Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

How Inflammasomes Inform Adaptive Immunity

(2018) Charles L. Evavold et al.   JOURNAL OF MOLECULAR BIOLOGY

An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication

(2018) Megan H. Orzalli et al.   MOLECULAR CELL

Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection

(2017) Yutao Wang et al.   IMMUNITY

A noncanonical function of cGAMP in inflammasome priming and activation

(2017) Karen V. Swanson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular mechanisms of inflammasome signaling

(2017) Anukriti Mathur et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Human cytomegalovirus triggers the assembly of AIM2 inflammasome in THP-1-derived macrophages

(2017) Yuan Huang et al.   JOURNAL OF MEDICAL VIROLOGY

Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway

(2017) Bryan Gall et al.   JOURNAL OF VIROLOGY

Inflammasome Priming in Sterile Inflammatory Disease

(2017) Meghana N. Patel et al.   TRENDS IN MOLECULAR MEDICINE

A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses

(2017) Kara M. Pryke et al.   mBio

Human Cytomegalovirus IE2 86 kDa Protein Induces STING Degradation and Inhibits cGAMP-Mediated IFN-β Induction

(2017) Jung-Eun Kim et al.   Frontiers in Microbiology

The Major Immediate-Early Protein IE2 of Human Cytomegalovirus Is Sufficient to Induce Proteasomal Degradation of CD83 on Mature Dendritic Cells

(2017) Christiane S. Heilingloh et al.   Frontiers in Microbiology

Cytomegalovirus Infection and Relative Risk of Cardiovascular Disease (Ischemic Heart Disease, Stroke, and Cardiovascular Death): A Meta‐Analysis of Prospective Studies Up to 2016

(2017) Haoran Wang et al.   Journal of the American Heart Association

The Role of Interferons in Inflammation and Inflammasome Activation

(2017) Nataša Kopitar-Jerala   Frontiers in Immunology

Epstein-Barr virus infection-induced inflammasome activation in human monocytes

(2017) Yuka Torii et al.   PLoS One

Epigenetically repressing human cytomegalovirus lytic infection and reactivation from latency in THP-1 model by targeting H3K9 and H3K27 histone demethylases

(2017) Xin Gan et al.   PLoS One

Inflammasomes and its importance in viral infections

(2016) Gaurav Shrivastava et al.   IMMUNOLOGIC RESEARCH

IFN-γ Primes Keratinocytes for HSV-1–Induced Inflammasome Activation

(2016) Gerhard E. Strittmatter et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection

(2016) Chan-Wang J. Lio et al.   JOURNAL OF VIROLOGY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells

(2016) Jennifer Paijo et al.   PLoS Pathogens

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells

(2015) Jonathan L. Schmid-Burgk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice

(2015) David P. Sester et al.   JOURNAL OF IMMUNOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

(2015) Elena Viganò et al.   Nature Communications

Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses

(2015) Mairaj Ahmed Ansari et al.   PLoS Pathogens

BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses

(2015) Dipanjan Dutta et al.   PLoS Pathogens

Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses

(2015) Tina M. Sali et al.   PLoS Pathogens

Dynamic Protein Associations Define Two Phases of IL-1  Transcriptional Activation

(2014) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Bovine herpesvirus 1 productive infection stimulates inflammasome formation and caspase 1 activity

(2014) Jianlin Wang et al.   VIRUS RESEARCH

Isolation of Human Monocytes by Double Gradient Centrifugation and Their Differentiation to Macrophages in Teflon-coated Cell Culture Bags

(2014) Kerstin Menck et al.   Jove-Journal of Visualized Experiments

Human Cytomegalovirus Tegument Protein pUL83 Inhibits IFI16-Mediated DNA Sensing for Immune Evasion

(2013) Tuo Li et al.   Cell Host & Microbe

Mechanisms of NOD-like Receptor-Associated Inflammasome Activation

(2013) Haitao Wen et al.   IMMUNITY

An Endothelial Cell-Specific Requirement for the UL133-UL138 Locus of Human Cytomegalovirus for Efficient Virus Maturation

(2013) F. Bughio et al.   JOURNAL OF VIROLOGY

Herpes Simplex Virus 1 Infection Induces Activation and Subsequent Inhibition of the IFI16 and NLRP3 Inflammasomes

(2013) K. E. Johnson et al.   JOURNAL OF VIROLOGY

Kaposi's Sarcoma-Associated Herpesvirus Latency in Endothelial and B Cells Activates Gamma Interferon-Inducible Protein 16-Mediated Inflammasomes

(2013) V. V. Singh et al.   JOURNAL OF VIROLOGY

Type I IFN-mediated regulation of IL-1 production in inflammatory disorders

(2012) Kristina Ludigs et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human CMV transcripts: an overview

(2012) Yanping Ma et al.   Future Microbiology

Diverse immune evasion strategies by human cytomegalovirus

(2012) Vanessa Noriega et al.   IMMUNOLOGIC RESEARCH

NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223

(2012) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Human Cytomegalovirus Infection of M1 and M2 Macrophages Triggers Inflammation and Autologous T-Cell Proliferation

(2012) C. Bayer et al.   JOURNAL OF VIROLOGY

Human cytomegalovirus infection of THP-1 derived macrophages reveals strain-specific regulation of actin dynamics

(2012) V. Sanchez et al.   VIROLOGY

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Varicella-Zoster Virus Infection Triggers Formation of an Interleukin-1β (IL-1β)-processing Inflammasome Complex

(2011) Adel M. Nour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pattern Recognition Receptors and the Innate Immune Response to Viral Infection

(2011) Mikayla R. Thompson et al.   Viruses-Basel

Activation of the Interferon Response by Human Cytomegalovirus Occurs via Cytoplasmic Double-Stranded DNA but Not Glycoprotein B

(2010) V. R. DeFilippis et al.   JOURNAL OF VIROLOGY

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Neuropathogenesis of Congenital Cytomegalovirus Infection: Disease Mechanisms and Prospects for Intervention

(2009) M. C.-J. Cheeran et al.   CLINICAL MICROBIOLOGY REVIEWS

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Human Cytomegalovirus Induces the Interferon Response via the DNA Sensor ZBP1

(2009) V. R. DeFilippis et al.   JOURNAL OF VIROLOGY

Degradation of RIG-I following cytomegalovirus infection is independent of apoptosis

(2009) Iain Scott   MICROBES AND INFECTION

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses

(2009) Christina Paulus et al.   Viruses-Basel

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Cytomegalovirus Reactivation in Critically Ill Immunocompetent Patients

(2008)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

NF- B-Mediated Activation of the Chemokine CCL22 by the Product of the Human Cytomegalovirus Gene UL144 Escapes Regulation by Viral IE86

(2008) E. Poole et al.   JOURNAL OF VIROLOGY

Inhibition of IL-1β transcription by peptides derived from the hCMV IE2 transactivator

(2008) James A. Listman et al.   MOLECULAR IMMUNOLOGY

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE