Substrate‐selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains

Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling

(2019) Yifang Xie et al.   CLINICAL SCIENCE

Interleukin-6: designing specific therapeutics for a complex cytokine

(2018) Christoph Garbers et al.   NATURE REVIEWS DRUG DISCOVERY

Redundancy of protein disulfide isomerases in the catalysis of the inactivating disulfide switch in A Disintegrin and Metalloprotease 17

(2018) Sebastian Krossa et al.   Scientific Reports

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex

(2018) Ulrike Künzel et al.   eLife

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

(2018) Ioanna Oikonomidi et al.   eLife

Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2–ADAM17-dependent proteolysis

(2017) Xue Li et al.   JOURNAL OF CELL SCIENCE

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

(2017) Miguel Cavadas et al.   Cell Reports

Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling

(2017) Adam Graham Grieve et al.   eLife

Phosphatidylserine exposure is required for ADAM17 sheddase function

(2016) Anselm Sommer et al.   Nature Communications

Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity

(2015) Stefan Düsterhöft et al.   BIOCHEMISTRY

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

(2015) Xue Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Disintegrin and Metalloprotease 17 Dynamic Interaction Sequence, the Sweet Tooth for the Human Interleukin 6 Receptor

(2014) Stefan Düsterhöft et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17

(2013) Jeanette Schwarz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Membrane-Proximal Domain of a Disintegrin and Metalloprotease-17 Represents the Putative Molecular Switch of Its Shedding Activity Operated by Protein-disulfide Isomerase

(2013) Stefan Düsterhöft et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding

(2013) T. Maretzky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-6: From basic biology to selective blockade of pro-inflammatory activities

(2013) Jürgen Scheller et al.   SEMINARS IN IMMUNOLOGY

iRhom2 is required for the secretion of mouse TNF 

(2012) O. M. Siggs et al.   BLOOD

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(2012) Christine M. Ardito et al.   CANCER CELL

Ectodomain shedding and ADAMs in development

(2012) S. Weber et al.   DEVELOPMENT

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand–dependent terminal keratinocyte differentiation

(2012) Claus-Werner Franzke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

(2012) Asuka Inoue et al.   NATURE METHODS

A Disintegrin and Metalloenzyme (ADAM) 17 Activation Is Regulated by α5β1 Integrin in Kidney Mesangial Cells

(2012) Pal Gooz et al.   PLoS One

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

TACE Activation by MAPK-Mediated Regulation of Cell Surface Dimerization and TIMP3 Association

(2012) P. Xu et al.   Science Signaling

LPA-producing enzyme PA-PLA1α regulates hair follicle development by modulating EGFR signalling

(2011) Asuka Inoue et al.   EMBO JOURNAL

Inflammatory Skin and Bowel Disease Linked toADAM17Deletion

(2011) Diana C. Blaydon et al.   NEW ENGLAND JOURNAL OF MEDICINE

ADAM17: a molecular switch to control inflammation and tissue regeneration

(2011) Jürgen Scheller et al.   TRENDS IN IMMUNOLOGY

Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17

(2011) Thorsten Maretzky et al.   Nature Communications

Thiol isomerases negatively regulate the cellular shedding activity of ADAM17

(2010) Sofie H. Willems et al.   BIOCHEMICAL JOURNAL

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

(2010) S. M. Le Gall et al.   JOURNAL OF CELL SCIENCE

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

(2010) Athena Chalaris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Direct Activation of TACE-Mediated Ectodomain Shedding by p38 MAP Kinase Regulates EGF Receptor-Dependent Cell Proliferation

(2010) Pinglong Xu et al.   MOLECULAR CELL

ADAMs 10 and 17 Represent Differentially Regulated Components of a General Shedding Machinery for Membrane Proteins Such as Transforming Growth Factor α, L-Selectin, and Tumor Necrosis Factor α

(2009) Sylvain M. Le Gall et al.   MOLECULAR BIOLOGY OF THE CELL