AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity

The NMR solution structure of AIM2 PYD domain from Mus musculus reveals a distinct α2–α3 helix conformation from its human homologues

(2015) Xianhui Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

(2015) Si Ming Man et al.   CELL

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

(2015) Ruth Wassermann et al.   Cell Host & Microbe

Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection

(2015) Rajendra Karki et al.   Cell Host & Microbe

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease

(2015) Lucia de Almeida et al.   IMMUNITY

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Guanylate Binding Proteins Enable Rapid Activation of Canonical and Noncanonical Inflammasomes in Chlamydia-Infected Macrophages

(2015) Ryan Finethy et al.   INFECTION AND IMMUNITY

Inflammasome signaling pathways exert antiviral effect against Chikungunya virus in human dermal fibroblasts

(2015) Peeraya Ekchariyawat et al.   INFECTION GENETICS AND EVOLUTION

Strong Upregulation of AIM2 and IFI16 Inflammasomes in the Mucosa of Patients with Active Inflammatory Bowel Disease

(2015) Wiebe Vanhove et al.   INFLAMMATORY BOWEL DISEASES

Absent in melanoma 2 triggers a heightened inflammasome response in ascitic fluid macrophages of patients with cirrhosis

(2015) Beatriz Lozano-Ruiz et al.   JOURNAL OF HEPATOLOGY

Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice

(2015) David P. Sester et al.   JOURNAL OF IMMUNOLOGY

cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response toFrancisellaInfection

(2015) Kelly M. Storek et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

(2015) Si Ming Man et al.   NATURE IMMUNOLOGY

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

(2015) Etienne Meunier et al.   NATURE IMMUNOLOGY

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

(2015) Justin E Wilson et al.   NATURE MEDICINE

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3

(2015) Adam Denes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential expression of inflammasomes in lung cancer cell lines and tissues

(2015) Hui Kong et al.   TUMOR BIOLOGY

Expression of AIM2 is correlated with increased inflammation in chronic hepatitis B patients

(2015) Yongtao Han et al.   Virology Journal

Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC

(2015) Seamus R. Morrone et al.   Nature Communications

Inflammasome control of viral infection

(2015) Christopher Lupfer et al.   Current Opinion in Virology

AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis

(2015) Christopher Jakobs et al.   PLoS One

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

(2014) Xin Cai et al.   CELL

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Type I Interferon Signaling Regulates Activation of the Absent in Melanoma 2 Inflammasome during Streptococcus pneumoniae Infection

(2014) R. Fang et al.   INFECTION AND IMMUNITY

Lack of Absent in Melanoma 2 (AIM2) expression in tumor cells is closely associated with poor survival in colorectal cancer patients

(2014) Susanne Dihlmann et al.   INTERNATIONAL JOURNAL OF CANCER

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

(2014) Stephanie E Adamczak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation

(2014) Mary A. Rodgers et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: AIM2 and Endosomal TLRs Differentially Regulate Arthritis and Autoantibody Production in DNase II–Deficient Mice

(2014) Rebecca Baum et al.   JOURNAL OF IMMUNOLOGY

The Recombinant BCG ΔureC::hlyVaccine Targets the AIM2 Inflammasome to Induce Autophagy and Inflammation

(2014) Hiroyuki Saiga et al.   JOURNAL OF INFECTIOUS DISEASES

Crystal Structure of the F27G AIM2 PYD Mutant and Similarities of Its Self-Association to DED/DED Interactions

(2014) Alvin Lu et al.   JOURNAL OF MOLECULAR BIOLOGY

Critical role for the AIM2 inflammasome during acute CNS bacterial infection

(2014) Richa Hanamsagar et al.   JOURNAL OF NEUROCHEMISTRY

Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis

(2014) Timea Csak et al.   LIVER INTERNATIONAL

AIM2 Mediates Inflammation-Associated Renal Damage in Hepatitis B Virus-Associated Glomerulonephritis by Regulating Caspase-1, IL-1β, and IL-18

(2014) Junhui Zhen et al.   MEDIATORS OF INFLAMMATION

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

(2014) Xin Cai et al.   MOLECULAR CELL

The PYRIN domain–only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

(2014) Sonal Khare et al.   NATURE IMMUNOLOGY

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

(2014) S. M. Man et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome

(2014) S. Kailasan Vanaja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A CRISPR-Cas system enhances envelope integrity mediating antibiotic resistance and inflammasome evasion

(2014) T. R. Sampson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex-dependent differential activation of NLRP3 and AIM2 inflammasomes in SLE macrophages

(2014) C.-A. Yang et al.   RHEUMATOLOGY

Dual Engagement of the NLRP3 and AIM2 Inflammasomes by Plasmodium-Derived Hemozoin and DNA during Malaria

(2014) Parisa Kalantari et al.   Cell Reports

Mitochondrial ROS potentiates indirect activation of the AIM2 inflammasome

(2014) Deborah D. Crane et al.   Frontiers in Microbiology

HPV16 activates the AIM2 inflammasome in keratinocytes

(2013) M. Reinholz et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes

(2013) Tae-Min Kim et al.   CELL

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

(2013) V Sagulenko et al.   CELL DEATH AND DIFFERENTIATION

Recognition of cytosolic DNA by cGAS and other STING-dependent sensors

(2013) Numana Bhat et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Correlation of AIM2 expression in peripheral blood mononuclear cells from humans with acute and chronic hepatitis B

(2013) Dian-Lei Wu et al.   HUMAN IMMUNOLOGY

Activation of NLRP3 and AIM2 Inflammasomes by Porphyromonas gingivalis Infection

(2013) Eunjoo Park et al.   INFECTION AND IMMUNITY

Structure of the Absent in Melanoma 2 (AIM2) Pyrin Domain Provides Insights into the Mechanisms of AIM2 Autoinhibition and Inflammasome Assembly

(2013) Tengchuan Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repression of Inflammasome by Francisella tularensis during Early Stages of Infection

(2013) Rachel J. Dotson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic Oligodeoxynucleotides Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation

(2013) J. J. Kaminski et al.   JOURNAL OF IMMUNOLOGY

Molecular Basis of DNA Recognition in the Immune System

(2013) M. K. Atianand et al.   JOURNAL OF IMMUNOLOGY

Critical Role of ASC Inflammasomes and Bacterial Type IV Secretion System in Caspase-1 Activation and Host Innate Resistance to Brucella abortus Infection

(2013) M. T. R. Gomes et al.   JOURNAL OF IMMUNOLOGY

Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors

(2013) K. A. Horan et al.   JOURNAL OF IMMUNOLOGY

The AIM2 Inflammasome Is Involved in Macrophage Activation During Infection With Virulent Mycobacterium bovis Strain

(2013) Yang Yang et al.   JOURNAL OF INFECTIOUS DISEASES

AIM2, an IFN-Inducible Cytosolic DNA Sensor, in the Development of Benign Prostate Hyperplasia and Prostate Cancer

(2013) Larissa Ponomareva et al.   MOLECULAR CANCER RESEARCH

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

(2013) Hideki Hara et al.   NATURE IMMUNOLOGY

Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation

(2013) Qian Yin et al.   Cell Reports

Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop

(2013) C. Juruj et al.   Frontiers in Cellular and Infection Microbiology

The mammalian PYHIN gene family: Phylogeny, evolution and expression

(2012) Jasmyn A Cridland et al.   BMC EVOLUTIONARY BIOLOGY

Overexpression of the DNA sensor proteins, absent in melanoma 2 and interferon-inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation

(2012) Yuudai Kondo et al.   CANCER SCIENCE

AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages

(2012) R Pierini et al.   CELL DEATH AND DIFFERENTIATION

Tumour inflammasome-derived IL-1β recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma

(2012) Lih-Chyang Chen et al.   EMBO Molecular Medicine

Strong induction of AIM2 expression in human epidermis in acute and chronic inflammatory skin conditions

(2012) Heleen D. de Koning et al.   EXPERIMENTAL DERMATOLOGY

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

(2012) Tengchuan Jin et al.   IMMUNITY

A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii

(2012) Masahiro Yamamoto et al.   IMMUNITY

Induction of type I IFNs by intracellular DNA-sensing pathways

(2012) Taner Cavlar et al.   IMMUNOLOGY AND CELL BIOLOGY

Francisella tularensis Live Vaccine Strain Folate Metabolism and Pseudouridine Synthase Gene Mutants Modulate Macrophage Caspase-1 Activation

(2012) Tyler K. Ulland et al.   INFECTION AND IMMUNITY

Critical role of AIM2 in Mycobacterium tuberculosis infection

(2012) H. Saiga et al.   INTERNATIONAL IMMUNOLOGY

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

(2012) Rebecca L. Brunette et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interactome-wide Analysis Identifies End-binding Protein 1 as a Crucial Component for the Speck-like Particle Formation of Activated Absence in Melanoma 2 (AIM2) Inflammasomes

(2012) Li-Jie Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking

(2012) J. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated AIM2-mediated pyroptosis triggered by hypercytotoxic Francisella mutant strains is attributed to increased intracellular bacteriolysis

(2011) Kaitian Peng et al.   CELLULAR MICROBIOLOGY

Francisella infection triggers activation of the AIM2 inflammasome in murine dendritic cells

(2011) Kamila Belhocine et al.   CELLULAR MICROBIOLOGY

Francisella tularensisReveals a Disparity between Human and Mouse NLRP3 Inflammasome Activation

(2011) Maninjay K. Atianand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Roles of ASC Inflammasomes in Caspase-1 Activation and Host Innate Resistance to Streptococcus pneumoniae Infection

(2011) R. Fang et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Detection of prokaryotic mRNA signifies microbial viability and promotes immunity

(2011) Leif E. Sander et al.   NATURE

IFI16 Protein Mediates the Anti-inflammatory Actions of the Type-I Interferons through Suppression of Activation of Caspase-1 by Inflammasomes

(2011) Sudhakar Veeranki et al.   PLoS One

Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions

(2011) Y. Dombrowski et al.   Science Translational Medicine

Listeria monocytogenes Triggers AIM2-Mediated Pyroptosis upon Infrequent Bacteriolysis in the Macrophage Cytosol

(2010) John-Demian Sauer et al.   Cell Host & Microbe

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

(2010) Sarah Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Involvement of the AIM2, NLRC4, and NLRP3 Inflammasomes in Caspase-1 Activation by Listeria monocytogenes

(2010) Jianghong Wu et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella

(2010) Petr Broz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Mutation of Francisella tularensis mviN Leads to Increased Macrophage Absent in Melanoma 2 Inflammasome Activation and a Loss of Virulence

(2010) T. K. Ulland et al.   JOURNAL OF IMMUNOLOGY

Deletion of ripA Alleviates Suppression of the Inflammasome and MAPK by Francisella tularensis

(2010) M. T.-H. Huang et al.   JOURNAL OF IMMUNOLOGY

Involvement of Absent in Melanoma 2 in Inflammasome Activation in Macrophages Infected with Listeria monocytogenes

(2010) K. Tsuchiya et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Cytosolic Bacterial DNA Activates the Inflammasome via Aim2

(2010) S. E. Warren et al.   JOURNAL OF IMMUNOLOGY

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

(2010) Teresa Fernandes-Alnemri et al.   NATURE IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

(2010) J. W. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

(2009) B. M. Javierre et al.   GENOME RESEARCH

Expression profile of HIN200 in leukocytes and renal biopsy of SLE patients by real-time RT-PCR

(2009) I Kimkong et al.   LUPUS

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

Interferon-inducible Ifi200-family genes in systemic lupus erythematosus

(2008) Divaker Choubey et al.   IMMUNOLOGY LETTERS

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE