Alpha‐1‐antitrypsin : A possible host protective factor against Covid‐19

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A Novel Coronavirus Emerging in China — Key Questions for Impact Assessment

(2020) Vincent J. Munster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

(2020) Xiaobo Yang et al.   Lancet Respiratory Medicine

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors

(2020) Iziah E Sama et al.   EUROPEAN HEART JOURNAL

COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-Chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?

(2020) Donato Gemmati et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study

(2020) Kelvin Kai-Wang To et al.   LANCET INFECTIOUS DISEASES

Alpha1-Antitrypsin Deficiency

(2020) Pavel Strnad et al.   NEW ENGLAND JOURNAL OF MEDICINE

COVID-19 Epidemic in the Middle Province of Northern Italy: Impact, Logistics, and Strategy in the First Line Hospital

(2020) Annalisa Gagliano et al.   Disaster Medicine and Public Health Preparedness

COVID-19 cytokine storm: the interplay between inflammation and coagulation

(2020) Ricardo J Jose et al.   Lancet Respiratory Medicine

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

(2020) Lei Fang et al.   Lancet Respiratory Medicine

Expression of SARS-CoV-2 receptor, ACE2, and TMPRSS2 in the lung airways is lower in children compared to adults and increases due to smoking and COPD

(2020) Narjes Saheb Sharif-Askari et al.   Molecular Therapy-Methods & Clinical Development

Can atmospheric pollution be considered a co-factor in extremely high level of SARS-CoV-2 lethality in Northern Italy?

(2020) Edoardo Conticini et al.   ENVIRONMENTAL POLLUTION

Chronic obstructive pulmonary disease is associated with severe coronavirus disease 2019 (COVID-19)

(2020) Giuseppe Lippi et al.   RESPIRATORY MEDICINE

ADAM17 Activity and IL-6 Trans-Signaling in Inflammation and Cancer

(2019) Schumacher et al.   Cancers

Impact of HIV infection on α1-antitrypsin in the lung

(2018) Sarah E. Stephenson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology

(2018) Marta Stolarczyk et al.   MEDIATORS OF INFLAMMATION

The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses

(2018) Nurit P. Azouz et al.   Science Translational Medicine

A1AT polymorphisms may be associated with clinical characteristics of retrovirus infections in a mixed ethnic population from the Brazilian Amazon region

(2017) Thalita Camêlo da Silva Ferreira et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Alpha-1-antitrypsin interacts with gp41 to block HIV-1 entry into CD4+ T lymphocytes

(2016) Xueyuan Zhou et al.   BMC MICROBIOLOGY

Phosphatidylserine exposure is required for ADAM17 sheddase function

(2016) Anselm Sommer et al.   Nature Communications

α1-Antitrypsin reduces rhinovirus infection in primary human airway epithelial cells exposed to cigarette smoke

(2016) Reena Berman et al.   International Journal of Chronic Obstructive Pulmonary Disease

α-1-Antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease

(2015) Nicola J. Sinden et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Acute-phase protein α1-anti-trypsin: diverting injurious innate and adaptive immune responses from non-authentic threats

(2015) O. Guttman et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

α1-antitrypsin increases interleukin-1 receptor antagonist production during pancreatic islet graft transplantation

(2014) Avishag Abecassis et al.   Cellular & Molecular Immunology

Alpha-1-antitrypsin inhibits acute liver failure in mice

(2014) Nils Jedicke et al.   HEPATOLOGY

Human Alpha-1-Antitrypsin Modifies B Lymphocyte Responses During Allograft Transplantation

(2013) Mark Mizrahi et al.   IMMUNOLOGY

α1-Antitrypsin inhibits ischemia reperfusion-induced lung injury by reducing inflammatory response and cell death

(2013) Wenxi Gao et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Low levels of circulating alpha-1 antitrypsin are associated with spontaneous abortions

(2013) Tamar Madar et al.   Journal of Maternal-Fetal & Neonatal Medicine

Increased prevalence of the alpha-1-antitrypsin (A1AT) deficiency-related S gene in patients infected with human immunodeficiency virus type 1

(2013) Thalita Camêlo da Silva Ferreira et al.   JOURNAL OF MEDICAL VIROLOGY

TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

(2013) A. Heurich et al.   JOURNAL OF VIROLOGY

Differential Surface Expression of ADAM10 and ADAM17 on Human T Lymphocytes and Tumor Cells

(2013) Henriette Ebsen et al.   PLoS One

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(2012) Angelia Lockett et al.   MOLECULAR MEDICINE

Influenza and SARS-Coronavirus Activating Proteases TMPRSS2 and HAT Are Expressed at Multiple Sites in Human Respiratory and Gastrointestinal Tracts

(2012) Stephanie Bertram et al.   PLoS One

Prevalence of α1-antitrypsin deficiency alleles PI*S and PI*Z worldwide and effective screening for each of the five phenotypic classes PI*MS, PI*MZ, PI*SS, PI*SZ, and PI*ZZ: a comprehensive review

(2012) Frederick J. de Serres et al.   Therapeutic Advances in Respiratory Disease

The Role of Retinoic Acid in Tolerance and Immunity

(2011) Jason A. Hall et al.   IMMUNITY

HIV Replication in CD4+ T Lymphocytes in the Presence and Absence of Follicular Dendritic Cells: Inhibition of Replication Mediated by  -1-Antitrypsin through Altered I B  Ubiquitination

(2011) X. Zhou et al.   JOURNAL OF IMMUNOLOGY

ADAM-17: the enzyme that does it all

(2010) Monika Gooz   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Angiotensin Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis and Diastolic Dysfunction

(2010) Gavin Y. Oudit et al.   JOURNAL OF CARDIAC FAILURE

α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8

(2010) David A. Bergin et al.   JOURNAL OF CLINICAL INVESTIGATION

Interactions of α1–proteinase inhibitor with small ligands of therapeutic potential: binding with retinoic acid

(2009) Elena Karnaukhova   AMINO ACIDS

SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS

(2009) G. Y. Oudit et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Mechanism of α-1 antitrypsin endocytosis by lung endothelium

(2009) Sadaf Sohrab et al.   FASEB JOURNAL

α-1-Antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood

(2009) Gregory B. Pott et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Alpha1-Antitrypsin Deficiency

(2009) Edwin K. Silverman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reference values for α1-acid glycoprotein, α1-antitrypsin, albumin, haptoglobin, C-reactive protein, IgA, IgG and IgM during pregnancy

(2008) Anders Larsson et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

Alpha-1 Antitrypsin Deficiency: Pathogenesis, Clinical Presentation, Diagnosis, and Treatment

(2008) Thomas Köhnlein et al.   AMERICAN JOURNAL OF MEDICINE

Alpha-1 antitrypsin deficiency: A conformational disease associated with lung and liver manifestations

(2008) C. M. Greene et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Modulation of TNF- -converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-  production and facilitates viral entry

(2008) S. Haga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA