Localized Immunomodulation with PD-L1 Results in Sustained Survival and Function of Allogeneic Islets without Chronic Immunosuppression

Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells

(2019) Leonardo Velazco-Cruz et al.   Stem Cell Reports

Anti-PD-L1 treatment results in functional remodeling of the macrophage compartment

(2019) Huizhong Xiong et al.   CANCER RESEARCH

Primed macrophages directly and specifically reject allografts

(2019) Zhulang Chu et al.   Cellular & Molecular Immunology

The Evolving Roles of Macrophages in Organ Transplantation

(2019) Junhui Li et al.   Journal of Immunology Research

Immune checkpoint inhibitors: The linchpins of modern immunotherapy

(2019) Breelyn A. Wilky   IMMUNOLOGICAL REVIEWS

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

(2019) Marco Orecchioni et al.   Frontiers in Immunology

Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes

(2019) Amar Singh et al.   Nature Communications

Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance

(2018) Devon M. Headen et al.   NATURE MATERIALS

The role of the PD-1/PD-L1 axis in macrophage differentiation and function during pregnancy

(2018) Yonghong Zhang et al.   HUMAN REPRODUCTION

Localized immune tolerance from FasL-functionalized PLG scaffolds

(2018) Michael Skoumal et al.   BIOMATERIALS

PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes

(2017) Moufida Ben Nasr et al.   Science Translational Medicine

Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

(2016) Bernhard J. Hering et al.   DIABETES CARE

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality

(2016) Asim Saha et al.   JOURNAL OF CLINICAL INVESTIGATION

IL4 induces IL6-producing M2 macrophages associated to inhibition of neuroinflammation in vitro and in vivo

(2016) Giacomo Casella et al.   Journal of Neuroinflammation

PD-L1 Deficiency within Islets Reduces Allograft Survival in Mice

(2016) Dongxia Ma et al.   PLoS One

Co-transplantation of autologous MSCs delays islet allograft rejection and generates a local immunoprivileged site

(2015) Moufida Ben Nasr et al.   ACTA DIABETOLOGICA

Metabolic Reprogramming of Immune Cells in Cancer Progression

(2015) Subhra K. Biswas   IMMUNITY

Combination Therapy Using IL-2/IL-2 Monoclonal Antibody Complexes, Rapamycin, and Islet Autoantigen Peptides Increases Regulatory T Cell Frequency and Protects against Spontaneous and Induced Type 1 Diabetes in Nonobese Diabetic Mice

(2015) J. N. Manirarora et al.   JOURNAL OF IMMUNOLOGY

Nitric oxide synthase in innate and adaptive immunity: an update

(2015) Christian Bogdan   TRENDS IN IMMUNOLOGY

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Cutting Edge: Foxp3-Mediated Induction of Pim 2 Allows Human T Regulatory Cells to Preferentially Expand in Rapamycin

(2014) Samik Basu et al.   JOURNAL OF IMMUNOLOGY

Induction of Tolerance to Cardiac Allografts Using Donor Splenocytes Engineered to Display on Their Surface an Exogenous Fas Ligand Protein

(2014) E. S. Yolcu et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Derived Suppressor Cells Accumulate in Kidney Allograft Tolerance and Specifically Suppress Effector T Cell Expansion

(2014) A.-S. Dugast et al.   JOURNAL OF IMMUNOLOGY

Macrophage Polarization in Bacterial Infections

(2014) M. Benoit et al.   JOURNAL OF IMMUNOLOGY

Programmed Death 1 Deficiency Induces the Polarization of Macrophages/Microglia to the M1 Phenotype After Spinal Cord Injury in Mice

(2014) Anhui Yao et al.   Neurotherapeutics

Cotransplantation With Myeloid-Derived Suppressor Cells Protects Cell Transplants

(2014) Yusuke Arakawa et al.   TRANSPLANTATION

Immunomodulation with donor regulatory T cells armed with Fas-ligand alleviates graft-versus-host disease

(2013) Esma S. Yolcu et al.   EXPERIMENTAL HEMATOLOGY

Immunomodulation with regulatory T cells and Fas-ligand ameliorate established inflammatory colitis

(2013) Ayelet Kaminitz et al.   GUT

A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

(2013) Taku Okazaki et al.   NATURE IMMUNOLOGY

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

Prolonged Survival of Allogeneic Islets in Cynomolgus Monkeys After Short-Term Triple Therapy

(2012) M. Koulmanda et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice

(2011) B. L. Mundy-Bosse et al.   CANCER RESEARCH

Killer Treg restore immune homeostasis and suppress autoimmune diabetes in prediabetic NOD mice

(2011) Ayelet Kaminitz et al.   JOURNAL OF AUTOIMMUNITY

Sustained suppression by Foxp3+regulatory T cells is vital for infectious transplantation tolerance

(2011) Adrian R. Kendal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pancreatic Islets Engineered with SA-FasL Protein Establish Robust Localized Tolerance by Inducing Regulatory T Cells in Mice

(2011) E. S. Yolcu et al.   JOURNAL OF IMMUNOLOGY

The Programmed Death-1 Ligand 1:B7-1 Pathway Restrains Diabetogenic Effector T Cells In Vivo

(2011) A. M. Paterson et al.   JOURNAL OF IMMUNOLOGY

The PDL1-PD1 Axis Converts Human TH1 Cells into Regulatory T Cells

(2011) S. Amarnath et al.   Science Translational Medicine

Rapamycin-Conditioned Donor Dendritic Cells Differentiate CD4+CD25+Foxp3+ T Cells In Vitro with TGF-β1 for Islet Transplantation

(2010) K. L. Pothoven et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Tumor cells engineered to codisplay on their surface 4-1BBL and LIGHT costimulatory proteins as a novel vaccine approach for cancer immunotherapy

(2010) R K Sharma et al.   CANCER GENE THERAPY

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PD-1-Mediated Suppression of IL-2 Production Induces CD8+ T Cell Anergy In Vivo

(2009) S. Chikuma et al.   JOURNAL OF IMMUNOLOGY

Differential Responses of Human Regulatory T Cells (Treg) and Effector T Cells to Rapamycin

(2009) Laura Strauss et al.   PLoS One

A New T-Cell Receptor Transgenic Model of the CD4+ Direct Pathway: Level of Priming Determines Acute Versus Chronic Rejection

(2009) Todd V. Brennan et al.   TRANSPLANTATION

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

(2008) M. Ohtani et al.   BLOOD

Critical Role of Donor Tissue Expression of Programmed Death Ligand-1 in Regulating Cardiac Allograft Rejection and Vasculopathy

(2008) Jun Yang et al.   CIRCULATION

Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells

(2008) Frank Schmitz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY

CD3-specific antibody–induced immune tolerance involves transforming growth factor-β from phagocytes digesting apoptotic T cells

(2008) Sylvain Perruche et al.   NATURE MEDICINE

ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms

(2008) X. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA