AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia

DNA Sensing in the Innate Immune Response

(2020) Benoit Briard et al.   PHYSIOLOGY

Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage

(2020) Bin Yuan et al.   Cell Death & Disease

AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice

(2020) Hyunha Kim et al.   BRAIN BEHAVIOR AND IMMUNITY

Ischemia-Triggered Glutamate Excitotoxicity From the Perspective of Glial Cells

(2020) Denisa Belov Kirdajova et al.   Frontiers in Cellular Neuroscience

NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia

(2019) Rebecca Ward et al.   PHARMACOLOGICAL RESEARCH

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Epidemiology of Vascular Dementia

(2019) Frank J. Wolters et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

AIM2 deletion promotes neuroplasticity and spatial memory of mice

(2019) Jian Chen et al.   BRAIN RESEARCH BULLETIN

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Emerging Activators and Regulators of Inflammasomes and Pyroptosis

(2019) Yansong Xue et al.   TRENDS IN IMMUNOLOGY

Neutrophil extracellular traps and dsDNA predict outcomes among patients with ST-elevation myocardial infarction

(2019) Jing Liu et al.   Scientific Reports

Animal Models of Chronic Cerebral Hypoperfusion: From Mouse to Primate

(2019) Kazuo Washida et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bilateral carotid artery stenosis causes unexpected early changes in brain extracellular matrix and blood-brain barrier integrity in mice

(2018) Jill M. Roberts et al.   PLoS One

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

(2018) Brienne A. McKenzie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular cognitive impairment

(2018) Wiesje M. van der Flier et al.   Nature Reviews Disease Primers

Evidence that NLRC4 Inflammasome Mediates Apoptotic and Pyroptotic Microglial Death Following Ischemic Stroke

(2018) Luting Poh et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

(2018) Richard Gordon et al.   Science Translational Medicine

Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke

(2017) David Yang-Wei Fann et al.   MOLECULAR NEUROBIOLOGY

Chronic Remote Ischemic Conditioning Is Cerebroprotective and Induces Vascular Remodeling in a VCID Model

(2017) Mohammad Badruzzaman Khan et al.   Translational Stroke Research

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

AIM 2 inflammasomes regulate neuronal morphology and influence anxiety and memory in mice

(2016) Pei-Jung Wu et al.   Scientific Reports

DAMPs as mediators of sterile inflammation in aging-related pathologies

(2015) Noa Feldman et al.   AGEING RESEARCH REVIEWS

Postnatal TLR2 activation impairs learning and memory in adulthood

(2015) Ravit Madar et al.   BRAIN BEHAVIOR AND IMMUNITY

NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients

(2015) Sonja Johann et al.   GLIA

The nucleic acid-sensing inflammasomes

(2015) Tsan Sam Xiao   IMMUNOLOGICAL REVIEWS

Reduced Blood Flow in Normal White Matter Predicts Development of Leukoaraiosis

(2015) Manya Bernbaum et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

(2015) Justin E Wilson et al.   NATURE MEDICINE

Cytokine profiles and the role of cellular prion protein in patients with vascular dementia and vascular encephalopathy

(2015) Matthias Schmitz et al.   NEUROBIOLOGY OF AGING

Hippocampal CA2 Activity Patterns Change over Time to a Larger Extent than between Spatial Contexts

(2015) Emily A. Mankin et al.   NEURON

What are White Matter Hyperintensities Made of? Relevance to Vascular Cognitive Impairment

(2015) Joanna M. Wardlaw et al.   Journal of the American Heart Association

AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis

(2015) Christopher Jakobs et al.   PLoS One

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Pathogenesis of acute stroke and the role of inflammasomes

(2013) David Yang-Wei Fann et al.   AGEING RESEARCH REVIEWS

Immune Cell Infiltration in Malignant Middle Cerebral Artery Infarction: Comparison with Transient Cerebral Ischemia

(2013) Hannah X Chu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Why Is CA3 More Vulnerable Than CA1 in Experimental Models of Controlled Cortical Impact-Induced Brain Injury?

(2013) Haojie Mao et al.   JOURNAL OF NEUROTRAUMA

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

(2013) D Yang-Wei Fann et al.   Cell Death & Disease

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Pregnenolone Rescues Schizophrenia-Like Behavior in Dopamine Transporter Knockout Mice

(2012) Peiyan Wong et al.   PLoS One

The Inflammasomes

(2010) Kate Schroder et al.   CELL

A Mouse Model Characterizing Features of Vascular Dementia With Hippocampal Atrophy

(2010) Keiko Nishio et al.   STROKE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Inflammatory Mediators in the Frontal Lobe of Patients with Mixed and Vascular Dementia

(2008) Ezra Mulugeta et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS