VEGF-A and blood vessels: a beta cell perspective

VEGF in Signaling and Disease: Beyond Discovery and Development

(2019) Rajendra S. Apte et al.   CELL

Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice

(2019) Atsushi Obata et al.   DIABETOLOGIA

Vegf-A mRNA transfection as a novel approach to improve mouse and human islet graft revascularisation

(2018) Willem Staels et al.   DIABETOLOGIA

Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice

(2017) Masahiro Konishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Markers of Islet Endothelial Dysfunction Occur in Male db/db Mice and May Contribute to Reduced Insulin Release

(2016) Meghan F. Hogan et al.   ENDOCRINOLOGY

Clinical pancreatic islet transplantation

(2016) A. M. James Shapiro et al.   Nature Reviews Endocrinology

Angiopoetin-2 Signals Do Not Mediate the Hypervascularization of Islets in Type 2 Diabetes

(2016) Payal Shah et al.   PLoS One

The biomechanical properties of an epithelial tissue determine the location of its vasculature

(2016) Martin Kragl et al.   Nature Communications

Human Islets Have Fewer Blood Vessels than Mouse Islets and the Density of Islet Vascular Structures Is Increased in Type 2 Diabetes

(2015) Marcela Brissova et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Advanced Glycation End-Products Induce Apoptosis in Pancreatic Islet Endothelial Cells via NF-κB-Activated Cyclooxygenase-2/Prostaglandin E2 Up-Regulation

(2015) Kuo-Cheng Lan et al.   PLoS One

Islet Microenvironment, Modulated by Vascular Endothelial Growth Factor-A Signaling, Promotes β Cell Regeneration

(2014) Marcela Brissova et al.   Cell Metabolism

Connective Tissue Growth Factor Modulates Adult β-Cell Maturity and Proliferation to Promote β-Cell Regeneration in Mice

(2014) Kimberly G. Riley et al.   DIABETES

Conditional Hypovascularization and Hypoxia in Islets Do Not Overtly Influence Adult  -Cell Mass or Function

(2013) J. D'Hoker et al.   DIABETES

Inhibition of VEGFR-2 Reverses Type 1 Diabetes in NOD Mice by Abrogating Insulitis and Restoring Islet Function

(2013) S. Armando Villalta et al.   DIABETES

Short-term overexpression of VEGF-A in mouse beta cells indirectly stimulates their proliferation and protects against diabetes

(2013) Nico De Leu et al.   DIABETOLOGIA

Hypoglycemia Reduces Vascular Endothelial Growth Factor A Production by Pancreatic Beta Cells as a Regulator of Beta Cell Mass

(2013) Xiangwei Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation

(2012) Qing Cai et al.   DEVELOPMENTAL BIOLOGY

Vascular Endothelial Growth Factor-Mediated Islet Hypervascularization and Inflammation Contribute to Progressive Reduction of  -Cell Mass

(2012) J. Agudo et al.   DIABETES

Endothelial Progenitor Cell Cotransplantation Enhances Islet Engraftment by Rapid Revascularization

(2012) S. Kang et al.   DIABETES

The Peri-islet Basement Membrane, a Barrier to Infiltrating Leukocytes in Type 1 Diabetes in Mouse and Human

(2012) E. Korpos et al.   DIABETES

Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010

(2012) F. B. Barton et al.   DIABETES CARE

Human blood outgrowth endothelial cells improve islet survival and function when co-transplanted in a mouse model of diabetes

(2012) V. Coppens et al.   DIABETOLOGIA

Endothelial Colony-Forming Cell Coating of Pig Islets Prevents Xenogeneic Instant Blood-Mediated Inflammatory Reaction

(2011) Jae Hyeon Kim et al.   CELL TRANSPLANTATION

Blood vessels restrain pancreas branching, differentiation and growth

(2011) J. Magenheim et al.   DEVELOPMENT

Glucose and Inflammation Control Islet Vascular Density and β-Cell Function in NOD Mice

(2011) Eitan M. Akirav et al.   DIABETES

Donor Islet Endothelial Cells in Pancreatic Islet Revascularization

(2011) D. Nyqvist et al.   DIABETES

Type 2 diabetes across generations: from pathophysiology to prevention and management

(2011) Christopher J Nolan et al.   LANCET

Connective tissue growth factor acts within both endothelial cells and   cells to promote proliferation of developing   cells

(2011) M. A. Guney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose-dependent blood flow dynamics in murine pancreatic islets in vivo

(2010) Lara R. Nyman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas

(2010) Christophe E. Pierreux et al.   DEVELOPMENTAL BIOLOGY

Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications

(2010) Corey E. Tabit et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Integration of Blood Outgrowth Endothelial Cells in Dermal Fibroblast Sheets Promotes Full Thickness Wound Healing

(2010) Benoit Hendrickx et al.   STEM CELLS

Prolongation of Islet Graft Survival Using Concomitant Transplantation of Islets and Vascular Endothelial Cells in Diabetic Rats

(2010) H.-J. Song et al.   TRANSPLANTATION PROCEEDINGS

Normal islet vascularization is dispensable for expansion of beta-cell mass in response to high-fat diet induced insulin resistance

(2009) Yukiko Toyofuku et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Current Advances and Travails in Islet Transplantation

(2009) D. M. Harlan et al.   DIABETES

Islet Endothelial Activation and Oxidative Stress Gene Expression Is Reduced by IL-1Ra Treatment in the Type 2 Diabetic GK Rat

(2009) Grégory Lacraz et al.   PLoS One

Improved Vascular Engraftment and Graft Function After Inhibition of the Angiostatic Factor Thrombospondin-1 in Mouse Pancreatic Islets

(2008) J. Olerud et al.   DIABETES

Blood vessels of human islets of Langerhans are surrounded by a double basement membrane

(2008) I. Virtanen et al.   DIABETOLOGIA

Molecular composition of the peri-islet basement membrane in NOD mice: a barrier against destructive insulitis

(2008) H. F. Irving-Rodgers et al.   DIABETOLOGIA

Prolactin Treatment Improves Engraftment and Function of Transplanted Pancreatic Islets

(2008) Magnus Johansson et al.   ENDOCRINOLOGY