Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca 2+ Sensitivity of Insulin Secretion Vesicles

(2018) Chen Huang et al.   DEVELOPMENTAL CELL

Disallowed and Allowed Gene Expression: Two Faces of Mature Islet Beta Cells

(2016) Katleen Lemaire et al.   Annual Review of Nutrition

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

(2016) H. Efsun Arda et al.   Cell Metabolism

ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells

(2016) Eiji Yoshihara et al.   Cell Metabolism

Mitochondrial Cristae: Where Beauty Meets Functionality

(2016) Sara Cogliati et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dynamics and Regulation of Insulin Secretion in Pancreatic Islets from Normal Young Children

(2016) Jean-Claude Henquin et al.   PLoS One

Islet formation in mice and men: lessons for the generation of functional insulin-producing β-cells from human pluripotent stem cells

(2015) Gopika Nair et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Weaning Triggers a Maturation Step of Pancreatic β Cells

(2015) Miri Stolovich-Rain et al.   DEVELOPMENTAL CELL

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function

(2015) David W. Scoville et al.   DIABETES

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

DNA methylation directs functional maturation of pancreatic β cells

(2015) Sangeeta Dhawan et al.   JOURNAL OF CLINICAL INVESTIGATION

Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning

(2015) Cécile Jacovetti et al.   Nature Communications

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Differentiated human stem cells resemble fetal, not adult, β cells

(2014) Sinisa Hrvatin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

(2013) Brandon L. Taylor et al.   Cell Reports

Sympathetic Innervation during Development Is Necessary for Pancreatic Islet Architecture and Functional Maturation

(2013) Philip Borden et al.   Cell Reports

Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010

(2012) F. B. Barton et al.   DIABETES CARE

Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life

(2012) Brigid E. Gregg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pax6 Is Crucial for β-Cell Function, Insulin Biosynthesis, and Glucose-Induced Insulin Secretion

(2012) Yvan Gosmain et al.   MOLECULAR ENDOCRINOLOGY

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3

(2012) Barak Blum et al.   NATURE BIOTECHNOLOGY

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells

(2011) A. Jermendy et al.   DIABETOLOGIA

Transcriptomes of the major human pancreatic cell types

(2011) C. Dorrell et al.   DIABETOLOGIA

Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets

(2011) C. Dai et al.   DIABETOLOGIA

Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas

(2011) M. J. Riedel et al.   DIABETOLOGIA

Microfluidic perifusion and imaging device for multi-parametric islet function assessment

(2010) Adeola F. Adewola et al.   BIOMEDICAL MICRODEVICES

Pancreatic β Cells Require NeuroD to Achieve and Maintain Functional Maturity

(2010) Chunyan Gu et al.   Cell Metabolism

Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells

(2010) C. Aguayo-Mazzucato et al.   DIABETOLOGIA

Quantitative analysis of cell composition and purity of human pancreatic islet preparations

(2010) Anna Pisania et al.   LABORATORY INVESTIGATION

Pseudoislets as primary islet replacements for research

(2010) Shanta J. Persaud et al.   Islets

Islet-1 is Required for the Maturation, Proliferation, and Survival of the Endocrine Pancreas

(2009) A. Du et al.   DIABETES

Endocrine Cell Clustering During Human Pancreas Development

(2009) Jongmin Jeon et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

The importance of chromogranin A in the development and function of endocrine pancreas

(2008) G.M. Portela-Gomes et al.   REGULATORY PEPTIDES