Monica De la Fuente
Article
Cell Biology
Irene Martinez de Toda, Carmen Vida, Luis Sanz San Miguel, Monica De la Fuente
MECHANISMS OF AGEING AND DEVELOPMENT
(2019)
Article
Geriatrics & Gerontology
L. Gimenez-Llort, P. Ramirez-Boix, M. de la Fuente
EXPERIMENTAL GERONTOLOGY
(2019)
Editorial Material
Biochemistry & Molecular Biology
Monica De la Fuente
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Geriatrics & Gerontology
Irene Martinez de Toda, Carmen Vida, Marta Garcia-Salmones, Patricia Alonso-Fernandez, Monica De La Fuente
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Endocrinology & Metabolism
Noemi Redondo Useros, Alina Gheorghe, Fatima Perez de Heredia, Ligia E. Diaz, Gyselle Chrystina Baccan, Monica de la Fuente, Ascension Marcos
OBESITY RESEARCH & CLINICAL PRACTICE
(2019)
Article
Clinical Neurology
Felix Bermejo-Pareja, Teodoro del Ser, Meritxell Valenti, Monica de la Fuente, Fernando Bartolome, Eva Carro
ALZHEIMERS & DEMENTIA
(2020)
Article
Immunology
A. Garrido, J. Cruces, N. Ceprian, E. Diaz-Del Cerro, J. Felix, M. De la Fuente
JOURNAL OF NEUROIMMUNOLOGY
(2020)
Article
Chemistry, Physical
Blanca Gonzalez-Bermudez, Hikaru Kobayashi, Alvaro Navarrete, Cesar Nyblad, Monica Gonzalez-Sanchez, Monica de la Fuente, Gonzalo Fuentes, Gustavo V. Guinea, Claudio Garcia, Gustavo R. Plaza