Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?

Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells

(2020) Nathaniel J. Hogrebe et al.   NATURE BIOTECHNOLOGY

Beta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability

(2020) Aref G. Ebrahimi et al.   Molecular Metabolism

Localized Immunomodulation with PD-L1 Results in Sustained Survival and Function of Allogeneic Islets without Chronic Immunosuppression

(2020) Lalit Batra et al.   JOURNAL OF IMMUNOLOGY

Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice

(2020) Kristina G. Maxwell et al.   Science Translational Medicine

A method for the generation of human stem cell-derived alpha cells

(2020) Quinn P. Peterson et al.   Nature Communications

SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro

(2020) Leonardo Velazco-Cruz et al.   Cell Reports

Engineering designer beta cells with a CRISPR-Cas9 conjugation platform

(2020) Donghyun Lim et al.   Nature Communications

Paracrine regulation of somatostatin secretion by insulin and glucagon in mouse pancreatic islets

(2020) Berit Svendsen et al.   DIABETOLOGIA

Transcription factors that shape the mammalian pancreas

(2020) Rachel E. Jennings et al.   DIABETOLOGIA

Immune-evasive human islet-like organoids ameliorate diabetes

(2020) Eiji Yoshihara et al.   NATURE

Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation

(2020) Punn Augsornworawat et al.   Cell Reports

Single-Cell RNA-Seq Reveals that CD9 Is a Negative Marker of Glucose-Responsive Pancreatic β-like Cells Derived from Human Pluripotent Stem Cells

(2020) Xisheng Li et al.   Stem Cell Reports

Immunotherapy via PD-L1–presenting biomaterials leads to long-term islet graft survival

(2020) María M. Coronel et al.   Science Advances

Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells

(2019) Leonardo Velazco-Cruz et al.   Stem Cell Reports

A Double Fail-Safe Approach to Prevent Tumorigenesis and Select Pancreatic β Cells from Human Embryonic Stem Cells

(2019) Mirza Muhammad Fahd Qadir et al.   Stem Cell Reports

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

(2019) Gopika G. Nair et al.   NATURE CELL BIOLOGY

Charting cellular identity during human in vitro β-cell differentiation

(2019) Adrian Veres et al.   NATURE

Generation of hypoimmunogenic human pluripotent stem cells

(2019) Xiao Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A

(2019) Fabian L. Cardenas-Diaz et al.   Cell Stem Cell

VEGF-A and blood vessels: a beta cell perspective

(2019) Willem Staels et al.   DIABETOLOGIA

Next-generation regulatory T cell therapy

(2019) Leonardo M. R. Ferreira et al.   NATURE REVIEWS DRUG DISCOVERY

Immunomodulation Followed By Antigen-Specific Treg Infusion Controls Islet Autoimmunity

(2019) Cecilia Cabello-Kindelan et al.   DIABETES

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity

(2019) Masaya Oshima et al.   DIABETOLOGIA

Role of TGF-β/Smad Pathway in the Transcription of Pancreas-Specific Genes During Beta Cell Differentiation

(2019) Yuhua Gao et al.   Frontiers in Cell and Developmental Biology

Initial Clinical Evaluation of VC-01TM Combination Product—A Stem Cell–Derived Islet Replacement for Type 1 Diabetes (T1D)

(2018) ROBERT R. HENRY et al.   DIABETES

Vegf-A mRNA transfection as a novel approach to improve mouse and human islet graft revascularisation

(2018) Willem Staels et al.   DIABETOLOGIA

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men

(2018) Patrik Rorsman et al.   PHYSIOLOGICAL REVIEWS

The journey of islet cell transplantation and future development

(2018) Anissa Gamble et al.   Islets

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes

(2018) Marcela Brissova et al.   Cell Reports

Using Mesenchymal Stromal Cells in Islet Transplantation

(2018) Ahmed A. Arzouni et al.   Stem Cells Translational Medicine

Mesenchymal stromal cell secretory factors induce sustained improvements in islet function pre- and post-transplantation

(2018) Chloe L. Rackham et al.   CYTOTHERAPY

Insulin Secretion Depends on Intra-islet Glucagon Signaling

(2018) Berit Svendsen et al.   Cell Reports

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

(2018) Diego Balboa et al.   eLife

Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell–Derived Cells: Universal Donor for Cell Therapy

(2018) Saidulu Mattapally et al.   Journal of the American Heart Association

ROCKII inhibition promotes the maturation of human pancreatic beta-like cells

(2017) Zaniar Ghazizadeh et al.   Nature Communications

PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration

(2017) Yaxi Zhu et al.   Stem Cell Research & Therapy

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

(2017) Jonna Saarimäki-Vire et al.   Cell Reports

GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells

(2017) Amita Tiyaboonchai et al.   Stem Cell Reports

Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells

(2017) Heidrun Vethe et al.   Scientific Reports

Disallowed and Allowed Gene Expression: Two Faces of Mature Islet Beta Cells

(2016) Katleen Lemaire et al.   Annual Review of Nutrition

Progress and challenges in macroencapsulation approaches for type 1 diabetes (T1D) treatment: Cells, biomaterials, and devices

(2016) Shang Song et al.   BIOTECHNOLOGY AND BIOENGINEERING

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery

(2016) Hui Zeng et al.   Cell Stem Cell

Wolfram Syndrome: Diagnosis, Management, and Treatment

(2016) Fumihiko Urano   Current Diabetes Reports

Mesenchymal stem cells to promote islet transplant survival

(2016) Karen English   Current Opinion in Organ Transplantation

Islet Pericytes Are Required for β-Cell Maturity

(2016) Adi Sasson et al.   DIABETES

Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes

(2016) Yisheng Yang et al.   ENDOCRINE REVIEWS

Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population

(2016) Hanna Huopio et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Identification of proliferative and mature β-cells in the islets of Langerhans

(2016) Erik Bader et al.   NATURE

Advances in islet encapsulation technologies

(2016) Tejal Desai et al.   NATURE REVIEWS DRUG DISCOVERY

The Pancreatic β-Cell: A Bioenergetic Perspective

(2016) David G. Nicholls   PHYSIOLOGICAL REVIEWS

Human pancreatic beta-like cells converted from fibroblasts

(2016) Saiyong Zhu et al.   Nature Communications

Generation of stem cell-derived β-cells from patients with type 1 diabetes

(2016) Jeffrey R. Millman et al.   Nature Communications

Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia

(2016) Adrian Kee Keong Teo et al.   Stem Cell Reports

Co-transplantation of autologous MSCs delays islet allograft rejection and generates a local immunoprivileged site

(2015) Moufida Ben Nasr et al.   ACTA DIABETOLOGICA

Tolerance Induction and Reversal of Diabetes in Mice Transplanted with Human Embryonic Stem Cell-Derived Pancreatic Endoderm

(2015) Gregory L. Szot et al.   Cell Stem Cell

The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas

(2015) Patrick S. McGrath et al.   DIABETES

Accessory cells for β-cell transplantation

(2015) W. Staels et al.   DIABETES OBESITY & METABOLISM

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

An Inducible Caspase-9 Suicide Gene to Improve the Safety of Therapy Using Human Induced Pluripotent Stem Cells

(2015) Shigeki Yagyu et al.   MOLECULAR THERAPY

Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion

(2015) Talitha van der Meulen et al.   NATURE MEDICINE

Genome, Exome, and Targeted Next-Generation Sequencing in Neonatal Diabetes

(2015) Elisa De Franco et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Concise Review: Macrophages: Versatile Gatekeepers During Pancreatic β-Cell Development, Injury, and Regeneration

(2015) Naomi Van Gassen et al.   Stem Cells Translational Medicine

Targeted Disruption of the β2-Microglobulin Gene Minimizes the Immunogenicity of Human Embryonic Stem Cells

(2015) Dachun Wang et al.   Stem Cells Translational Medicine

Efficient Generation of NKX6-1+ Pancreatic Progenitors from Multiple Human Pluripotent Stem Cell Lines

(2015) M. Cristina Nostro et al.   Stem Cell Reports

Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice

(2015) Jennifer E. Bruin et al.   Stem Cell Reports

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Islet Microenvironment, Modulated by Vascular Endothelial Growth Factor-A Signaling, Promotes β Cell Regeneration

(2014) Marcela Brissova et al.   Cell Metabolism

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

(2014) Tao Gao et al.   Cell Metabolism

Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9

(2014) Pankaj K. Mandal et al.   Cell Stem Cell

An Effective Approach to Prevent Immune Rejection of Human ESC-Derived Allografts

(2014) Zhili Rong et al.   Cell Stem Cell

Therapy of type 1 diabetes with CD4+CD25highCD127-regulatory T cells prolongs survival of pancreatic islets — Results of one year follow-up

(2014) Natalia Marek-Trzonkowska et al.   CLINICAL IMMUNOLOGY

GATA4 Mutations Are a Cause of Neonatal and Childhood-Onset Diabetes

(2014) C. Shaw-Smith et al.   DIABETES

Neurogenin 3 is important but not essential for pancreatic islet development in humans

(2014) Oscar Rubio-Cabezas et al.   DIABETOLOGIA

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Differentiated human stem cells resemble fetal, not adult, β cells

(2014) Sinisa Hrvatin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential and Limitation of HLA-Based Banking of Human Pluripotent Stem Cells for Cell Therapy

(2014) Casimir de Rham et al.   Journal of Immunology Research

Selective Elimination of Human Pluripotent Stem Cells by an Oleate Synthesis Inhibitor Discovered in a High-Throughput Screen

(2013) Uri Ben-David et al.   Cell Stem Cell

SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity

(2013) Masatoshi Nomura et al.   DIABETOLOGIA

Short-term overexpression of VEGF-A in mouse beta cells indirectly stimulates their proliferation and protects against diabetes

(2013) Nico De Leu et al.   DIABETOLOGIA

Phenotypic characteristics of early Wolfram syndrome

(2013) Bess A Marshall et al.   Orphanet Journal of Rare Diseases

Extremely rare cause of congenital diarrhea: Enteric anendocrinosis

(2013) Ersin Sayar et al.   PEDIATRICS INTERNATIONAL

Immunologic and chemical targeting of the tight-junction protein Claudin-6 eliminates tumorigenic human pluripotent stem cells

(2013) Uri Ben-David et al.   Nature Communications

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

(2013) Brandon L. Taylor et al.   Cell Reports

Sympathetic Innervation during Development Is Necessary for Pancreatic Islet Architecture and Functional Maturation

(2013) Philip Borden et al.   Cell Reports

Regulatory T-Cell Therapy in Transplantation: Moving to the Clinic

(2013) Q. Tang et al.   Cold Spring Harbor Perspectives in Medicine

Generating an iPSC Bank for HLA-Matched Tissue Transplantation Based on Known Donor and Recipient HLA Types

(2012) Craig J. Taylor et al.   Cell Stem Cell

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

Administration of CD4+CD25highCD127- Regulatory T Cells Preserves  -Cell Function in Type 1 Diabetes in Children

(2012) N. Marek-Trzonkowska et al.   DIABETES CARE

Early Loss of the Glucagon Response to Hypoglycemia in Adolescents With Type 1 Diabetes

(2012) A. Siafarikas et al.   DIABETES CARE

Mesenchymal stem cells differentially mediate regulatory T cells and conventional effector T cells to protect fully allogeneic islet grafts in mice

(2012) D. M. Xu et al.   DIABETOLOGIA

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

(2012) Roger H. Unger et al.   JOURNAL OF CLINICAL INVESTIGATION

Pax6 Is Crucial for β-Cell Function, Insulin Biosynthesis, and Glucose-Induced Insulin Secretion

(2012) Yvan Gosmain et al.   MOLECULAR ENDOCRINOLOGY

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3

(2012) Barak Blum et al.   NATURE BIOTECHNOLOGY

A Scalable System for Production of Functional Pancreatic Progenitors from Human Embryonic Stem Cells

(2012) Thomas C. Schulz et al.   PLoS One

Longevity of human islet α- and β-cells

(2011) M. Cnop et al.   DIABETES OBESITY & METABOLISM

Adoptive cell therapy using antigen-specific CD4−CD8− T regulatory cells to prevent autoimmune diabetes and promote islet allograft survival in NOD mice

(2011) D. Zhang et al.   DIABETOLOGIA

Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas

(2011) M. J. Riedel et al.   DIABETOLOGIA

Neonatal Diabetes and Congenital Malabsorptive Diarrhea Attributable to a Novel Mutation in the Human Neurogenin-3 Gene Coding Sequence

(2011) Sara E. Pinney et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Type 2 diabetes across generations: from pathophysiology to prevention and management

(2011) Christopher J Nolan et al.   LANCET

An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells

(2011) Chad Tang et al.   NATURE BIOTECHNOLOGY

GATA6 haploinsufficiency causes pancreatic agenesis in humans

(2011) Hana Lango Allen et al.   NATURE GENETICS

Immunological considerations for embryonic and induced pluripotent stem cell banking

(2011) C. J. Taylor et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Reduced Progression of Diabetic Microvascular Complications With Islet Cell Transplantation Compared With Intensive Medical Therapy

(2011) David M. Thompson et al.   TRANSPLANTATION

Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity

(2010) Chunyan Gu et al.   Cell Metabolism

Mesenchymal Stem Cells Enhance Allogeneic Islet Engraftment in Nonhuman Primates

(2010) D. M. Berman et al.   DIABETES

Production of Functional Glucagon-Secreting  -Cells From Human Embryonic Stem Cells

(2010) A. Rezania et al.   DIABETES

Mesenchymal Stem Cells Prevent Acute Rejection and Prolong Graft Function in Pancreatic Islet Transplantation

(2010) Biancamaria Longoni et al.   Diabetes Technology & Therapeutics

Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined byin VivoThymidine Analog Incorporation and Radiocarbon Dating

(2010) S. Perl et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene

(2010) Julie Støy et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth

(2010) Ming Liu et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation

(2009) M. Cnop et al.   DIABETOLOGIA

Transforming Growth Factor-β/Smad3 Signaling Regulates Insulin Gene Transcription and Pancreatic Islet β-Cell Function

(2009) Huei-Min Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription Factor Glis3, a Novel Critical Player in the Regulation of Pancreatic  -Cell Development and Insulin Gene Expression

(2009) H. S. Kang et al.   MOLECULAR AND CELLULAR BIOLOGY

Separation of SSEA-4 and TRA-1–60 Labelled Undifferentiated Human Embryonic Stem Cells from A Heterogeneous Cell Population Using Magnetic-Activated Cell Sorting (MACS) and Fluorescence-Activated Cell Sorting (FACS)

(2009) Chui Yee Fong et al.   Stem Cell Reviews and Reports

The Clinical Impact of Islet Transplantation

(2008) P. Fiorina et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Impaired islet turnover in human donor pancreata with aging

(2008) Christina Reers et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus

(2008) Carlo Colombo et al.   JOURNAL OF CLINICAL INVESTIGATION

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

A Multi-Year Analysis of Islet Transplantation Compared With Intensive Medical Therapy on Progression of Complications in Type 1 Diabetes

(2008) Garth L. Warnock et al.   TRANSPLANTATION