A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

An on-chip microfluidic pressure regulator that facilitates reproducible loading of cells and hydrogels into microphysiological system platforms

(2016) Xiaolin Wang et al.   LAB ON A CHIP

Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue

(2016) Mandy B. Esch et al.   LAB ON A CHIP

Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels

(2016) Xiaolin Wang et al.   LAB ON A CHIP

3D microtumors in vitro supported by perfused vascular networks

(2016) Agua Sobrino et al.   Scientific Reports

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

(2015) Jacquelyn A. Brown et al.   Biomicrofluidics

Instantaneous room temperature bonding of a wide range of non-silicon substrates with poly(dimethylsiloxane) (PDMS) elastomer mediated by a mercaptosilane

(2015) Wenming Wu et al.   LAB ON A CHIP

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

(2015) Anurag Mathur et al.   Scientific Reports

Organs-on-chips (microphysiological systems): tools to expedite efficacy and toxicity testing in human tissue

(2014) Kristin M Fabre et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase II and Phase III attrition rates 2011–2012

(2013) John Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Full range physiological mass transport control in 3D tissue cultures

(2012) Yu-Hsiang Hsu et al.   LAB ON A CHIP

Synapse microarray identification of small molecules that enhance synaptogenesis

(2011) Peng Shi et al.   Nature Communications

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Plastic masters—rigid templates for soft lithography

(2009) Salil P. Desai et al.   LAB ON A CHIP