Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity

Endogenous Fatty Acids are Essential Signaling Factors of Pancreaticβ-Cells and Insulin Secretion

(2018) Sebastian Hauke et al.   DIABETES

Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets

(2018) Lara Bellini et al.   DIABETOLOGIA

Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus

(2018) Xavier Palomer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pivotal role of human stearoyl-CoA desaturases (SCD1 and 5) in breast cancer progression: oleic acid-based effect of SCD1 on cell migration and a novel pro-cell survival role for SCD5

(2018) Cristiana Angelucci et al.   Oncotarget

Modeling human pancreatic beta cell dedifferentiation

(2018) Marc Diedisheim et al.   Molecular Metabolism

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates

(2018) Violeta Georgieva Tsonkova et al.   Molecular Metabolism

Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats

(2018) Mélanie Campana et al.   Molecular Metabolism

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

(2018) Cristina Cosentino et al.   NUCLEIC ACIDS RESEARCH

Use of human islets to understand islet biology and diabetes: progress, challenges and suggestions

(2018) Nathaniel J. Hart et al.   DIABETOLOGIA

EndoC-βH1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium

(2017) Camilla Krizhanovskii et al.   Islets

The Role of ABO Blood Group in Cerebral Vasospasm, Associated Intracranial Hemorrhage, and Delayed Cerebral Ischemia in 470 Patients with Subarachnoid Hemorrhage

(2017) Daniel Dubinski et al.   World Neurosurgery

Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets

(2017) Federica Ciregia et al.   Scientific Reports

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

When β-cells fail: lessons from dedifferentiation

(2016) D. Accili et al.   DIABETES OBESITY & METABOLISM

Mass production of functional human pancreatic β-cells: why and how?

(2016) R. Scharfmann et al.   DIABETES OBESITY & METABOLISM

Sensitivity profile of the human EndoC-βH1 beta cell line to proinflammatory cytokines

(2016) Ewa Gurgul-Convey et al.   DIABETOLOGIA

Islet β-cell failure in type 2 diabetes – Within the network of toxic lipids

(2015) Justyna Janikiewicz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin-producing cells

(2015) Rikard G. Fred et al.   CLINICAL SCIENCE

Loss of β-Cell Identity Occurs in Type 2 Diabetes and Is Associated With Islet Amyloid Deposits

(2015) H. Siebe Spijker et al.   DIABETES

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

(2015) David M. Blodgett et al.   DIABETES

Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion

(2014) Nie Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets

(2014) Elin Hall et al.   BMC Medicine

Differentiated human stem cells resemble fetal, not adult, β cells

(2014) Sinisa Hrvatin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus

(2014) Trevor J. Biden et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Oleate rescues INS-1E β-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response

(2013) Dietlind Sommerweiss et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolic Signaling in Fuel-Induced Insulin Secretion

(2013) Marc Prentki et al.   Cell Metabolism

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

(2013) Miriam Cnop et al.   DIABETES

Mechanisms of islet amyloidosis toxicity in type 2 diabetes

(2013) Andisheh Abedini et al.   FEBS LETTERS

VHL-mediated disruption of Sox9 activity compromises  -cell identity and results in diabetes mellitus

(2013) S. Puri et al.   GENES & DEVELOPMENT

Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic β-Cells

(2013) Ebru Boslem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes

(2012) Miriam Cnop et al.   ANNALS OF NEUROLOGY

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress-Mitochondrial Dialog Triggering Lipotoxic Rodent and Human  -Cell Apoptosis

(2012) D. A. Cunha et al.   DIABETES

Regulation and functional effects of ZNT8 in human pancreatic islets

(2012) Bruno Lefebvre et al.   JOURNAL OF ENDOCRINOLOGY

StearoylCoA Desaturase-5: A Novel Regulator of Neuronal Cell Proliferation and Differentiation

(2012) Debora I. Sinner et al.   PLoS One

Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6

(2011) Christopher D. Green et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ceramide synthase 4 andde novoproduction of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells

(2011) Julien Véret et al.   BIOCHEMICAL JOURNAL

A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking

(2011) Ebru Boslem et al.   BIOCHEMICAL JOURNAL

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

Glycerolipid/free fatty acid cycle and islet β-cell function in health, obesity and diabetes

(2011) Marc Prentki et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

(2010) M. Igoillo-Esteve et al.   DIABETOLOGIA

Decrease in Membrane Phospholipid Unsaturation Induces Unfolded Protein Response

(2010) Hiroyuki Ariyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

(2010) Lorella Marselli et al.   PLoS One

Glucolipotoxicity of the pancreatic beta cell

(2009) Vincent Poitout et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Susceptibility of Pancreatic Beta Cells to Fatty Acids Is Regulated by LXR/PPARα-Dependent Stearoyl-Coenzyme A Desaturase

(2009) Karine H. Hellemans et al.   PLoS One

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

Carboxypeptidase E mediates palmitate-induced  -cell ER stress and apoptosis

(2008) K. D. Jeffrey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA