FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex

ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling

(2018) Stefanie Schmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

(2017) Miguel Cavadas et al.   Cell Reports

Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

(2017) Adam Graham Grieve et al.   eLife

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING

(2016) Wei-Wei Luo et al.   NATURE IMMUNOLOGY

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

(2016) Hugo J.R. Fernandes et al.   Stem Cell Reports

Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17

(2016) Steffen Riethmueller et al.   Scientific Reports

Control of ADAM17 activity by regulation of its cellular localisation

(2016) Inken Lorenzen et al.   Scientific Reports

TNF biology, pathogenic mechanisms and emerging therapeutic strategies

(2015) George D. Kalliolias et al.   Nature Reviews Rheumatology

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

(2015) Xue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17

(2015) Sathish K. Maney et al.   Science Signaling

Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17

(2015) Sathish K. Maney et al.   Science Signaling

The Rhomboid-Like Superfamily: Molecular Mechanisms and Biological Roles

(2014) Matthew Freeman   Annual Review of Cell and Developmental Biology

Anti-TNF therapy: past, present and future

(2014) C. Monaco et al.   INTERNATIONAL IMMUNOLOGY

Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin

(2014) V. Hosur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice

(2014) O. M. Siggs et al.   Biology Open

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

(2013) Yonka Christova et al.   EMBO REPORTS

iRHOM2 takes control of rheumatoid arthritis

(2013) Stefan F. Lichtenthaler   JOURNAL OF CLINICAL INVESTIGATION

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis

(2013) Priya Darshinee A. Issuree et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

ADAM17, shedding, TACE as therapeutic targets

(2013) Stefan Rose-John   PHARMACOLOGICAL RESEARCH

Efficient, Long Term Production of Monocyte-Derived Macrophages from Human Pluripotent Stem Cells under Partly-Defined and Fully-Defined Conditions

(2013) Bonnie van Wilgenburg et al.   PLoS One

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding

(2013) T. Maretzky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RHBDF2 Mutations Are Associated with Tylosis, a Familial Esophageal Cancer Syndrome

(2012) Diana C. Blaydon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells

(2012) Kosuke Yamamoto et al.   BIOCHEMICAL JOURNAL

Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer

(2012) Silva Saarinen et al.   Familial Cancer

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

(2010) Athena Chalaris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bili Inhibits Wnt/β-Catenin Signaling by Regulating the Recruitment of Axin to LRP6

(2009) Lorna S. Kategaya et al.   PLoS One

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY