Molecular basis for the mechanism of action of an anti-TACE antibody

Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models

(2016) Caterina Camodeca et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways

(2015) J. Rios-Doria et al.   MOLECULAR CANCER THERAPEUTICS

Development of a ‘mouse and human cross-reactive’ affinity-matured exosite inhibitory human antibody specific to TACE (ADAM17) for cancer immunotherapy

(2014) Hang Fai Kwok et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Activity of ADAM17 (a Disintegrin and Metalloprotease 17) Is Regulated by Its Noncatalytic Domains and Secondary Structure of its Substrates

(2013) Roma Stawikowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Selective Small Molecular TACE Inhibitors for the Treatment of Rheumatoid Arthritis

(2012) N. -G. Li et al.   CURRENT MEDICINAL CHEMISTRY

Novel methods and strategies in the discovery of TACE inhibitors

(2012) Prashant R Murumkar et al.   Expert Opinion on Drug Discovery

2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors

(2011) Chaoyang Dai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cross-domain inhibition of TACE ectodomain

(2011) C. J. Tape et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure analysis reveals the flexibility of the ADAMTS-5 active site

(2011) Huey-Sheng Shieh et al.   PROTEIN SCIENCE

Biaryl substituted hydantoin compounds as TACE inhibitors

(2010) Wensheng Yu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Studies on novel 2-imidazolidinones and tetrahydropyrimidin-2(1H)-ones as potential TACE inhibitors: Design, synthesis, molecular modeling, and preliminary biological evaluation

(2009) Shirshendu DasGupta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structural Characterization of the Ectodomain of a Disintegrin and Metalloproteinase-22 (ADAM22), a Neural Adhesion Receptor Instead of Metalloproteinase

(2009) Heli Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current perspective of TACE inhibitors: A review

(2008) Shirshendu DasGupta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of novel hydroxamates as highly potent tumor necrosis factor-α converting enzyme inhibitors. Part II: Optimization of the S3′ pocket

(2008) Robert D. Mazzola et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural Determinants of the ADAM Inhibition by TIMP-3: Crystal Structure of the TACE-N-TIMP-3 Complex

(2008) Magdalena Wisniewska et al.   JOURNAL OF MOLECULAR BIOLOGY

The ADAM metalloproteinases

(2008) D EDWARDS et al.   MOLECULAR ASPECTS OF MEDICINE

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

(2007) Lidia Mosyak et al.   PROTEIN SCIENCE