Role of Extracellular Matrix in Development and Cancer Progression

FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis

(2018) Dariusz Lachowski et al.   FASEB JOURNAL

In vivo migration of endogenous brain progenitor cells guided by an injectable peptide amphiphile biomaterial

(2018) Reza Motalleb et al.   Journal of Tissue Engineering and Regenerative Medicine

Mechanotransduction in talin through the interaction of the R8 domain with DLC1

(2018) Alexander William M. Haining et al.   PLOS BIOLOGY

Linking Extracellular Matrix Agrin to the Hippo Pathway in Liver Cancer and Beyond

(2018) Sayan Chakraborty et al.   Cancers

RAP2 mediates mechanoresponses of the Hippo pathway

(2018) Zhipeng Meng et al.   NATURE

Extracellular matrix type modulates cell migration on mechanical gradients

(2017) Christopher D. Hartman et al.   EXPERIMENTAL CELL RESEARCH

The Solid Mechanics of Cancer and Strategies for Improved Therapy

(2017) Triantafyllos Stylianopoulos   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Aligned fibers direct collective cell migration to engineer closing and nonclosing wound gaps

(2017) Puja Sharma et al.   MOLECULAR BIOLOGY OF THE CELL

The extracellular matrix protein agrin promotes heart regeneration in mice

(2017) Elad Bassat et al.   NATURE

Regulation of genome organization and gene expression by nuclear mechanotransduction

(2017) Caroline Uhler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration

(2017) Tianhong Wang et al.   Nature Communications

Fluid shear stress activates YAP1 to promote cancer cell motility

(2017) Hyun Jung Lee et al.   Nature Communications

Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway

(2017) Sayan Chakraborty et al.   Cell Reports

Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

(2017) A J Rice et al.   Oncogenesis

Integrins as Therapeutic Targets: Successes and Cancers

(2017) Sabine Raab-Westphal et al.   Cancers

Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells

(2017) Dariusz Lachowski et al.   Scientific Reports

Spatiotemporal variation of endogenous cell-generated stresses within 3D multicellular spheroids

(2017) Adam A. Lucio et al.   Scientific Reports

All Subdomains of the Talin Rod Are Mechanically Vulnerable and May Contribute To Cellular Mechanosensing

(2016) Alexander William M. Haining et al.   ACS Nano

Impact of the physical microenvironment on tumor progression and metastasis

(2016) Fabian Spill et al.   CURRENT OPINION IN BIOTECHNOLOGY

Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

(2016) Sirio Dupont   EXPERIMENTAL CELL RESEARCH

Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs

(2016) Agata Jabłońska-Trypuć et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Dynamics of ferrofluid drop deformations under spatially uniform magnetic fields

(2016) P. Rowghanian et al.   JOURNAL OF FLUID MECHANICS

The extracellular matrix - the under-recognized element in lung disease?

(2016) Janette K Burgess et al.   JOURNAL OF PATHOLOGY

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

(2016) Li Wang et al.   NATURE

In vivo quantification of spatially varying mechanical properties in developing tissues

(2016) Friedhelm Serwane et al.   NATURE METHODS

Oriented collagen fibers direct tumor cell intravasation

(2016) Weijing Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

(2016) Kuei-Chun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease

(2016) FuiBoon Kai et al.   TRENDS IN CELL BIOLOGY

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

(2016) Antonios Chronopoulos et al.   Nature Communications

Syntenin: Key player in cancer exosome biogenesis and uptake?

(2016) Joanna Fares et al.   Cell Adhesion & Migration

Quantitative analysis of 3D extracellular matrix remodelling by pancreatic stellate cells

(2016) Benjamin K. Robinson et al.   Biology Open

Solid stress and elastic energy as measures of tumour mechanopathology

(2016) Hadi T. Nia et al.   Nature Biomedical Engineering

ATRA modulates mechanical activation of TGF-β by pancreatic stellate cells

(2016) Muge Sarper et al.   Scientific Reports

Adhesive ligand tether length affects the size and length of focal adhesions and influences cell spreading and attachment

(2016) Simon J. Attwood et al.   Scientific Reports

Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery

(2015) Fotios Mpekris et al.   Biomechanics and Modeling in Mechanobiology

The lymph node pre-metastatic niche

(2015) Jonathan P. Sleeman   JOURNAL OF MOLECULAR MEDICINE-JMM

Matrix metalloproteinases in stem cell regulation and cancer

(2015) Kai Kessenbrock et al.   MATRIX BIOLOGY

Matrix remodeling by MMPs during wound repair

(2015) Maryam G. Rohani et al.   MATRIX BIOLOGY

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

(2015) Thomas R. Cox et al.   NATURE

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer

(2015) Ruchi Malik et al.   TRENDS IN BIOTECHNOLOGY

An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma

(2015) Sayan Chakraborty et al.   Nature Communications

Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer

(2015) Suniti Misra et al.   Frontiers in Immunology

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

Extracellular matrix: A dynamic microenvironment for stem cell niche

(2014) Francesca Gattazzo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

3D Collagen Alignment Limits Protrusions to Enhance Breast Cancer Cell Persistence

(2014) Kristin M. Riching et al.   BIOPHYSICAL JOURNAL

Compression of Pancreatic Tumor Blood Vessels by Hyaluronan Is Caused by Solid Stress and Not Interstitial Fluid Pressure

(2014) Vikash P. Chauhan et al.   CANCER CELL

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Complex metastatic niches: already a target for therapy?

(2014) Paloma Ordóñez-Morán et al.   CURRENT OPINION IN CELL BIOLOGY

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

(2014) X. Varelas   DEVELOPMENT

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

(2014) Boon Chuan Low et al.   FEBS LETTERS

Hypoxia-inducible factors in regulation of immune responses in tumour microenvironment

(2014) Vinit Kumar et al.   IMMUNOLOGY

Traversing the basement membrane in vivo: A diversity of strategies

(2014) Laura C. Kelley et al.   JOURNAL OF CELL BIOLOGY

Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

(2014) Ovijit Chaudhuri et al.   NATURE MATERIALS

Extracellular matrix assembly: a multiscale deconstruction

(2014) Janna K. Mouw et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

An Indirect Way to Tame Cancer

(2014) Rakesh K. Jain   SCIENTIFIC AMERICAN

Haemodynamic and extracellular matrix cues regulate the mechanical phenotype and stiffness of aortic endothelial cells

(2014) Caitlin Collins et al.   Nature Communications

Structure and functions of syndecans in vertebrates

(2013) E. I. Leonova et al.   BIOCHEMISTRY-MOSCOW

The pre-metastatic niche: finding common ground

(2013) Jaclyn Sceneay et al.   CANCER AND METASTASIS REVIEWS

LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis

(2013) T. R. Cox et al.   CANCER RESEARCH

External Mechanical Cues Trigger the Establishment of the Anterior-Posterior Axis in Early Mouse Embryos

(2013) Ryuji Hiramatsu et al.   DEVELOPMENTAL CELL

The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo

(2013) Elliott J. Hagedorn et al.   JOURNAL OF CELL BIOLOGY

Syndecan-4 signaling at a glance

(2013) A. Elfenbein et al.   JOURNAL OF CELL SCIENCE

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Quantifying cell-generated mechanical forces within living embryonic tissues

(2013) Otger Campàs et al.   NATURE METHODS

Using transmission electron microscopy and 3View to determine collagen fibril size and three-dimensional organization

(2013) Tobias Starborg et al.   Nature Protocols

Nonmuscle myosin II powered transport of newly formed collagen fibrils at the plasma membrane

(2013) N. S. Kalson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combining two strategies to improve perfusion and drug delivery in solid tumors

(2013) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collagen as a double-edged sword in tumor progression

(2013) Min Fang et al.   TUMOR BIOLOGY

Effects of Membrane Trafficking on Signaling by Receptor Tyrosine Kinases

(2013) M. Miaczynska   Cold Spring Harbor Perspectives in Biology

Laminins in basement membrane assembly

(2013) Erhard Hohenester et al.   Cell Adhesion & Migration

Functional Diversity of Laminins

(2012) Anna Domogatskaya et al.   Annual Review of Cell and Developmental Biology

Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation

(2012) John P. Iredale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Molecular assembly and mechanical properties of the extracellular matrix: A fibrous protein perspective

(2012) Lisa D. Muiznieks et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Alpha-actinin interactions with syndecan-4 are integral to fibroblast–matrix adhesion and regulate cytoskeletal architecture

(2012) E. Okina et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Epidermal Basement Membrane Is a Composite of Separate Laminin- or Collagen IV-containing Networks Connected by Aggregated Perlecan, but Not by Nidogens

(2012) Daniel Timo Behrens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Cancer-Associated Fibroblasts Drive the Progression of Metastasis through both Paracrine and Mechanical Pressure on Cancer Tissue

(2012) G. S. Karagiannis et al.   MOLECULAR CANCER RESEARCH

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

(2012) Georg Halder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

(2012) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The YAP and TAZ transcription co-activators: Key downstream effectors of the mammalian Hippo pathway

(2012) Wanjin Hong et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Regulation of the Hippo pathway by cell architecture and mechanical signals

(2012) Molly C. Schroeder et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Prostate Cancer Increases Hyaluronan in Surrounding Nonmalignant Stroma, and This Response Is Associated with Tumor Growth and an Unfavorable Outcome

(2011) Andreas Josefsson et al.   AMERICAN JOURNAL OF PATHOLOGY

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

Degrading Devices: Invadosomes in Proteolytic Cell Invasion

(2011) Stefan Linder et al.   Annual Review of Cell and Developmental Biology

The Fluid Mechanics of Cancer and Its Therapy

(2011) Petros Koumoutsakos et al.   Annual Review of Fluid Mechanics

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Molecular organization of the basement membrane zone

(2011) Sana Hashmi et al.   CLINICS IN DERMATOLOGY

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton

(2011) Maria L. Lombardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor

(2011) Soo-Hyun Kim et al.   JOURNAL OF ENDOCRINOLOGY

Tumor Stress Inside Out: Cell-Extrinsic Effects of the Unfolded Protein Response in Tumor Cells Modulate the Immunological Landscape of the Tumor Microenvironment

(2011) N. R. Mahadevan et al.   JOURNAL OF IMMUNOLOGY

Interstitial guidance of cancer invasion

(2011) Pavlo G. Gritsenko et al.   JOURNAL OF PATHOLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Basement membrane sliding and targeted adhesion remodels tissue boundaries during uterine–vulval attachment in Caenorhabditis elegans

(2011) Shinji Ihara et al.   NATURE CELL BIOLOGY

Extracellular Matrix in Development: Insights from Mechanisms Conserved between Invertebrates and Vertebrates

(2011) N. H. Brown   Cold Spring Harbor Perspectives in Biology

Molecular Architecture and Function of Matrix Adhesions

(2011) B. Geiger et al.   Cold Spring Harbor Perspectives in Biology

Fibronectins, Their Fibrillogenesis, and In Vivo Functions

(2011) J. E. Schwarzbauer et al.   Cold Spring Harbor Perspectives in Biology

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Interactions Between Nuclei and the Cytoskeleton Are Mediated by SUN-KASH Nuclear-Envelope Bridges

(2010) Daniel A. Starr et al.   Annual Review of Cell and Developmental Biology

Assembly of Fibronectin Extracellular Matrix

(2010) Purva Singh et al.   Annual Review of Cell and Developmental Biology

Gr-1+CD11b+ Myeloid Cells Tip the Balance of Immune Protection to Tumor Promotion in the Premetastatic Lung

(2010) H. H. Yan et al.   CANCER RESEARCH

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Proteoglycans in health and disease: emerging concepts and future directions

(2010) Renato V. Iozzo et al.   FEBS Journal

Endogenous patterns of mechanical stress are required for branching morphogenesis

(2010) Nikolce Gjorevski et al.   Integrative Biology

Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination

(2010) Einar K. Rofstad et al.   INTERNATIONAL JOURNAL OF CANCER

Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia

(2010) Marie Schoumacher et al.   JOURNAL OF CELL BIOLOGY

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

The role of small leucine-rich proteoglycans in collagen fibrillogenesis

(2010) Sebastian Kalamajski et al.   MATRIX BIOLOGY

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

(2010) Robert W. Tilghman et al.   PLoS One

TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

(2010) Li Yang et al.   TRENDS IN IMMUNOLOGY

The Collagen Family

(2010) S. Ricard-Blum   Cold Spring Harbor Perspectives in Biology

Collagen Structure and Stability

(2009) Matthew D. Shoulders et al.   Annual Review of Biochemistry

PECAM-1 Is Necessary for Flow-Induced Vascular Remodeling

(2009) Zhongming Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Suprastructures of extracellular matrices: paradigms of functions controlled by aggregates rather than molecules

(2009) Peter Bruckner   CELL AND TISSUE RESEARCH

The extracellular matrix in development and morphogenesis: A dynamic view

(2009) Tania Rozario et al.   DEVELOPMENTAL BIOLOGY

Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma

(2009) S. A. Arnold et al.   Disease Models & Mechanisms

Integrin signalling at a glance

(2009) D. S. Harburger et al.   JOURNAL OF CELL SCIENCE

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells

(2009) Gang Cheng et al.   PLoS One

Defining the role of syndecan-4 in mechanotransduction using surface-modification approaches

(2009) Robert M. Bellin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

The 67 kDa laminin receptor: structure, function and role in disease

(2008) John Nelson et al.   BIOSCIENCE REPORTS

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Tube Travel: The Role of Proteases in Individual and Collective Cancer Cell Invasion

(2008) P. Friedl et al.   CANCER RESEARCH

Matrix metalloproteinase inhibitors as anticancer agents

(2007) P KONSTANTINOPOULOS et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

MMPs as therapeutic targets—Still a viable option?

(2007) B FINGLETON   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY