The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels

p21 limits S phase DNA damage caused by the Wee1 inhibitor MK1775

(2019) Sissel Hauge et al.   CELL CYCLE

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

(2019) Christian Zierhut et al.   CELL

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses

(2018) Tanggang Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING promotes homeostasis via regulation of cell proliferation and chromosomal stability

(2018) Diana Rose E. Ranoa et al.   CANCER RESEARCH

Stimulator of IFN genes–mediated DNA-sensing pathway is suppressed by NLRP3 agonists and regulated by mitofusin 1 and TBC1D15, mitochondrial dynamics mediators

(2017) Dohyeong Kwon et al.   FASEB JOURNAL

NEMO–IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS–STING Pathway

(2017) Run Fang et al.   JOURNAL OF IMMUNOLOGY

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is inflammatory micronucleation the key to a successful anti-mitotic cancer drug?

(2017) T. J. Mitchison et al.   Open Biology

The Role of Chromosomal Instability in Cancer and Therapeutic Responses

(2017) Natalia Vargas-Rondón et al.   Cancers

Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis

(2015) Smitha Pillai et al.   Nature Communications

Mechanisms and pathways of innate immune activation and regulation in health and cancer

(2015) Jun Cui et al.   Human Vaccines & Immunotherapeutics

The mechanism of double-stranded DNA sensing through the cGAS-STING pathway

(2014) Chang Shu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

(2013) Xin Li et al.   IMMUNITY

Stabilization of p21 (Cip1/WAF1) following Tip60-dependent acetylation is required for p21-mediated DNA damage response

(2012) M-S Lee et al.   CELL DEATH AND DIFFERENTIATION

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Forced Mitotic Entry of S-Phase Cells as a Therapeutic Strategy Induced by Inhibition of WEE1

(2012) Marieke Aarts et al.   Cancer Discovery

WEE1 Kinase Targeting Combined with DNA-Damaging Cancer Therapy Catalyzes Mitotic Catastrophe

(2011) P. C. De Witt Hamer et al.   CLINICAL CANCER RESEARCH

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

(2010) M. Fenech et al.   MUTAGENESIS

p53- and p21-dependent premature APC/C–Cdh1 activation in G2 is part of the long-term response to genotoxic stress

(2010) L Wiebusch et al.   ONCOGENE

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

(2009) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells

(2008) D M Moran et al.   ONCOGENE