The Trinity of cGAS, TLR9, and ALRs Guardians of the Cellular Galaxy Against Host-Derived Self-DNA

STING Pathway Expression Identifies NSCLC With an Immune-Responsive Phenotype

(2020) Carminia M. Della Corte et al.   Journal of Thoracic Oncology

Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP

(2020) Vladislav Pokatayev et al.   NATURE IMMUNOLOGY

AIM2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics

(2020) Miao Qi et al.   ONCOGENE

Dysregulation of TLR9 in neonates leads to fatal inflammatory disease driven by IFN-γ

(2020) Alison G. Stanbery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

WASP family proteins regulate the mobility of the B cell receptor during signaling activation

(2020) Ivan Rey-Suarez et al.   Nature Communications

Dual Role of Inflammasome Adaptor ASC in Cancer

(2020) Maria Pia Protti et al.   Frontiers in Cell and Developmental Biology

Cell free DNA as a diagnostic and prognostic marker for cardiovascular diseases

(2020) Iuliia A. Polina et al.   CLINICA CHIMICA ACTA

Inhibition of double‐strand DNA‐sensing cGAS ameliorates brain injury after ischemic stroke

(2020) Qian Li et al.   EMBO Molecular Medicine

The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels

(2020) Abdul Basit et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Long noncoding RNA MALAT1 sponges miR-129-5p to regulate the development of bronchopulmonary dysplasia by increasing the expression of HMGB1

(2020) Rongwe Yangi et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation

(2020) Jay Luther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg

(2020) Joseph S. Dolina et al.   Cell Reports

STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection

(2020) Wenbiao Wang et al.   PLoS Pathogens

Adjuvant Effect of Toll-Like Receptor 9 Activation on Cancer Immunotherapy Using Checkpoint Blockade

(2020) Yu-Chen Chuang et al.   Frontiers in Immunology

LncRNA NEAT1 Interacted With DNMT1 to Regulate Malignant Phenotype of Cancer Cell and Cytotoxic T Cell Infiltration via Epigenetic Inhibition of p53, cGAS, and STING in Lung Cancer

(2020) Fang Ma et al.   Frontiers in Genetics

STING couples with PI3K to regulate actin reorganization during BCR activation

(2020) Yukai Jing et al.   Science Advances

Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation

(2020) J. Guerra et al.   Science Advances

Potent STING activation stimulates immunogenic cell death to enhance antitumor immunity in neuroblastoma

(2020) Lihong Wang-Bishop et al.   Journal for ImmunoTherapy of Cancer

Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis

(2020) Li Zhong et al.   Cell Discovery

Comparative Analysis of CpG Sites and Islands Distributed in Mitochondrial DNA of Model Organisms

(2020) Krzysztof Kowal et al.   Animals

Aging aggravated liver ischemia and reperfusion injury by promoting STING‐mediated NLRP3 activation in macrophages

(2020) Weizhe Zhong et al.   AGING CELL

Autoimmunity gene IRGM suppresses cGAS ‐ STING and RIG ‐I‐ MAVS signaling to control interferon response

(2020) Kautilya Kumar Jena et al.   EMBO REPORTS

Emerging Human Coronavirus Infections (SARS, MERS, and COVID-19): Where They Are Leading Us

(2020) Vijay Kumar   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase

(2020) Salim Abdisalaam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome

(2020) Zimu Deng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

(2020) Alice Lepelley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease

(2020) Manish Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING differentially regulates experimental GVHD mediated by CD8 versus CD4 T cell subsets

(2020) Cameron S. Bader et al.   Science Translational Medicine

Mitochondrial DNA: A New Predictor of Diabetic Kidney Disease

(2020) Yajing Huang et al.   International Journal of Endocrinology

PPP6C Negatively Regulates STING-Dependent Innate Immune Responses

(2020) Guoxin Ni et al.   mBio

A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells

(2020) Alex J. Pollock et al.   Nature Communications

TLR4 896A/G and TLR9 1174G/A polymorphisms are associated with the risk of infectious mononucleosis

(2020) Agnieszka Jabłońska et al.   Scientific Reports

Obesity and STING1 genotype associate with 23-valent pneumococcal vaccination efficacy

(2020) Mathew Sebastian et al.   JCI Insight

Influenza Virus-Induced Oxidized DNA Activates Inflammasomes

(2020) Miyu Moriyama et al.   iScience

Mitochondrial stress-activated cGAS-STING pathway inhibits thermogenic program and contributes to overnutrition-induced obesity in mice

(2020) Juli Bai et al.   Communications Biology

Attenuation of cGAS/STING activity during mitosis

(2020) Brittany L Uhlorn et al.   Life Science Alliance

Structural basis for nucleosome-mediated inhibition of cGAS activity

(2020) Duanfang Cao et al.   CELL RESEARCH

EGFR ‐mediated tyrosine phosphorylation of STING determines its trafficking route and cellular innate immunity functions

(2020) Chenyao Wang et al.   EMBO JOURNAL

Long non‐coding RNA MALAT1 targeting STING transcription promotes bronchopulmonary dysplasia through regulation of CREB

(2020) Jia‐He Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Deficiency in Aim2 affects viability and calcification of vascular smooth muscle cells from murine aortas and angiotensin-II induced aortic aneurysms

(2020) Markus Wortmann et al.   MOLECULAR MEDICINE

C9orf72 in myeloid cells suppresses STING-induced inflammation

(2020) Madelyn E. McCauley et al.   NATURE

The Molecular Basis of Tight Nuclear Tethering and Inactivation of cGAS

(2020) Baoyu Zhao et al.   NATURE

Structural basis for sequestration and autoinhibition of cGAS by chromatin

(2020) Sebastian Michalski et al.   NATURE

Structural mechanism of cGAS inhibition by the nucleosome

(2020) Ganesh R. Pathare et al.   NATURE

KAT5 acetylates cGAS to promote innate immune response to DNA virus

(2020) Ze-Min Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

(2020) Baptiste Guey et al.   SCIENCE

Structural basis for the inhibition of cGAS by nucleosomes

(2020) Tomoya Kujirai et al.   SCIENCE

Structural basis of nucleosome-dependent cGAS inhibition

(2020) Joshua A. Boyer et al.   SCIENCE

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

(2020) Jasper Iske et al.   Nature Communications

Cellular uptake of extracellular nucleosomes induces innate immune responses by binding and activating cGMP-AMP synthase (cGAS)

(2020) Huawei Wang et al.   Scientific Reports

MYSM1 Represses Innate Immunity and Autoimmunity through Suppressing the cGAS-STING Pathway

(2020) Mingfu Tian et al.   Cell Reports

Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model

(2020) Gantsetseg Tumurkhuu et al.   Frontiers in Immunology

DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection

(2020) Yue Lu et al.   Frontiers in Immunology

Notch signaling protects CD4 T cells from STING-mediated apoptosis during acute systemic inflammation

(2020) Junke Long et al.   Science Advances

cGAS suppresses genomic instability as a decelerator of replication forks

(2020) Hao Chen et al.   Science Advances

Mitophagy-Mediated mtDNA Release Aggravates Stretching-Induced Inflammation and Lung Epithelial Cell Injury via the TLR9/MyD88/NF-κB Pathway

(2020) Ren Jing et al.   Frontiers in Cell and Developmental Biology

Streptavidin Promotes DNA Binding and Activation of cGAS to Enhance Innate Immunity

(2020) Yanqiong Zhang et al.   iScience

STING Mediates Lupus via the Activation of Conventional Dendritic Cell Maturation and Plasmacytoid Dendritic Cell Differentiation

(2020) Arthid Thim-uam et al.   iScience

Electronic Cigarettes Induce Mitochondrial DNA Damage and Trigger TLR 9 (Toll-Like Receptor 9)-Mediated Atherosclerosis

(2020) Jieliang Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

(2020) V. Kumar   INTERNATIONAL IMMUNOPHARMACOLOGY

STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain

(2020) Tara D. Fischer et al.   JOURNAL OF CELL BIOLOGY

AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia

(2020) Luting Poh et al.   MOLECULAR PSYCHIATRY

cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing

(2020) Carolina Uggenti et al.   NATURE GENETICS

2′3′-cGAMP triggers a STING- and NF-κB–dependent broad antiviral response in Drosophila

(2020) Hua Cai et al.   Science Signaling

DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity

(2020) Xiaona Sun et al.   Nature Communications

Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict

(2020) James B Eaglesham et al.   eLife

STING-dependent autophagy suppresses Nosema bombycis infection in silkworms, Bombyx mori

(2020) Xiaoting Hua et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

STING-mediated intestinal barrier dysfunction contributes to lethal sepsis

(2019) Qiongyuan Hu et al.   EBioMedicine

Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer

(2019) Triparna Sen et al.   Cancer Discovery

Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome

(2019) Sara Botto et al.   mBio

STINGing revelations

(2019) Paulina Strzyz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes

(2019) Alf Håkon Lystad et al.   NATURE CELL BIOLOGY

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling

(2019) James B. Eaglesham et al.   NATURE

STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death

(2019) Jianjun Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model

(2019) Nanyang Xiao et al.   JOURNAL OF AUTOIMMUNITY

Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA

(2019) Katherine C. Barnett et al.   CELL

Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production

(2019) Ruifang Wang et al.   Autophagy

Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization

(2019) Zhonghua Liu et al.   IMMUNITY

The complement system, toll-like receptors and inflammasomes in host defense: three musketeers’ one target

(2019) Vijay Kumar   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS

(2019) Matthieu Gratia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activating cGAS-STING pathway for the optimal effect of cancer immunotherapy

(2019) Anping Li et al.   Journal of Hematology & Oncology

A STING to inflammation and autoimmunity

(2019) Vijay Kumar   JOURNAL OF LEUKOCYTE BIOLOGY

The innate immune DNA sensor cGAS: A membrane, cytosolic, or nuclear protein?

(2019) Nelson O. Gekara et al.   Science Signaling

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation

(2019) Carina C. de Oliveira Mann et al.   Cell Reports

Toll‐Like Receptor 9 Plays a Pivotal Role in Angiotensin II–Induced Atherosclerosis

(2019) Daiju Fukuda et al.   Journal of the American Heart Association

Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes

(2019) Jung Hwan Bae et al.   Cells

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

(2019) Christian Zierhut et al.   CELL

Toll-like receptors in the pathogenesis of neuroinflammation

(2019) V. Kumar   JOURNAL OF NEUROIMMUNOLOGY

TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages

(2019) Yang Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR9 is essential for HMGB1-mediated post-myocardial infarction tissue repair through affecting apoptosis, cardiac healing, and angiogenesis

(2019) Fang-Yuan Liu et al.   Cell Death & Disease

Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death

(2019) Hui Jiang et al.   EMBO JOURNAL

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

Gasdermin D activity in inflammation and host defense

(2019) Judy Lieberman et al.   Science Immunology

Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses

(2019) Miyu Moriyama et al.   Nature Communications

Sepsis roadmap: What we know, what we learned, and where we are going

(2019) Vijay Kumar   CLINICAL IMMUNOLOGY

T Cells Produce IFN-α in the TREX1 D18N Model of Lupus-like Autoimmunity

(2019) Sean R. Simpson et al.   JOURNAL OF IMMUNOLOGY

Tight nuclear tethering of cGAS is essential for preventing autoreactivity

(2019) Hannah E Volkman et al.   eLife

Novel TMEM173 Mutation and the Role of Disease Modifying Alleles

(2019) Salla Keskitalo et al.   Frontiers in Immunology

cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING

(2018) Zhao Lei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

CRP polymorphisms and DNA methylation of the AIM2 gene influence associations between trauma exposure, PTSD, and C-reactive protein

(2018) M.W. Miller et al.   BRAIN BEHAVIOR AND IMMUNITY

DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway

(2018) Yoshinobu Saito et al.   CELL DEATH AND DIFFERENTIATION

Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication

(2018) Yuhei Maruzuru et al.   Cell Host & Microbe

Cpg-ODN, a TLR9 Agonist, Aggravates Myocardial Ischemia/Reperfusion Injury by Activation of TLR9-P38 MAPK Signaling

(2018) Liang Xie et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

(2018) Thaneas Prabakaran et al.   EMBO JOURNAL

The WD40 domain of ATG16L1 is required for its non‐canonical role in lipidation of LC3 at single membranes

(2018) Katherine Fletcher et al.   EMBO JOURNAL

T cells and their immunometabolism: a novel way to understanding sepsis immunopathogenesis and future therapeutics

(2018) V. Kumar   EUROPEAN JOURNAL OF CELL BIOLOGY

The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport

(2018) Karin Pelka et al.   IMMUNITY

Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation

(2018) Umeharu Ohto et al.   IMMUNITY

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

(2018) Kumar Vijay   INTERNATIONAL IMMUNOPHARMACOLOGY

Stimulator of interferon genes (STING) provides insect antiviral immunity by promoting Dredd caspase–mediated NF-kB activation

(2018) Xiaoting Hua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kidney Proximal Tubular TLR9 Exacerbates Ischemic Acute Kidney Injury

(2018) Sang Jun Han et al.   JOURNAL OF IMMUNOLOGY

Herpes Simplex Virus 1 Tegument Protein VP22 Abrogates cGAS/STING-Mediated Antiviral Innate Immunity

(2018) Jian Huang et al.   JOURNAL OF VIROLOGY

Role of Bruton’s tyrosine kinase in B cells and malignancies

(2018) Simar Pal Singh et al.   Molecular Cancer

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Digital signaling network drives the assembly of the AIM2-ASC inflammasome

(2018) Mariusz Matyszewski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition

(2018) Zhonghua Liu et al.   STRUCTURE

Peripheral blood mitochondrial DNA copy number as a novel potential biomarker for diabetic nephropathy in type�2 diabetes patients

(2018) Ghada Al‑Kafaji et al.   Experimental and Therapeutic Medicine

Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes

(2018) Adriana Carolina Gonzalez et al.   Cell Reports

Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function

(2018) Marina Martin et al.   Cell Reports

Identification of DEAD-Box RNA Helicase DDX41 as a Trafficking Protein That Involves in Multiple Innate Immune Signaling Pathways in a Zebrafish Model

(2018) Jun-xia Ma et al.   Frontiers in Immunology

NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation

(2018) Xavier Lahaye et al.   CELL

Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16

(2018) Pei‐Hui Wang et al.   EMBO REPORTS

The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila

(2018) Akira Goto et al.   IMMUNITY

Ion Man: GSDMD Punches Pores to Knock Out cGAS

(2018) Rebecca Feltham et al.   IMMUNITY

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis

(2018) Ishita Banerjee et al.   IMMUNITY

AIM2 deficiency reduces the development of hepatocellular carcinoma in mice

(2018) Claudia Martínez-Cardona et al.   INTERNATIONAL JOURNAL OF CANCER

TLR9 and IL-1R1 Promote Mobilization of Pulmonary Dendritic Cells During Beryllium Sensitization

(2018) Morgan F. Wade et al.   JOURNAL OF IMMUNOLOGY

PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing

(2018) Amanda L. Gavin et al.   NATURE IMMUNOLOGY

Differential Activation of NLRP3, AIM2, and IFI16 Inflammasomes in Humans with Acute and Chronic Hepatitis B

(2018) Hongtao Chen et al.   VIRAL IMMUNOLOGY

ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response

(2018) Huan Lian et al.   Nature Communications

The emerging role of stimulator of interferons genes signaling in sepsis: Inflammation, autophagy, and cell death

(2018) Qiongyuan Hu et al.   Acta Physiologica

The Janus face of HMGB1 in heart disease: a necessary update

(2018) Angela Raucci et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice

(2018) Xianjun Luo et al.   GASTROENTEROLOGY

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

(2018) Yongsheng Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

(2018) Haipeng Liu et al.   NATURE

The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex

(2018) Swarupa Panda et al.   Nature Communications

The allosteric activation of cGAS underpins its dynamic signaling landscape

(2018) Richard M Hooy et al.   eLife

An Analysis of the Expression and Association with Immune Cell Infiltration of the cGAS/STING Pathway in Pan-Cancer

(2018) Xiang An et al.   Molecular Therapy-Nucleic Acids

By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation

(2017) Ivan Zanoni et al.   IMMUNITY

The AIM2 inflammasome: Sensor of pathogens and cellular perturbations

(2017) Jérôme Lugrin et al.   IMMUNOLOGICAL REVIEWS

Palmitic acid dysregulates the Hippo–YAP pathway and inhibits angiogenesis by inducing mitochondrial damage and activating the cytosolic DNA sensor cGAS–STING–IRF3 signaling mechanism

(2017) Liangshuai Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STING-associated vasculopathy develops independently of IRF3 in mice

(2017) James D. Warner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deficiency of the AIM2–ASC Signal Uncovers the STING-Driven Overreactive Response of Type I IFN and Reciprocal Depression of Protective IFN-γ Immunity in Mycobacterial Infection

(2017) Shanshan Yan et al.   JOURNAL OF IMMUNOLOGY

Selectivity of Human TLR9 for Double CpG Motifs and Implications for the Recognition of Genomic DNA

(2017) Jelka Pohar et al.   JOURNAL OF IMMUNOLOGY

Common Polymorphisms in IFI16 and AIM2 Genes Are Associated With Periodontal Disease

(2017) Julie T. Marchesan et al.   JOURNAL OF PERIODONTOLOGY

AIM2 inflammasome activation and regulation: A structural perspective

(2017) Bing Wang et al.   JOURNAL OF STRUCTURAL BIOLOGY

Herpes Simplex Virus 1 Abrogates the cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway via Its Virion Host Shutoff Protein, UL41

(2017) Chenhe Su et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Tegument Protein pp65 (pUL83) Dampens Type I Interferon Production by Inactivating the DNA Sensor cGAS without Affecting STING

(2017) Matteo Biolatti et al.   JOURNAL OF VIROLOGY

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

(2017) Liudmila Andreeva et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic evidence reveals a radiation of placental mammals uninterrupted by the KPg boundary

(2017) Liang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury

(2017) Julius C. Fischer et al.   Science Translational Medicine

STING and TRIF Contribute to Mouse Sepsis, Depending on Severity of the Disease Model

(2017) Erica L. Heipertz et al.   SHOCK

Evolutionary Origins of cGAS-STING Signaling

(2017) Shally R. Margolis et al.   TRENDS IN IMMUNOLOGY

Interaction between HCMV pUL83 and human AIM2 disrupts the activation of the AIM2 inflammasome

(2017) Yuan Huang et al.   Virology Journal

AIM2-Like Receptors Positively and Negatively Regulate the Interferon Response Induced by Cytosolic DNA

(2017) Yuki Nakaya et al.   mBio

Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9

(2017) Jelka Pohar et al.   Nature Communications

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

(2017) Claire Vanpouille-Box et al.   Nature Communications

Tumor cell-specific AIM2 regulates growth and invasion of cutaneous squamous cell carcinoma

(2017) Mehdi Farshchian et al.   Oncotarget

The protective effect of the anti-Toll-like receptor 9 antibody against acute cytokine storm caused by immunostimulatory DNA

(2017) Yusuke Murakami et al.   Scientific Reports

Phosphodiester backbone of the CpG motif within immunostimulatory oligodeoxynucleotides augments activation of Toll-like receptor 9

(2017) Jelka Pohar et al.   Scientific Reports

Interstitial Lung Disease Caused by STING-associated Vasculopathy with Onset in Infancy

(2016) Sarah L. N. Clarke et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mitochondrial DNA

(2016) Simon T. Schäfer et al.   ANESTHESIOLOGY

The cGAS-STING Defense Pathway and Its Counteraction by Viruses

(2016) Zhe Ma et al.   Cell Host & Microbe

Post-translational regulation of inflammasomes

(2016) Jie Yang et al.   Cellular & Molecular Immunology

Atherosclerosis and aortic aneurysm - is inflammation a common denominator?

(2016) Iuliia O. Peshkova et al.   FEBS Journal

Cytosolic DNA Sensing: The Field Narrows

(2016) Russell E. Vance   IMMUNITY

The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA

(2016) Elizabeth E. Gray et al.   IMMUNITY

TLR4: The Winding Road to the Discovery of the LPS Receptor

(2016) Jessica L. Murdock et al.   JOURNAL OF IMMUNOLOGY

Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA

(2016) Leticia Corrales et al.   JOURNAL OF IMMUNOLOGY

Natural STING Agonist as an “Ideal” Adjuvant for Cutaneous Vaccination

(2016) Ji Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Srebp2: A master regulator of sterol and fatty acid synthesis

(2016) Blair B. Madison   JOURNAL OF LIPID RESEARCH

Of Inflammasomes and Alarmins: IL-1  and IL-1  in Kidney Disease

(2016) H.-J. Anders   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved

(2016) Hannah K. Long et al.   NUCLEIC ACIDS RESEARCH

Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins

(2016) Baoyu Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoimmune disease: Conceptual history and contributions of ocular immunology

(2016) Curtis E. Margo et al.   SURVEY OF OPHTHALMOLOGY

Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway

(2016) Xiaomin Ma et al.   Oncotarget

TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy

(2016) Tao Liu et al.   Cell Reports

Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance

(2016) S. Nishimoto et al.   Science Advances

TLR9 -1486T/C and 2848C/T SNPs Are Associated with Human Cytomegalovirus Infection in Infants

(2016) Edyta Paradowska et al.   PLoS One

Toll-like Receptor 9 Can be Activated by Endogenous Mitochondrial DNA to Induce Podocyte Apoptosis

(2016) Wenduona Bao et al.   Scientific Reports

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

(2015) Si Ming Man et al.   CELL

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

(2015) Robert O. Watson et al.   Cell Host & Microbe

AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity

(2015) Si Ming Man et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

(2015) Anetta Härtlova et al.   IMMUNITY

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator–dependent autoimmunity

(2015) Anne-Laure Mathieu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

B cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens

(2015) Janie Akerlund et al.   JOURNAL OF AUTOIMMUNITY

Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice

(2015) David P. Sester et al.   JOURNAL OF IMMUNOLOGY

Species-Specific Minimal Sequence Motif for Oligodeoxyribonucleotides Activating Mouse TLR9

(2015) Jelka Pohar et al.   JOURNAL OF IMMUNOLOGY

Minimal Sequence Requirements for Oligodeoxyribonucleotides Activating Human TLR9

(2015) Jelka Pohar et al.   JOURNAL OF IMMUNOLOGY

Variants of the IFI16 Gene Affecting the Levels of Expression of mRNA Are Associated with Susceptibility to Behcet Disease

(2015) L. Ortiz-Fernandez et al.   JOURNAL OF RHEUMATOLOGY

Role of Mitochondrial DNA in Septic AKI via Toll-Like Receptor 9

(2015) N. Tsuji et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Conservation of the STING-Mediated Cytosolic DNA Sensing Pathway in Zebrafish

(2015) Rui Ge et al.   JOURNAL OF VIROLOGY

Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling

(2015) Philip J. Kranzusch et al.   MOLECULAR CELL

COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis

(2015) Levi B Watkin et al.   NATURE GENETICS

TLR9 regulates adipose tissue inflammation and obesity-related metabolic disorders

(2015) Chun-Pyo Hong et al.   Obesity

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC

(2015) Seamus R. Morrone et al.   Nature Communications

Anti-HMGB1 antibody reduces weight gain in mice fed a high-fat diet

(2015) V N Montes et al.   Nutrition & Diabetes

AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis

(2015) Christopher Jakobs et al.   PLoS One

Massive expansion and functional divergence of innate immune genes in a protostome

(2015) Linlin Zhang et al.   Scientific Reports

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses

(2014) Qiming Liang et al.   Cell Host & Microbe

Sepsis-induced acute kidney injury revisited

(2014) Alexander Zarbock et al.   Current Opinion in Critical Care

Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion

(2014) Hyo-Yeon Kim et al.   FEBS Journal

Alarmin high-mobility group B1 (HMGB1) is regulated in human adipocytes in insulin resistance and influences insulin secretion in β-cells

(2014) R Guzmán-Ruiz et al.   INTERNATIONAL JOURNAL OF OBESITY

Toll-Like Receptor 9-Mediated Protection of Enterovirus 71 Infection in Mice Is Due to the Release of Danger-Associated Molecular Patterns

(2014) H.-B. Hsiao et al.   JOURNAL OF VIROLOGY

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis

(2014) Timea Csak et al.   LIVER INTERNATIONAL

Activated STING in a Vascular and Pulmonary Syndrome

(2014) Yin Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING

(2014) Xiaomei Wu et al.   NUCLEIC ACIDS RESEARCH

UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5

(2014) J.-W. Huh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trafficking of endosomal Toll-like receptors

(2014) Bettina L. Lee et al.   TRENDS IN CELL BIOLOGY

The TLR9 Ligand, CpG‐ODN, Induces Protection against Cerebral Ischemia/Reperfusion Injury via Activation of PI3K/Akt Signaling

(2014) Chen Lu et al.   Journal of the American Heart Association

Streptavidin: A Novel Immunostimulant for the Selection and Delivery of Autologous and Syngeneic Tumor Vaccines

(2014) C. Weir et al.   Cancer Immunology Research

Interleukin-12 (IL-12p70) Promotes Induction of Highly Potent Th1-Like CD4+CD25+ T Regulatory Cells That Inhibit Allograft Rejection in Unmodified Recipients

(2014) Nirupama Darshan Verma et al.   Frontiers in Immunology

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

(2013) Pu Gao et al.   CELL

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

(2013) Xin Li et al.   IMMUNITY

The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells

(2013) Xavier Lahaye et al.   IMMUNITY

Structure of the Absent in Melanoma 2 (AIM2) Pyrin Domain Provides Insights into the Mechanisms of AIM2 Autoinhibition and Inflammasome Assembly

(2013) Tengchuan Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the HIN Domain in Regulation of Innate Immune Responses

(2013) N. Shaw et al.   MOLECULAR AND CELLULAR BIOLOGY

AIM2, an IFN-Inducible Cytosolic DNA Sensor, in the Development of Benign Prostate Hyperplasia and Prostate Cancer

(2013) Larissa Ponomareva et al.   MOLECULAR CANCER RESEARCH

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Small Interfering RNA Targeting Toll-Like Receptor 9 Protects Mice against Polymicrobial Septic Acute Kidney Injury

(2013) Lixia Liu et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

(2013) J. Petrasek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Placental Mammal Ancestor and the Post-K-Pg Radiation of Placentals

(2013) M. A. O'Leary et al.   SCIENCE

Sensing the Dark Side of DNA

(2013) L. A. J. O'Neill   SCIENCE

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation

(2013) Qian Yin et al.   Cell Reports

The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

(2013) Elie J. Diner et al.   Cell Reports

UNC93B1 mediates differential trafficking of endosomal TLRs

(2013) Bettina L Lee et al.   eLife

CpG-ODN, the TLR9 agonist, attenuates myocardial ischemia/reperfusion injury: Involving activation of PI3K/Akt signaling

(2012) Zhijuan Cao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The mammalian PYHIN gene family: Phylogeny, evolution and expression

(2012) Jasmyn A Cridland et al.   BMC EVOLUTIONARY BIOLOGY

Overexpression of the DNA sensor proteins, absent in melanoma 2 and interferon-inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation

(2012) Yuudai Kondo et al.   CANCER SCIENCE

The role of S6K1 in ER-positive breast cancer

(2012) Marina K. Holz   CELL CYCLE

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

(2012) Tengchuan Jin et al.   IMMUNITY

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

(2012) Rebecca L. Brunette et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HMGB1 Is Associated with Atherosclerotic Plaque Composition and Burden in Patients with Stable Coronary Artery Disease

(2012) Martin Andrassy et al.   PLoS One

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

The STING in the Tail for Cytosolic DNA-Dependent Activation of IRF3

(2012) A. Bowie   Science Signaling

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

(2011) Huihui Chen et al.   CELL

TLR9 polymorphisms and systemic lupus erythematosus risk in Asians: A meta-analysis study

(2011) Zaixing Yang et al.   CYTOKINE

DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature

(2011) Yue Li et al.   EMBO JOURNAL

Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling

(2011) Boyoun Park et al.   IMMUNITY

Transmembrane Mutations in Toll-like Receptor 9 Bypass the Requirement for Ectodomain Proteolysis and Induce Fatal Inflammation

(2011) Maria L. Mouchess et al.   IMMUNITY

Special Delivery: Granulin Brings CpG DNA to Toll-like Receptor 9

(2011) Eva Marie Y. Moresco et al.   IMMUNITY

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

PLD4 Is Involved in Phagocytosis of Microglia: Expression and Localization Changes of PLD4 Are Correlated with Activation State of Microglia

(2011) Yoshinori Otani et al.   PLoS One

The value of serial plasma nuclear and mitochondrial DNA levels in patients with acute ischemic stroke

(2010) Nai-Wen Tsai et al.   CLINICA CHIMICA ACTA

COPII-mediated vesicle formation at a glance

(2010) D. Jensen et al.   JOURNAL OF CELL SCIENCE

Virology, epidemiology, pathogenesis, and control of enterovirus 71

(2010) Tom Solomon et al.   LANCET INFECTIOUS DISEASES

PYHIN proteins: center stage in DNA sensing

(2010) Delphine Goubau et al.   NATURE IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Cell-free DNA levels in acute myocardial infarction patients during hospitalization

(2009) A. Destouni et al.   ACTA CARDIOLOGICA

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

Increased serum HMGB1 level is associated with coronary artery disease in nondiabetic and type 2 diabetic patients

(2008) Xiao Xiang Yan et al.   ATHEROSCLEROSIS

IL-18 Contributes to Renal Damage after Ischemia-Reperfusion

(2008) H. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

(2008) You-Me Kim et al.   NATURE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Toll-like receptors — taking an evolutionary approach

(2008) François Leulier et al.   NATURE REVIEWS GENETICS