Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom Revolution

Substrate‐selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains

(2020) Beiyu Tang et al.   FASEB JOURNAL

ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1)

(2020) Gisela Weskamp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel ADAM-17 inhibitor ZLDI-8 inhibits the metastasis of hepatocellular carcinoma by reversing epithelial-mesenchymal transition in vitro and in vivo

(2020) Hong-Yuan Lu et al.   LIFE SCIENCES

A Bispecific Inhibitor of the EGFR/ADAM17 Axis Decreases Cell Proliferation and Migration of EGFR-Dependent Cancer Cells

(2020) Abel Soto-Gamez et al.   Cancers

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

Recent developments and strategies for the discovery of TACE inhibitors

(2020) Prashant R. Murumkar et al.   Expert Opinion on Drug Discovery

COVID-19 cytokine storm: the interplay between inflammation and coagulation

(2020) Ricardo J Jose et al.   Lancet Respiratory Medicine

Expression of SARS-CoV-2 receptor, ACE2, and TMPRSS2 in the lung airways is lower in children compared to adults and increases due to smoking and COPD

(2020) Narjes Saheb Sharif-Askari et al.   Molecular Therapy-Methods & Clinical Development

Challenges in Matrix Metalloproteinases Inhibition

(2020) Helena Laronha et al.   Biomolecules

Negatively charged amino acids in the stalk region of membrane proteins reduce ectodomain shedding

(2020) Ryo Iwagishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis

(2020) Hiroyuki Nakamura et al.   Scientific Reports

TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1

(2020) Anna P. Carreca et al.   Scientific Reports

Alpha‐1‐antitrypsin : A possible host protective factor against Covid‐19

(2020) Mariana Braccialli Loyola et al.   REVIEWS IN MEDICAL VIROLOGY

Epigenetic Regulation of a Disintegrin and Metalloproteinase (ADAM) Transcription in Colorectal Cancer Cells: Involvement of β-Catenin, BRG1, and KDM4

(2020) Lina Sun et al.   Frontiers in Cell and Developmental Biology

The role of NF-κB and Elk-1 in the regulation of mouse ADAM17 expression

(2019) Karolina Wawro et al.   Biology Open

The molecular, cellular and pathophysiological roles of iRhom pseudoproteases

(2019) Iqbal Dulloo et al.   Open Biology

Loss of RHBDF2 results in an early‐onset spontaneous murine colitis

(2019) Ramasatyaveni Geesala et al.   JOURNAL OF LEUKOCYTE BIOLOGY

ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury

(2019) Daniela Sommer et al.   BRAIN BEHAVIOR AND IMMUNITY

Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation

(2019) Egor Pavlenko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Degradome of soluble ADAM10 and ADAM17 metalloproteases

(2019) Franka Scharfenberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Functions of ‘A disintegrin and metalloproteases (ADAMs)’ in the mammalian nervous system

(2019) Hung-En Hsia et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Novel TNF-α Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-Ay Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice

(2019) Mariko Maekawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Novel ADAM-17 inhibitor ZLDI-8 inhibits the proliferation and metastasis of chemo-resistant non-small-cell lung cancer by reversing Notch and epithelial mesenchymal transition in vitro and in vivo

(2019) Hong-Yuan Lu et al.   PHARMACOLOGICAL RESEARCH

ADAM17 Activity and IL-6 Trans-Signaling in Inflammation and Cancer

(2019) Schumacher et al.   Cancers

Proteolytic processing of PD-L1 by ADAM proteases in breast cancer cells

(2019) Yeni Romero et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis

(2018) Jean-Guy Boiteau et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNFα pathway

(2018) Coline Haxaire et al.   BLOOD

ADAM metalloproteinases as potential drug targets

(2018) Caterina Camodeca et al.   CURRENT MEDICINAL CHEMISTRY

Proteolytic ectodomain shedding of membrane proteins in mammals—hardware, concepts, and recent developments

(2018) Stefan F Lichtenthaler et al.   EMBO JOURNAL

iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling

(2018) Xiaoping Qing et al.   JOURNAL OF CLINICAL INVESTIGATION

ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling

(2018) Stefanie Schmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology

(2018) Marta Stolarczyk et al.   MEDIATORS OF INFLAMMATION

A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease

(2018) Daniela Hartl et al.   MOLECULAR PSYCHIATRY

Novel ADAM-17 inhibitor ZLDI-8 enhances the in vitro and in vivo chemotherapeutic effects of Sorafenib on hepatocellular carcinoma cells

(2018) Yingshi Zhang et al.   Cell Death & Disease

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex

(2018) Ulrike Künzel et al.   eLife

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

(2018) Ioanna Oikonomidi et al.   eLife

A novel inhibitor of ADAM17 sensitizes colorectal cancer cells to 5-Fluorouracil by reversing Notch and epithelial-mesenchymal transition in vitro and in vivo

(2018) Dan-Dan Li et al.   CELL PROLIFERATION

Specific inhibition of ADAM17/TACE promotes neurogenesis in the injured motor cortex

(2018) Noelia Geribaldi-Doldán et al.   Cell Death & Disease

Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor

(2018) Simone D. Scilabra et al.   Scientific Reports

IL-6 inhibitor for the treatment of rheumatoid arthritis: A comprehensive review

(2018) Atsushi Ogata et al.   Modern Rheumatology

Tyrosine phosphorylation directs TACE into extracellular vesicles via unconventional secretion

(2018) Zhe Zhao et al.   TRAFFIC

Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2–ADAM17-dependent proteolysis

(2017) Xue Li et al.   JOURNAL OF CELL SCIENCE

Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation

(2017) Marcia L. Moss et al.   MEDIATORS OF INFLAMMATION

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

The role of IL-6 in host defence against infections: immunobiology and clinical implications

(2017) Stefan Rose-John et al.   Nature Reviews Rheumatology

ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157

(2017) Dominik Feuerbach et al.   NEUROSCIENCE LETTERS

Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency

(2017) Joseph Dosch et al.   Oncotarget

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

(2017) Miguel Cavadas et al.   Cell Reports

Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

(2017) Adam Graham Grieve et al.   eLife

Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis

(2017) Kazuhiro Yamamoto et al.   Arthritis & Rheumatology

Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma

(2017) Viviana Casagrande et al.   Scientific Reports

Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in MiceHighlights

(2016) Alexandros Nicolaou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes

(2016) Esther Groth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Novel Insights in the Regulation of Phosphatidylserine Exposure in Human Red Blood Cells

(2016) Mauro C. Wesseling et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Targeting ADAM17 Sheddase Activity in Cancer

(2016) Armando Rossello et al.   CURRENT DRUG TARGETS

Anti-TNF-α therapies for the treatment of Crohn’s disease: the past, present and future

(2016) Marc Berns et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Molecular basis for the mechanism of action of an anti-TACE antibody

(2016) Li Peng et al.   mAbs

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

(2016) Kazuhiro Yamamoto et al.   MATRIX BIOLOGY

Developing anti-inflammatory therapeutics for patients with osteoarthritis

(2016) Ashleigh M. Philp et al.   RHEUMATOLOGY

Phosphatidylserine exposure is required for ADAM17 sheddase function

(2016) Anselm Sommer et al.   Nature Communications

Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo

(2016) Eitan Wong et al.   Scientific Reports

Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets

(2016) Shinji Hirata et al.   Stem Cells Translational Medicine

Epithelial Cell-Derived a Disintegrin and Metalloproteinase-17 Confers Resistance to Colonic Inflammation Through EGFR Activation

(2016) Masayuki Shimoda et al.   EBioMedicine

Targeting ADAM-17 with an inhibitory monoclonal antibody has antitumour effects in triple-negative breast cancer cells

(2015) F Caiazza et al.   BRITISH JOURNAL OF CANCER

iRhoms in the brain – a new frontier?

(2015) Stefan F Lichtenthaler et al.   CELL CYCLE

Adam17, a Target of Mir-326, Promotes Emt-Induced Cells Invasion in Lung Adenocarcinoma

(2015) Ming Cai et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

(2015) Chung-Hang Leung et al.   CHEMICAL COMMUNICATIONS

The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site

(2015) Eitan Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses

(2015) Isabell Yan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes

(2015) Anna M. Knapinska et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways

(2015) J. Rios-Doria et al.   MOLECULAR CANCER THERAPEUTICS

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

(2015) Xue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design of selective TACE inhibitors using molecular docking studies: Synthesis and preliminary evaluation of anti-inflammatory and TACE inhibitory activity

(2015) A.P. Sarkate et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

MicroRNA-145 Targets the Metalloprotease ADAM17 and Is Suppressed in Renal Cell Carcinoma Patients

(2015) Kai Doberstein et al.   NEOPLASIA

MicroRNA-152 targets ADAM17 to suppress NSCLC progression

(2014) Yunshu Su et al.   FEBS LETTERS

Anti-TNF therapy: past, present and future

(2014) C. Monaco et al.   INTERNATIONAL IMMUNOLOGY

Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4)

(2014) Kazuhiro Yamamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis

(2014) M. A. Nowell et al.   JOURNAL OF IMMUNOLOGY

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

IL-6 biology: implications for clinical targeting in rheumatic disease

(2014) Leonard H. Calabrese et al.   Nature Reviews Rheumatology

Microglia actions in Alzheimer’s disease

(2013) Stefan Prokop et al.   ACTA NEUROPATHOLOGICA

Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition

(2013) Anais Chavaroche et al.   ANALYTICAL BIOCHEMISTRY

Analysis of cognition, motor performance and anxiety in young and aged tumor necrosis factor alpha receptor 1 and 2 deficient mice

(2013) Petrus J.W. Naude et al.   BEHAVIOURAL BRAIN RESEARCH

NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)

(2013) R. Romee et al.   BLOOD

Human breast cancer-associated fibroblasts enhance cancer cell proliferation through increased TGF-α cleavage by ADAM17

(2013) Ming-Qing Gao et al.   CANCER LETTERS

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines

(2013) Yang Sun et al.   CELL RESEARCH

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

(2013) Yonka Christova et al.   EMBO REPORTS

miR-145 suppresses cell invasion in hepatocellular carcinoma cells: miR-145 targets ADAM17

(2013) Xue-wei Yang et al.   HEPATOLOGY RESEARCH

TACE-dependent TGFα shedding drives triple-negative breast cancer cell invasion

(2013) Orsi Giricz et al.   INTERNATIONAL JOURNAL OF CANCER

TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment

(2013) X. Chen et al.   JOURNAL OF IMMUNOLOGY

ADAM17 silencing by adenovirus encoding miRNA-embedded siRNA revealed essential signal transduction by angiotensin II in vascular smooth muscle cells

(2013) Katherine J. Elliott et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ADAM17 Controls Endochondral Ossification by Regulating Terminal Differentiation of Chondrocytes

(2013) Katherine C. Hall et al.   MOLECULAR AND CELLULAR BIOLOGY

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding

(2013) T. Maretzky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ADAM17 cleaves CD16b (FcγRIIIb) in human neutrophils

(2012) Yue Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

TIMP3 Overexpression in Macrophages Protects From Insulin Resistance, Adipose Inflammation, and Nonalcoholic Fatty Liver Disease in Mice

(2012) R. Menghini et al.   DIABETES

Lung endothelial ADAM17 regulates the acute inflammatory response to lipopolysaccharide

(2012) Daniela Dreymueller et al.   EMBO Molecular Medicine

Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion

(2012) Robin R. Hodges et al.   EXPERIMENTAL EYE RESEARCH

LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage

(2012) Kazuhiro Yamamoto et al.   FASEB JOURNAL

The ADAM family

(2012) Laura Christian   FLY

Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis

(2012) Aditya Murthy et al.   IMMUNITY

Discovery of Novel Inhibitors of a Disintegrin and Metalloprotease 17 (ADAM17) Using Glycosylated and Non-glycosylated Substrates

(2012) Dmitriy Minond et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand–dependent terminal keratinocyte differentiation

(2012) Claus-Werner Franzke et al.   JOURNAL OF CELL BIOLOGY

MiR-145 reduces ADAM17 expression and inhibits in vitro migration and invasion of glioma cells

(2012) YONG LU et al.   ONCOLOGY REPORTS

Interleukin-1 Stimulates ADAM17 through a Mechanism Independent of its Cytoplasmic Domain or Phosphorylation at Threonine 735

(2012) Katherine C. Hall et al.   PLoS One

ADAM17 Silencing in Mouse Colon Carcinoma Cells: The Effect on Tumoricidal Cytokines and Angiogenesis

(2012) Sudipta Das et al.   PLoS One

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

TACE Activation by MAPK-Mediated Regulation of Cell Surface Dimerization and TIMP3 Association

(2012) P. Xu et al.   Science Signaling

Ablation of TNF-RI/RII Expression in Alzheimer's Disease Mice Leads to an Unexpected Enhancement of Pathology

(2011) Sara L. Montgomery et al.   AMERICAN JOURNAL OF PATHOLOGY

Overexpression of Tissue Inhibitor of Metalloproteinase 3 in Macrophages Reduces Atherosclerosis in Low-Density Lipoprotein Receptor Knockout Mice

(2011) Viviana Casagrande et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

TNFR1-induced activation of the classical NF-κB pathway

(2011) Harald Wajant et al.   FEBS Journal

COGNITIVE IMPROVEMENT WITH INTRATHECAL ADMINISTRATION OF INFLIXIMAB IN A WOMAN WITH ALZHEIMER'S DISEASE

(2011) Jian-Quan Shi et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Inflammatory Skin and Bowel Disease Linked toADAM17Deletion

(2011) Diana C. Blaydon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Leukocyte ADAM17 Regulates Acute Pulmonary Inflammation

(2011) Patrick G. Arndt et al.   PLoS One

Cross-domain inhibition of TACE ectodomain

(2011) C. J. Tape et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF-α–Converting Enzyme/A Disintegrin and Metalloprotease−17 Mediates Mechanotransduction in Murine Tracheal Epithelial Cells

(2010) Tetsuya Shiomi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications

(2010) Ngee H. Lim et al.   BIOCHEMICAL JOURNAL

Thiol isomerases negatively regulate the cellular shedding activity of ADAM17

(2010) Sofie H. Willems et al.   BIOCHEMICAL JOURNAL

The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity

(2010) Keith Brew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Novel TNF-α converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases

(2010) Vinay M. Girijavallabhan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Clinical Benefit of INCB7839, a Potent and Selective Inhibitor of ADAM10 and ADAM17, in Combination with Trastuzumab in Metastatic HER2 Positive Breast Cancer Patients.

(2010) S. Friedman et al.   CANCER RESEARCH

Pathological Neovascularization Is Reduced by Inactivation of ADAM17 in Endothelial Cells but Not in Pericytes

(2010) Gisela Weskamp et al.   CIRCULATION RESEARCH

Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease

(2010) H.-C. REINECKER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

(2010) Paul Saftig et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

(2010) S. M. Le Gall et al.   JOURNAL OF CELL SCIENCE

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

(2010) Athena Chalaris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In vivo role of leukocyte ADAM17 in the inflammatory and host responses during E. coli -mediated peritonitis

(2010) Chunmei Long et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages

(2010) Matvey Gorovoy et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10

(2009) Cristina I. Caescu et al.   BIOCHEMICAL JOURNAL

Decreased behavioral impairments in an Alzheimer mice model by interfering with TNF-alpha metabolism

(2009) Fabienne Giuliani et al.   BRAIN RESEARCH BULLETIN

Conditional Inactivation of TACE by a Sox9 Promoter Leads to Osteoporosis and Increased Granulopoiesis via Dysregulation of IL-17 and G-CSF

(2009) K. Horiuchi et al.   JOURNAL OF IMMUNOLOGY

Microglia Protect Neurons against Ischemia by Synthesis of Tumor Necrosis Factor

(2009) K. L. Lambertsen et al.   JOURNAL OF NEUROSCIENCE

LRP1 shedding in human brain: roles of ADAM10 and ADAM17

(2009) Qiang Liu et al.   Molecular Neurodegeneration

Role for TNF in atherosclerosis? Lessons from autoimmune disease

(2009) Gayle E. McKellar et al.   Nature Reviews Cardiology

Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis

(2009) Peter C. Taylor et al.   Nature Reviews Rheumatology

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

(2009) Fiona E. McAlpine et al.   NEUROBIOLOGY OF DISEASE

The Second Dimer Interface of MT1-MMP, the Transmembrane Domain, Is Essential for ProMMP-2 Activation on the Cell Surface

(2008) Yoshifumi Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Determinants of the ADAM Inhibition by TIMP-3: Crystal Structure of the TACE-N-TIMP-3 Complex

(2008) Magdalena Wisniewska et al.   JOURNAL OF MOLECULAR BIOLOGY

Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion

(2008) P Arora et al.   ONCOGENE

Modulation of TNF- -converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-  production and facilitates viral entry

(2008) S. Haga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clipping, shedding and RIPping keep immunity on cue

(2008) Gillian Murphy et al.   TRENDS IN IMMUNOLOGY

Mapping and characterization of the functional epitopes of tissue inhibitor of metalloproteinases (TIMP)-3 using TIMP-1 as the scaffold: A new frontier in TIMP engineering

(2002) Meng-Huee Lee et al.   PROTEIN SCIENCE