Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

(2016) Marissa J. Schafer et al.   DIABETES

Insulin resistance and sarcopenia: mechanistic links between common co-morbidities

(2016) Mark E Cleasby et al.   JOURNAL OF ENDOCRINOLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice

(2016) Michael B. Stout et al.   Aging-US

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice

(2015) Dmitriy Kolodin et al.   Cell Metabolism

IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance

(2015) Dov B. Ballak et al.   CYTOKINE

Stewing in Not-So-Good Juices: Interactions of Skeletal Muscle With Adipose Secretions: Figure 1

(2015) David E. Kelley et al.   DIABETES

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

(2015) Allyson K. Palmer et al.   DIABETES

Human Adipocytes Induce Inflammation and Atrophy in Muscle Cells During Obesity

(2015) Vanessa Pellegrinelli et al.   DIABETES

Role of insulin in the regulation of human skeletal muscle protein synthesis and breakdown: a systematic review and meta-analysis

(2015) Haitham Abdulla et al.   DIABETOLOGIA

Clinical strategies and animal models for developing senolytic agents

(2015) James L. Kirkland et al.   EXPERIMENTAL GERONTOLOGY

Sodium nitrite supplementation improves motor function and skeletal muscle inflammatory profile in old male mice

(2015) Jamie N. Justice et al.   JOURNAL OF APPLIED PHYSIOLOGY

Intramyocellular Lipid and Impaired Myofiber Contraction in Normal Weight and Obese Older Adults

(2015) Seung J. Choi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Prostate cancer: 4 big questions

(2015) Richard Hodson   NATURE

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Inflammation and the depot-specific secretome of human preadipocytes

(2015) Yi Zhu et al.   Obesity

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth hormone in adipose dysfunction and senescence

(2015) Michael B. Stout et al.   Oncotarget

Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice

(2015) Michael B. Stout et al.   Oncotarget

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

Ageing, adipose tissue, fatty acids and inflammation

(2014) Chathyan Pararasa et al.   BIOGERONTOLOGY

The Frailty Syndrome: Clinical measurements and basic underpinnings in humans and animals

(2014) M. Jane Mohler et al.   EXPERIMENTAL GERONTOLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Obesity accelerates epigenetic aging of human liver

(2014) S. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength

(2013) Karel G. M. Beenakker et al.   AGING CELL

Associations between body composition and gait-speed decline: results from the Health, Aging, and Body Composition study

(2013) Kristen M Beavers et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mechanisms and Metabolic Implications of Regional Differences among Fat Depots

(2013) Tamara Tchkonia et al.   Cell Metabolism

Changes in Adipose Tissue Macrophages and T Cells During Aging

(2013) Sanjay K. Garg et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Frailty and Safety

(2013) Angela M. Abbatecola et al.   DRUG SAFETY

Macrophages, fat, and the emergence of immunometabolism

(2013) Anthony W. Ferrante   JOURNAL OF CLINICAL INVESTIGATION

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Frailty in elderly people

(2013) Andrew Clegg et al.   LANCET

Pro-Inflammatory macrophages increase in skeletal muscle of high fat-Fed mice and correlate with metabolic risk markers in humans

(2013) Lisbeth N. Fink et al.   Obesity

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Chronic inflammation role in the obesity-diabetes association: a case-cohort study

(2013) Vivian C Luft et al.   Diabetology & Metabolic Syndrome

Clinical frailty and long-term mortality in elderly subjects with diabetes

(2012) Francesco Cacciatore et al.   ACTA DIABETOLOGICA

Diabetes in Older Adults

(2012) M. S. Kirkman et al.   DIABETES CARE

Translating advances from the basic biology of aging into clinical application

(2012) James L. Kirkland   EXPERIMENTAL GERONTOLOGY

Peripheral fat loss and decline in adipogenesis in older humans

(2012) Giuseppe Caso et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Role and potential mechanisms of anabolic resistance in sarcopenia

(2012) Prashanth H. Haran et al.   Journal of Cachexia Sarcopenia and Muscle

Inflammation and mortality in a frail mouse model

(2011) Fred Ko et al.   AGE

Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet-Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis

(2011) F. C. McGillicuddy et al.   DIABETES

Skeletal Muscle Power

(2011) Kieran F. Reid et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Low serum IL-6 is associated with high 6-minute walking performance in asymptomatic women aged 20 to 70years

(2011) Hubert Blain et al.   EXPERIMENTAL GERONTOLOGY

Gait Speed and Survival in Older Adults

(2011) Stephanie Studenski   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue

(2011) C. N. Lumeng et al.   JOURNAL OF IMMUNOLOGY

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model

(2010) Balindiwe Sishi et al.   EXPERIMENTAL PHYSIOLOGY

Prevalence and 10-Year Outcomes of Frailty in Older Adults in Relation to Deficit Accumulation

(2010) Xiaowei Song et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Aging, Depot Origin, and Preadipocyte Gene Expression

(2010) Mark J. Cartwright et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The metabolic syndrome in older persons: a loosely defined constellation of symptoms or a distinct entity?

(2009) John E. Morley et al.   AGE AND AGEING

Age-related changes in total and regional fat distribution

(2009) Jennifer L. Kuk et al.   AGEING RESEARCH REVIEWS

Inflammation and impaired adipogenesis in hypertrophic obesity in man

(2009) Birgit Gustafson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Functional analyses reveal the greater potency of preadipocytes compared with adipocytes as endothelial cell activator under normoxia, hypoxia, and TNFα exposure

(2009) Isabelle Mack et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Impaired Preadipocyte Differentiation in Human Abdominal Obesity: Role of Wnt, Tumor Necrosis Factor- , and Inflammation

(2009) P. Isakson et al.   DIABETES

Age-Associated Increase in Cytokine Production During Systemic Inflammation: Adipose Tissue as a Major Source of IL-6

(2009) M. E. Starr et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Two-Year Body Composition Analyses of Long-Lived GHR Null Mice

(2009) D. E. Berryman et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Nonlinear Multisystem Physiological Dysregulation Associated With Frailty in Older Women: Implications for Etiology and Treatment

(2009) L. P. Fried et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Connecting obesity, aging and diabetes

(2009) Rexford S. Ahima   NATURE MEDICINE

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Regional Anatomic and Age Effects on Cell Function of Human Adipose-Derived Stem Cells

(2008) Bret M. Schipper et al.   ANNALS OF PLASTIC SURGERY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Insulin resistance associated to obesity: the link TNF-alpha

(2008) Iria Nieto-Vazquez et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Insulin resistance induced by tumor necrosis factor-α in myocytes and brown adipocytes12

(2007) M. Lorenzo et al.   JOURNAL OF ANIMAL SCIENCE