Human Cytomegalovirus Tegument Protein pp65 (pUL83) Dampens Type I Interferon Production by Inactivating the DNA Sensor cGAS without Affecting STING

Human cytomegalovirus triggers the assembly of AIM2 inflammasome in THP-1-derived macrophages

(2017) Yuan Huang et al.   JOURNAL OF MEDICAL VIROLOGY

Congenital Human Cytomegalovirus Infection and the Enigma of Maternal Immunity

(2017) William J. Britt   JOURNAL OF VIROLOGY

Herpes Simplex Virus 1 Abrogates the cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway via Its Virion Host Shutoff Protein, UL41

(2017) Chenhe Su et al.   JOURNAL OF VIROLOGY

Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways

(2017) Alessandra Zevini et al.   TRENDS IN IMMUNOLOGY

Interaction between HCMV pUL83 and human AIM2 disrupts the activation of the AIM2 inflammasome

(2017) Yuan Huang et al.   Virology Journal

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

(2017) K. L. Jønsson et al.   Nature Communications

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

(2017) Jessica F. Almine et al.   Nature Communications

The cGAS-STING Defense Pathway and Its Counteraction by Viruses

(2016) Zhe Ma et al.   Cell Host & Microbe

Viral evasion of DNA-stimulated innate immune responses

(2016) Maria H Christensen et al.   Cellular & Molecular Immunology

Diverse mechanisms evolved by DNA viruses to inhibit early host defenses

(2016) Marni S. Crow et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

HSV‐1 ICP27 targets the TBK1‐activated STING signalsome to inhibit virus‐induced type I IFN expression

(2016) Maria H Christensen et al.   EMBO JOURNAL

The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA

(2016) Elizabeth E. Gray et al.   IMMUNITY

Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression

(2016) Benedetta Pignoloni et al.   JOURNAL OF IMMUNOLOGY

Relative Contributions of Herpes Simplex Virus 1 ICP0 and vhs to Loss of Cellular IFI16 Vary in Different Human Cell Types

(2016) Megan H. Orzalli et al.   JOURNAL OF VIROLOGY

Regulatory Interaction between the Cellular Restriction Factor IFI16 and Viral pp65 (pUL83) Modulates Viral Gene Expression and IFI16 Protein Stability

(2016) Matteo Biolatti et al.   JOURNAL OF VIROLOGY

cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection

(2016) Chan-Wang J. Lio et al.   JOURNAL OF VIROLOGY

ReGLUation of cGAS

(2016) Andrea Ablasser   NATURE IMMUNOLOGY

Viral evasion of intracellular DNA and RNA sensing

(2016) Ying Kai Chan et al.   NATURE REVIEWS MICROBIOLOGY

Evasion of host antiviral innate immunity by HSV-1, an update

(2016) Chenhe Su et al.   Virology Journal

The Role of Nuclear Antiviral Factors against Invading DNA Viruses: The Immediate Fate of Incoming Viral Genomes

(2016) Tetsuro Komatsu et al.   Viruses-Basel

Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus Infection

(2016) Benjamin A. Diner et al.   mBio

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells

(2016) Jennifer Paijo et al.   PLoS Pathogens

DNA sensor cGAS-mediated immune recognition

(2016) Pengyan Xia et al.   Protein & Cell

Blowing Off Steam: Virus Inhibition of cGAS DNA Sensing

(2015) Benjamin A. Diner et al.   Cell Host & Microbe

Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein

(2015) Jian-jun Wu et al.   Cell Host & Microbe

The Emerging Role of Nuclear Viral DNA Sensors

(2015) Benjamin A. Diner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dengue Virus Control of Type I IFN Responses: A History of Manipulation and Control

(2015) Jorge Andrés Castillo Ramirez et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Activation and Regulation of DNA-Driven Immune Responses

(2015) Søren R. Paludan   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection

(2015) Megan H. Orzalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear sensing of viral DNA, epigenetic regulation of herpes simplex virus infection, and innate immunity

(2015) David M. Knipe   VIROLOGY

Ubiquitination in the antiviral immune response

(2015) Meredith E. Davis et al.   VIROLOGY

Innate immune recognition of DNA: A recent history

(2015) Alan Dempsey et al.   VIROLOGY

TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING

(2015) Yanming Wang et al.   PLoS Pathogens

Cellular Sensing of Viral DNA and Viral Evasion Mechanisms

(2014) Megan H. Orzalli et al.   Annual Review of Microbiology

Interferon γ-inducible Protein (IFI) 16 Transcriptionally Regulates Type I Interferons and Other Interferon-stimulated Genes and Controls the Interferon Response to both DNA and RNA Viruses

(2014) Mikayla R. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The pathogenesis of human cytomegalovirus

(2014) Paul Griffiths et al.   JOURNAL OF PATHOLOGY

Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways

(2014) Yinghui Liu et al.   JOURNAL OF VIROLOGY

Innate Nuclear Sensor IFI16 Translocates into the Cytoplasm during the Early Stage of In Vitro Human Cytomegalovirus Infection and Is Entrapped in the Egressing Virions during the Late Stage

(2014) V. Dell'Oste et al.   JOURNAL OF VIROLOGY

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

HSV-1 degrades, stabilizes, requires, or is stung by STING depending on ICP0, the US3 protein kinase, and cell derivation

(2014) Maria Kalamvoki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

Human Cytomegalovirus Tegument Protein pUL83 Inhibits IFI16-Mediated DNA Sensing for Immune Evasion

(2013) Tuo Li et al.   Cell Host & Microbe

Recognition of cytosolic DNA by cGAS and other STING-dependent sensors

(2013) Numana Bhat et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors

(2013) K. A. Horan et al.   JOURNAL OF IMMUNOLOGY

Herpes Simplex Virus 1-Encoded Tegument Protein VP16 Abrogates the Production of Beta Interferon (IFN) by Inhibiting NF- B Activation and Blocking IFN Regulatory Factor 3 To Recruit Its Coactivator CBP

(2013) J. Xing et al.   JOURNAL OF VIROLOGY

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein

(2012) M. H. Orzalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16

(2012) T. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor for Human Cytomegalovirus Replication

(2012) Grazia Rosaria Gariano et al.   PLoS Pathogens

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Innate immune sensing of DNA viruses

(2011) Vijay A.K. Rathinam et al.   VIROLOGY

Pattern Recognition Receptors and the Innate Immune Response to Viral Infection

(2011) Mikayla R. Thompson et al.   Viruses-Basel

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

Human Cytomegalovirus Induces the Interferon Response via the DNA Sensor ZBP1

(2009) V. R. DeFilippis et al.   JOURNAL OF VIROLOGY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Major Tegument Protein pp65 of Human Cytomegalovirus Is Required for the Incorporation of pUL69 and pUL97 into the Virus Particle and for Viral Growth in Macrophages

(2008) M. Chevillotte et al.   JOURNAL OF VIROLOGY

Role for herpes simplex virus 1 ICP27 in the inhibition of type I interferon signaling

(2008) Karen E. Johnson et al.   VIROLOGY