Transcription factors that shape the mammalian pancreas

Point mutations in the PDX1 transactivation domain impair human β-cell development and function

(2019) Xianming Wang et al.   Molecular Metabolism

A Specific CNOT1 Mutation Results in a Novel Syndrome of Pancreatic Agenesis and Holoprosencephaly through Impaired Pancreatic and Neurological Development

(2019) Elisa De Franco et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Targeting transcription factors in multiple myeloma: evolving therapeutic strategies

(2019) Shirong Li et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The cellular regulators PTEN and BMI1 help mediate NEUROGENIN-3–induced cell cycle arrest

(2019) R. Sergio Solorzano-Vargas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human stem cell models: lessons for pancreatic development and disease

(2019) Bjoern Gaertner et al.   GENES & DEVELOPMENT

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

(2018) Cindy J.M. Loomans et al.   Stem Cell Reports

Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally

(2018) Holly A. Cyphert et al.   DIABETES

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

(2018) Diego Balboa et al.   eLife

Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance

(2017) Kashyap A. Patel et al.   Nature Communications

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

(2016) H. Efsun Arda et al.   Cell Metabolism

An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery

(2016) Hui Zeng et al.   Cell Stem Cell

Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes

(2016) Zengrong Zhu et al.   Cell Stem Cell

Human pancreas development

(2015) R. E. Jennings et al.   DEVELOPMENT

Modeling mouse and human development using organoid cultures

(2015) M. Huch et al.   DEVELOPMENT

The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas

(2015) Patrick S. McGrath et al.   DIABETES

Ex Vivo Expansion and Differentiation of Human and Mouse Fetal Pancreatic Progenitors Are Modulated by Epidermal Growth Factor

(2015) Paola Bonfanti et al.   STEM CELLS AND DEVELOPMENT

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

The window period of NEUROGENIN3 during human gestation

(2014) Rachel J Salisbury et al.   Islets

RFX6 Regulates Insulin Secretion by Modulating Ca2+ Homeostasis in Human β Cells

(2014) Vikash Chandra et al.   Cell Reports

Rfx6 Maintains the Functional Identity of Adult Pancreatic β Cells

(2014) Julie Piccand et al.   Cell Reports

Transcriptional control of mammalian pancreas organogenesis

(2013) David A. Cano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Artificial three-dimensional niches deconstruct pancreas development in vitro

(2013) C. Greggio et al.   DEVELOPMENT

Mouse Muscle As an Ectopic Permissive Site for Human Pancreatic Development

(2013) C. Capito et al.   DIABETES

Development of the Human Pancreas From Foregut to Endocrine Commitment

(2013) R. E. Jennings et al.   DIABETES

BiallelicPDX1(insulin promoter factor 1) mutations causing neonatal diabetes without exocrine pancreatic insufficiency

(2013) E. De Franco et al.   DIABETIC MEDICINE

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

(2013) Meritxell Huch et al.   EMBO JOURNAL

Neonatal diabetes, gallbladder agenesis, duodenal atresia, and intestinal malrotation caused by a novel homozygous mutation inRFX6

(2013) Jennifer P Concepcion et al.   PEDIATRIC DIABETES

Pancreas organogenesis: From bud to plexus to gland

(2011) Fong Cheng Pan et al.   DEVELOPMENTAL DYNAMICS

Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in NEUROG3

(2011) O. Rubio-Cabezas et al.   DIABETES

MafA and MafB activity in pancreatic β cells

(2011) Yan Hang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Rfx6 directs islet formation and insulin production in mice and humans

(2010) Stuart B. Smith et al.   NATURE

Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development

(2009) Josselin Soyer et al.   DEVELOPMENT

A Novel Hypomorphic PDX1 Mutation Responsible for Permanent Neonatal Diabetes With Subclinical Exocrine Deficiency

(2009) M. Nicolino et al.   DIABETES

Endocrine Cell Clustering During Human Pancreas Development

(2009) Jongmin Jeon et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Neonatal diabetes mellitus with pancreatic agenesis in an infant with homozygous IPF-1 Pro63fsX60 mutation

(2009) Inas H Thomas et al.   PEDIATRIC DIABETES

Neonatal Diabetes Mellitus

(2008) Lydia Aguilar-Bryan et al.   ENDOCRINE REVIEWS