Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo

The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site

(2015) Eitan Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

(2015) Shiri Gur-Cohen et al.   NATURE MEDICINE

Cytokine secretion and NK cell activity in human ADAM17 deficiency

(2015) Pinchas Tsukerman et al.   Oncotarget

ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A

(2014) Erez Romi et al.   Nature Communications

ADAM17, shedding, TACE as therapeutic targets

(2013) Stefan Rose-John   PHARMACOLOGICAL RESEARCH

Inflammatory Skin and Bowel Disease Linked toADAM17Deletion

(2011) Diana C. Blaydon et al.   NEW ENGLAND JOURNAL OF MEDICINE

ADAM17: a molecular switch to control inflammation and tissue regeneration

(2011) Jürgen Scheller et al.   TRENDS IN IMMUNOLOGY

ADAM-17: the enzyme that does it all

(2010) Monika Gooz   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

(2010) Paul Saftig et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The Study of the Inhibition of the Recombinant TACE Prodomain to Endotoxemia in Mice

(2009) Xiaoou Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of Key Sequence Determinants for the Inhibitory Function of the Prodomain of TACE†

(2008) Patricia E. Gonzales et al.   BIOCHEMISTRY

VEGF-A Stimulates ADAM17-Dependent Shedding of VEGFR2 and Crosstalk Between VEGFR2 and ERK Signaling

(2008) Steven Swendeman et al.   CIRCULATION RESEARCH

The regulation of TACE catalytic function by its prodomain

(2008) Xiaoou Li et al.   MOLECULAR BIOLOGY REPORTS

Expression, purification and insights into structure and folding of the ADAM22 pro domain

(2008) Hans Peter Sørensen et al.   PROTEIN EXPRESSION AND PURIFICATION

Drug Insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis

(2008) Marcia L Moss et al.   Nature clinical practice. Rheumatology