Blood–Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Pericyte degeneration causes white matter dysfunction in the mouse central nervous system

(2018) Axel Montagne et al.   NATURE MEDICINE

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Blood-Brain Barrier Disruption Induced Cognitive Impairment Is Associated With Increase of Inflammatory Cytokine

(2018) Jieli Geng et al.   Frontiers in Aging Neuroscience

Investigation of Matrix Metalloproteinases, MMP-2 and MMP-9, in Plasma Reveals a Decrease of MMP-2 in Alzheimer's Disease

(2018) Nastasia K.-H. Lim et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeting Thrombin: An Inflammatory Neurotoxin in Alzheimer's Disease

(2018) Paula Grammas et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of brain vasculature in neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   NATURE NEUROSCIENCE

Blood-Brain Barrier: From Physiology to Disease and Back

(2018) Melanie D. Sweeney et al.   PHYSIOLOGICAL REVIEWS

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

(2017) Axel Montagne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells

(2017) Scott G. Canfield et al.   JOURNAL OF NEUROCHEMISTRY

Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells

(2017) Antje Appelt-Menzel et al.   Stem Cell Reports

Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening

(2016) Ying I. Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Immortalized endothelial cell lines for in vitro blood–brain barrier models: A systematic review

(2016) Nurul Adhwa Rahman et al.   BRAIN RESEARCH

High-Throughput Screening for Identification of Blood-Brain Barrier Integrity Enhancers: A Drug Repurposing Opportunity to Rectify Vascular Amyloid Toxicity

(2016) Hisham Qosa et al.   JOURNAL OF ALZHEIMERS DISEASE

Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit

(2016) Jacquelyn A. Brown et al.   Journal of Neuroinflammation

Astrocytes in physiological aging and Alzheimer’s disease

(2016) J.J. Rodríguez-Arellano et al.   NEUROSCIENCE

Blood-brain barrier mechanisms of neurodegeneration in Alzheimer’s disease

(2015) Berislav Zlokovic   Alzheimers & Dementia

A human in vitro blood–brain barrier model for measuring drug transport in Alzheimer’s disease

(2015) Jennifer L. Mantle et al.   Alzheimers & Dementia

The blood–brain barrier endothelium: a target for pro-inflammatory cytokines: Figure 1

(2015) Keith D. Rochfort et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Interferon-Gamma Increases Endothelial Permeability by Causing Activation of p38 MAP Kinase and Actin Cytoskeleton Alteration

(2015) Chin Theng Ng et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

A 3D human neural cell culture system for modeling Alzheimer's disease

(2015) Young Hye Kim et al.   Nature Protocols

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Mixed oligomers and monomeric amyloid-β disrupts endothelial cells integrity and reduces monomeric amyloid-β transport across hCMEC/D3 cell line as an in vitro blood–brain barrier model

(2014) Hisham Qosa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Interferon-gamma induced cell death: Regulation and contributions of nitric oxide, cJun N-terminal kinase, reactive oxygen species and peroxynitrite

(2014) Srabanti Rakshit et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Interferon-γ promotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)-1 and transforming growth factor (TGF) β2

(2013) Izabela Chrobak et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Autocrine MMP-2/9 secretion increases the BBB permeability in neuromyelitis optica

(2013) A. Tasaki et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Amyloid Beta Induces Oxidative Stress-Mediated Blood–Brain Barrier Changes in Capillary Amyloid Angiopathy

(2011) Anna Carrano et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuronal and Vascular Oxidative Stress in Alzheimers Disease

(2011) Cynthia A. Massaad   Current Neuropharmacology

Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins

(2011) Saran Feng et al.   PLoS One

Matrix Metalloproteinase 2 (MMP-2) Degrades Soluble Vasculotropic Amyloid-β E22Q and L34V Mutants, Delaying Their Toxicity for Human Brain Microvascular Endothelial Cells

(2010) Mar Hernandez-Guillamon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

The Concentration of Soluble Extracellular Amyloid-β Protein in Acute Brain Slices from CRND8 Mice

(2010) Jack Waters   PLoS One

Amyloid-β-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation

(2009) L.M. Tai et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Amyloid   Interaction with Receptor for Advanced Glycation End Products Up-Regulates Brain Endothelial CCR5 Expression and Promotes T Cells Crossing the Blood-Brain Barrier

(2009) M. Li et al.   JOURNAL OF IMMUNOLOGY