ROCKII inhibition promotes the maturation of human pancreatic beta-like cells

ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells

(2016) Eiji Yoshihara et al.   Cell Metabolism

Closing in on Mass Production of Mature Human Beta Cells

(2016) Timothy J. Kieffer   Cell Stem Cell

Generation of polyhormonal and multipotent pancreatic progenitor lineages from human pluripotent stem cells

(2016) Roman Korytnikov et al.   METHODS

β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1

(2015) Rowena Suriben et al.   CELL

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

(2015) David M. Blodgett et al.   DIABETES

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

MAFA and T3Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC

(2015) Cristina Aguayo-Mazzucato et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Involvement of RhoA/ROCK in insulin secretion of pancreatic β-cells in 3D culture

(2014) Xiaofang Liu et al.   CELL AND TISSUE RESEARCH

Small Molecules Facilitate the Reprogramming of Mouse Fibroblasts into Pancreatic Lineages

(2014) Ke Li et al.   Cell Stem Cell

Glucagon-Like Peptide 1 Stimulates Insulin Secretion via Inhibiting RhoA/ROCK Signaling and Disassembling Glucotoxicity-Induced Stress Fibers

(2014) Xiangchen Kong et al.   ENDOCRINOLOGY

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Suppression of Epithelial-to-Mesenchymal Transitioning Enhances Ex Vivo Reprogramming of Human Exocrine Pancreatic Tissue Toward Functional Insulin-Producing β-Like Cells

(2013) Maria João Lima et al.   DIABETES

A Novel Strategy to Increase the Proliferative Potential of Adult Human β-Cells While Maintaining Their Differentiated Phenotype

(2013) Haytham Aly et al.   PLoS One

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Single-vector inducible lentiviral RNAi system for oncology target validation

(2011) Dmitri Wiederschain et al.   CELL CYCLE

Stage-specific signaling through TGF  family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells

(2011) M. C. Nostro et al.   DEVELOPMENT

Noggin, Retinoids, and Fibroblast Growth Factor Regulate Hepatic or Pancreatic Fate of Human Embryonic Stem Cells

(2010) Josué Kunjom Mfopou et al.   GASTROENTEROLOGY

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells

(2009) Donghui Zhang et al.   CELL RESEARCH

A Small Molecule Primes Embryonic Stem Cells for Differentiation

(2009) Shoutian Zhu et al.   Cell Stem Cell

Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells

(2009) Malgorzata Borowiak et al.   Cell Stem Cell

A small molecule that directs differentiation of human ESCs into the pancreatic lineage

(2009) Shuibing Chen et al.   Nature Chemical Biology

Generation of pluripotent stem cells from patients with type 1 diabetes

(2009) R. Maehr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of Homogeneous PDX1+ Pancreatic Progenitors from Human ES Cell-derived Endoderm Cells

(2009) Jun Cai et al.   Journal of Molecular Cell Biology

Role of the Rho-ROCK (Rho-Associated Kinase) Signaling Pathway in the Regulation of Pancreatic β-Cell Function

(2008) Eva Hammar et al.   ENDOCRINOLOGY

Generation of Insulin-secreting Islet-like Clusters from Human Skin Fibroblasts

(2008) Keisuke Tateishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY