Microfluidic cell chips for high-throughput drug screening

Synthetic microfluidic paper: high surface area and high porosity polymer micropillar arrays

(2016) Jonas Hansson et al.   LAB ON A CHIP

Interdependence of initial cell density, drug concentration and exposure time revealed by real-time impedance spectroscopic cytotoxicity assay

(2015) C. Caviglia et al.   ANALYST

Drug cytotoxicity and signaling pathway analysis with three-dimensional tumor spheroids in a microwell-based microfluidic chip for drug screening

(2015) Yongli Chen et al.   ANALYTICA CHIMICA ACTA

Impedimetric Toxicity Assay in Microfluidics Using Free and Liposome-Encapsulated Anticancer Drugs

(2015) Claudia Caviglia et al.   ANALYTICAL CHEMISTRY

Anti-fouling Coatings of Poly(dimethylsiloxane) Devices for Biological and Biomedical Applications

(2015) Hongbin Zhang et al.   Journal of Medical and Biological Engineering

A convection-driven long-range linear gradient generator with dynamic control

(2015) Hao Wang et al.   LAB ON A CHIP

Artery-on-a-chip platform for automated, multimodal assessment of cerebral blood vessel structure and function

(2015) Sanjesh Yasotharan et al.   LAB ON A CHIP

High-Throughput Microfluidic Platform for 3D Cultures of Mesenchymal Stem Cells, Towards Engineering Developmental Processes

(2015) Paola Occhetta et al.   Scientific Reports

Recent Developments in Paper-Based Microfluidic Devices

(2014) David M. Cate et al.   ANALYTICAL CHEMISTRY

Three Dimensional Microfluidic Cell Arrays for ex Vivo Drug Screening with Mimicked Vascular Flow

(2014) Zeynep Dereli-Korkut et al.   ANALYTICAL CHEMISTRY

Microfluidic System Based High Throughput Drug Screening System for Curcumin/TRAIL Combinational Chemotherapy in Human Prostate Cancer PC3 Cells

(2014) Dami An et al.   Biomolecules & Therapeutics

Selection of aptamers targeting the sialic acid receptor of hemagglutinin by epitope-specific SELEX

(2014) Yeh-Hsing Lao et al.   CHEMICAL COMMUNICATIONS

Research highlights: printing the future of microfabrication

(2014) Peter Tseng et al.   LAB ON A CHIP

Mail-order microfluidics: evaluation of stereolithography for the production of microfluidic devices

(2014) Anthony K. Au et al.   LAB ON A CHIP

Validating Antimetastatic Effects of Natural Products in an Engineered Microfluidic Platform Mimicking Tumor Microenvironment

(2014) Yiming Niu et al.   MOLECULAR PHARMACEUTICS

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

Dynamics of Microvalve Operations in Integrated Microfluidics

(2014) Alan Lau et al.   Micromachines

Materials for Microfluidic Chip Fabrication

(2013) Kangning Ren et al.   ACCOUNTS OF CHEMICAL RESEARCH

On-chip investigation of cell–drug interactions

(2013) Xin Ting Zheng et al.   ADVANCED DRUG DELIVERY REVIEWS

Microfluidic Image Cytometry (μFIC) Assessments of Silver Nanoparticle Cytotoxicity

(2013) Jonghoon Park et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Microfluidic heart on a chip for higher throughput pharmacological studies

(2013) Ashutosh Agarwal et al.   LAB ON A CHIP

Paper-based microfluidic point-of-care diagnostic devices

(2013) Ali Kemal Yetisen et al.   LAB ON A CHIP

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

A programmable microfluidic cell array for combinatorial drug screening

(2012) Jeongyun Kim et al.   LAB ON A CHIP

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

An integrated microfluidic cell culture system for high-throughput perfusion three-dimensional cell culture-based assays: effect of cell culture model on the results of chemosensitivity assays

(2012) Song-Bin Huang et al.   LAB ON A CHIP

Development of Polydimethylsiloxane Substrates with Tunable Elastic Modulus to Study Cell Mechanobiology in Muscle and Nerve

(2012) Rachelle N. Palchesko et al.   PLoS One

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Surface chemistry modification of PDMS elastomers with boiling water improves cellular adhesion

(2012) Joong Yull Park et al.   SENSORS AND ACTUATORS B-CHEMICAL

Development of an Indirect Stereolithography Technology for Scaffold Fabrication with a Wide Range of Biomaterial Selectivity

(2012) Hyun-Wook Kang et al.   TISSUE ENGINEERING PART C-METHODS

Let there be chip—towards rapid prototyping of microfluidic devices: one-step manufacturing processes

(2011) Ansgar Waldbaur et al.   Analytical Methods

Cultivation and recovery of vascular endothelial cells in microchannels of a separable micro-chemical chip

(2011) Tadahiro Yamashita et al.   BIOMATERIALS

Surface modification for PDMS-based microfluidic devices

(2011) Jinwen Zhou et al.   ELECTROPHORESIS

Imitation of drug metabolism in human liver and cytotoxicity assay using a microfluidic device coupled to mass spectrometric detection

(2011) Sifeng Mao et al.   LAB ON A CHIP

Impact of high-throughput screening in biomedical research

(2011) Ricardo Macarron et al.   NATURE REVIEWS DRUG DISCOVERY

Microvalves and Micropumps for BioMEMS

(2011) Anthony K. Au et al.   Micromachines

Bioprinting Endothelial Cells With Alginate for 3D Tissue Constructs

(2010) Saif Khalil et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers

(2010) Jane Wang et al.   Organogenesis

Bio-microfluidics: Biomaterials and Biomimetic Designs

(2009) Peter Domachuk et al.   ADVANCED MATERIALS

Flow-Based Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable, Competing Gradients

(2009) D. L. Englert et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

PMMA/PDMS valves and pumps for disposable microfluidics

(2009) Wenhua Zhang et al.   LAB ON A CHIP

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics

(2008) Colin L. Walsh et al.   LAB ON A CHIP

Generalized serial dilution module for monotonic and arbitrary microfluidic gradient generators

(2008) Kangsun Lee et al.   LAB ON A CHIP