Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes

Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases

(2018) Hiroyuki Nakayama et al.   BIOCHEMICAL JOURNAL

Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD

(2018) Takanori Komada et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder

(2018) Daniel Lindqvist et al.   NEUROPSYCHOPHARMACOLOGY

The expression and activation of the AIM2 inflammasome correlates with inflammation and disease severity in patients with acute pancreatitis

(2017) Francisco Algaba-Chueca et al.   PANCREATOLOGY

Mitochondrial DNA

(2016) Simon T. Schäfer et al.   ANESTHESIOLOGY

Decreased plasma α-Klotho predict progression of nephropathy with type 2 diabetic patients

(2016) Sang Soo Kim et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

(2016) Jong-Seok Moon et al.   NATURE MEDICINE

AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity

(2016) Antonia Di Micco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma Mitochondrial DNA—a Novel DAMP in Pediatric Sepsis

(2016) Valentina Di Caro et al.   SHOCK

Plasma Nuclear and Mitochondrial DNA Levels, and Markers of Inflammation, Shock, and Organ Damage in Patients with Septic Shock

(2016) Kim Timmermans et al.   SHOCK

Reduced cerebrospinal fluid mitochondrial DNA is a biomarker for early-stage Parkinson's disease

(2015) Angela Pyle et al.   ANNALS OF NEUROLOGY

Circulating Cell Free Mitochondrial DNA is a Biomarker in the Development of Coronary Heart Disease in the Patients with Type 2 Diabetes

(2015) Jing Liu et al.   Clinical Laboratory

Mitochondrial DNA and Toll-Like Receptor-9 Are Associated With Mortality in Critically Ill Patients

(2015) Konstantin A. Krychtiuk et al.   CRITICAL CARE MEDICINE

AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity

(2015) Si Ming Man et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Circulating cell-free mitochondrial DNA as the probable inducer of early endothelial dysfunction in the prediabetic patient

(2015) Noé Alvarado-Vásquez   EXPERIMENTAL GERONTOLOGY

The IL-1 Pathway in Type 2 Diabetes and Cardiovascular Complications

(2015) Christian Herder et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

(2015) Jong-Seok Moon et al.   Cell Reports

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Nonalbuminuric proteinuria as a biomarker for tubular damage in early development of nephropathy with type 2 diabetic patients

(2014) Sang Soo Kim et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Circulatory Mitochondrial DNA Is a Pro-Inflammatory Agent in Maintenance Hemodialysis Patients

(2014) Hongdi Cao et al.   PLoS One

Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation

(2014) Kiichi Nakahira et al.   PLOS MEDICINE

Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease

(2013) Petar Podlesniy et al.   ANNALS OF NEUROLOGY

Elevated Levels of Plasma Mitochondrial DNA DAMPs Are Linked to Clinical Outcome in Severely Injured Human Subjects

(2013) Jon D. Simmons et al.   ANNALS OF SURGERY

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Mechanisms of ATP release and signalling in the blood vessel wall

(2012) A. W. Lohman et al.   CARDIOVASCULAR RESEARCH

Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach: Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

(2012) S. E. Inzucchi et al.   DIABETES CARE

Increased circulating mitochondrial DNA after myocardial infarction

(2012) Marte Bliksøen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation, function and diagnostic value of mitochondrial DNA copy number alterations in human cancers

(2011) Man Yu   LIFE SCIENCES

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Dampening insulin signaling by an NLRP3 'meta-flammasome'

(2011) Augustine M K Choi et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction

(2010) M. Guescini et al.   EXPERIMENTAL CELL RESEARCH

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Mitochondrial DNA in serum of patients with prostate cancer: a predictor of biochemical recurrence after prostatectomy

(2008) Jörg Ellinger et al.   BJU INTERNATIONAL

Mitochondrial DNA oxidation and manganese superoxide dismutase activity in peripheral blood mononuclear cells from type 2 diabetic patients

(2008) M. García-Ramírez et al.   DIABETES & METABOLISM

Plasma Nuclear DNA and Mitochondrial DNA as Prognostic Markers in Corrosive Injury Patients

(2008) Chu-Chung Chou et al.   DIGESTIVE SURGERY