The molecular, cellular and pathophysiological roles of iRhom pseudoproteases

Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNFα pathway

(2018) Coline Haxaire et al.   BLOOD

Partners in crime: neutrophils and monocytes/macrophages in inflammation and disease

(2018) Kathryn Prame Kumar et al.   CELL AND TISSUE RESEARCH

Uev1A-Ubc13 catalyzes K63-linked ubiquitination of RHBDF2 to promote TACE maturation

(2018) Yiran Zhang et al.   CELLULAR SIGNALLING

Tylosis associated with squamous cell carcinoma of the oesophagus (TOC): Report of an African family with a novel RHBDF2 variant

(2018) T. Mokoena et al.   CLINICAL GENETICS

RHBDF1 regulates APC-mediated stimulation of the epithelial-to-mesenchymal transition and proliferation of colorectal cancer cells in part via the Wnt/β-catenin signalling pathway

(2018) Huiping Yuan et al.   EXPERIMENTAL CELL RESEARCH

iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling

(2018) Xiaoping Qing et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil and macrophage cell surface CSF-1 shed by ADAM17 drives mouse macrophage proliferation in acute and chronic inflammation

(2018) Jingjing Tang et al.   MOLECULAR AND CELLULAR BIOLOGY

p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response

(2018) Paola Arcidiacono et al.   Nature Communications

Role of iRhom2 in intestinal ischemia-reperfusion-mediated acute lung injury

(2018) Jee Hyun Kim et al.   Scientific Reports

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex

(2018) Ulrike Künzel et al.   eLife

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

(2018) Ioanna Oikonomidi et al.   eLife

The discovery of proteases and intramembrane proteolysis

(2018) Sandra Paschkowsky et al.   Biochemistry and Cell Biology

The Rhomboid Superfamily: Structural Mechanisms and Chemical Biology Opportunities

(2018) Anežka Tichá et al.   TRENDS IN BIOCHEMICAL SCIENCES

Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing

(2017) Vishnu Hosur et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells

(2017) Takatsugu Ishimoto et al.   GASTROENTEROLOGY

Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2–ADAM17-dependent proteolysis

(2017) Xue Li et al.   JOURNAL OF CELL SCIENCE

Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16

(2017) Thiviyani Maruthappu et al.   Nature Communications

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

(2017) Miguel Cavadas et al.   Cell Reports

iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA

(2017) Wei-Wei Luo et al.   PLoS Pathogens

Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

(2017) Adam Graham Grieve et al.   eLife

Genetic deletion of amphiregulin restores the normal skin phenotype in a mouse model of the human skin disease tylosis

(2017) Vishnu Hosur et al.   Biology Open

Pathophysiology of Hemophilic Arthropathy

(2017) Daniela Melchiorre et al.   Journal of Clinical Medicine

iRhom2 Uncv mutation blocks bulge stem cells assuming the fate of hair follicle

(2016) Leilei Yang et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

(2016) Philippe Gascard et al.   GENES & DEVELOPMENT

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING

(2016) Wei-Wei Luo et al.   NATURE IMMUNOLOGY

Inactive rhomboid proteins: New mechanisms with implications in health and disease

(2016) Marius K. Lemberg et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Proteomic analysis of differentially expressed skin proteins in iRhom2Uncvmice

(2015) Bing Liu et al.   BMB Reports

iRhoms in the brain – a new frontier?

(2015) Stefan F Lichtenthaler et al.   CELL CYCLE

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

(2015) Xue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17

(2015) Sathish K. Maney et al.   Science Signaling

iRhom1 regulates proteasome activity via PAC1/2 under ER stress

(2015) WonJae Lee et al.   Scientific Reports

Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17

(2015) Sathish K. Maney et al.   Science Signaling

The Rhomboid-Like Superfamily: Molecular Mechanisms and Biological Roles

(2014) Matthew Freeman   Annual Review of Cell and Developmental Biology

Human Rhomboid Family-1 Suppresses Oxygen-Independent Degradation of Hypoxia-Inducible Factor-1  in Breast Cancer

(2014) Z. Zhou et al.   CANCER RESEARCH

iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function

(2014) Matthew A. Brooke et al.   HUMAN MOLECULAR GENETICS

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

(2014) Katie Lunnon et al.   NATURE NEUROSCIENCE

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

iRhom2 Mutation Leads to Aberrant Hair Follicle Differentiation in Mice

(2014) Yang Leilei et al.   PLoS One

Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin

(2014) V. Hosur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice

(2014) O. M. Siggs et al.   Biology Open

Emerging role of rhomboid family proteins in mammalian biology and disease

(2013) Nina Bergbold et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation

(2013) Yonka Christova et al.   EMBO REPORTS

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding

(2013) T. Maretzky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RHBDF2 Mutations Are Associated with Tylosis, a Familial Esophageal Cancer Syndrome

(2012) Diana C. Blaydon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

iRhom2 is required for the secretion of mouse TNF 

(2012) O. M. Siggs et al.   BLOOD

Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer

(2012) Silva Saarinen et al.   Familial Cancer

A Role for cGMP in Inducible Nitric-oxide Synthase (iNOS)-induced Tumor Necrosis Factor (TNF) α-converting Enzyme (TACE/ADAM17) Activation, Translocation, and TNF Receptor 1 (TNFR1) Shedding in Hepatocytes

(2012) R. Savanh Chanthaphavong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms

(2012) Colin Adrain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling

(2011) Markus Zettl et al.   CELL

Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum

(2011) Ethan J Greenblatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Expanding role of ubiquitination in NF-κB signaling

(2010) Siqi Liu et al.   CELL RESEARCH

The STING pathway and regulation of innate immune signaling in response to DNA pathogens

(2010) Hiroki Ishikawa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The structural basis for catalysis and substrate specificity of a rhomboid protease

(2010) Kutti R Vinothkumar et al.   EMBO JOURNAL

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

(2010) Paul Saftig et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

(2010) S. M. Le Gall et al.   JOURNAL OF CELL SCIENCE

Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells

(2008) Huafei Zou et al.   FASEB JOURNAL

Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth

(2008) Zhenwen Yan et al.   MOLECULAR CANCER THERAPEUTICS