Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice

Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells

(2020) Nathaniel J. Hogrebe et al.   NATURE BIOTECHNOLOGY

Measurement of Energy Metabolism in Explanted Retinal Tissue Using Extracellular Flux Analysis

(2019) Jeffrey R. Millman et al.   Jove-Journal of Visualized Experiments

Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells

(2019) Leonardo Velazco-Cruz et al.   Stem Cell Reports

Point mutations in the PDX1 transactivation domain impair human β-cell development and function

(2019) Xianming Wang et al.   Molecular Metabolism

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

(2019) Gopika G. Nair et al.   NATURE CELL BIOLOGY

A hydrogel platform for in vitro three dimensional assembly of human stem cell-derived islet cells and endothelial cells

(2019) Punn Augsornworawat et al.   Acta Biomaterialia

Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A

(2019) Fabian L. Cardenas-Diaz et al.   Cell Stem Cell

Current Landscape of Treatments for Wolfram Syndrome

(2019) Damien Abreu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation

(2019) Alyssa A. Lombardi et al.   Nature Communications

Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes

(2018) Anoop Arunagiri et al.   Annals of the New York Academy of Sciences

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Report of the Key Opinion Leaders Meeting on Stem Cell-Derived Beta Cells

(2018) Jon Odorico et al.   TRANSPLANTATION

3-D physiomimetic extracellular matrix hydrogels provide a supportive microenvironment for rodent and human islet culture

(2018) K. Jiang et al.   BIOMATERIALS

Rebuilding a better home for transplanted islets

(2018) Daniel M. Tremmel et al.   Organogenesis

Extracellular matrix scaffold and hydrogel derived from decellularized and delipidized human pancreas

(2018) Sara Dutton Sackett et al.   Scientific Reports

Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development

(2018) Peter Karagiannis et al.   PHYSIOLOGICAL REVIEWS

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

(2018) Diego Balboa et al.   eLife

β Cell Replacement after Gene Editing of a Neonatal Diabetes-Causing Mutation at the Insulin Locus

(2018) Shuangyu Ma et al.   Stem Cell Reports

Single-Cell Gene Expression Analysis of a Human ESC Model of Pancreatic Endocrine Development Reveals Different Paths to β-Cell Differentiation

(2017) Maja Borup Kjær Petersen et al.   Stem Cell Reports

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

(2016) H. Efsun Arda et al.   Cell Metabolism

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

Wolfram Syndrome: Diagnosis, Management, and Treatment

(2016) Fumihiko Urano   Current Diabetes Reports

Generation of stem cell-derived β-cells from patients with type 1 diabetes

(2016) Jeffrey R. Millman et al.   Nature Communications

Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome

(2016) Michal Cagalinec et al.   PLOS BIOLOGY

A Single-Cell Transcriptome Atlas of the Human Pancreas

(2016) Mauro J. Muraro et al.   Cell Systems

A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure

(2016) Maayan Baron et al.   Cell Systems

Fibrin gels engineered with pro-angiogenic growth factors promote engraftment of pancreatic islets in extrahepatic sites in mice

(2015) Mejdi Najjar et al.   BIOTECHNOLOGY AND BIOENGINEERING

Development of an encapsulated stem cell-based therapy for diabetes

(2015) Alice Anna Tomei et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

A high-throughput screening strategy for detecting CRISPR-Cas9 induced mutations using next-generation sequencing

(2014) Charles C Bell et al.   BMC GENOMICS

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells

(2014) Mitsutoshi Yamada et al.   NATURE

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

(2014) Simin Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Encapsulated islets for diabetes therapy: History, current progress, and critical issues requiring solution

(2013) David W. Scharp et al.   ADVANCED DRUG DELIVERY REVIEWS

Macroporous Three-Dimensional PDMS Scaffolds for Extrahepatic Islet Transplantation

(2013) Eileen Pedraza et al.   CELL TRANSPLANTATION

 -Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome

(2013) L. Shang et al.   DIABETES

Genotypic classification of patients with Wolfram syndrome: insights into the natural history of the disease and correlation with phenotype

(2013) Miguel López de Heredia et al.   GENETICS IN MEDICINE

iPSC-derived β cells model diabetes due to glucokinase deficiency

(2013) Haiqing Hua et al.   JOURNAL OF CLINICAL INVESTIGATION

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

Phenotypic characteristics of early Wolfram syndrome

(2013) Bess A Marshall et al.   Orphanet Journal of Rare Diseases

The Role of Endoplasmic Reticulum Stress in Autoimmune-Mediated Beta-Cell Destruction in Type 1 Diabetes

(2012) Jixin Zhong et al.   Experimental Diabetes Research

Intrapatient Variations in Type 1 Diabetes-specific iPS Cell Differentiation Into Insulin-producing Cells

(2012) Tayaramma Thatava et al.   MOLECULAR THERAPY

Dynamics of insulin secretion and the clinical implications for obesity and diabetes

(2011) Susumu Seino et al.   JOURNAL OF CLINICAL INVESTIGATION

Somatic coding mutations in human induced pluripotent stem cells

(2011) Athurva Gore et al.   NATURE

Endoplasmic reticulum stress and pancreatic β-cell death

(2011) Sonya G. Fonseca et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

(2010) Sonya G. Fonseca et al.   JOURNAL OF CLINICAL INVESTIGATION

Wolfram syndrome: a clinicopathologic correlation

(2009) Justin B. Hilson et al.   ACTA NEUROPATHOLOGICA

Generation of pluripotent stem cells from patients with type 1 diabetes

(2009) R. Maehr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA