Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells

Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells

(2019) Leonardo Velazco-Cruz et al.   Stem Cell Reports

Point mutations in the PDX1 transactivation domain impair human β-cell development and function

(2019) Xianming Wang et al.   Molecular Metabolism

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

(2019) Gopika G. Nair et al.   NATURE CELL BIOLOGY

Charting cellular identity during human in vitro β-cell differentiation

(2019) Adrian Veres et al.   NATURE

Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development

(2019) Nadav Sharon et al.   Cell Reports

Independent control of matrix adhesiveness and stiffness within a 3D self-assembling peptide hydrogel

(2018) Nathaniel J. Hogrebe et al.   Acta Biomaterialia

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells

(2018) Lay Teng Ang et al.   Cell Reports

Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification

(2018) Stephen L. Trisno et al.   Cell Stem Cell

Mechanosignalling via integrins directs fate decisions of pancreatic progenitors

(2018) Anant Mamidi et al.   NATURE

Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing

(2018) Shaunak S. Adkar et al.   STEM CELLS

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

(2018) Diego Balboa et al.   eLife

β Cell Replacement after Gene Editing of a Neonatal Diabetes-Causing Mutation at the Insulin Locus

(2018) Shuangyu Ma et al.   Stem Cell Reports

ROCKII inhibition promotes the maturation of human pancreatic beta-like cells

(2017) Zaniar Ghazizadeh et al.   Nature Communications

Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling

(2016) Meike Hohwieler et al.   GUT

Direct influence of culture dimensionality on human mesenchymal stem cell differentiation at various matrix stiffnesses using a fibrous self-assembling peptide hydrogel

(2016) Nathaniel J. Hogrebe et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Human pancreas development

(2015) R. E. Jennings et al.   DEVELOPMENT

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

Development of an encapsulated stem cell-based therapy for diabetes

(2015) Alice Anna Tomei et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Efficient Generation of NKX6-1+ Pancreatic Progenitors from Multiple Human Pluripotent Stem Cell Lines

(2015) M. Cristina Nostro et al.   Stem Cell Reports

Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo

(2015) Stacy R. Finkbeiner et al.   Stem Cell Reports

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Spatial control of adult stem cell fate using nanotopographic cues

(2014) Eun Hyun Ahn et al.   BIOMATERIALS

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Human Pluripotent Stem Cell Culture: Considerations for Maintenance, Expansion, and Therapeutics

(2014) Kevin G. Chen et al.   Cell Stem Cell

Cdc42/N-WASP signaling links actin dynamics to pancreatic   cell delamination and differentiation

(2014) G. Kesavan et al.   JOURNAL OF CELL SCIENCE

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

(2014) Kyle W. McCracken et al.   NATURE

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

(2013) Xiaolei Yin et al.   NATURE METHODS

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Self-Renewing Endodermal Progenitor Lines Generated from Human Pluripotent Stem Cells

(2012) Xin Cheng et al.   Cell Stem Cell

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

Lateral spacing of adhesion peptides influences human mesenchymal stem cell behaviour

(2012) J. E. Frith et al.   JOURNAL OF CELL SCIENCE

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

A Scalable System for Production of Functional Pancreatic Progenitors from Human Embryonic Stem Cells

(2012) Thomas C. Schulz et al.   PLoS One

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

A pharmacological cocktail for arresting actin dynamics in living cells

(2011) Grace E. Peng et al.   MOLECULAR BIOLOGY OF THE CELL

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Generating human intestinal tissue from pluripotent stem cells in vitro

(2011) Kyle W McCracken et al.   Nature Protocols

Thickness sensing of hMSCs on collagen gel directs stem cell fate

(2010) Wen Shing Leong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms of mechanical signaling in development and disease

(2010) P. A. Janmey et al.   JOURNAL OF CELL SCIENCE

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Linking actin dynamics and gene transcription to drive cellular motile functions

(2010) Eric N. Olson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

GEF-H1 Couples Nocodazole-induced Microtubule Disassembly to Cell Contractility via RhoA

(2008) Yuan-Chen Chang et al.   MOLECULAR BIOLOGY OF THE CELL

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY