Loss of RHBDF2 results in an early‐onset spontaneous murine colitis

iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling

(2018) Xiaoping Qing et al.   JOURNAL OF CLINICAL INVESTIGATION

Principles and approaches for reproducible scoring of tissue stains in research

(2018) David K. Meyerholz et al.   LABORATORY INVESTIGATION

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

S100A4 contributes to colitis development by increasing the adherence of Citrobacter rodentium in intestinal epithelial cells

(2017) Jinhua Zhang et al.   Scientific Reports

Biologic Therapies and Risk of Infection and Malignancy in Patients With Inflammatory Bowel Disease: A Systematic Review and Network Meta-analysis

(2016) Stefanos Bonovas et al.   Clinical Gastroenterology and Hepatology

Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility

(2016) Byong Duk Ye et al.   Expert Review of Clinical Immunology

An overview of the bacterial contribution to Crohn disease pathogenesis

(2016) Moftah H. Alhagamhmad et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids

(2016) Alexandra L. Matthews et al.   PLATELETS

Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases

(2016) Ulrike Billmeier et al.   WORLD JOURNAL OF GASTROENTEROLOGY

ADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phospholipase C γ1 and protein kinase C pathways

(2016) Cristina Wolf  et al.   Scientific Reports

IL10-Deficiency in CD4+ T Cells Exacerbates the IFNγ and IL17 Response During Bacteria Induced Colitis

(2015) Virginia Seiffart et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Intestinal Microbiota in Inflammatory Bowel Disease

(2015) Christoph Becker et al.   ILAR JOURNAL

TNF biology, pathogenic mechanisms and emerging therapeutic strategies

(2015) George D. Kalliolias et al.   Nature Reviews Rheumatology

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

(2015) Xue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of TACE in colon inflammation: A novel mechanism of regulation via SIRT-1 activation

(2014) Manoranjan Sharma et al.   CYTOKINE

Activation of the Epidermal Growth Factor Receptor in Macrophages Regulates Cytokine Production and Experimental Colitis

(2014) N. Lu et al.   JOURNAL OF IMMUNOLOGY

Intestinal Cell Barrier Function In Vitro Is Severely Compromised by Keratin 8 and 18 Mutations Identified in Patients with Inflammatory Bowel Disease

(2014) Tina Zupancic et al.   PLoS One

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

(2013) Yonka Christova et al.   EMBO REPORTS

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding

(2013) T. Maretzky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host-compound foraging by intestinal microbiota revealed by single-cell stable isotope probing

(2013) D. Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of growth factors in intestinal regeneration and repair in necrotizing enterocolitis

(2013) Kathryn J. Rowland et al.   Seminars in Pediatric Surgery

Comprehensive review: antitumor necrosis factor agents in inflammatory bowel disease and factors implicated in treatment response

(2013) Gary R. Lichtenstein   Therapeutic Advances in Gastroenterology

iRhom2 is required for the secretion of mouse TNF 

(2012) O. M. Siggs et al.   BLOOD

Murine CD4+CD25- cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo

(2012) Anna Majowicz et al.   BMC GASTROENTEROLOGY

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand–dependent terminal keratinocyte differentiation

(2012) Claus-Werner Franzke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel Murine Model of Inflammatory Bowel Disease and Inflammation-Associated Colon Cancer with Ulcerative Colitis-Like Features

(2012) Laura P. Hale et al.   PLoS One

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

(2012) Xochitl C Morgan et al.   GENOME BIOLOGY

Inflammatory Skin and Bowel Disease Linked toADAM17Deletion

(2011) Diana C. Blaydon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Current and emerging drugs for the treatment of inflammatory bowel disease

(2011) John Triantafillidis   Drug Design Development and Therapy

Commensal gut flora reduces susceptibility to experimentally induced colitis via T-cell-derived interleukin-101

(2010) Marina C. Pils et al.   INFLAMMATORY BOWEL DISEASES

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

(2010) Athena Chalaris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow mononuclear cells protect neurons and modulate microglia in cell culture models of ischemic stroke

(2010) Sushil Sharma et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Immunoregulatory Actions of Epithelial Cell PPAR γ at the Colonic Mucosa of Mice with Experimental Inflammatory Bowel Disease

(2010) Saroj K. Mohapatra et al.   PLoS One

Characterization of fecal microbiota in cats using universal 16S rRNA gene and group-specific primers for Lactobacillus and Bifidobacterium spp.

(2010) Lauren E. Ritchie et al.   VETERINARY MICROBIOLOGY

The role of COX-2 in intestinal inflammation and colorectal cancer

(2009) D Wang et al.   ONCOGENE

Tumor Necrosis Factor Signaling Mediates Resistance to Mycobacteria by Inhibiting Bacterial Growth and Macrophage Death

(2008) Hilary Clay et al.   IMMUNITY

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

(2008) Andre Franke et al.   NATURE GENETICS

Therapeutic correction of bacterial dysbiosis discovered by molecular techniques

(2008) R. B. Sartor   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA