Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets

Storage of washed platelets in BRS-A platelet additive solutions based on two types of clinically available bicarbonated Ringer's solutions with different electrolyte concentrations

(2015) Shinji Oikawa et al.   TRANSFUSION AND APHERESIS SCIENCE

Platelet bioreactor-on-a-chip

(2014) J. N. Thon et al.   BLOOD

Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells

(2014) Sou Nakamura et al.   Cell Stem Cell

Matrix Metalloproteinase-8 Plays a Pivotal Role in Neuroinflammation by Modulating TNF-α Activation

(2014) Eun-Jung Lee et al.   JOURNAL OF IMMUNOLOGY

Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8)

(2014) Derong Ding et al.   MedChemComm

Scalable Generation of Universal Platelets from Human Induced Pluripotent Stem Cells

(2014) Qiang Feng et al.   Stem Cell Reports

Dietary  -linolenic acid increases the platelet count in ApoE-/- mice by reducing clearance

(2013) S. Stivala et al.   BLOOD

A novel flow cytometry-based platelet aggregation assay

(2013) I. M. De Cuyper et al.   BLOOD

Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling

(2013) Shinji Hirata et al.   JOURNAL OF CLINICAL INVESTIGATION

Platelet IκB Kinase-β Deficiency Increases Mouse Arterial Neointima Formation via Delayed Glycoprotein Ibα Shedding

(2012) Shujian Wei et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

RNAi screen identifies MAPK14 as a druggable suppressor of human hematopoietic stem cell expansion

(2012) A. Baudet et al.   BLOOD

In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling

(2011) S. Nishimura et al.   BLOOD

Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice

(2011) Shi-Jiang Lu et al.   CELL RESEARCH

Species Specificity of ADAM10 and ADAM17 Proteins in Interleukin-6 (IL-6) Trans-signaling and Novel Role of ADAM10 in Inducible IL-6 Receptor Shedding

(2011) Christoph Garbers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM17: a molecular switch to control inflammation and tissue regeneration

(2011) Jürgen Scheller et al.   TRENDS IN IMMUNOLOGY

The role of calpain in the regulation of ADAM17-dependent GPIbα ectodomain shedding

(2010) Zhicheng Wang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases

(2010) M. Bender et al.   BLOOD

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

(2010) S. M. Le Gall et al.   JOURNAL OF CELL SCIENCE

Transient activation ofc-MYCexpression is critical for efficient platelet generation from human induced pluripotent stem cells

(2010) Naoya Takayama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GPVI and CLEC-2 in hemostasis and vascular integrity

(2010) S. P. WATSON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations

(2009) B. Dumont et al.   BLOOD

p38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivo

(2009) M. Canault et al.   BLOOD

Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion

(2009) A. Brill et al.   CARDIOVASCULAR RESEARCH

A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder

(2009) C. HERMANS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors

(2008) N. Takayama et al.   BLOOD

Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells

(2008) Hidekazu Nishikii et al.   JOURNAL OF EXPERIMENTAL MEDICINE