Functions of ‘A disintegrin and metalloproteases (ADAMs)’ in the mammalian nervous system

NrCAM is a marker for substrate‐selective activation of ADAM10 in Alzheimer's disease

(2019) Tobias Brummer et al.   EMBO Molecular Medicine

Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling

(2018) Gregory Farber et al.   ANGIOGENESIS

In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15

(2018) Lisa Seipold et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Excessive Glutamate Stimulation Impairs ACE2 Activity Through ADAM17-Mediated Shedding in Cultured Cortical Neurons

(2018) Jiaxi Xu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Berberine alleviates amyloid-beta pathology in the brain of APP/PS1 transgenic mice via inhibiting β/γ-secretases activity and enhancing α-secretases

(2018) Zhiyou Cai et al.   Current Alzheimer Research

Non‐cell‐autonomous function of DR6 in Schwann cell proliferation

(2018) Alessio Colombo et al.   EMBO JOURNAL

Proteolytic ectodomain shedding of membrane proteins in mammals—hardware, concepts, and recent developments

(2018) Stefan F Lichtenthaler et al.   EMBO JOURNAL

The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation

(2018) Tobias Brummer et al.   FASEB JOURNAL

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism

(2018) Wilbur M. Song et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A disintegrin and metalloprotease 10-containing exosomes derived from nasal polyps promote angiogenesis and vascular permeability

(2018) Wei Zhang et al.   Molecular Medicine Reports

Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein

(2018) Luise Linsenmeier et al.   Molecular Neurodegeneration

A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease

(2018) Daniela Hartl et al.   MOLECULAR PSYCHIATRY

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3

(2018) Celeste Sassi et al.   NEUROBIOLOGY OF AGING

Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22

(2018) Atsushi Yamagata et al.   Nature Communications

Intriguing Roles for Endothelial ADAM10/Notch Signaling in the Development of Organ-Specific Vascular Beds

(2018) Rolake O. Alabi et al.   PHYSIOLOGICAL REVIEWS

ADAM10 controls the differentiation of the coronary arterial endothelium

(2018) Gregory Farber et al.   ANGIOGENESIS

Oxidative stress and genes regulation of cerebral malaria upon Zizyphus spina-christi treatment in a murine model

(2017) Murad A. Mubaraki et al.   MICROBIAL PATHOGENESIS

Multiple non-catalytic ADAMs are novel integrin α4 ligands

(2017) Lei Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

(2017) Humsa S. Venkatesh et al.   NATURE

ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157

(2017) Dominik Feuerbach et al.   NEUROSCIENCE LETTERS

The LGI1–ADAM22 protein complex in synaptic transmission and synaptic disorders

(2017) Yuko Fukata et al.   NEUROSCIENCE RESEARCH

Tumor-derived fibulin-3 activates pro-invasive NF-κB signaling in glioblastoma cells and their microenvironment

(2017) M S Nandhu et al.   ONCOGENE

Leucine-rich glioma inactivated 3: integrative analyses support its prognostic role in glioma

(2017) Nyoun Soo Kwon et al.   OncoTargets and Therapy

Overexpression of a disintegrin and metalloproteinase 21 is associated with motility, metastasis, and poor prognosis in hepatocellular carcinoma

(2017) Hiroki Honda et al.   Scientific Reports

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

(2017) Miguel Cavadas et al.   Cell Reports

Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

(2017) Adam Graham Grieve et al.   eLife

Glutamate-dependent ectodomain shedding of neuregulin-1 type II precursors in rat forebrain neurons

(2017) Yuriko Iwakura et al.   PLoS One

Mechanistic insights into ectodomain shedding: susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation

(2017) Kyoko Shirakabe et al.   Scientific Reports

Regulation of the α-secretase ADAM10 at transcriptional, translational and post-translational levels

(2016) Bruno Vincent   BRAIN RESEARCH BULLETIN

The ADAMs family of proteases as targets for the treatment of cancer

(2016) Maeve Mullooly et al.   CANCER BIOLOGY & THERAPY

iRhom2 regulates CSF1R cell surface expression and non-steady state myelopoiesis in mice

(2016) Xiaoping Qing et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic cell expression of ADAM23 governs T cell proliferation and cytokine production through the α(v)β(3) integrin receptor

(2016) D. M. Elizondo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Metalloproteinases ADAM10 and ADAM17 Mediate Migration and Differentiation in Glioblastoma Sphere-Forming Cells

(2016) Elodie J. Siney et al.   MOLECULAR NEUROBIOLOGY

Notch signalling in context

(2016) Sarah J. Bray   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Secretion-Positive LGI1 Mutations Linked to Lateral Temporal Epilepsy Impair Binding to ADAM22 and ADAM23 Receptors

(2016) Emanuela Dazzo et al.   PLoS Genetics

A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions

(2016) Nives Giebeler et al.   Toxins

Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics

(2016) Carmen Capone et al.   eLife

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

(2016) Peer-Hendrik Kuhn et al.   eLife

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

(2016) Florent Letronne et al.   EBioMedicine

Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons

(2016) Erika Borcel et al.   Scientific Reports

ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets

(2015) Daniela Dreymueller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes

(2015) Ning Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

iRhoms in the brain – a new frontier?

(2015) Stefan F Lichtenthaler et al.   CELL CYCLE

TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization

(2015) Stéphanie Jouannet et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases

(2015) Susan van Erp et al.   DEVELOPMENTAL CELL

The Cytoplasmic Domain of A Disintegrin and Metalloproteinase 10 (ADAM10) Regulates Its Constitutive Activity but Is Dispensable for Stimulated ADAM10-dependent Shedding

(2015) Thorsten Maretzky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions

(2015) Peter J. Noy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site

(2015) Eitan Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM10 and BACE1 are localized to synaptic vesicles

(2015) Jolanta L. Lundgren et al.   JOURNAL OF NEUROCHEMISTRY

Neuronal ADAM10 Promotes Outgrowth of Small-Caliber Myelinated Axons in the Peripheral Nervous System

(2015) Gerd Meyer zu Horste et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Oligodendrocyte Regeneration and CNS Remyelination Require TACE/ADAM17

(2015) J. Palazuelos et al.   JOURNAL OF NEUROSCIENCE

Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing

(2015) M. J. Kole et al.   JOURNAL OF NEUROSCIENCE

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

Impact of gold nanoparticles on brain of mice infected with Schistosoma mansoni

(2015) Mohamed A. Dkhil et al.   PARASITOLOGY RESEARCH

The LGI1–ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function

(2015) Kathryn L. Lovero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

(2015) Xue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain

(2015) Paul Saftig et al.   PROGRESS IN NEUROBIOLOGY

ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function

(2015) Dan Cui et al.   Scientific Reports

The sheddase ADAM10 is a potent modulator of prion disease

(2015) Hermann C Altmeppen et al.   eLife

Glutamatergic neuron-targeted loss of LGI1 epilepsy gene results in seizures

(2014) Morgane Boillot et al.   BRAIN

Functional phylogenetic analysis of LGI proteins identifies an interaction motif crucial for myelination

(2014) L. Kegel et al.   DEVELOPMENT

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

(2014) Robert Vassar et al.   JOURNAL OF NEUROCHEMISTRY

TACE/ADAM17 Is Essential for Oligodendrocyte Development and CNS Myelination

(2014) J. Palazuelos et al.   JOURNAL OF NEUROSCIENCE

ADAM Metallopeptidase Domain 33 (ADAM33): A Promising Target for Asthma

(2014) Priya Tripathi et al.   MEDIATORS OF INFLAMMATION

Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy

(2014) Norihiko Yokoi et al.   NATURE MEDICINE

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

(2014) David J Marchant et al.   NATURE MEDICINE

Ultra-rapid axon-axon ephaptic inhibition of cerebellar Purkinje cells by the pinceau

(2014) Antonin Blot et al.   NATURE NEUROSCIENCE

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

Increased CSF APPs-  levels in patients with Alzheimer disease treated with acitretin

(2014) K. Endres et al.   NEUROLOGY

Molecular and Cellular Changes in the Lumbar Spinal Cord following Thoracic Injury: Regulation by Treadmill Locomotor Training

(2014) Hae Young Shin et al.   PLoS One

Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10

(2014) Wei Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A

(2014) Erez Romi et al.   Nature Communications

Oligodendrocyte Precursor Cells Modulate the Neuronal Network by Activity-Dependent Ectodomain Cleavage of Glial NG2

(2014) Dominik Sakry et al.   PLOS BIOLOGY

LGI Proteins in the Nervous System

(2013) Linde Kegel et al.   ASN Neuro

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Brain Angiotensin-Converting Enzyme Type 2 Shedding Contributes to the Development of Neurogenic Hypertension

(2013) Huijing Xia et al.   CIRCULATION RESEARCH

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

(2013) Yonka Christova et al.   EMBO REPORTS

Adrenergic Regulation of IgE Involves Modulation of CD23 and ADAM10 Expression on Exosomes

(2013) C. J. Padro et al.   JOURNAL OF IMMUNOLOGY

EphrinA/EphA-induced ectodomain shedding of neural cell adhesion molecule regulates growth cone repulsion through ADAM10 metalloprotease

(2013) Leann H. Brennaman et al.   JOURNAL OF NEUROCHEMISTRY

Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions

(2013) J. Prox et al.   JOURNAL OF NEUROSCIENCE

Dual Cleavage of Neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling

(2013) D. Fleck et al.   JOURNAL OF NEUROSCIENCE

Autoantibodies to Epilepsy-Related LGI1 in Limbic Encephalitis Neutralize LGI1-ADAM22 Interaction and Reduce Synaptic AMPA Receptors

(2013) T. Ohkawa et al.   JOURNAL OF NEUROSCIENCE

ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function

(2013) Jaehong Suh et al.   NEURON

ADAM17 Is Critical for Multipolar Exit and Radial Migration of Neuronal Intermediate Progenitor Cells in Mice Cerebral Cortex

(2013) Qingyu Li et al.   PLoS One

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding

(2013) T. Maretzky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ectodomain shedding and ADAMs in development

(2012) S. Weber et al.   DEVELOPMENT

ADAM13 function is required in the 3 dimensional context of the embryo during cranial neural crest cell migration in Xenopus laevis

(2012) Hélène Cousin et al.   DEVELOPMENTAL BIOLOGY

LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11

(2012) Koji Sagane et al.   International Journal of Biological Sciences

Cellular Prion Protein Regulates Its Own α-Cleavage through ADAM8 in Skeletal Muscle

(2012) Jingjing Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TspanC8 Subgroup of Tetraspanins Interacts with A Disintegrin and Metalloprotease 10 (ADAM10) and Regulates Its Maturation and Cell Surface Expression

(2012) Elizabeth J. Haining et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2

(2012) Sika Zheng et al.   NATURE NEUROSCIENCE

Testicular and epididymal ADAMs: expression and function during fertilization

(2012) Chunghee Cho   Nature Reviews Urology

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

(2012) Alessio Colombo et al.   NEUROBIOLOGY OF DISEASE

Activity-Dependent Proteolytic Cleavage of Neuroligin-1

(2012) Kunimichi Suzuki et al.   NEURON

Differential expression of ADAM15 and ADAM17 metalloproteases in the rat brain after severe hypobaric hypoxia and hypoxic preconditioning

(2012) Elena Rybnikova et al.   NEUROSCIENCE RESEARCH

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

Lack of ADAM15 in mice is associated with increased osteoblast function and bone mass

(2011) Marilena Marzia et al.   BIOLOGICAL CHEMISTRY

Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation

(2011) Atsushi Oyagi et al.   BRAIN RESEARCH

Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function

(2011) Charlotte Selvais et al.   FASEB JOURNAL

Cleavage of Neuregulin-1 by BACE1 or ADAM10 Protein Produces Differential Effects on Myelination

(2011) Xiaoyang Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM9 Inhibition Increases Membrane Activity of ADAM10 and Controls α-Secretase Processing of Amyloid Precursor Protein

(2011) Marcia L. Moss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

COGNITIVE IMPROVEMENT WITH INTRATHECAL ADMINISTRATION OF INFLIXIMAB IN A WOMAN WITH ALZHEIMER'S DISEASE

(2011) Jian-Quan Shi et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo

(2011) Hermann C Altmeppen et al.   Molecular Neurodegeneration

TACE (ADAM17) inhibits Schwann cell myelination

(2011) Rosa La Marca et al.   NATURE NEUROSCIENCE

TACE cleaves neogenin to desensitize cortical neurons to the repulsive guidance molecule

(2011) Yusuke Okamura et al.   NEUROSCIENCE RESEARCH

A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins

(2011) Emanuela Leonardi et al.   PLoS One

Regulation of alpha-secretase ADAM10 expression and activity

(2011) Kristina Endres et al.   EXPERIMENTAL BRAIN RESEARCH

Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia

(2010) Sarosh R. Irani et al.   BRAIN

Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains

(2010) Jian-Quan Shi et al.   BRAIN RESEARCH

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Expression analysis of the Adam21 gene in mouse testis

(2010) Chongil Yi et al.   GENE EXPRESSION PATTERNS

Processing of the Synaptic Cell Adhesion Molecule Neurexin-3β by Alzheimer Disease α- and γ-Secretases

(2010) Nathalie Bot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Kv1.2 Channelopathy Underlying Cerebellar Ataxia

(2010) Gang Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

(2010) S. M. Le Gall et al.   JOURNAL OF CELL SCIENCE

Lgi4 Promotes the Proliferation and Differentiation of Glial Lineage Cells throughout the Developing Peripheral Nervous System

(2010) J. Nishino et al.   JOURNAL OF NEUROSCIENCE

Tumor Necrosis Factor-  (TNF- ) Regulates Shedding of TNF-  Receptor 1 by the Metalloprotease-Disintegrin ADAM8: Evidence for a Protease-Regulated Feedback Loop in Neuroprotection

(2010) J. W. Bartsch et al.   JOURNAL OF NEUROSCIENCE

Synaptic Localization and Activity of ADAM10 Regulate Excitatory Synapses through N-Cadherin Cleavage

(2010) M. Malinverno et al.   JOURNAL OF NEUROSCIENCE

ADAM22, A Kv1 Channel-Interacting Protein, Recruits Membrane-Associated Guanylate Kinases to Juxtaparanodes of Myelinated Axons

(2010) Y. Ogawa et al.   JOURNAL OF NEUROSCIENCE

The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex

(2010) E. Jorissen et al.   JOURNAL OF NEUROSCIENCE

Adam22 Is a Major Neuronal Receptor for Lgi4-Mediated Schwann Cell Signaling

(2010) E. Ozkaynak et al.   JOURNAL OF NEUROSCIENCE

Active Metalloproteases of the A Disintegrin And Metalloprotease (ADAM) Family: Biological Function and Structure

(2010) Theo Klein et al.   JOURNAL OF PROTEOME RESEARCH

Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series

(2010) Meizan Lai et al.   LANCET NEUROLOGY

Activation of TNF receptor 2 in microglia promotes induction of anti-inflammatory pathways

(2010) Caterina Veroni et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Disruption of LGI1–linked synaptic complex causes abnormal synaptic transmission and epilepsy

(2010) Yuko Fukata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The metzincins - Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc-peptidases

(2010) Walter Stöcker et al.   PROTEIN SCIENCE

Loss of the Metalloprotease ADAM9 Leads to Cone-Rod Dystrophy in Humans and Retinal Degeneration in Mice

(2009) David A. Parry et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Up-Regulation of Soluble Axl and Mer Receptor Tyrosine Kinases Negatively Correlates with Gas6 in Established Multiple Sclerosis Lesions

(2009) Jason G. Weinger et al.   AMERICAN JOURNAL OF PATHOLOGY

ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala271

(2009) Marc D. Zack et al.   ARTHRITIS AND RHEUMATISM

Decreased behavioral impairments in an Alzheimer mice model by interfering with TNF-alpha metabolism

(2009) Fabienne Giuliani et al.   BRAIN RESEARCH BULLETIN

ADAM23 Negatively Modulates αvβ3 Integrin Activation during Metastasis

(2009) Newton V. Verbisck et al.   CANCER RESEARCH

ADAM8/MS2/CD156, an Emerging Drug Target in the Treatment of Inflammatory and Invasive Pathologies

(2009) Garrit Koller et al.   CURRENT PHARMACEUTICAL DESIGN

Up-regulation of the α-secretase ADAM10 by retinoic acid receptors and acitretin

(2009) Frank Tippmann et al.   FASEB JOURNAL

The effects of α-secretase ADAM10 on the proteolysis of neuregulin-1

(2009) Christian Freese et al.   FEBS Journal

Involvement of ADAM10 in axonal outgrowth and myelination of the peripheral nerve

(2009) Parastoo Jangouk et al.   GLIA

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate α-secretase activity

(2009) Minji Kim et al.   HUMAN MOLECULAR GENETICS

Structural Characterization of the Ectodomain of a Disintegrin and Metalloproteinase-22 (ADAM22), a Neural Adhesion Receptor Instead of Metalloproteinase

(2009) Heli Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

(2009) Thomas Tousseyn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM9 Is Involved in Pathological Retinal Neovascularization

(2009) V. Guaiquil et al.   MOLECULAR AND CELLULAR BIOLOGY

LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology

(2009) Katherine Owuor et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

LRP1 shedding in human brain: roles of ADAM10 and ADAM17

(2009) Qiang Liu et al.   Molecular Neurodegeneration

Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimer's disease

(2009) Lin Cong et al.   NEUROBIOLOGY OF AGING

Characterization of a specific interaction between ADAM23 and cellular prion protein

(2009) Michele D.M. Costa et al.   NEUROSCIENCE LETTERS

Regulation of βAPP and PrPc Cleavage by α-Secretase: Mechanistic and Therapeutic Perspectives

(2008) Bruno Vincent et al.   Current Alzheimer Research

ADAM2 promotes migration of neuroblasts in the rostral migratory stream to the olfactory bulb

(2008) Shin-ichi Murase et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Roles of Meltrin-β/ADAM19 in Progression of Schwann Cell Differentiation and Myelination during Sciatic Nerve Regeneration

(2008) Shuji Wakatsuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM8 is selectively up-regulated in endothelial cells and is associated with angiogenesis after spinal cord injury in adult mice

(2008) Edward T. Mahoney et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration

(2008) Edward L Tobinick et al.   Journal of Neuroinflammation

The ADAM metalloproteinases

(2008) D EDWARDS et al.   MOLECULAR ASPECTS OF MEDICINE

Non-proteolytic effect of β-site APP-cleaving enzyme 1 (BACE1) on sodium channel function

(2008) Tobias Huth et al.   NEUROBIOLOGY OF DISEASE

mGluR1/5-Dependent Long-Term Depression Requires the Regulated Ectodomain Cleavage of Neuronal Pentraxin NPR by TACE

(2008) Richard W. Cho et al.   NEURON

Abnormal axonal guidance and brain anatomy in mouse mutants for the cell recognition molecules close homolog of L1 and NgCAM-related cell adhesion molecule

(2008) A. Heyden et al.   NEUROSCIENCE

Meltrin β/ADAM19 Interacting with EphA4 in Developing Neural Cells Participates in Formation of the Neuromuscular Junction

(2008) Norihiro Yumoto et al.   PLoS One

ADAM-10 over-expression increases cortical synaptogenesis

(2006) Karen F.S. Bell et al.   NEUROBIOLOGY OF AGING