A novel inhibitor of ADAM17 sensitizes colorectal cancer cells to 5-Fluorouracil by reversing Notch and epithelial-mesenchymal transition in vitro and in vivo

Terfenadine combined with epirubicin impedes the chemo-resistant human non-small cell lung cancer both in vitro and in vivo through EMT and Notch reversal

(2017) Li An et al.   PHARMACOLOGICAL RESEARCH

Exploring brusatol as a new anti-pancreatic cancer adjuvant: biological evaluation and mechanistic studies

(2017) Zheng Lu et al.   Oncotarget

Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency

(2017) Joseph Dosch et al.   Oncotarget

Disparities found in chemotherapy administration for human immunodeficiency virus-associated lymphoma

(2016) Mary Kay Barton   CA-A CANCER JOURNAL FOR CLINICIANS

Niclosamide inhibits colon cancer progression through downregulation of the Notch pathway and upregulation of the tumor suppressor miR-200 family

(2016) Mohammed A. Suliman et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Recent Advances in Scaffold Hopping

(2016) Ye Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling

(2016) Rui Wang et al.   Stem Cells Translational Medicine

Notch signaling: An emerging therapeutic target for cancer treatment

(2015) Xun Yuan et al.   CANCER LETTERS

The Notch pathway in colorectal cancer

(2015) Kaitlyn E. Vinson et al.   INTERNATIONAL JOURNAL OF CANCER

Notch-1 Promotes Stemness and Epithelial to Mesenchymal Transition in Colorectal Cancer

(2015) Alexander W. Fender et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Prometastatic NOTCH Signaling in Colon Cancer

(2015) Onno Kranenburg   Cancer Discovery

EMT, CTCs and CSCs in tumor relapse and drug-resistance

(2015) Abhisek Mitra et al.   Oncotarget

Structure-based virtual screening and ADME/T-based profiling for low molecular weight chemical starting points as p21-activated kinase 4 inhibitors

(2015) Ruijuan Li et al.   RSC Advances

The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells

(2015) Ning Wei et al.   Oncotarget

Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application

(2014) Xun Yuan et al.   Journal of Hematology & Oncology

Fast Identification of Novel Lymphoid Tyrosine Phosphatase Inhibitors Using Target–Ligand Interaction-Based Virtual Screening

(2014) Xuben Hou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1

(2013) Jia Lu et al.   CANCER CELL

Synergistic antitumor effect of 5-fluorouracil in combination with parthenolide in human colorectal cancer

(2013) Se-Lim Kim et al.   CANCER LETTERS

The Notch signaling pathway as a mediator of tumor survival

(2013) K. M. Capaccione et al.   CARCINOGENESIS

Notch inhibitors for cancer treatment

(2013) Ingrid Espinoza et al.   PHARMACOLOGY & THERAPEUTICS

Role of targeted agents in metastatic colorectal cancer

(2013) Hans Prenen et al.   Targeted Oncology

Anti-Tumour Effects of a Specific Anti-ADAM17 Antibody in an Ovarian Cancer Model In Vivo

(2012) Frances M. Richards et al.   PLoS One

Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links

(2012) Christina Scheel et al.   SEMINARS IN CANCER BIOLOGY

Notch Signaling

(2012) R. Kopan   Cold Spring Harbor Perspectives in Biology

2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors

(2011) Chaoyang Dai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Notch signaling: Emerging molecular targets for cancer therapy

(2010) Ling Yin et al.   BIOCHEMICAL PHARMACOLOGY

Discovery and SAR of hydantoin TACE inhibitors

(2010) Wensheng Yu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biaryl substituted hydantoin compounds as TACE inhibitors

(2010) Wensheng Yu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure and activity relationships of tartrate-based TACE inhibitors

(2010) Dansu Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ADAM17 Regulates Epidermal Growth Factor Receptor Expression through the Activation of Notch1 in Non-Small Cell Lung Cancer

(2010) A. Baumgart et al.   CANCER RESEARCH

Chemotherapy-Induced Activation of ADAM-17: A Novel Mechanism of Drug Resistance in Colorectal Cancer

(2010) J. N. Kyula et al.   CLINICAL CANCER RESEARCH

ADAM-17: the enzyme that does it all

(2010) Monika Gooz   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

(2010) Paul Saftig et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-α converting enzyme (TACE) inhibitors

(2009) Kaapjoo Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The discovery of novel tartrate-based TNF-α converting enzyme (TACE) inhibitors

(2009) Kristin E. Rosner et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

 -Secretase Inhibitors Abrogate Oxaliplatin-Induced Activation of the Notch-1 Signaling Pathway in Colon Cancer Cells Resulting in Enhanced Chemosensitivity

(2009) R. D. Meng et al.   CANCER RESEARCH

Role of Notch signaling in colorectal cancer

(2009) L. Qiao et al.   CARCINOGENESIS

Discovery of novel hydroxamates as highly potent tumor necrosis factor-α converting enzyme inhibitors. Part II: Optimization of the S3′ pocket

(2008) Robert D. Mazzola et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones

(2007) Upul K. Bandarage et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS