ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling
Authors
Keywords
-
Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 215, Issue 4, Pages 1205-1225
Publisher
Rockefeller University Press
Online
2018-02-22
DOI
10.1084/jem.20171696
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients
- (2017) Sriram Srivatsa et al. GASTROENTEROLOGY
- IL-6 Signaling Regulates Small Intestinal Crypt Homeostasis
- (2017) Victoria Jeffery et al. JOURNAL OF IMMUNOLOGY
- The role of IL-6 in host defence against infections: immunobiology and clinical implications
- (2017) Stefan Rose-John et al. Nature Reviews Rheumatology
- EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis
- (2017) D M Hardbower et al. ONCOGENE
- YAP–IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis
- (2017) Koji Taniguchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion
- (2017) Mariana X. Byndloss et al. SCIENCE
- A subcellular map of the human proteome
- (2017) Peter J. Thul et al. SCIENCE
- Jagged-2 (JAG2) enhances tumorigenicity and chemoresistance of colorectal cancer cells
- (2017) Vivek Vaish et al. Oncotarget
- Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation
- (2017) Steffen Riethmueller et al. PLOS BIOLOGY
- Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling
- (2017) Adam Graham Grieve et al. eLife
- Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in MiceHighlights
- (2016) Alexandros Nicolaou et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Cancer statistics, 2016
- (2016) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet–associated Colon Cancer
- (2016) Reba Mustafi et al. CLINICAL CANCER RESEARCH
- Heterogeneity of Acquired Resistance to Anti-EGFR Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer
- (2016) Filippo Pietrantonio et al. CLINICAL CANCER RESEARCH
- Uncoupling of mucosal gene regulation, mRNA splicing and adherent microbiota signatures in inflammatory bowel disease
- (2016) Robert Häsler et al. GUT
- IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice
- (2016) Juri Bergmann et al. HEPATOLOGY
- Oxygen metabolism and barrier regulation in the intestinal mucosa
- (2016) Louise E. Glover et al. JOURNAL OF CLINICAL INVESTIGATION
- EGFR regulates macrophage activation and function in bacterial infection
- (2016) Dana M. Hardbower et al. JOURNAL OF CLINICAL INVESTIGATION
- Diet, microorganisms and their metabolites and colon cancer
- (2016) Stephen J. D. O'Keefe Nature Reviews Gastroenterology & Hepatology
- Phosphatidylserine exposure is required for ADAM17 sheddase function
- (2016) Anselm Sommer et al. Nature Communications
- Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics
- (2016) Carmen Capone et al. eLife
- Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair
- (2016) K Aden et al. Oncogenesis
- Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance
- (2015) Michael J. Kraakman et al. Cell Metabolism
- Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles
- (2015) Neele Schumacher et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The importance of molecular markers for diagnosis and selection of targeted treatments in patients with cancer
- (2015) N. P. Tobin et al. JOURNAL OF INTERNAL MEDICINE
- ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses
- (2015) Isabell Yan et al. JOURNAL OF LEUKOCYTE BIOLOGY
- A gp130–Src–YAP module links inflammation to epithelial regeneration
- (2015) Koji Taniguchi et al. NATURE
- iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling
- (2015) Xue Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Klf2 and Tfcp2l1, Two Wnt/β-Catenin Targets, Act Synergistically to Induce and Maintain Naive Pluripotency
- (2015) Dongbo Qiu et al. Stem Cell Reports
- Acquired resistance to EGFR-targeted therapies in colorectal cancer
- (2014) Beth O. Van Emburgh et al. Molecular Oncology
- Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin
- (2014) Jan Mauer et al. NATURE IMMUNOLOGY
- Development of a Dual-Index Sequencing Strategy and Curation Pipeline for Analyzing Amplicon Sequence Data on the MiSeq Illumina Sequencing Platform
- (2013) James J. Kozich et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Trp53 Deficiency Protects against Acute Intestinal Inflammation
- (2013) M. E. Spehlmann et al. JOURNAL OF IMMUNOLOGY
- Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
- (2013) Morgan G I Langille et al. NATURE BIOTECHNOLOGY
- oPOSSUM-3: Advanced Analysis of Regulatory Motif Over-Representation Across Genes or ChIP-Seq Datasets
- (2013) Andrew T. Kwon et al. G3-Genes Genomes Genetics
- Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation
- (2012) Alexandre Calon et al. CANCER CELL
- Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma
- (2012) Thomas Knösel et al. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
- The pro- and anti-inflammatory properties of the cytokine interleukin-6
- (2011) Jürgen Scheller et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer
- (2011) Marina Lesina et al. CANCER CELL
- Brachyury expression predicts poor prognosis at early stages of colorectal cancer
- (2011) Nerbil Kilic et al. EUROPEAN JOURNAL OF CANCER
- Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
- (2011) Simon A. Jones et al. JOURNAL OF CLINICAL INVESTIGATION
- Feedback regulation of EGFR signalling: decision making by early and delayed loops
- (2011) Roi Avraham et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- ADAM17: a molecular switch to control inflammation and tissue regeneration
- (2011) Jürgen Scheller et al. TRENDS IN IMMUNOLOGY
- Identifying biologically relevant differences between metagenomic communities
- (2010) Donovan H. Parks et al. BIOINFORMATICS
- Inflammation and Colon Cancer
- (2010) Janoš Terzić et al. GASTROENTEROLOGY
- Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice
- (2010) Athena Chalaris et al. JOURNAL OF EXPERIMENTAL MEDICINE
- IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer
- (2009) Sergei Grivennikov et al. CANCER CELL
- GATA4 and GATA5 are Potential Tumor Suppressors and Biomarkers in Colorectal Cancer
- (2009) D. M.E.I. Hellebrekers et al. CLINICAL CANCER RESEARCH
- STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
- (2009) Geethanjali Pickert et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Essential Roles of IL-6 Trans-Signaling in Colonic Epithelial Cells, Induced by the IL-6/Soluble-IL-6 Receptor Derived from Lamina Propria Macrophages, on the Development of Colitis-Associated Premalignant Cancer in a Murine Model
- (2009) S. Matsumoto et al. JOURNAL OF IMMUNOLOGY
- Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
- (2009) Toshiro Sato et al. NATURE
- Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
- (2008) Helena Linardou et al. LANCET ONCOLOGY
- Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
- (2008) Sandra Rebouissou et al. NATURE
- STRING 8--a global view on proteins and their functional interactions in 630 organisms
- (2008) L. J. Jensen et al. NUCLEIC ACIDS RESEARCH
- Apc mice: Models, modifiers and mutants
- (2008) Amy E. McCart et al. PATHOLOGY RESEARCH AND PRACTICE
- Interleukin-6 and cachexia in ApcMin/+ mice
- (2007) Kristen A. Baltgalvis et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now