Human pancreatic beta-like cells converted from fibroblasts

Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming

(2015) Abdenour Soufi et al.   CELL

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Direct Lineage Reprogramming: Strategies, Mechanisms, and Applications

(2015) Jun Xu et al.   Cell Stem Cell

Tolerance Induction and Reversal of Diabetes in Mice Transplanted with Human Embryonic Stem Cell-Derived Pancreatic Endoderm

(2015) Gregory L. Szot et al.   Cell Stem Cell

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

Reprogramming fibroblasts toward cardiomyocytes, neural stem cells and hepatocytes by cell activation and signaling-directed lineage conversion

(2015) Saiyong Zhu et al.   Nature Protocols

Single Transcription Factor Conversion of Human Blood Fate to NPCs with CNS and PNS Developmental Capacity

(2015) Jong-Hee Lee et al.   Cell Reports

Efficient Generation of NKX6-1+ Pancreatic Progenitors from Multiple Human Pluripotent Stem Cell Lines

(2015) M. Cristina Nostro et al.   Stem Cell Reports

Endothelial Cells Control Pancreatic Cell Fate at Defined Stages through EGFL7 Signaling

(2015) Der-I Kao et al.   Stem Cell Reports

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Small Molecules Facilitate the Reprogramming of Mouse Fibroblasts into Pancreatic Lineages

(2014) Ke Li et al.   Cell Stem Cell

Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification

(2014) C.-R. Xu et al.   EMBO JOURNAL

Taming the young and restless--epigenetic gene regulation in pancreas and beta-cell precursors

(2014) H. A. Russ et al.   EMBO JOURNAL

Mouse liver repopulation with hepatocytes generated from human fibroblasts

(2014) Saiyong Zhu et al.   NATURE

Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells

(2014) Weida Li et al.   NATURE BIOTECHNOLOGY

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Small Molecules Enable Cardiac Reprogramming of Mouse Fibroblasts with a Single Factor, Oct4

(2014) Haixia Wang et al.   Cell Reports

Conversion of Human Fibroblasts to Functional Endothelial Cells by Defined Factors

(2013) Jun Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells

(2013) Saiyong Zhu et al.   CELL RESEARCH

Chemical Approaches to Stem Cell Biology and Therapeutics

(2013) Wenlin Li et al.   Cell Stem Cell

Dynamic Chromatin Remodeling Mediated by Polycomb Proteins Orchestrates Pancreatic Differentiation of Human Embryonic Stem Cells

(2013) Ruiyu Xie et al.   Cell Stem Cell

Next-Generation Regenerative Medicine: Organogenesis from Stem Cells in 3D Culture

(2013) Yoshiki Sasai   Cell Stem Cell

Factors Expressed by Murine Embryonic Pancreatic Mesenchyme Enhance Generation of Insulin-Producing Cells From hESCs

(2013) T. Guo et al.   DIABETES

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

(2013) Kathryn Blaschke et al.   NATURE

VMAT2 identified as a regulator of late-stage β-cell differentiation

(2013) Daisuke Sakano et al.   Nature Chemical Biology

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

(2013) Brandon L. Taylor et al.   Cell Reports

Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome

(2012) Abdenour Soufi et al.   CELL

A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells

(2012) Jose M. Polo et al.   CELL

Self-Renewing Endodermal Progenitor Lines Generated from Human Pluripotent Stem Cells

(2012) Xin Cheng et al.   Cell Stem Cell

The Harmonies Played by TGF-β in Stem Cell Biology

(2012) Naoki Oshimori et al.   Cell Stem Cell

Direct lineage reprogramming to neural cells

(2012) Janghwan Kim et al.   CURRENT OPINION IN NEUROBIOLOGY

A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation

(2012) H. P. Shih et al.   DEVELOPMENT

Neonatal β Cell Development in Mice and Humans Is Regulated by Calcineurin/NFAT

(2012) William R. Goodyer et al.   DEVELOPMENTAL CELL

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

Lineage conversion methodologies meet the reprogramming toolbox

(2012) Ignacio Sancho-Martinez et al.   NATURE CELL BIOLOGY

Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all–iPS cell mice from terminally differentiated B cells

(2012) Matthias Stadtfeld et al.   NATURE GENETICS

Conversion of human fibroblasts to angioblast-like progenitor cells

(2012) Leo Kurian et al.   NATURE METHODS

Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine

(2012) Maria Cristina Nostro et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Chemical Strategies for Stem Cell Biology and Regenerative Medicine

(2011) Saiyong Zhu et al.   Annual Review of Biomedical Engineering

Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells

(2011) Ori Bar-Nur et al.   Cell Stem Cell

The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner

(2011) Tao Wang et al.   Cell Stem Cell

Stage-specific signaling through TGF  family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells

(2011) M. C. Nostro et al.   DEVELOPMENT

Pancreas organogenesis: From bud to plexus to gland

(2011) Fong Cheng Pan et al.   DEVELOPMENTAL DYNAMICS

Historical Perspective: Beginnings of the  -Cell: Current Perspectives in  -Cell Development

(2011) P. A. Seymour et al.   DIABETES

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells

(2011) Olivia G Kelly et al.   NATURE BIOTECHNOLOGY

Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy

(2011) Jem A. Efe et al.   NATURE CELL BIOLOGY

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

Insulin-Producing Cells Generated from Dedifferentiated Human Pancreatic Beta Cells Expanded In Vitro

(2011) Holger A. Russ et al.   PLoS One

Direct reprogramming of mouse fibroblasts to neural progenitors

(2011) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells

(2011) Yuya Kunisada et al.   Stem Cell Research

Reprogramming of Human Primary Somatic Cells by OCT4 and Chemical Compounds

(2010) Saiyong Zhu et al.   Cell Stem Cell

Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells

(2010) Miguel Angel Esteban et al.   Cell Stem Cell

Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells

(2009) Donghui Zhang et al.   CELL RESEARCH

Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells

(2009) Malgorzata Borowiak et al.   Cell Stem Cell

Sox17 Regulates Organ Lineage Segregation of Ventral Foregut Progenitor Cells

(2009) Jason R. Spence et al.   DEVELOPMENTAL CELL

A small molecule that directs differentiation of human ESCs into the pancreatic lineage

(2009) Shuibing Chen et al.   Nature Chemical Biology

Teratoma formation by human embryonic stem cells: Evaluation of essential parameters for future safety studies

(2009) Hannes Hentze et al.   Stem Cell Research

On the origin of the   cell

(2008) J. M. Oliver-Krasinski et al.   GENES & DEVELOPMENT

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY