Post-translational regulation of inflammasomes

Specificity and disease in the ubiquitin system

(2016) V. K. Chaugule et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

The kinase activity of PKR represses inflammasome activity

(2016) Howard CH Yim et al.   CELL RESEARCH

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

E3 ubiquitin ligases as novel targets for inflammatory diseases

(2016) Santosh Kumar Goru et al.   PHARMACOLOGICAL RESEARCH

Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis

(2016) Ismail Sergin et al.   Science Signaling

The Ball and Chain of Polyubiquitin Structures

(2016) Caterina Alfano et al.   TRENDS IN BIOCHEMICAL SCIENCES

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

(2016) Mausita Karmakar et al.   Nature Communications

p58IPK suppresses NLRP3 inflammasome activation and IL-1β production via inhibition of PKR in macrophages

(2016) Evgenii Boriushkin et al.   Scientific Reports

Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis

(2016) Ismail Sergin et al.   Science Signaling

The Inflammasomes and Autoinflammatory Syndromes

(2015) Lori Broderick et al.   Annual Review of Pathology-Mechanisms of Disease

Ginsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS

(2015) Sung-Jin Yoon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

(2015) Ruth Wassermann et al.   Cell Host & Microbe

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

A20 Restricts Ubiquitination of Pro-Interleukin-1β Protein Complexes and Suppresses NLRP3 Inflammasome Activity

(2015) Bao H. Duong et al.   IMMUNITY

Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2E3 Ligase

(2015) SeungHye Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

(2015) Jonathan L. Schmid-Burgk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the Mouse

(2015) Carlo Marchetti et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3

(2015) Kai Guan et al.   JOURNAL OF IMMUNOLOGY

cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response toFrancisellaInfection

(2015) Kelly M. Storek et al.   JOURNAL OF IMMUNOLOGY

Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K+Efflux

(2015) Mausita Karmakar et al.   JOURNAL OF IMMUNOLOGY

Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization

(2015) Ying-Cing Lin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

(2015) Ingrid E. Wertz et al.   NATURE

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

(2015) Qing Zhou et al.   NATURE GENETICS

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

(2015) Magdalena Matusiak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection

(2015) Megan H. Orzalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

(2015) L. Zhang et al.   SCIENCE

Structural and biochemical basis for induced self-propagation of NLRC4

(2015) Z. Hu et al.   SCIENCE

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

The demographics of the ubiquitin system

(2015) Michael J. Clague et al.   TRENDS IN CELL BIOLOGY

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome

(2015) Hongbin Wang et al.   Cell Reports

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

(2014) Marta Wlodarska et al.   CELL

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Innate signaling in the inflammatory immune disorders

(2014) Cheng Qian et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation

(2014) Mary A. Rodgers et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An inherited mutation inNLRC4causes autoinflammation in human and mice

(2014) Akiko Kitamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammasome Priming by Lipopolysaccharide Is Dependent upon ERK Signaling and Proteasome Function

(2014) M. G. Ghonime et al.   JOURNAL OF IMMUNOLOGY

The Recombinant BCG ΔureC::hlyVaccine Targets the AIM2 Inflammasome to Induce Autophagy and Inflammation

(2014) Hiroyuki Saiga et al.   JOURNAL OF INFECTIOUS DISEASES

Inflammasomes and Metabolic Disorders: Old Genes in Modern Diseases

(2014) Gregory R. Robbins et al.   MOLECULAR CELL

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

(2014) Katrin D. Mayer-Barber et al.   NATURE

Inefficient star formation in extremely metal poor galaxies

(2014) Yong Shi et al.   NATURE

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

(2014) Neil Romberg et al.   NATURE GENETICS

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

(2014) Scott W Canna et al.   NATURE GENETICS

Inflammasome: Cancer's friend or foe?

(2014) Michela Terlizzi et al.   PHARMACOLOGY & THERAPEUTICS

HSV-1 degrades, stabilizes, requires, or is stung by STING depending on ICP0, the US3 protein kinase, and cell derivation

(2014) Maria Kalamvoki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-binding domains: Mechanisms of ubiquitin recognition and use as tools to investigate ubiquitin-modified proteomes

(2014) Daniel Scott et al.   PROTEOMICS

ADP-Ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS Toxin Regulates Inflammasome Activity

(2014) Santanu Bose et al.   mBio

Inflammasomes

(2014) M. R. de Zoete et al.   Cold Spring Harbor Perspectives in Biology

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

(2014) Nina Van Opdenbosch et al.   Nature Communications

IKKα negatively regulates ASC-dependent inflammasome activation

(2014) Bradley N. Martin et al.   Nature Communications

The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge

(2014) Kaiwen W. Chen et al.   Cell Reports

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

(2014) Monica Yabal et al.   Cell Reports

Update on enterovirus 71 infection

(2014) Peng-Nien Huang et al.   Current Opinion in Virology

Shigella Type III Secretion Protein MxiI Is Recognized by Naip2 to Induce Nlrc4 Inflammasome Activation Independently of Pkcδ

(2014) Shiho Suzuki et al.   PLoS Pathogens

Inflammasomes in cancer: a double-edged sword

(2014) Ryan Kolb et al.   Protein & Cell

Inflammasomes and Metabolic Disease

(2013) Jorge Henao-Mejia et al.   Annual Review of Physiology

The Pivotal Role of IKKα in the Development of Spontaneous Lung Squamous Cell Carcinomas

(2013) Zuoxiang Xiao et al.   CANCER CELL

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling

(2013) Lan K Nguyen et al.   Cell Communication and Signaling

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2013) Kairui Mao et al.   CELL RESEARCH

Ubiquitin in the immune system

(2013) Julia Zinngrebe et al.   EMBO REPORTS

The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages

(2013) Yuan He et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human astrocytes express a novel NLRP2 inflammasome

(2013) Julia Minkiewicz et al.   GLIA

3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome

(2013) Yuan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice

(2013) Ning Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome

(2013) T. Fernandes-Alnemri et al.   JOURNAL OF IMMUNOLOGY

The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity

(2013) S. Park et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Mycobacterium tuberculosis but Not Nonvirulent Mycobacteria Inhibits IFN-  and AIM2 Inflammasome-Dependent IL-1  Production via Its ESX-1 Secretion System

(2013) S. Shah et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Mouse NAIP1 Detects the Type III Secretion System Needle Protein

(2013) M. Rayamajhi et al.   JOURNAL OF IMMUNOLOGY

The Viral Ubiquitin Ligase ICP0 Is neither Sufficient nor Necessary for Degradation of the Cellular DNA Sensor IFI16 during Herpes Simplex Virus 1 Infection

(2013) D. Cuchet-Lourenco et al.   JOURNAL OF VIROLOGY

Constitutive Interferon-Inducible Protein 16-Inflammasome Activation during Epstein-Barr Virus Latency I, II, and III in B and Epithelial Cells

(2013) M. A. Ansari et al.   JOURNAL OF VIROLOGY

Herpes Simplex Virus 1 Infection Induces Activation and Subsequent Inhibition of the IFI16 and NLRP3 Inflammasomes

(2013) K. E. Johnson et al.   JOURNAL OF VIROLOGY

Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis

(2013) Erik C Hett et al.   Nature Chemical Biology

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

(2013) Hideki Hara et al.   NATURE IMMUNOLOGY

Inflammasome-derived IL-1β production induces nitric oxide–mediated resistance to Leishmania

(2013) Djalma S Lima-Junior et al.   NATURE MEDICINE

PNAS Plus: From the Cover: IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication

(2013) M. R. Jakobsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

(2013) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism

(2013) Z. Hu et al.   SCIENCE

IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

(2013) K. M. Monroe et al.   SCIENCE

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Enterovirus 71 Protease 2Apro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses

(2013) Bei Wang et al.   PLoS Pathogens

Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor

(2013) Joseph Chavarría-Smith et al.   PLoS Pathogens

Mycobacterium tuberculosis and the host cell inflammasome: a complex relationship

(2013) Volker Briken et al.   Frontiers in Cellular and Infection Microbiology

Mycoplasma pneumoniaeCARDS Toxin Induces Pulmonary Eosinophilic and Lymphocytic Inflammation

(2012) Jorge L. Medina et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

The NLRP12 Inflammasome Recognizes Yersinia pestis

(2012) Gregory I. Vladimer et al.   IMMUNITY

An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages

(2012) Sonal Khare et al.   IMMUNITY

Regulation of NF-κB by deubiquitinases

(2012) Edward W. Harhaj et al.   IMMUNOLOGICAL REVIEWS

Critical role of AIM2 in Mycobacterium tuberculosis infection

(2012) H. Saiga et al.   INTERNATIONAL IMMUNOLOGY

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

(2012) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation and Structure of a NAIP5-NLRC4 Inflammasome Induced by Direct Interactions with Conserved N- and C-terminal Regions of Flagellin

(2012) Els F. Halff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome

(2012) Gloria Lopez-Castejon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome

(2012) E. Hernandez-Cuellar et al.   JOURNAL OF IMMUNOLOGY

Cleavage of Interferon Regulatory Factor 7 by Enterovirus 71 3C Suppresses Cellular Responses

(2012) Xiaobo Lei et al.   JOURNAL OF VIROLOGY

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

(2012) Rune Busk Damgaard et al.   MOLECULAR CELL

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

Phosphorylation of NLRC4 is critical for inflammasome activation

(2012) Yan Qu et al.   NATURE

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β

(2012) Bibhuti B Mishra et al.   NATURE IMMUNOLOGY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Activation of an NLRP3 Inflammasome Restricts Mycobacterium kansasii Infection

(2012) Chang-Chieh Chen et al.   PLoS One

Anthrax Lethal Factor Cleaves Mouse Nlrp1b in Both Toxin-Sensitive and Toxin-Resistant Macrophages

(2012) Kristina A. Hellmich et al.   PLoS One

Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein

(2012) M. H. Orzalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orchestrating Inflammasomes

(2012) L. Franchi et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Allosteric post-translational modification codes

(2012) Ruth Nussinov et al.   TRENDS IN BIOCHEMICAL SCIENCES

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

(2012) Jonathan L. Levinsohn et al.   PLoS Pathogens

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

Critical role for NLRP3 in necrotic death triggered by Mycobacterium tuberculosis

(2011) Ka-Wing Wong et al.   CELLULAR MICROBIOLOGY

Activation of the NLRP3 inflammasome byMycobacterium tuberculosisis uncoupled from susceptibility to active tuberculosis

(2011) Anca Dorhoi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Innate and Adaptive Interferons Suppress IL-1α and IL-1β Production by Distinct Pulmonary Myeloid Subsets during Mycobacterium tuberculosis Infection

(2011) Katrin D. Mayer-Barber et al.   IMMUNITY

The PYHIN protein family as mediators of host defenses

(2011) Stefan A. Schattgen et al.   IMMUNOLOGICAL REVIEWS

MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP

(2011) L. Jin et al.   JOURNAL OF IMMUNOLOGY

Engineering and Structural Characterization of a Linear Polyubiquitin-Specific Antibody

(2011) Marissa L. Matsumoto et al.   JOURNAL OF MOLECULAR BIOLOGY

Interferon-inducible p200-family protein IFI16, an innate immune sensor for cytosolic and nuclear double-stranded DNA: Regulation of subcellular localization

(2011) Sudhakar Veeranki et al.   MOLECULAR IMMUNOLOGY

China's academic autocracy must go

(2011) Nai-Zhuo Zhao   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

NLR functions in plant and animal immune systems: so far and yet so close

(2011) Takaki Maekawa et al.   NATURE IMMUNOLOGY

Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database

(2011) George A. Khoury et al.   Scientific Reports

Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death

(2010) Yatender Kumar et al.   BIOCHEMICAL JOURNAL

Tumor suppressor death-associated protein kinase is required for full IL-1  production

(2010) Y.-T. Chuang et al.   BLOOD

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Chemical probing reveals insights into the signaling mechanism of inflammasome activation

(2010) Yi-Nan Gong et al.   CELL RESEARCH

Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome

(2010) Bibhuti B. Mishra et al.   CELLULAR MICROBIOLOGY

Ubiquitin Makes Its Mark on Immune Regulation

(2010) Barbara A. Malynn et al.   IMMUNITY

A Novel Pathway for Inducible Nitric-oxide Synthase Activation through Inflammasomes

(2010) Carina L. Buzzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Caspase-1 Independent IL-1  Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo

(2010) K. D. Mayer-Barber et al.   JOURNAL OF IMMUNOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

(2010) Najwane Saïd-Sadier et al.   PLoS One

Granuloma Formation and Host Defense in Chronic Mycobacterium tuberculosis Infection Requires PYCARD/ASC but Not NLRP3 or Caspase-1

(2010) Erin McElvania TeKippe et al.   PLoS One

Host-Detrimental Role of Esx-1-Mediated Inflammasome Activation in Mycobacterial Infection

(2010) Fredric Carlsson et al.   PLoS Pathogens

Pathogen recognition in the innate immune response

(2009) Himanshu Kumar et al.   BIOCHEMICAL JOURNAL

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

(2009) Eric M Cooper et al.   EMBO JOURNAL

Restriction of Legionella pneumophila Replication in Macrophages Requires Concerted Action of the Transcriptional Regulators Irf1 and Irf8 and Nod-Like Receptors Naip5 and Nlrc4

(2009) A. Fortier et al.   INFECTION AND IMMUNITY

Expression of Nlrp1b Inflammasome Components in Human Fibroblasts Confers Susceptibility to Anthrax Lethal Toxin

(2009) K.-C. Liao et al.   INFECTION AND IMMUNITY

The RD1 Locus in the Mycobacterium tuberculosis Genome Contributes to Activation of Caspase-1 via Induction of Potassium Ion Efflux in Infected Macrophages

(2009) T. Kurenuma et al.   INFECTION AND IMMUNITY

Asc and Ipaf Inflammasomes Direct Distinct Pathways for Caspase-1 Activation in Response to Legionella pneumophila

(2009) C. L. Case et al.   INFECTION AND IMMUNITY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Calcium-Independent Phospholipase A2β Is Dispensable in Inflammasome Activation and Its Inhibition by Bromoenol Lactone

(2009) Luigi Franchi et al.   Journal of Innate Immunity

The Nek6 and Nek7 Protein Kinases Are Required for Robust Mitotic Spindle Formation and Cytokinesis

(2009) L. O'Regan et al.   MOLECULAR AND CELLULAR BIOLOGY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

(2009) Marina Tiemi Shio et al.   PLoS Pathogens

Mycobacterium tuberculosis Prevents Inflammasome Activation

(2008) Sharon S. Master et al.   Cell Host & Microbe

ESX-1-dependent cytolysis in lysosome secretion and inflammasome activation during mycobacterial infection

(2008) Ingrid C. Koo et al.   CELLULAR MICROBIOLOGY

The NLR Gene Family: A Standard Nomenclature

(2008) Jenny P.-Y. Ting et al.   IMMUNITY

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

A20: Central Gatekeeper in Inflammation and Immunity

(2008) Beatrice Coornaert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

(2008) Karla L Lightfield et al.   NATURE IMMUNOLOGY