Recent advances in microfluidic technology and applications for anti-cancer drug screening

On-chip MIC by Combining Concentration Gradient Generator and Flanged Chamber Arrays

(2020) Xiao-Yan Zhang et al.   Micromachines

Urothelial Carcinoma of the Bladder Induces Endothelial Cell Activation and Hypercoagulation

(2020) Axel John et al.   MOLECULAR CANCER RESEARCH

Miniaturized technologies for high-throughput drug screening enzymatic assays and diagnostics – A review

(2020) Sarah A.P. Pereira et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

An integrated array chip for high-throughput screening species differences in metabolism

(2020) Xiaoni Ai et al.   ANALYTICAL CHEMISTRY

Cancer cell migration and cancer drug screening in oxygen tension gradient chip

(2020) Hyeono Nam et al.   Biomicrofluidics

Building three-dimensional lung models for studying pharmacokinetics of inhaled drugs

(2020) Andreia Sofia Barros et al.   ADVANCED DRUG DELIVERY REVIEWS

Recent advances in microfluidic devices for bacteria and fungus research

(2019) Wenting Zhou et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Tumor Extracellular Matrix Remodeling: New Perspectives as a Circulating Tool in the Diagnosis and Prognosis of Solid Tumors

(2019) Marta Giussani et al.   Cells

Patient-specific organotypic blood vessels as an in vitro model for anti-angiogenic drug response testing in renal cell carcinoma

(2019) José A. Jiménez-Torres et al.   EBioMedicine

Single step fabrication of Silicon resistors on SOI substrate used as Thermistors

(2019) Serena Rollo et al.   Scientific Reports

A novel microfluidic device capable of maintaining functional thyroid carcinoma specimens ex vivo provides a new drug screening platform

(2019) Andrew Riley et al.   BMC CANCER

On-Chip Anticancer Drug Screening – Recent Progress in Microfluidic Platforms to Address Challenges in Chemotherapy

(2019) Nandini Dhiman et al.   BIOSENSORS & BIOELECTRONICS

A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy

(2019) Hee-Gyeong Yi et al.   Nature Biomedical Engineering

The extracellular matrix in tumor progression and metastasis

(2019) Johannes A. Eble et al.   CLINICAL & EXPERIMENTAL METASTASIS

Matrix metalloproteinases participation in the metastatic process and their diagnostic and therapeutic applications in cancer

(2019) Georgina Gonzalez-Avila et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Recent advances in microfluidic platforms for single-cell analysis in cancer biology, diagnosis and therapy

(2019) Hamed Tavakoli et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Cell-based Drug Screening on Microfluidics

(2019) Jiao Zhai et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Colorectal tumor-on-a-chip system: A 3D tool for precision onco-nanomedicine

(2019) M. R. Carvalho et al.   Science Advances

Microphysiological Engineering of Self-Assembled and Perfusable Microvascular Beds for the Production of Vascularized Three-Dimensional Human Microtissues

(2019) Jungwook Paek et al.   ACS Nano

Bi-layer blood vessel mimicking microfluidic platform for antitumor drug screening based on co-culturing 3D tumor spheroids and endothelial layers

(2019) Wentao Shi et al.   Biomicrofluidics

In vitro lung cancer multicellular tumor spheroid formation using a microfluidic device

(2019) Sang Woo Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

In vitro humanized 3D microfluidic chip for testing personalized immunotherapeutics for head and neck cancer patients

(2019) Ahmed Al-Samadi et al.   EXPERIMENTAL CELL RESEARCH

Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics

(2019) Christopher W. McAleer et al.   Science Translational Medicine

Mechanical characterization of single cells based on microfluidic techniques

(2019) Jianyong Huang et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Digital microfluidics for cell manipulation

(2019) Long Pang et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

An on-chip model of protein paracellular and transcellular permeability in the microcirculation

(2019) Giovanni S. Offeddu et al.   BIOMATERIALS

Indistinguishable Photons from Deterministically Integrated Single Quantum Dots in Heterogeneous GaAs/Si3N4 Quantum Photonic Circuits

(2019) Peter Schnauber et al.   NANO LETTERS

A 3D tumor spheroid model for the T98G Glioblastoma cell line phenotypic characterization

(2019) Mariam-Eleni Oraiopoulou et al.   TISSUE & CELL

Blood–Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease

(2019) Yoojin Shin et al.   Advanced Science

A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling

(2019) Duc-Huy T. Nguyen et al.   Science Advances

A view on drug resistance in cancer

(2019) Neil Vasan et al.   NATURE

Leveling Up Hydrogels: Hybrid Systems in Tissue Engineering

(2019) Sara C. Neves et al.   TRENDS IN BIOTECHNOLOGY

Increased Flexibility in Lab-on-Chip Design with a Polymer Patchwork Approach

(2019) Denise Pezzuoli et al.   Nanomaterials

Three-gradient constructions in a flow-rate insensitive microfluidic system for drug screening towards personalized treatment

(2019) Shaofei Shen et al.   TALANTA

A novel 3D breast-cancer-on-chip platform for therapeutic evaluation of drug delivery systems

(2018) Yongli Chen et al.   ANALYTICA CHIMICA ACTA

Droplet Array-Based 3D Coculture System for High-Throughput Tumor Angiogenesis Assay

(2018) Xiaohui Du et al.   ANALYTICAL CHEMISTRY

Gene Expression on DNA Biochips Patterned with Strand-Displacement Lithography

(2018) Günther Pardatscher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microfluidic chip for non-invasive analysis of tumor cells interaction with anti-cancer drug doxorubicin by AFM and Raman spectroscopy

(2018) Han Zhang et al.   Biomicrofluidics

Patient-Customized Drug Combination Prediction and Testing for T-cell Prolymphocytic Leukemia Patients

(2018) Liye He et al.   CANCER RESEARCH

DCE-MRI–Derived Measures of Tumor Hypoxia and Interstitial Fluid Pressure Predict Outcomes in Cervical Carcinoma

(2018) Trude G. Simonsen et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Nanofiber membrane supported lung-on-a-chip microdevice for anti-cancer drug testing

(2018) Xingyuan Yang et al.   LAB ON A CHIP

A Spontaneous 3D Bone-On-a-Chip for Bone Metastasis Study of Breast Cancer Cells

(2018) Sijie Hao et al.   Small

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro

(2018) Bryan A. Hassell et al.   Cell Reports

Isolation and Identification of Proteins Secreted by Cells Cultured within Synthetic Hydrogel-Based Matrices

(2018) Lisa A. Sawicki et al.   ACS Biomaterials-Science & Engineering

Isolation and Identification of Proteins Secreted by Cells Cultured within Synthetic Hydrogel-Based Matrices

(2018) Lisa A. Sawicki et al.   ACS Biomaterials Science & Engineering

Single-cell assay on microfluidic devices

(2018) Qiushi Huang et al.   ANALYST

Reconstituting Glioma Perivascular Niches on a Chip for Insights into Chemoresistance of Glioma

(2018) Caihou Lin et al.   ANALYTICAL CHEMISTRY

Engineered 3D tumour model for study of glioblastoma aggressiveness and drug evaluation on a detachably assembled microfluidic device

(2018) Jingyun Ma et al.   BIOMEDICAL MICRODEVICES

Applications of tumor chip technology

(2018) Stephanie J. Hachey et al.   LAB ON A CHIP

Scalable Multiplexed Drug-Combination Screening Platforms Using 3D Microtumor Model for Precision Medicine

(2018) Zhixiong Zhang et al.   Small

3D microfluidic in vitro model and bioinformatics integration to study the effects of Spatholobi Caulis tannin in cervical cancer

(2018) Nijia Wang et al.   Scientific Reports

Tumor-Vasculature-on-a-Chip for Investigating Nanoparticle Extravasation and Tumor Accumulation

(2018) Hao-Fei Wang et al.   ACS Nano

Role of Extracellular Matrix in Development and Cancer Progression

(2018) Cameron Walker et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glass-based organ-on-a-chip device for restricting small molecular absorption

(2018) Hirotada Hirama et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Near-physiological microenvironment simulation on chip to evaluate drug resistance of different loci in tumour mass

(2018) Shiqi Wang et al.   TALANTA

One-Step Generation of a Drug-Releasing Hydrogel Microarray-On-A-Chip for Large-Scale Sequential Drug Combination Screening

(2018) Seo Woo Song et al.   Advanced Science

Tumor Microenvironment and Metabolism

(2017) Li Yang   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting Immunotherapy to the Tumor Microenvironment

(2017) Michael Dougan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Differential response to doxorubicin in breast cancer subtypes simulated by a microfluidic tumor model

(2017) Altug Ozcelikkale et al.   JOURNAL OF CONTROLLED RELEASE

Improved bovine embryo production in an oviduct-on-a-chip system: prevention of poly-spermic fertilization and parthenogenic activation

(2017) Marcia A. M. M. Ferraz et al.   LAB ON A CHIP

A novel 3-D bio-microfluidic system mimicking in vivo heterogeneous tumour microstructures reveals complex tumour–stroma interactions

(2017) Qihui Fan et al.   LAB ON A CHIP

A tuneable microfluidic system for long duration chemotaxis experiments in a 3D collagen matrix

(2017) Koceila Aizel et al.   LAB ON A CHIP

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

(2017) Duc T. T. Phan et al.   LAB ON A CHIP

Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets

(2017) Giovanni Lenguito et al.   LAB ON A CHIP

Orthotopic patient-derived xenografts of paediatric solid tumours

(2017) Elizabeth Stewart et al.   NATURE

Mechanical confinement regulates cartilage matrix formation by chondrocytes

(2017) Hong-pyo Lee et al.   NATURE MATERIALS

Recent advances in microfluidic 3D cellular scaffolds for drug assays

(2017) Jing Wu et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro

(2017) Bryan A. Hassell et al.   Cell Reports

Pharmacokinetics-on-a-Chip Using Label-Free SERS Technique for Programmable Dual-Drug Analysis

(2017) Jiayuan Fei et al.   ACS Sensors

Microfluidic cell isolation technology for drug testing of single tumor cells and their clusters

(2017) Swastika S. Bithi et al.   Scientific Reports

Drug screening of cancer cell lines and human primary tumors using droplet microfluidics

(2017) Ada Hang-Heng Wong et al.   Scientific Reports

A review of chemical gradient systems for cell analysis

(2016) Himali Somaweera et al.   ANALYTICA CHIMICA ACTA

Enzyme responsive GAG-based natural-synthetic hybrid hydrogel for tunable growth factor delivery and stem cell differentiation

(2016) Fraz Anjum et al.   BIOMATERIALS

Screening applications in drug discovery based on microfluidic technology

(2016) P. Eribol et al.   Biomicrofluidics

Polyethylene glycol (PEG) gel arrays for differentiating oligopeptide fragments and on-chip protease assays

(2016) Qingdi Zhu et al.   BIOSENSORS & BIOELECTRONICS

Cells on chip for multiplex screening

(2016) Ophélie I. Berthuy et al.   BIOSENSORS & BIOELECTRONICS

Sepsis-induced impairment of neutrophil chemotaxis on a microfluidic chip

(2016) Xiaoguang Lu et al.   IMMUNOLOGY LETTERS

Combination therapeutics in complex diseases

(2016) Bing He et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Transitioning from multi-phase to single-phase microfluidics for long-term culture and treatment of multicellular spheroids

(2016) Kay S. McMillan et al.   LAB ON A CHIP

Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics

(2016) Nachiket Shembekar et al.   LAB ON A CHIP

Generation and functional assessment of 3D multicellular spheroids in droplet based microfluidics platform

(2016) P. Sabhachandani et al.   LAB ON A CHIP

Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment

(2016) R. Portillo-Lara et al.   LAB ON A CHIP

Development of DNA-based signal amplification and microfluidic technology for protein assay: A review

(2016) Xuexia Lin et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Biomaterial-based microfluidics for cell culture and analysis

(2016) Ruizhi Ning et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Chemical and biochemical analysis on lab-on-a-chip devices fabricated using three-dimensional printing

(2016) Yan Zhang et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Droplet microfluidics: A tool for biology, chemistry and nanotechnology

(2016) Samaneh Mashaghi et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Microfluidic cell chips for high-throughput drug screening

(2016) Chun-Wei Chi et al.   Bioanalysis

Engineering a Brain Cancer Chip for High-throughput Drug Screening

(2016) Yantao Fan et al.   Scientific Reports

Investigation of the Influence of Glucose Concentration on Cancer Cells by Using a Microfluidic Gradient Generator without the Induction of Large Shear Stress

(2016) Tadashi Ishida et al.   Micromachines

Excessive collagen turnover products are released during colorectal cancer progression and elevated in serum from metastatic colorectal cancer patients

(2016) S. N. Kehlet et al.   Scientific Reports

3D microtumors in vitro supported by perfused vascular networks

(2016) Agua Sobrino et al.   Scientific Reports

Development and characterization of a microfluidic model of the tumour microenvironment

(2016) Jose M. Ayuso et al.   Scientific Reports

On-chip gradient generation in 256 microfluidic cell cultures: simulation and experimental validation

(2015) Himali Somaweera et al.   ANALYST

Drug cytotoxicity and signaling pathway analysis with three-dimensional tumor spheroids in a microwell-based microfluidic chip for drug screening

(2015) Yongli Chen et al.   ANALYTICA CHIMICA ACTA

Microfluidic Platform for Studying Chemotaxis of Adhesive Cells Revealed a Gradient-Dependent Migration and Acceleration of Cancer Stem Cells

(2015) Heng Zou et al.   ANALYTICAL CHEMISTRY

A novel microfluidic platform for studying mammalian cell chemotaxis in different oxygen environments under zero-flow conditions

(2015) Wei Yang et al.   Biomicrofluidics

A microengineered pathophysiological model of early-stage breast cancer

(2015) Yoonseok Choi et al.   LAB ON A CHIP

Collagen matrix as a tool in studying fibroblastic cell behavior

(2015) Jiří Kanta   Cell Adhesion & Migration

A novel hanging spherical drop system for the generation of cellular spheroids and high throughput combinatorial drug screening

(2015) A. I. Neto et al.   Biomaterials Science

Spherical Cancer Models in Tumor Biology

(2015) Louis-Bastien Weiswald et al.   NEOPLASIA

Superhydrophobic Chips for Cell Spheroids High-Throughput Generation and Drug Screening

(2014) Mariana B. Oliveira et al.   ACS Applied Materials & Interfaces

Addressable droplet microarrays for single cell protein analysis

(2014) Ali Salehi-Reyhani et al.   ANALYST

Mixed hydrogel bead-based tumor spheroid formation and anticancer drug testing

(2014) Yaolei Wang et al.   ANALYST

Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions

(2014) Naveen S. Vasudev et al.   ANGIOGENESIS

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

(2014) Fatemeh Sadat Tabatabaei Mirakabad et al.   Asian Pacific Journal of Cancer Prevention

Parallel microfluidic chemosensitivity testing on individual slice cultures

(2014) Tim C. Chang et al.   LAB ON A CHIP

The present and future role of microfluidics in biomedical research

(2014) Eric K. Sackmann et al.   NATURE

Cell-Based Drug Combination Screening with a Microfluidic Droplet Array System

(2013) Guan-Sheng Du et al.   ANALYTICAL CHEMISTRY

On-chip magnetic separation and encapsulation of cells in droplets

(2013) Aaron Chen et al.   LAB ON A CHIP

A reduced-order model for whole-chip thermal analysis of microfluidic lab-on-a-chip systems

(2013) Yi Wang et al.   Microfluidics and Nanofluidics

Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro

(2013) K. Alessandri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integration of Self-Assembled Microvascular Networks with Microfabricated PEG-Based Hydrogels

(2012) Michael P. Cuchiara et al.   ADVANCED FUNCTIONAL MATERIALS

Multiple and High-Throughput Droplet Reactions via Combination of Microsampling Technique and Microfluidic Chip

(2012) Jinbo Wu et al.   ANALYTICAL CHEMISTRY

Stem cell microencapsulation for phenotypic control, bioprocessing, and transplantation

(2012) Jenna L. Wilson et al.   BIOTECHNOLOGY AND BIOENGINEERING

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Substrate Rigidity Regulates Human T Cell Activation and Proliferation

(2012) R. S. O'Connor et al.   JOURNAL OF IMMUNOLOGY

DropletMicroarray: facile formation of arrays of microdroplets and hydrogel micropads for cell screening applications

(2012) Erica Ueda et al.   LAB ON A CHIP

Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

(2012) Helge Wiig et al.   PHYSIOLOGICAL REVIEWS

Microfluidic Encapsulation of Cells in Polymer Microgels

(2012) Diego Velasco et al.   Small

A novel core–shell microcapsule for encapsulation and 3D culture of embryonic stem cells

(2012) Wujie Zhang et al.   Journal of Materials Chemistry B

Biomimetic tissues on a chip for drug discovery

(2011) Amir M. Ghaemmaghami et al.   DRUG DISCOVERY TODAY

Design properties of hydrogel tissue-engineering scaffolds

(2011) Junmin Zhu et al.   Expert Review of Medical Devices

Mechanisms of cancer cell metastasis to the bone: a multistep process

(2011) Lalit R Patel et al.   Future Oncology

Phase-separated chitosan–fibrin microbeads for cell delivery

(2011) Zhewei Chen et al.   JOURNAL OF MICROENCAPSULATION

A digital microfluidic method for multiplexed cell-based apoptosis assays

(2011) Dario Bogojevic et al.   LAB ON A CHIP

Synthesis and gelation characteristics of photo-crosslinkable star Poly(ethylene oxide-co-lactide-glycolide acrylate) macromonomers

(2011) Seyedsina Moeinzadeh et al.   POLYMER

Biocompatibility and Reduced Drug Absorption of Sol−Gel-Treated Poly(dimethyl siloxane) for Microfluidic Cell Culture Applications

(2010) Rafael Gomez-Sjoberg et al.   ANALYTICAL CHEMISTRY

Cell encapsulation using biopolymer gels for regenerative medicine

(2010) Nicola C. Hunt et al.   BIOTECHNOLOGY LETTERS

Tumors on chips: oncology meets microfluidics

(2010) Donald Wlodkowic et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Microfluidic Single-Cell Array Cytometry for the Analysis of Tumor Apoptosis

(2009) Donald Wlodkowic et al.   ANALYTICAL CHEMISTRY

Living-Cell Microarrays

(2009) Martin L. Yarmush et al.   Annual Review of Biomedical Engineering

A History of Cancer Chemotherapy

(2008) Vincent T. DeVita et al.   CANCER RESEARCH

Cell migration into scaffolds under co-culture conditions in a microfluidic platform

(2008) Seok Chung et al.   LAB ON A CHIP

Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays

(2008) Ansgar Huebner et al.   LAB ON A CHIP