Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Authors
Keywords
-
Journal
PHYSIOLOGICAL REVIEWS
Volume 98, Issue 1, Pages 117-214
Publisher
American Physiological Society
Online
2017-12-06
DOI
10.1152/physrev.00008.2017
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes
- (2017) Nikhil R. Gandasi et al. JOURNAL OF CLINICAL INVESTIGATION
- Functional identification of islet cell types by electrophysiological fingerprinting
- (2017) Linford J. B. Briant et al. Journal of the Royal Society Interface
- Molecular Determinants of BK Channel Functional Diversity and Functioning
- (2017) Ramon Latorre et al. PHYSIOLOGICAL REVIEWS
- Neonatal Diabetes and the K ATP Channel: From Mutation to Therapy
- (2017) Frances M. Ashcroft et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Anti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM
- (2017) Gregory M Martin et al. eLife
- Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating
- (2017) Gregory M Martin et al. eLife
- Amylin structure-function relationships and receptor pharmacology: implications for amylin mimetic drug development
- (2016) Rebekah L Bower et al. BRITISH JOURNAL OF PHARMACOLOGY
- Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose
- (2016) Natalie R. Johnston et al. Cell Metabolism
- Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk
- (2016) Jennifer H. Stern et al. Cell Metabolism
- RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes
- (2016) Yurong Xin et al. Cell Metabolism
- Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes
- (2016) Åsa Segerstolpe et al. Cell Metabolism
- A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human β-Cells and Is Impaired in Type 2 Diabetes
- (2016) Richard Yan-Do et al. DIABETES
- Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATPChannel Activity
- (2016) Trillian Gregg et al. DIABETES
- How Kiss-and-Run Can Make Us Sick:SOX4Puts a Break on the Pore
- (2016) Sebastian Barg et al. DIABETES
- Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells
- (2016) Subhankar Dolai et al. DIABETES
- Endogenous α2A-Adrenoceptor–Operated Sympathoadrenergic Tones Attenuate Insulin Secretion via cAMP/TRPM2 Signaling
- (2016) Kiyonori Ito et al. DIABETES
- Increased Expression of the Diabetes GeneSOX4Reduces Insulin Secretion by Impaired Fusion Pore Expansion
- (2016) Stephan C. Collins et al. DIABETES
- Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets
- (2016) Alice E. Adriaenssens et al. DIABETOLOGIA
- Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk
- (2016) Natascia Vedovato et al. DIABETOLOGIA
- Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes
- (2016) Tarig Babiker et al. DIABETOLOGIA
- Glucagon is the key factor in the development of diabetes
- (2016) Young H. Lee et al. DIABETOLOGIA
- Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells
- (2016) Masataka Kunii et al. JOURNAL OF CELL BIOLOGY
- Perspective on the Genetics and Diagnosis of Congenital Hyperinsulinism Disorders
- (2016) Charles A. Stanley JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology
- (2016) Annette C. Dolphin JOURNAL OF PHYSIOLOGY-LONDON
- p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion
- (2016) Aharon Helman et al. NATURE MEDICINE
- Fatty acids stimulate insulin secretion from human pancreatic islets at fasting glucose concentrations via mitochondria-dependent and -independent mechanisms
- (2016) Jing Cen et al. Nutrition & Metabolism
- Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells
- (2016) Catherine E. Moss et al. PEPTIDES
- Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels
- (2016) Peter Proks et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- The Pancreatic β-Cell: A Bioenergetic Perspective
- (2016) David G. Nicholls PHYSIOLOGICAL REVIEWS
- Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells
- (2016) Melissa F. Brereton et al. Nature Communications
- MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes
- (2016) Elvira Ganic et al. Cell Reports
- Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets
- (2016) Michael R. DiGruccio et al. Molecular Metabolism
- Potentiation of Glucose-stimulated Insulin Secretion by the GPR40–PLC–TRPC Pathway in Pancreatic β-Cells
- (2016) Hodaka Yamada et al. Scientific Reports
- Granuphilin exclusively mediates functional granule docking to the plasma membrane
- (2016) Kouichi Mizuno et al. Scientific Reports
- Dynamics of glucose-induced insulin secretion in normal human islets
- (2015) Jean-Claude Henquin et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Inwardly rectifying Kir2.1 currents in human β-cells control electrical activity: Characterisation and mathematical modelling
- (2015) Michela Riz et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts
- (2015) Bei-Bei Chu et al. CELL
- Rare and Common Genetic Events in Type 2 Diabetes: What Should Biologists Know?
- (2015) Amélie Bonnefond et al. Cell Metabolism
- Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function
- (2015) Dana Avrahami et al. Cell Metabolism
- Type 2 Diabetes–Associated K+Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis
- (2015) Nicholas C. Vierra et al. DIABETES
- The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice
- (2015) Ghislaine Fontés et al. DIABETES
- β-Cell MicroRNAs: Small but Powerful
- (2015) Stephen R. Filios et al. DIABETES
- Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets
- (2015) David M. Blodgett et al. DIABETES
- Slow potentials encode intercellular coupling and insulin demand in pancreatic beta cells
- (2015) Fanny Lebreton et al. DIABETOLOGIA
- A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium
- (2015) Alice Adriaenssens et al. ENDOCRINOLOGY
- Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance
- (2015) Eunjung Lee et al. FASEB JOURNAL
- Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells
- (2015) Abdelilah Arredouani et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Store-operated Ca2+Entry Mediated by Orai1 and TRPC1 Participates to Insulin Secretion in Rat β-Cells
- (2015) Jessica Sabourin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis
- (2015) Fan Fan et al. JOURNAL OF CLINICAL INVESTIGATION
- Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells
- (2015) Mourad Ferdaoussi et al. JOURNAL OF CLINICAL INVESTIGATION
- GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation
- (2015) Makoto Shigeto et al. JOURNAL OF CLINICAL INVESTIGATION
- GLP1 and GIP cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness
- (2015) Berit Svendsen et al. JOURNAL OF ENDOCRINOLOGY
- TASK-1 Potassium Channels Limit Pancreatic α-Cell Calcium Influx and Glucagon Secretion
- (2015) Prasanna K. Dadi et al. MOLECULAR ENDOCRINOLOGY
- Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment
- (2015) Jan Marquard et al. NATURE MEDICINE
- Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion
- (2015) Caroline Bonner et al. NATURE MEDICINE
- Anoctamin 1 (Ano1) is required for glucose-induced membrane potential oscillations and insulin secretion by murine β-cells
- (2015) Raphaël Crutzen et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Paternal allelic mutation at theKcnq1locus reduces pancreatic β-cell mass by epigenetic modification ofCdkn1c
- (2015) Shun-ichiro Asahara et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synaptotagmin-7 phosphorylation mediates GLP-1–dependent potentiation of insulin secretion from β-cells
- (2015) Bingbing Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Two-photon fluorescence lifetime imaging of primed SNARE complexes in presynaptic terminals and β cells
- (2015) Noriko Takahashi et al. Nature Communications
- Genetics of Type 2 Diabetes—Pitfalls and Possibilities
- (2015) Rashmi Prasad et al. Genes
- The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelin
- (2015) Tomoyuki Kurashina et al. Scientific Reports
- Sodium Channels, Inherited Epilepsy, and Antiepileptic Drugs
- (2014) William A. Catterall Annual Review of Pharmacology and Toxicology
- Neural control of the endocrine pancreas
- (2014) Rayner Rodriguez-Diaz et al. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
- The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression
- (2014) Christopher Benner et al. BMC GENOMICS
- CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells
- (2014) Anna Edlund et al. BMC Medicine
- SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
- (2014) Zhaozhu Qiu et al. CELL
- Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy
- (2014) Zhiyu Wang et al. Cell Metabolism
- Control of Insulin Secretion by Cholinergic Signaling in the Human Pancreatic Islet
- (2014) J. Molina et al. DIABETES
- Role of Epac2A/Rap1 Signaling in Interplay Between Incretin and Sulfonylurea in Insulin Secretion
- (2014) Harumi Takahashi et al. DIABETES
- Involvement of cAMP/EPAC/TRPM2 Activation in Glucose- and Incretin-Induced Insulin Secretion
- (2014) M. Yosida et al. DIABETES
- Defects in -Cell Ca2+ Dynamics in Age-Induced Diabetes
- (2014) L. Li et al. DIABETES
- Neurotransmitter control of islet hormone pulsatility
- (2014) E. Gylfe et al. DIABETES OBESITY & METABOLISM
- Neural regulation of pancreatic islet cell mass and function
- (2014) B. Thorens DIABETES OBESITY & METABOLISM
- Autocrine activation of P2Y1 receptors couples Ca2+ influx to Ca2+ release in human pancreatic beta cells
- (2014) Shara Khan et al. DIABETOLOGIA
- DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake
- (2014) Jia Li et al. DIABETOLOGIA
- Doc2b enrichment enhances glucose homeostasis in mice via potentiation of insulin secretion and peripheral insulin sensitivity
- (2014) Latha Ramalingam et al. DIABETOLOGIA
- GLUT2, glucose sensing and glucose homeostasis
- (2014) Bernard Thorens DIABETOLOGIA
- Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature
- (2014) Jiun T. Low et al. DIABETOLOGIA
- Activators of PKA and Epac Distinctly Influence Insulin Secretion and Cytosolic Ca2+in Female Mouse Islets Stimulated by Glucose and Tolbutamide
- (2014) Jean-Claude Henquin et al. ENDOCRINOLOGY
- New insights into the role of connexins in pancreatic islet function and diabetes
- (2014) Nikki L. Farnsworth et al. FEBS LETTERS
- A review of maternally inherited diabetes and deafness
- (2014) Hui-Zhen Li Frontiers in Bioscience-Landmark
- Genome-wide copy number variation study reveals KCNIP1 as a modulator of insulin secretion
- (2014) Heun-Sik Lee et al. GENOMICS
- A Fresh View of Glycolysis and Glucokinase Regulation: History and Current Status
- (2014) Sigurd Lenzen JOURNAL OF BIOLOGICAL CHEMISTRY
- MicroRNA-7a regulates pancreatic β cell function
- (2014) Mathieu Latreille et al. JOURNAL OF CLINICAL INVESTIGATION
- Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATPchannels: A mechanistic study
- (2014) Peter Proks et al. JOURNAL OF GENERAL PHYSIOLOGY
- Role for the TRPV1 Channel in Insulin Secretion from Pancreatic Beta Cells
- (2014) Carlos Manlio Diaz-Garcia et al. JOURNAL OF MEMBRANE BIOLOGY
- Neurotransmitters act as paracrine signals to regulate insulin secretion from the human pancreatic islet
- (2014) Rayner Rodriguez-Diaz et al. JOURNAL OF PHYSIOLOGY-LONDON
- Na+current properties in islet α- and β-cells reflect cell-specificScn3aandScn9aexpression
- (2014) Quan Zhang et al. JOURNAL OF PHYSIOLOGY-LONDON
- Minireview: MicroRNA Function in Pancreatic β Cells
- (2014) Sabire Özcan MOLECULAR ENDOCRINOLOGY
- Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
- (2014) Alireza Rezania et al. NATURE BIOTECHNOLOGY
- Role of the SIK2–p35–PJA2 complex in pancreatic β-cell functional compensation
- (2014) Jun-Ichi Sakamaki et al. NATURE CELL BIOLOGY
- Loss-of-function mutations in SLC30A8 protect against type 2 diabetes
- (2014) Jason Flannick et al. NATURE GENETICS
- Young capillary vessels rejuvenate aged pancreatic islets
- (2014) Joana Almaça et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genotype-based treatment of type 2 diabetes with an 2A-adrenergic receptor antagonist
- (2014) Y. Tang et al. Science Translational Medicine
- Distinct Actions of Rab3 and Rab27 GTPases on Late Stages of Exocytosis of Insulin
- (2014) Victor A. Cazares et al. TRAFFIC
- Here come the newcomer granules, better late than never
- (2014) Herbert Y. Gaisano TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site
- (2014) Nikhil R. Gandasi et al. Nature Communications
- Reversible changes in pancreatic islet structure and function produced by elevated blood glucose
- (2014) Melissa F. Brereton et al. Nature Communications
- Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR
- (2014) Jing Hui Guo et al. Nature Communications
- Glutamate Acts as a Key Signal Linking Glucose Metabolism to Incretin/cAMP Action to Amplify Insulin Secretion
- (2014) Ghupurjan Gheni et al. Cell Reports
- Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs
- (2014) Jonathan Esguerra et al. Genes
- Long-term disruption of maternal glucose homeostasis induced by prenatal glucocorticoid treatment correlates with miR-29 upregulation
- (2013) Patrícia R. Gomes et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Metabolic Signaling in Fuel-Induced Insulin Secretion
- (2013) Marc Prentki et al. Cell Metabolism
- Enteroendocrine hormone mimetics for the treatment of obesity and diabetes
- (2013) Nigel Irwin et al. CURRENT OPINION IN PHARMACOLOGY
- A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1
- (2013) K. Shimomura et al. DIABETES
- Identification and Characterization of GLP-1 Receptor-Expressing Cells Using a New Transgenic Mouse Model
- (2013) P. Richards et al. DIABETES
- Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin
- (2013) S. Asahara et al. DIABETOLOGIA
- Are we overestimating the loss of beta cells in type 2 diabetes?
- (2013) Lorella Marselli et al. DIABETOLOGIA
- Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell
- (2013) Jiun T. Low et al. DIABETOLOGIA
- P2Y1 receptor-dependent diacylglycerol signaling microdomains in β cells promote insulin secretion
- (2013) Anne Wuttke et al. FASEB JOURNAL
- Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome
- (2013) A. C. Nica et al. GENOME RESEARCH
- Actin Dynamics Regulated by the Balance of Neuronal Wiskott-Aldrich Syndrome Protein (N-WASP) and Cofilin Activities Determines the Biphasic Response of Glucose-induced Insulin Secretion
- (2013) Eita Uenishi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Proteome Analysis and Conditional Deletion of the EAAT2 Glutamate Transporter Provide Evidence against a Role of EAAT2 in Pancreatic Insulin Secretion in Mice
- (2013) Yun Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance
- (2013) Motoyuki Tamaki et al. JOURNAL OF CLINICAL INVESTIGATION
- Lipotoxicity disrupts incretin-regulated human β cell connectivity
- (2013) David J. Hodson et al. JOURNAL OF CLINICAL INVESTIGATION
- ATP Regulates Sodium Channel Kinetics in Pancreatic Islet Beta Cells
- (2013) Na Zou et al. JOURNAL OF MEMBRANE BIOLOGY
- The islet ghrelin cell
- (2013) Nils Wierup et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Mitochondrial function and insulin secretion
- (2013) Pierre Maechler MOLECULAR AND CELLULAR ENDOCRINOLOGY
- KATP channels and islet hormone secretion: new insights and controversies
- (2013) Frances M. Ashcroft et al. Nature Reviews Endocrinology
- Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
- (2013) Thomas C. Südhof NEURON
- MicroRNA Expression in Alpha and Beta Cells of Human Pancreatic Islets
- (2013) Dagmar Klein et al. PLoS One
- Leptin promotes KATP channel trafficking by AMPK signaling in pancreatic -cells
- (2013) S.-H. Park et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antidiabetic Sulfonylureas and cAMP Cooperatively Activate Epac2A
- (2013) T. Takahashi et al. Science Signaling
- The Functional Significance of Synaptotagmin Diversity in Neuroendocrine Secretion
- (2013) Paanteha K. Moghadam et al. Frontiers in Endocrinology
- SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells
- (2012) Balrik Kailey et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Regulation of Insulin Secretion in Human Pancreatic Islets
- (2012) Patrik Rorsman et al. Annual Review of Physiology
- The use of animal models in diabetes research
- (2012) Aileen JF King BRITISH JOURNAL OF PHARMACOLOGY
- Diabetes Mellitus and the β Cell: The Last Ten Years
- (2012) Frances M. Ashcroft et al. CELL
- Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
- (2012) Chutima Talchai et al. CELL
- Regulation of ATP production by mitochondrial Ca2+
- (2012) Andrei I. Tarasov et al. CELL CALCIUM
- Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes
- (2012) Taman Mahdi et al. Cell Metabolism
- A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets
- (2012) Jalal Taneera et al. Cell Metabolism
- Dual Role of VAMP8 in Regulating Insulin Exocytosis and Islet β Cell Growth
- (2012) Dan Zhu et al. Cell Metabolism
- Reduced Insulin Exocytosis in Human Pancreatic -Cells With Gene Variants Linked to Type 2 Diabetes
- (2012) A. H. Rosengren et al. DIABETES
- Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets
- (2012) M. E. Travers et al. DIABETES
- Autocrine regulation of insulin secretion
- (2012) M. Braun et al. DIABETES OBESITY & METABOLISM
- The diabetic β-cell: hyperstimulated vs. hyperexcited
- (2012) C. G. Nichols et al. DIABETES OBESITY & METABOLISM
- γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes
- (2012) J. Taneera et al. DIABETOLOGIA
- Syntaxin-3 regulates newcomer insulin granule exocytosis and compound fusion in pancreatic beta cells
- (2012) D. Zhu et al. DIABETOLOGIA
- The human L-type calcium channel Cav1.3 regulates insulin release and polymorphisms in CACNA1D associate with type 2 diabetes
- (2012) T. M. Reinbothe et al. DIABETOLOGIA
- SLC2A2 mutations can cause neonatal diabetes, suggesting GLUT2 may have a role in human insulin secretion
- (2012) F. H. Sansbury et al. DIABETOLOGIA
- A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets
- (2012) P. Marchetti et al. DIABETOLOGIA
- Synapsins I and II Are Not Required for Insulin Secretion from Mouse Pancreatic β-cells
- (2012) Anna Wendt et al. ENDOCRINOLOGY
- Vesicular Nucleotide Transporter-Mediated ATP Release Regulates Insulin Secretion
- (2012) Jessica C. Geisler et al. ENDOCRINOLOGY
- Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes
- (2012) Sofia A. Andersson et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- α2δ expression sets presynaptic calcium channel abundance and release probability
- (2012) Michael B. Hoppa et al. NATURE
- Real-time detection of acetylcholine release from the human endocrine pancreas
- (2012) Rayner Rodriguez-Diaz et al. Nature Protocols
- G protein-coupled receptors for energy metabolites as new therapeutic targets
- (2012) Clara C. Blad et al. NATURE REVIEWS DRUG DISCOVERY
- The Presynaptic Active Zone
- (2012) Thomas C. Südhof NEURON
- Frequency-dependent mitochondrial Ca2+ accumulation regulates ATP synthesis in pancreatic β cells
- (2012) Andrei I. Tarasov et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Distinct Initial SNARE Configurations Underlying the Diversity of Exocytosis
- (2012) Haruo Kasai et al. PHYSIOLOGICAL REVIEWS
- The Mitochondrial Ca2+ Uniporter MCU Is Essential for Glucose-Induced ATP Increases in Pancreatic β-Cells
- (2012) Andrei I. Tarasov et al. PLoS One
- Comparative proteomic analysis of the ATP-sensitive K+channel complex in different tissue types
- (2012) Eirini Kefaloyianni et al. PROTEOMICS
- AMPA Receptors Regulate Exocytosis and Insulin Release in Pancreatic β Cells
- (2012) Zhen-Yong Wu et al. TRAFFIC
- Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics
- (2011) Nicolai M. Doliba et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Perspectives on Kiss-and-Run: Role in Exocytosis, Endocytosis, and Neurotransmission
- (2011) AbdulRasheed A. Alabi et al. Annual Review of Physiology
- High resolution electrophysiological techniques for the study of calcium-activated exocytosis
- (2011) Manfred Lindau BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Regulation of calcium in pancreatic α- and β-cells in health and disease
- (2011) Patrik Rorsman et al. CELL CALCIUM
- A Common Variant in TFB1M Is Associated with Reduced Insulin Secretion and Increased Future Risk of Type 2 Diabetes
- (2011) Thomas Koeck et al. Cell Metabolism
- Innervation Patterns of Autonomic Axons in the Human Endocrine Pancreas
- (2011) Rayner Rodriguez-Diaz et al. Cell Metabolism
- Somatostatin Receptor Type 2 Antagonism Improves Glucagon and Corticosterone Counterregulatory Responses to Hypoglycemia in Streptozotocin-Induced Diabetic Rats
- (2011) J. T. Y. Yue et al. DIABETES
- Acute Sulfonylurea Therapy at Disease Onset Can Cause Permanent Remission of KATP-Induced Diabetes
- (2011) M. S. Remedi et al. DIABETES
- SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans
- (2011) Xiao-Qing Dai et al. DIABETES
- Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?
- (2011) J. N. Walker et al. DIABETES OBESITY & METABOLISM
- Multivesicular exocytosis in rat pancreatic beta cells
- (2011) M. B. Hoppa et al. DIABETOLOGIA
- Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
- (2011) E. L. Lim et al. DIABETOLOGIA
- Effects of GABAB receptor agonists and antagonists on glycemia regulation in mice
- (2011) María M. Bonaventura et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Inhibition or Ablation of p21-activated Kinase (PAK1) Disrupts Glucose Homeostatic Mechanismsin Vivo
- (2011) Zhanxiang Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Munc18-1 and Munc18-2 Proteins Modulate β-Cell Ca2+Sensitivity and Kinetics of Insulin Exocytosis Differently
- (2011) Slavena A. Mandic et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Loss of Granuphilin and Loss of Syntaxin-1A Cause Differential Effects on Insulin Granule Docking and Fusion
- (2011) Hao Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dynamics of insulin secretion and the clinical implications for obesity and diabetes
- (2011) Susumu Seino et al. JOURNAL OF CLINICAL INVESTIGATION
- Time-dependent changes in membrane excitability during glucose-induced bursting activity in pancreatic β cells
- (2011) Chae Young Cha et al. JOURNAL OF GENERAL PHYSIOLOGY
- Ionic mechanisms and Ca2+dynamics underlying the glucose response of pancreatic β cells: a simulation study
- (2011) Chae Young Cha et al. JOURNAL OF GENERAL PHYSIOLOGY
- Clinical characteristics of recessive and dominant congenital hyperinsulinism due to mutation(s) in the ABCC8/KCNJ11 genes encoding the ATP-sensitive potasium channel in the pancreatic beta cell
- (2011) Gönül Öçal et al. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
- Effects of leptin and adiponectin on pancreatic β-cell function
- (2011) Yong-ho Lee et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells
- (2011) Nicole Feldmann et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: Implications for understanding genetic association signals at this locus
- (2011) Laura J. McCulloch et al. MOLECULAR GENETICS AND METABOLISM
- Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans
- (2011) Rayner Rodriguez-Diaz et al. NATURE MEDICINE
- Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex
- (2011) Cong Ma et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- RIM Determines Ca2+ Channel Density and Vesicle Docking at the Presynaptic Active Zone
- (2011) Yunyun Han et al. NEURON
- Rapid functional evaluation of beta-cells by extracellular recording of membrane potential oscillations with microelectrode arrays
- (2011) Thomas Pfeiffer et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus
- (2011) Per Westermark et al. PHYSIOLOGICAL REVIEWS
- Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR)
- (2011) D. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells
- (2011) Colin A. Leech et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans
- (2011) Patrik Rorsman et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Synapsin regulation of vesicle organization and functional pools
- (2011) Maria Bykhovskaia SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Obesity, insulin resistance and free fatty acids
- (2011) Guenther Boden Current Opinion in Endocrinology Diabetes and Obesity
- Calcium Control of Neurotransmitter Release
- (2011) T. C. Sudhof Cold Spring Harbor Perspectives in Biology
- Exocytosis from pancreatic -cells: mathematical modelling of the exit of low-molecular-weight granule content
- (2011) J. Galvanovskis et al. Interface Focus
- Mapping Dynamic Protein Interactions to Insulin Secretory Granule Behavior with TIRF-FRET
- (2010) Alice D. Lam et al. BIOPHYSICAL JOURNAL
- Age- and sex-related prevalence of diabetes mellitus among immigrants to Ontario, Canada
- (2010) M. I. Creatore et al. CANADIAN MEDICAL ASSOCIATION JOURNAL
- SNARE Conformational Changes that Prepare Vesicles for Exocytosis
- (2010) Noriko Takahashi et al. Cell Metabolism
- Rim2α Determines Docking and Priming States in Insulin Granule Exocytosis
- (2010) Takao Yasuda et al. Cell Metabolism
- Electrical activity and exocytotic correlates of biphasic insulin secretion from β-cells of canine islets of Langerhans: Contribution of tuning two modes of Ca2+entry-dependent exocytosis to two modes of glucose-induced electrical activity
- (2010) Stanley Misler et al. Channels
- Phasic and tonic modes of depolarization-exocytosis coupling in β-cells of porcine islets of Langerhans
- (2010) Stanley Misler et al. Channels
- Rab GEFs and GAPs
- (2010) Francis Barr et al. CURRENT OPINION IN CELL BIOLOGY
- -Aminobutyric Acid (GABA) Is an Autocrine Excitatory Transmitter in Human Pancreatic -Cells
- (2010) M. Braun et al. DIABETES
- Progression of Diet-Induced Diabetes in C57BL6J Mice Involves Functional Dissociation of Ca2+ Channels From Secretory Vesicles
- (2010) S. C. Collins et al. DIABETES
- Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in -Cells Inhibits Glucagon Secretion From Human Islets
- (2010) R. Ramracheya et al. DIABETES
- Unique Arrangement of - and -Cells in Human Islets of Langerhans
- (2010) D. Bosco et al. DIABETES
- BK channels affect glucose homeostasis and cell viability of murine pancreatic beta cells
- (2010) M. Düfer et al. DIABETOLOGIA
- A mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a glucose-intolerant phenotype in the mouse
- (2010) A. Hugill et al. DIABETOLOGIA
- Characteristics and Functions of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionate Receptors Expressed in Mouse Pancreatic α-Cells
- (2010) Jung-Hwa Cho et al. ENDOCRINOLOGY
- Tissue-specific disallowance of housekeeping genes: The other face of cell differentiation
- (2010) L. Thorrez et al. GENOME RESEARCH
- The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice
- (2010) Antonia Sassmann et al. JOURNAL OF CLINICAL INVESTIGATION
- Activation of the KATPchannel by Mg-nucleotide interaction with SUR1
- (2010) Peter Proks et al. JOURNAL OF GENERAL PHYSIOLOGY
- BK channels mediate a novel ionic mechanism that regulates glucose-dependent electrical activity and insulin secretion in mouse pancreatic β-cells
- (2010) Khaled M. Houamed et al. JOURNAL OF PHYSIOLOGY-LONDON
- Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses
- (2010) David A. Jacobson et al. JOURNAL OF PHYSIOLOGY-LONDON
- TRPM2: a multifunctional ion channel for calcium signalling
- (2010) Adriana Sumoza-Toledo et al. JOURNAL OF PHYSIOLOGY-LONDON
- Leucine metabolism in regulation of insulin secretion from pancreatic beta cells
- (2010) Jichun Yang et al. NUTRITION REVIEWS
- Glutamate Receptor Ion Channels: Structure, Regulation, and Function
- (2010) S. F. Traynelis et al. PHARMACOLOGICAL REVIEWS
- Ca2+-Activated K+ Channels: From Protein Complexes to Function
- (2010) Henrike Berkefeld et al. PHYSIOLOGICAL REVIEWS
- Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
- (2010) Hiroshi Hibino et al. PHYSIOLOGICAL REVIEWS
- Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes
- (2010) Lorella Marselli et al. PLoS One
- Neuronal Calcium Sensor Synaptotagmin-9 Is Not Involved in the Regulation of Glucose Homeostasis or Insulin Secretion
- (2010) Natalia Gustavsson et al. PLoS One
- ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic cell
- (2010) M. C. Jacques-Silva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice
- (2010) B. Colsoul et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Channel-Mediated Tonic GABA Release from Glia
- (2010) S. Lee et al. SCIENCE
- Doc2b Is a High-Affinity Ca2+ Sensor for Spontaneous Neurotransmitter Release
- (2010) A. J. Groffen et al. SCIENCE
- The insulin secretory granule as a signaling hub
- (2010) Jakob Suckale et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Exocytotic Properties of Human Pancreatic β-cells
- (2009) Matthias Braun et al. Annals of the New York Academy of Sciences
- Single-Molecule Studies of the Neuronal SNARE Fusion Machinery
- (2009) Axel T. Brunger et al. Annual Review of Biochemistry
- PIP2-Binding Site in Kir Channels: Definition by Multiscale Biomolecular Simulations
- (2009) Phillip J. Stansfeld et al. BIOCHEMISTRY
- Suppression of Sulfonylurea- and Glucose-Induced Insulin Secretion In Vitro and In Vivo in Mice Lacking the Chloride Transport Protein ClC-3
- (2009) Dai-Qing Li et al. Cell Metabolism
- Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca2+ Channels from Secretory Granules
- (2009) Michael B. Hoppa et al. Cell Metabolism
- Rac1 GTPase: A “Rac” of All Trades
- (2009) E. E. Bosco et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Munc18c Depletion Selectively Impairs the Sustained Phase of Insulin Release
- (2009) E. Oh et al. DIABETES
- Enhanced Glucose Tolerance by SK4 Channel Inhibition in Pancreatic -Cells
- (2009) M. Dufer et al. DIABETES
- Niflumic acid-sensitive ion channels play an important role in the induction of glucose-stimulated insulin secretion by cyclic AMP in mice
- (2009) W. Fujimoto et al. DIABETOLOGIA
- Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes
- (2009) M. J. MacDonald et al. DIABETOLOGIA
- The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation
- (2009) M. Cnop et al. DIABETOLOGIA
- Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells
- (2009) M. Braun et al. DIABETOLOGIA
- The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic β-cell line
- (2009) Leigh Anne Swayne et al. EMBO REPORTS
- NALCN: a regulated leak channel
- (2009) Patrick Gilon et al. EMBO REPORTS
- Impaired Insulin Exocytosis in Neural Cell Adhesion Molecule−/−Mice Due to Defective Reorganization of the Submembrane F-Actin Network
- (2009) Charlotta S. Olofsson et al. ENDOCRINOLOGY
- Regulation of voltage-gated K+channels by glucose metabolism in pancreatic β-cells
- (2009) Masashi Yoshida et al. FEBS LETTERS
- Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis
- (2009) Kenji Sugawara et al. GENES TO CELLS
- The Ca2+Affinity of Synaptotagmin 1 Is Markedly Increased by a Specific Interaction of Its C2B Domain with Phosphatidylinositol 4,5-Bisphosphate
- (2009) Anand Radhakrishnan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Characterization of Erg K+Channels in α- and β-Cells of Mouse and Human Islets
- (2009) Alexandre B. Hardy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins
- (2009) Z. Wang et al. JOURNAL OF CELL SCIENCE
- NAADP mobilizes calcium from acidic organelles through two-pore channels
- (2009) Peter J. Calcraft et al. NATURE
- Synaptotagmin IV: a multifunctional regulator of peptidergic nerve terminals
- (2009) Zhenjie Zhang et al. NATURE NEUROSCIENCE
- Electrophysiological and Immunocytochemical Evidence for P2X Purinergic Receptors in Pancreatic β Cells
- (2009) Amélia M. Silva et al. PANCREAS
- Hyperpolarization-Activated Cation Channels: From Genes to Function
- (2009) Martin Biel et al. PHYSIOLOGICAL REVIEWS
- Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice
- (2009) K. Lemaire et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3
- (2009) A. Ragvin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- miR-375 maintains normal pancreatic - and -cell mass
- (2009) M. N. Poy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The cAMP Sensor Epac2 Is a Direct Target of Antidiabetic Sulfonylurea Drugs
- (2009) C.-L. Zhang et al. SCIENCE
- Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes
- (2009) A. H. Rosengren et al. SCIENCE
- Membrane Fusion: Grappling with SNARE and SM Proteins
- (2009) T. C. Sudhof et al. SCIENCE
- Metabolic cycling in control of glucose-stimulated insulin secretion
- (2008) Mette V. Jensen et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Insulin Signaling in the Pancreatic β-Cell
- (2008) Ingo B. Leibiger et al. Annual Review of Nutrition
- Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs
- (2008) Pascal Lovis et al. BIOLOGICAL CHEMISTRY
- Glutamate Is a Positive Autocrine Signal for Glucagon Release
- (2008) Over Cabrera et al. Cell Metabolism
- CAPS1 and CAPS2 Regulate Stability and Recruitment of Insulin Granules in Mouse Pancreatic β Cells
- (2008) Dina Speidel et al. Cell Metabolism
- Glucose-Induced Cyclic AMP Oscillations Regulate Pulsatile Insulin Secretion
- (2008) Oleg Dyachok et al. Cell Metabolism
- Voltage-Gated Ion Channels in Human Pancreatic -Cells: Electrophysiological Characterization and Role in Insulin Secretion
- (2008) M. Braun et al. DIABETES
- Pancreatic β-cell mass in European subjects with type 2 diabetes
- (2008) J. Rahier et al. DIABETES OBESITY & METABOLISM
- Adipose tissue fatty acid metabolism in insulin-resistant men
- (2008) A. S. T. Bickerton et al. DIABETOLOGIA
- Inhibition of Cholesterol Biosynthesis Impairs Insulin Secretion and Voltage-Gated Calcium Channel Function in Pancreatic β-Cells
- (2008) Fuzhen Xia et al. ENDOCRINOLOGY
- Deletion of the G Protein-Coupled Receptor 30 Impairs Glucose Tolerance, Reduces Bone Growth, Increases Blood Pressure, and Eliminates Estradiol-Stimulated Insulin Release in Female Mice
- (2008) Ulrika E. A. Mårtensson et al. ENDOCRINOLOGY
- Obesity and Free Fatty Acids
- (2008) Guenther Boden ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
- Insulin secretion is highly sensitive to desorption of plasma membrane cholesterol
- (2008) Jenny Vikman et al. FASEB JOURNAL
- pVHL is a regulator of glucose metabolism and insulin secretion in pancreatic cells
- (2008) J. Zehetner et al. GENES & DEVELOPMENT
- Filamentous Actin Regulates Insulin Exocytosis through Direct Interaction with Syntaxin 4
- (2008) Jenna L. Jewell et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of Insulin Granule Turnover in Pancreatic β-Cells by Cleaved ICA512
- (2008) Mirko Trajkovski et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Deletion of the von Hippel–Lindau gene in pancreatic β cells impairs glucose homeostasis in mice
- (2008) James Cantley et al. JOURNAL OF CLINICAL INVESTIGATION
- Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic β cells recapitulates neonatal diabetes
- (2008) Christophe A. Girard et al. JOURNAL OF CLINICAL INVESTIGATION
- How ATP Inhibits the Open KATPChannel
- (2008) Tim J. Craig et al. JOURNAL OF GENERAL PHYSIOLOGY
- Role of the Vesicular Chloride Transporter ClC-3 in Neuroendocrine Tissue
- (2008) T. Maritzen et al. JOURNAL OF NEUROSCIENCE
- Kinetics of Rab27a-dependent actions on vesicle docking and priming in pancreatic β-cells
- (2008) Matthew J. Merrins et al. JOURNAL OF PHYSIOLOGY-LONDON
- Novel aspects of the molecular mechanisms controlling insulin secretion
- (2008) Lena Eliasson et al. JOURNAL OF PHYSIOLOGY-LONDON
- The Orphan Transporter Rxt1/NTT4 (SLC6A17) Functions as a Synaptic Vesicle Amino Acid Transporter Selective for Proline, Glycine, Leucine, and Alanine
- (2008) L. A. Parra et al. MOLECULAR PHARMACOLOGY
- Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
- (2008) Kazuki Yasuda et al. NATURE GENETICS
- SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
- (2008) Hiroyuki Unoki et al. NATURE GENETICS
- The fusion pores of Ca2+-triggered exocytosis
- (2008) Meyer B Jackson et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Kiss-and-run exocytosis and fusion pores of secretory vesicles in human β-cells
- (2008) Salma T. Hanna et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Adrenaline-induced hyperpolarization of mouse pancreatic islet cells is mediated by G protein-gated inwardly rectifying potassium (GIRK) channels
- (2008) Shachar Iwanir et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Cell coupling in mouse pancreatic -cells measured in intact islets of Langerhans
- (2008) Q. Zhang et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
- Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice
- (2008) N. Gustavsson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of a vesicular nucleotide transporter
- (2008) K. Sawada et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Docking is not a Prerequisite but a Temporal Constraint for Fusion of Secretory Granules
- (2008) Kazuo Kasai et al. TRAFFIC
- Type 2 diabetes: new genes, new understanding
- (2008) Inga Prokopenko et al. TRENDS IN GENETICS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started