Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation

ADAM17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer

(2019) Mohamed I Saad et al.   EMBO Molecular Medicine

ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling

(2018) Stefanie Schmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells

(2018) Anne-Sophie Cabron et al.   JOURNAL OF IMMUNOLOGY

EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients

(2017) Sriram Srivatsa et al.   GASTROENTEROLOGY

Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation

(2017) Marcia L. Moss et al.   MEDIATORS OF INFLAMMATION

Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis

(2017) Ester Pagano et al.   PHARMACOLOGICAL RESEARCH

SATB2/β-catenin/TCF-LEF pathway induces cellular transformation by generating cancer stem cells in colorectal cancer

(2017) Wei Yu et al.   Scientific Reports

ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet–associated Colon Cancer

(2016) Reba Mustafi et al.   CLINICAL CANCER RESEARCH

Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo

(2016) Eitan Wong et al.   Scientific Reports

Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17

(2016) Steffen Riethmueller et al.   Scientific Reports

Driver and Passenger Mutations in Cancer

(2015) Julia R. Pon et al.   Annual Review of Pathology-Mechanisms of Disease

The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site

(2015) Eitan Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Colorectal cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition

(2013) Anais Chavaroche et al.   ANALYTICAL BIOCHEMISTRY

Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17

(2013) Jeanette Schwarz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Role of IL-6Trans-Signaling in Vascular Leakage: Implications for Ovarian Hyperstimulation Syndrome in a Murine Model

(2013) Lin-Hung Wei et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II

(2012) Inken Lorenzen et al.   FEBS LETTERS

TACE Activation by MAPK-Mediated Regulation of Cell Surface Dimerization and TIMP3 Association

(2012) P. Xu et al.   Science Signaling

Inflammatory Skin and Bowel Disease Linked toADAM17Deletion

(2011) Diana C. Blaydon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17

(2011) Thorsten Maretzky et al.   Nature Communications

The cytoplasmic domains of TNFα-converting enzyme (TACE/ADAM17) and L-selectin are regulated differently by p38 MAPK and PKC to promote ectodomain shedding

(2010) David J. Killock et al.   BIOCHEMICAL JOURNAL

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

(2010) S. M. Le Gall et al.   JOURNAL OF CELL SCIENCE

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

(2010) Athena Chalaris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Direct Activation of TACE-Mediated Ectodomain Shedding by p38 MAP Kinase Regulates EGF Receptor-Dependent Cell Proliferation

(2010) Pinglong Xu et al.   MOLECULAR CELL

The regulation of TACE catalytic function by its prodomain

(2008) Xiaoou Li et al.   MOLECULAR BIOLOGY REPORTS