Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

(2016) Kazuhiro Yamamoto et al.   MATRIX BIOLOGY

Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)

(2015) S. Santamaria et al.   BIOCHEMICAL JOURNAL

Emerging targets in osteoarthritis therapy

(2015) Mary B Goldring et al.   CURRENT OPINION IN PHARMACOLOGY

Membrane-type matrix metalloproteinases: Their functions and regulations

(2015) Yoshifumi Itoh   MATRIX BIOLOGY

Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification

(2015) J. Larkin et al.   OSTEOARTHRITIS AND CARTILAGE

Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4)

(2014) Kazuhiro Yamamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Who decides when to cleave an ectodomain?

(2013) Monika Hartmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage

(2012) Kazuhiro Yamamoto et al.   FASEB JOURNAL

Defining Requirements for Collagenase Cleavage in Collagen Type III Using a Bacterial Collagen System

(2012) Zhuoxin Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Regulation of Extracellular Tissue Inhibitor of Metalloproteinases-3 Levels by Cell Membrane-bound and Shed Low Density Lipoprotein Receptor-related Protein 1

(2012) Simone D. Scilabra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of LRP1 in transport of CCN2 protein in chondrocytes

(2012) Kazumi Kawata et al.   JOURNAL OF CELL SCIENCE

Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function

(2011) Charlotte Selvais et al.   FASEB JOURNAL

Cross-domain inhibition of TACE ectodomain

(2011) C. J. Tape et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages

(2010) Matvey Gorovoy et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3

(2009) Linda Troeberg et al.   MATRIX BIOLOGY

Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases

(2008) Linda Troeberg et al.   FASEB JOURNAL

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS