Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

Diminished glucagon suppression after β-cell reduction is due to impaired α-cell function rather than an expansion of α-cell mass

(2011) Juris J. Meier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Chronic reduction of insulin receptors in the ventromedial hypothalamus produces glucose intolerance and islet dysfunction in the absence of weight gain

(2011) Sachin A. Paranjape et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

(2011) Jianxin Yang et al.   BMC GENOMICS

Glucagon as a Critical Factor in the Pathology of Diabetes

(2011) D. S. Edgerton et al.   DIABETES

Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice

(2011) Y. Lee et al.   DIABETES

Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice

(2011) Fabrizio Thorel et al.   DIABETES

Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis

(2011) Safina Ali et al.   JOURNAL OF CLINICAL INVESTIGATION

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

(2011) Judith Y. Altarejos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Unique Arrangement of  - and  -Cells in Human Islets of Langerhans

(2010) D. Bosco et al.   DIABETES

Influence of Insulin in the Ventromedial Hypothalamus on Pancreatic Glucagon Secretion In Vivo

(2010) S. A. Paranjape et al.   DIABETES

Glucose Suppression of Glucagon Secretion

(2010) Sylvain J. Le Marchand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paracrinology of islets and the paracrinopathy of diabetes

(2010) R. H. Unger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin therapy in insulin-deficient type I diabetes

(2010) M.-y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice

(2010) T. Fujikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; a benefit beyond weight and appetite regulation

(2009) Satya P. Kalra   PEPTIDES

The Glucagon Receptor Is Required for the Adaptive Metabolic Response to Fasting

(2008) Christine Longuet et al.   Cell Metabolism

Making insulin-deficient type 1 diabetic rodents thrive without insulin

(2008) X. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA