Attenuation of cGAS/STING activity during mitosis

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

(2020) Chun Zhou et al.   IMMUNITY

Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis

(2020) Li Zhong et al.   Cell Discovery

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

(2019) Guijun Shang et al.   NATURE

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

African swine fever virus Armenia/07 virulent strain controls IFN-β production through cGAS-STING pathway

(2019) Raquel García-Belmonte et al.   JOURNAL OF VIROLOGY

Cellular Requirements for Sensing and Elimination of Incoming HSV-1 DNA and Capsids

(2019) Chenglong Sun et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

SLC19A1 Is an Importer of the Immunotransmitter cGAMP

(2019) Christopher Ritchie et al.   MOLECULAR CELL

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

(2019) Christian Zierhut et al.   CELL

STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition

(2019) Sabrina L. Ergun et al.   CELL

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages

(2019) Yang Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SLC19A1 transports immunoreactive cyclic dinucleotides

(2019) Rutger D. Luteijn et al.   NATURE

Mitosis flips the switch on autophagy control

(2019) Joseph Willson   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tight nuclear tethering of cGAS is essential for preventing autoreactivity

(2019) Hannah E Volkman et al.   eLife

The binding of TBK1 to STING requires exocytic membrane traffic from the ER

(2018) Emari Ogawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human keratinocyte cultures (HaCaT) can be infected by DENV, triggering innate immune responses that include IFNλ and LL37

(2018) Moisés López-González et al.   IMMUNOBIOLOGY

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING

(2018) Hiroyasu Konno et al.   Cell Reports

STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice

(2018) Morten K. Skouboe et al.   PLoS Pathogens

An Update on Autoinflammatory Diseases: Interferonopathies

(2018) Sophia Davidson et al.   Current Rheumatology Reports

Dual RNA-Seq Analysis of Trichophyton rubrum and HaCat Keratinocyte Co-Culture Highlights Important Genes for Fungal-Host Interaction

(2018) Monise Petrucelli et al.   Genes

A Mutation Outside the Dimerization Domain Causing Atypical STING-Associated Vasculopathy With Onset in Infancy

(2018) Rohit G. Saldanha et al.   Frontiers in Immunology

Insights into ZIKV-Mediated Innate Immune Responses in Human Dermal Fibroblasts and Epidermal Keratinocytes

(2018) Ji-Ae Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

(2018) Gillian Dunphy et al.   MOLECULAR CELL

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

(2018) David Olagnier et al.   Nature Communications

The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum

(2018) Sonal Srikanth et al.   NATURE IMMUNOLOGY

TMED2 Potentiates Cellular IFN Responses to DNA Viruses by Reinforcing MITA Dimerization and Facilitating Its Trafficking

(2018) Ming-Shun Sun et al.   Cell Reports

STING Is Involved in Antiviral Immune Response against VZV Infection via the Induction of Type I and III IFN Pathways

(2017) Ji-Ae Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

(2017) Jessica F. Almine et al.   Nature Communications

Autophagy and the Cell Cycle: A Complex Landscape

(2017) Søs Grønbæk Mathiassen et al.   Frontiers in Oncology

Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding

(2016) Tone A. Fykerud et al.   CELL CYCLE

Severe Pulmonary Fibrosis as the First Manifestation of Interferonopathy (TMEM173 Mutation)

(2016) Cécile Picard et al.   CHEST

cGAS-cGAMP-STING: The three musketeers of cytosolic DNA sensing and signaling

(2016) Jianli Tao et al.   IUBMB LIFE

S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3

(2016) Fuan Wang et al.   NATURE IMMUNOLOGY

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING

(2016) Wei-Wei Luo et al.   NATURE IMMUNOLOGY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Activation of STING requires palmitoylation at the Golgi

(2016) Kojiro Mukai et al.   Nature Communications

ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs

(2016) Wei Chen et al.   PLoS Pathogens

JNK2 controls fragmentation of the Golgi complex and the G2/M transition through phosphorylation of GRASP65

(2015) R. I. Cervigni et al.   JOURNAL OF CELL SCIENCE

Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome

(2015) Elizabeth E. Gray et al.   JOURNAL OF IMMUNOLOGY

Membrane Perturbation-Associated Ca2+Signaling and Incoming Genome Sensing Are Required for the Host Response to Low-Level Enveloped Virus Particle Entry

(2015) David N. Hare et al.   JOURNAL OF VIROLOGY

Human keratinocytes restrict chikungunya virus replication at a post-fusion step

(2015) Eric Bernard et al.   VIROLOGY

TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus

(2015) Ruth E. Watkinson et al.   PLoS Pathogens

The Golgi complex in stress and death

(2015) Carolyn E. Machamer   Frontiers in Neuroscience

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Human Rhinovirus 16 Causes Golgi Apparatus Fragmentation without Blocking Protein Secretion

(2014) A. Mousnier et al.   JOURNAL OF VIROLOGY

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

Activated STING in a Vascular and Pulmonary Syndrome

(2014) Yin Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Modified Vaccinia Virus Ankara Triggers Type I IFN Production in Murine Conventional Dendritic Cells via a cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway

(2014) Peihong Dai et al.   PLoS Pathogens

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

(2013) Pu Gao et al.   CELL

Characterization of chikungunya virus infection of a human keratinocyte cell line: Role of mosquito salivary gland protein in suppressing the host immune response

(2013) Orapim Puiprom et al.   INFECTION GENETICS AND EVOLUTION

Statistical tests for measures of colocalization in biological microscopy

(2013) JOHN H. MCDONALD et al.   JOURNAL OF MICROSCOPY

Adenovirus Detection by the cGAS/STING/TBK1 DNA Sensing Cascade

(2013) E. Lam et al.   JOURNAL OF VIROLOGY

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

(2013) Andrea Ablasser et al.   NATURE

Cell cycle regulation of Golgi membrane dynamics

(2013) Danming Tang et al.   TRENDS IN CELL BIOLOGY

Interactions of pathogen-containing compartments with the secretory pathway

(2012) Johnathan Canton et al.   CELLULAR MICROBIOLOGY

Golgi complex fragmentation in G2/M transition: An organelle-based cell-cycle checkpoint

(2012) Daniela Corda et al.   IUBMB LIFE

TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination

(2012) Jing Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING

(2012) Qian Yin et al.   MOLECULAR CELL

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

Keratinocytes Are Cell Targets of West Nile Virus In Vivo

(2011) P.-Y. Lim et al.   JOURNAL OF VIROLOGY

Entry Pathways of Herpes Simplex Virus Type 1 into Human Keratinocytes Are Dynamin- and Cholesterol-Dependent

(2011) Elena Rahn et al.   PLoS One

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA

(2010) Tetsuo Tsuchida et al.   IMMUNITY

Sec16A defines the site for vesicle budding from the endoplasmic reticulum on exit from mitosis

(2010) Helen Hughes et al.   JOURNAL OF CELL SCIENCE

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Golgicide A reveals essential roles for GBF1 in Golgi assembly and function

(2009) José B Sáenz et al.   Nature Chemical Biology

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of membrane traffic between endoplasmic reticulum, ERGIC and Golgi to generate compartments for the replication of bacteria and viruses

(2009) Roberto Pierini et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction

(2008) Dagmar Heuer et al.   NATURE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE